Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms - Douse, Christopher H.; Bloor, Stuart; Liu, Yangci; Shamin, Maria; Tchasovnikarova, Iva A.; Timms, Richard T.; Lehner, Paul J.; Modis, Yorgo (Nature communications, 2018)
Keywords: 101/6; 13/106; 42/44; 631/208/176/2016; 631/337/100/102; 631/45/612/1233; 631/535/1266; 692/617/375/374; 82/16; 82/29; 96/31; 96/35; Adenosine triphosphatase; Adenosine Triphosphatases - metabolism; Adenosine Triphosphate - metabolism; Animals; Atrophy; Binding; Cellular structure; Charcot-Marie-Tooth disease; Charcot-Marie-Tooth Disease - genetics; Charcot-Marie-Tooth Disease - pathology; Crystal defects; Crystal structure; Crystallography, X-Ray; Deoxyribonucleic acid; Dimerization; DNA; DNA - metabolism; Epigenesis, Genetic; Epigenetics; Gene Silencing; HEK293 Cells; HeLa Cells; Humanities and Social Sciences; Humans; Missense mutation; multidisciplinary; Muscular Atrophy, Spinal; Mutation; Mutation, Missense; Nervous System Diseases - genetics; Nervous System Diseases - pathology; Neuromuscular diseases; Neuropathy; Protein Binding; Protein Conformation; Protein Multimerization; Science; Science (multidisciplinary); Sf9 Cells; Spinal muscular atrophy; Transcription Factors - chemistry; Transcription Factors - genetics; Transcription Factors - metabolism; Zinc finger proteins; Zinc Fingers