Age and sex differences in soluble ACE2 may give insights for COVID-19
SEE PDF] There was similar and low sACE2 in both sexes up to age 12. sACE2 increased more in boys with growth, so men from age 15 had higher sACE2 than women (Fig. 1). [...]sACE2 is low in children and increases more in boys than girls, resulting in sex differences in adolescence/young adulthood. Hi...
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| Published in | Critical care (London, England) Vol. 24; no. 1; pp. 221 - 3 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
BioMed Central
14.05.2020
BioMed Central Ltd Springer Nature B.V BMC |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1364-8535 1466-609X 1364-8535 1466-609X 1366-609X |
| DOI | 10.1186/s13054-020-02942-2 |
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| Abstract | SEE PDF] There was similar and low sACE2 in both sexes up to age 12. sACE2 increased more in boys with growth, so men from age 15 had higher sACE2 than women (Fig. 1). [...]sACE2 is low in children and increases more in boys than girls, resulting in sex differences in adolescence/young adulthood. High mACE2 and/or high ADAM-17 activity may therefore be risk factors for severe COVID-19 [1, 2]. Since high sACE2 could indicate high mACE2 and/or high ADAM-17 activity, sACE2 may be a marker of both susceptibility and severity of COVID-19. [...]this study shows that subjects with higher risk for severe COVID-19 [4] had higher sACE2 (adults>children and men>women). |
|---|---|
| AbstractList | SEE PDF] There was similar and low sACE2 in both sexes up to age 12. sACE2 increased more in boys with growth, so men from age 15 had higher sACE2 than women (Fig. 1). [...]sACE2 is low in children and increases more in boys than girls, resulting in sex differences in adolescence/young adulthood. High mACE2 and/or high ADAM-17 activity may therefore be risk factors for severe COVID-19 [1, 2]. Since high sACE2 could indicate high mACE2 and/or high ADAM-17 activity, sACE2 may be a marker of both susceptibility and severity of COVID-19. [...]this study shows that subjects with higher risk for severe COVID-19 [4] had higher sACE2 (adults>children and men>women). |
| ArticleNumber | 221 |
| Audience | Academic |
| Author | Karlsson, Magnus K. Rosengren, Björn E. Edsfeldt, Andreas Jehpsson, Lars Swärd, Per Reepalu, Anton |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32410690$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1001/jamacardio.2020.1329 10.1073/pnas.0711241105 10.3390/sports8040040 10.1016/j.yjmcc.2013.11.017 10.1001/jama.2020.4031 10.1007/s00134-020-05985-9 |
| ContentType | Journal Article |
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| CorporateAuthor | Clinical infection medicine Institutionen för translationell medicin Department of Translational Medicine Lunds universitet Profile areas and other strong research environments Department of Clinical Sciences, Malmö Lund University Strategiska forskningsområden (SFO) EpiHealth: Epidemiology for Health Orthopedics EXODIAB: Excellence of Diabetes Research in Sweden Faculty of Medicine Cardiovascular Research - Translational Studies Kardiovaskulär forskning - translationella studier Strategic research areas (SRA) Medicinska fakulteten Profilområden och andra starka forskningsmiljöer Institutionen för kliniska vetenskaper, Malmö Ortopedi Klinisk infektionsmedicin |
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| References | S Haga (2942_CR2) 2008; 105 2942_CR5 H Zhang (2942_CR1) 2020; 46 VB Patel (2942_CR3) 2014; 66 2942_CR6 2942_CR4 32631373 - Crit Care. 2020 Jul 6;24(1):396 |
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| Snippet | SEE PDF] There was similar and low sACE2 in both sexes up to age 12. sACE2 increased more in boys with growth, so men from age 15 had higher sACE2 than women... |
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| SubjectTerms | Adolescent Adults Age Factors Age groups Angiotensin-Converting Enzyme 2 Child Clinical Medicine Coronavirus Infections - enzymology Coronaviruses COVID-19 Critical care Critical Care Medicine Emergency Medicine Enzymes Female Gender differences Humans Infectious Medicine Infektionsmedicin Intensive Klinisk medicin Male Medical and Health Sciences Medicin och hälsovetenskap Medicine Medicine & Public Health Osteoporosis Pandemics Pediatrics Peptidyl-Dipeptidase A - blood Peptidyl-Dipeptidase A - chemistry Physiological aspects Pneumonia, Viral - enzymology Protein expression Proteins Research Letter Severe acute respiratory syndrome coronavirus 2 Sex Factors Solubility Young Adult |
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| Title | Age and sex differences in soluble ACE2 may give insights for COVID-19 |
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