TLR-9 agonist and CD40-targeting vaccination induces HIV-1 envelope-specific B cells with a diversified immunoglobulin repertoire in humanized mice - Godot, Véronique; Tcherakian, Colas; Gil, Laurine; Cervera-Marzal, Iñaki; Li, Guangming; Cheng, Liang; Ortonne, Nicolas; Lelièvre, Jean-Daniel; Pantaleo, Giuseppe; Fenwick, Craig; Centlivre, Mireille; Mouquet, Hugo; et al. (PLoS pathogens, 2020)
Keywords: Agonists; AIDS vaccines; AIDS Vaccines - immunology; Analysis; Animals; Antibodies; Antibodies, Neutralizing - immunology; Antibody-dependent cell-mediated cytotoxicity; Antigen-presenting cells; Antigens; B cells; B-Lymphocytes - immunology; Biology and life sciences; CD34 antigen; CD40 antigen; CD40 Antigens - immunology; Composition; CpG islands; Cytotoxicity; Dendritic cells; env Gene Products, Human Immunodeficiency Virus - immunology; Fetuses; Flow cytometry; Gag protein; Hematopoietic Stem Cells; Hepatocytes; HIV; HIV Antibodies - immunology; HIV Infections - immunology; HIV Infections - prevention & control; HIV Infections - virology; HIV-1 - immunology; Human immunodeficiency virus; Humans; Identification and classification; Immune system; Immunization; Immunodeficiency; Immunoglobulin G; Immunoglobulin G - immunology; Immunoglobulins; Immunological memory; Life Sciences; Lymphocytes; Lymphocytes B; Lymphocytes T; Medicine and health sciences; Memory cells; Methods; Mice; Nef protein; Pharmaceutical research; Proteins; Santé publique et épidémiologie; Spleen; T-Lymphocytes - immunology; TLR9; TLR9 protein; Toll-Like Receptor 9 - agonists; Toll-like receptors; Toxicity; Vaccination; Vaccines; Viral envelopes; Viruses; France; Spleen; HIV-1; Viral vaccines; Recombinant vaccines; Antibodies; Vaccine development; B cells; HIV vaccines