Leveraging type 1 diabetes human genetic and genomic data in the T1D knowledge portal
To address the challenge of translating genetic discoveries for type 1 diabetes (T1D) into mechanistic insight, we have developed the T1D Knowledge Portal (T1DKP), an open-access resource for hypothesis development and target discovery in T1D.
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| Published in | PLoS biology Vol. 21; no. 8; p. e3002233 |
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| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Public Library of Science
10.08.2023
Public Library of Science (PLoS) |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1545-7885 1544-9173 1545-7885 |
| DOI | 10.1371/journal.pbio.3002233 |
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| Abstract | To address the challenge of translating genetic discoveries for type 1 diabetes (T1D) into mechanistic insight, we have developed the T1D Knowledge Portal (T1DKP), an open-access resource for hypothesis development and target discovery in T1D. |
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| AbstractList | To address the challenge of translating genetic discoveries for type 1 diabetes (T1D) into mechanistic insight, we have developed the T1D Knowledge Portal (T1DKP), an open-access resource for hypothesis development and target discovery in T1D. To address the challenge of translating genetic discoveries for type 1 diabetes (T1D) into mechanistic insight, we have developed the T1D Knowledge Portal (T1DKP), an open-access resource for hypothesis development and target discovery in T1D. This Community Page presents the type 1 diabetes (T1D) Knowledge Portal, an open-access resource for hypothesis development and target discovery in T1D that aims to help address the challenge of translating genetic discoveries into mechanistic insight. To address the challenge of translating genetic discoveries for type 1 diabetes (T1D) into mechanistic insight, we have developed the T1D Knowledge Portal (T1DKP), an open-access resource for hypothesis development and target discovery in T1D.To address the challenge of translating genetic discoveries for type 1 diabetes (T1D) into mechanistic insight, we have developed the T1D Knowledge Portal (T1DKP), an open-access resource for hypothesis development and target discovery in T1D. |
| Audience | Academic |
| Author | Sun, Ying Rich, Stephen S. Burtt, Noël P. Jang, Dongkeun Koesterer, Ryan Kudtarkar, Parul Flannick, Jason A. Mychaleckyj, Josyf C. Costanzo, Maria C. Onengut-Gumuscu, Suna Nayak, Uma Gaulton, Kyle J. |
| AuthorAffiliation | 3 Program in Medical and Population Genetics, The Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America 1 Department of Pediatrics, University of California San Diego, La Jolla, California, United States of America 5 Division of Genetics and Genomics, Boston Children’s Hospital, Boston, Massachusetts, United States of America 2 Metabolism Program, The Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America 6 Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, United States of America 4 Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, United States of America |
| AuthorAffiliation_xml | – name: 2 Metabolism Program, The Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America – name: 1 Department of Pediatrics, University of California San Diego, La Jolla, California, United States of America – name: 6 Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, United States of America – name: 3 Program in Medical and Population Genetics, The Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America – name: 5 Division of Genetics and Genomics, Boston Children’s Hospital, Boston, Massachusetts, United States of America – name: 4 Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, United States of America |
| Author_xml | – sequence: 1 givenname: Parul surname: Kudtarkar fullname: Kudtarkar, Parul – sequence: 2 givenname: Maria C. surname: Costanzo fullname: Costanzo, Maria C. – sequence: 3 givenname: Ying surname: Sun fullname: Sun, Ying – sequence: 4 givenname: Dongkeun surname: Jang fullname: Jang, Dongkeun – sequence: 5 givenname: Ryan surname: Koesterer fullname: Koesterer, Ryan – sequence: 6 givenname: Josyf C. surname: Mychaleckyj fullname: Mychaleckyj, Josyf C. – sequence: 7 givenname: Uma surname: Nayak fullname: Nayak, Uma – sequence: 8 givenname: Suna surname: Onengut-Gumuscu fullname: Onengut-Gumuscu, Suna – sequence: 9 givenname: Stephen S. surname: Rich fullname: Rich, Stephen S. – sequence: 10 givenname: Jason A. surname: Flannick fullname: Flannick, Jason A. – sequence: 11 givenname: Kyle J. orcidid: 0000-0003-1318-7161 surname: Gaulton fullname: Gaulton, Kyle J. – sequence: 12 givenname: Noël P. surname: Burtt fullname: Burtt, Noël P. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/37561710$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_3389_fgene_2023_1254833 |
| Cites_doi | 10.1038/s41586-020-2493-4 10.1371/journal.pcbi.1004219 10.1016/j.cmet.2022.03.011 10.1038/s41586-021-03552-w 10.1038/s41586-019-1879-7 10.1101/cshperspect.a007641 10.1038/s41588-021-00880-5 10.1038/s41588-019-0505-9 10.1016/j.cell.2016.09.037 10.1093/bioinformatics/btv201 10.1056/NEJMoa1902226 10.1093/bioinformatics/btab186 |
| ContentType | Journal Article |
| Copyright | Copyright: © 2023 Kudtarkar et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. COPYRIGHT 2023 Public Library of Science 2023 Kudtarkar et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2023 Kudtarkar et al 2023 Kudtarkar et al |
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| DOI | 10.1371/journal.pbio.3002233 |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 I have read the journal’s policy and the authors of this manuscript have the following competing interests: KG holds stock in Neurocrine biosciences and has done consulting for Genentech. SSR, JAF, KJG, and NPB also contributed equally to this work. |
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| Snippet | To address the challenge of translating genetic discoveries for type 1 diabetes (T1D) into mechanistic insight, we have developed the T1D Knowledge Portal... |
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| SubjectTerms | Annotations Biobanks Bioinformatics Biology and Life Sciences Datasets Diabetes Diabetes mellitus Diabetes mellitus (insulin dependent) Disease prevention Genes Genetic aspects Genetic engineering Genomes Hypotheses Information services Knowledge Medicine and Health Sciences Online information services Online services Online tutorials Pathogenesis Service development Subject specialists Type 1 diabetes |
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| Title | Leveraging type 1 diabetes human genetic and genomic data in the T1D knowledge portal |
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