Optic Disc Perfusion in Primary Open Angle and Normal Tension Glaucoma Eyes Using Optical Coherence Tomography-Based Microangiography

To investigate optic disc perfusion differences in normal, primary open-angle glaucoma (POAG), and normal tension glaucoma (NTG) eyes using optical microangiography (OMAG) based optical coherence tomography (OCT) angiography technique. Cross-sectional, observational study. Twenty-eight normal, 30 PO...

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Published inPloS one Vol. 11; no. 5; p. e0154691
Main Authors Bojikian, Karine D., Chen, Chieh-Li, Wen, Joanne C., Zhang, Qinqin, Xin, Chen, Gupta, Divakar, Mudumbai, Raghu C., Johnstone, Murray A., Wang, Ruikang K., Chen, Philip P.
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 05.05.2016
Public Library of Science (PLoS)
Subjects
Online AccessGet full text
ISSN1932-6203
1932-6203
DOI10.1371/journal.pone.0154691

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Abstract To investigate optic disc perfusion differences in normal, primary open-angle glaucoma (POAG), and normal tension glaucoma (NTG) eyes using optical microangiography (OMAG) based optical coherence tomography (OCT) angiography technique. Cross-sectional, observational study. Twenty-eight normal, 30 POAG, and 31 NTG subjects. One eye from each subject was scanned with a 68 kHz Cirrus HD-OCT 5,000-based OMAG prototype system centered at the optic nerve head (ONH) (Carl Zeiss Meditec Inc, Dublin, CA). Microvascular images were generated from the OMAG dataset by detecting the differences in OCT signal between consecutive B-scans. The pre-laminar layer (preLC) was isolated by a semi-automatic segmentation program. Optic disc perfusion, quantified as flux, vessel area density, and normalized flux (flux normalized by the vessel area) within the ONH. Glaucomatous eyes had significantly lower optic disc perfusion in preLC in all three perfusion metrics (p<0.0001) compared to normal eyes. The visual field (VF) mean deviation (MD) and pattern standard deviation (PSD) were similar between the POAG and NTG groups, and no differences in optic disc perfusion were observed between POAG and NTG. Univariate analysis revealed significant correlation between optic disc perfusion and VF MD, VF PSD, and rim area in both POAG and NTG groups (p≤0.0288). However, normalized optic disc perfusion was correlated with some structural measures (retinal nerve fiber layer thickness and ONH cup/disc ratio) only in POAG eyes. Optic disc perfusion detected with OMAG was significantly reduced in POAG and NTG groups compared to normal controls, but no difference was seen between POAG and NTG groups with similar levels of VF damage. Disc perfusion was significantly correlated with VF MD, VF PSD, and rim area in glaucomatous eyes. Vascular changes at the optic disc as measured using OMAG may provide useful information for diagnosis and monitoring of glaucoma.
AbstractList PURPOSE:To investigate optic disc perfusion differences in normal, primary open-angle glaucoma (POAG), and normal tension glaucoma (NTG) eyes using optical microangiography (OMAG) based optical coherence tomography (OCT) angiography technique. DESIGN:Cross-sectional, observational study. SUBJECTS:Twenty-eight normal, 30 POAG, and 31 NTG subjects. METHODS:One eye from each subject was scanned with a 68 kHz Cirrus HD-OCT 5,000-based OMAG prototype system centered at the optic nerve head (ONH) (Carl Zeiss Meditec Inc, Dublin, CA). Microvascular images were generated from the OMAG dataset by detecting the differences in OCT signal between consecutive B-scans. The pre-laminar layer (preLC) was isolated by a semi-automatic segmentation program. MAIN OUTCOME MEASURES:Optic disc perfusion, quantified as flux, vessel area density, and normalized flux (flux normalized by the vessel area) within the ONH. RESULTS:Glaucomatous eyes had significantly lower optic disc perfusion in preLC in all three perfusion metrics (p<0.0001) compared to normal eyes. The visual field (VF) mean deviation (MD) and pattern standard deviation (PSD) were similar between the POAG and NTG groups, and no differences in optic disc perfusion were observed between POAG and NTG. Univariate analysis revealed significant correlation between optic disc perfusion and VF MD, VF PSD, and rim area in both POAG and NTG groups (p≤0.0288). However, normalized optic disc perfusion was correlated with some structural measures (retinal nerve fiber layer thickness and ONH cup/disc ratio) only in POAG eyes. CONCLUSIONS:Optic disc perfusion detected with OMAG was significantly reduced in POAG and NTG groups compared to normal controls, but no difference was seen between POAG and NTG groups with similar levels of VF damage. Disc perfusion was significantly correlated with VF MD, VF PSD, and rim area in glaucomatous eyes. Vascular changes at the optic disc as measured using OMAG may provide useful information for diagnosis and monitoring of glaucoma.
To investigate optic disc perfusion differences in normal, primary open-angle glaucoma (POAG), and normal tension glaucoma (NTG) eyes using optical microangiography (OMAG) based optical coherence tomography (OCT) angiography technique. Cross-sectional, observational study. One eye from each subject was scanned with a 68 kHz Cirrus HD-OCT 5,000-based OMAG prototype system centered at the optic nerve head (ONH) (Carl Zeiss Meditec Inc, Dublin, CA). Microvascular images were generated from the OMAG dataset by detecting the differences in OCT signal between consecutive B-scans. The pre-laminar layer (preLC) was isolated by a semi-automatic segmentation program. Optic disc perfusion, quantified as flux, vessel area density, and normalized flux (flux normalized by the vessel area) within the ONH. Glaucomatous eyes had significantly lower optic disc perfusion in preLC in all three perfusion metrics (p<0.0001) compared to normal eyes. The visual field (VF) mean deviation (MD) and pattern standard deviation (PSD) were similar between the POAG and NTG groups, and no differences in optic disc perfusion were observed between POAG and NTG. Univariate analysis revealed significant correlation between optic disc perfusion and VF MD, VF PSD, and rim area in both POAG and NTG groups (p[less than or equal to]0.0288). However, normalized optic disc perfusion was correlated with some structural measures (retinal nerve fiber layer thickness and ONH cup/disc ratio) only in POAG eyes. Optic disc perfusion detected with OMAG was significantly reduced in POAG and NTG groups compared to normal controls, but no difference was seen between POAG and NTG groups with similar levels of VF damage. Disc perfusion was significantly correlated with VF MD, VF PSD, and rim area in glaucomatous eyes. Vascular changes at the optic disc as measured using OMAG may provide useful information for diagnosis and monitoring of glaucoma.
Purpose To investigate optic disc perfusion differences in normal, primary open-angle glaucoma (POAG), and normal tension glaucoma (NTG) eyes using optical microangiography (OMAG) based optical coherence tomography (OCT) angiography technique. Design Cross-sectional, observational study. Subjects Twenty-eight normal, 30 POAG, and 31 NTG subjects. Methods One eye from each subject was scanned with a 68 kHz Cirrus HD-OCT 5,000-based OMAG prototype system centered at the optic nerve head (ONH) (Carl Zeiss Meditec Inc, Dublin, CA). Microvascular images were generated from the OMAG dataset by detecting the differences in OCT signal between consecutive B-scans. The pre-laminar layer (preLC) was isolated by a semi-automatic segmentation program. Main Outcome Measures Optic disc perfusion, quantified as flux, vessel area density, and normalized flux (flux normalized by the vessel area) within the ONH. Results Glaucomatous eyes had significantly lower optic disc perfusion in preLC in all three perfusion metrics (p<0.0001) compared to normal eyes. The visual field (VF) mean deviation (MD) and pattern standard deviation (PSD) were similar between the POAG and NTG groups, and no differences in optic disc perfusion were observed between POAG and NTG. Univariate analysis revealed significant correlation between optic disc perfusion and VF MD, VF PSD, and rim area in both POAG and NTG groups (p[less than or equal to]0.0288). However, normalized optic disc perfusion was correlated with some structural measures (retinal nerve fiber layer thickness and ONH cup/disc ratio) only in POAG eyes. Conclusions Optic disc perfusion detected with OMAG was significantly reduced in POAG and NTG groups compared to normal controls, but no difference was seen between POAG and NTG groups with similar levels of VF damage. Disc perfusion was significantly correlated with VF MD, VF PSD, and rim area in glaucomatous eyes. Vascular changes at the optic disc as measured using OMAG may provide useful information for diagnosis and monitoring of glaucoma.
Purpose To investigate optic disc perfusion differences in normal, primary open-angle glaucoma (POAG), and normal tension glaucoma (NTG) eyes using optical microangiography (OMAG) based optical coherence tomography (OCT) angiography technique. Design Cross-sectional, observational study. Subjects Twenty-eight normal, 30 POAG, and 31 NTG subjects. Methods One eye from each subject was scanned with a 68 kHz Cirrus HD-OCT 5,000-based OMAG prototype system centered at the optic nerve head (ONH) (Carl Zeiss Meditec Inc, Dublin, CA). Microvascular images were generated from the OMAG dataset by detecting the differences in OCT signal between consecutive B-scans. The pre-laminar layer (preLC) was isolated by a semi-automatic segmentation program. Main Outcome Measures Optic disc perfusion, quantified as flux, vessel area density, and normalized flux (flux normalized by the vessel area) within the ONH. Results Glaucomatous eyes had significantly lower optic disc perfusion in preLC in all three perfusion metrics (p<0.0001) compared to normal eyes. The visual field (VF) mean deviation (MD) and pattern standard deviation (PSD) were similar between the POAG and NTG groups, and no differences in optic disc perfusion were observed between POAG and NTG. Univariate analysis revealed significant correlation between optic disc perfusion and VF MD, VF PSD, and rim area in both POAG and NTG groups (p≤0.0288). However, normalized optic disc perfusion was correlated with some structural measures (retinal nerve fiber layer thickness and ONH cup/disc ratio) only in POAG eyes. Conclusions Optic disc perfusion detected with OMAG was significantly reduced in POAG and NTG groups compared to normal controls, but no difference was seen between POAG and NTG groups with similar levels of VF damage. Disc perfusion was significantly correlated with VF MD, VF PSD, and rim area in glaucomatous eyes. Vascular changes at the optic disc as measured using OMAG may provide useful information for diagnosis and monitoring of glaucoma.
To investigate optic disc perfusion differences in normal, primary open-angle glaucoma (POAG), and normal tension glaucoma (NTG) eyes using optical microangiography (OMAG) based optical coherence tomography (OCT) angiography technique.PURPOSETo investigate optic disc perfusion differences in normal, primary open-angle glaucoma (POAG), and normal tension glaucoma (NTG) eyes using optical microangiography (OMAG) based optical coherence tomography (OCT) angiography technique.Cross-sectional, observational study.DESIGNCross-sectional, observational study.Twenty-eight normal, 30 POAG, and 31 NTG subjects.SUBJECTSTwenty-eight normal, 30 POAG, and 31 NTG subjects.One eye from each subject was scanned with a 68 kHz Cirrus HD-OCT 5,000-based OMAG prototype system centered at the optic nerve head (ONH) (Carl Zeiss Meditec Inc, Dublin, CA). Microvascular images were generated from the OMAG dataset by detecting the differences in OCT signal between consecutive B-scans. The pre-laminar layer (preLC) was isolated by a semi-automatic segmentation program.METHODSOne eye from each subject was scanned with a 68 kHz Cirrus HD-OCT 5,000-based OMAG prototype system centered at the optic nerve head (ONH) (Carl Zeiss Meditec Inc, Dublin, CA). Microvascular images were generated from the OMAG dataset by detecting the differences in OCT signal between consecutive B-scans. The pre-laminar layer (preLC) was isolated by a semi-automatic segmentation program.Optic disc perfusion, quantified as flux, vessel area density, and normalized flux (flux normalized by the vessel area) within the ONH.MAIN OUTCOME MEASURESOptic disc perfusion, quantified as flux, vessel area density, and normalized flux (flux normalized by the vessel area) within the ONH.Glaucomatous eyes had significantly lower optic disc perfusion in preLC in all three perfusion metrics (p<0.0001) compared to normal eyes. The visual field (VF) mean deviation (MD) and pattern standard deviation (PSD) were similar between the POAG and NTG groups, and no differences in optic disc perfusion were observed between POAG and NTG. Univariate analysis revealed significant correlation between optic disc perfusion and VF MD, VF PSD, and rim area in both POAG and NTG groups (p≤0.0288). However, normalized optic disc perfusion was correlated with some structural measures (retinal nerve fiber layer thickness and ONH cup/disc ratio) only in POAG eyes.RESULTSGlaucomatous eyes had significantly lower optic disc perfusion in preLC in all three perfusion metrics (p<0.0001) compared to normal eyes. The visual field (VF) mean deviation (MD) and pattern standard deviation (PSD) were similar between the POAG and NTG groups, and no differences in optic disc perfusion were observed between POAG and NTG. Univariate analysis revealed significant correlation between optic disc perfusion and VF MD, VF PSD, and rim area in both POAG and NTG groups (p≤0.0288). However, normalized optic disc perfusion was correlated with some structural measures (retinal nerve fiber layer thickness and ONH cup/disc ratio) only in POAG eyes.Optic disc perfusion detected with OMAG was significantly reduced in POAG and NTG groups compared to normal controls, but no difference was seen between POAG and NTG groups with similar levels of VF damage. Disc perfusion was significantly correlated with VF MD, VF PSD, and rim area in glaucomatous eyes. Vascular changes at the optic disc as measured using OMAG may provide useful information for diagnosis and monitoring of glaucoma.CONCLUSIONSOptic disc perfusion detected with OMAG was significantly reduced in POAG and NTG groups compared to normal controls, but no difference was seen between POAG and NTG groups with similar levels of VF damage. Disc perfusion was significantly correlated with VF MD, VF PSD, and rim area in glaucomatous eyes. Vascular changes at the optic disc as measured using OMAG may provide useful information for diagnosis and monitoring of glaucoma.
To investigate optic disc perfusion differences in normal, primary open-angle glaucoma (POAG), and normal tension glaucoma (NTG) eyes using optical microangiography (OMAG) based optical coherence tomography (OCT) angiography technique. Cross-sectional, observational study. Twenty-eight normal, 30 POAG, and 31 NTG subjects. One eye from each subject was scanned with a 68 kHz Cirrus HD-OCT 5,000-based OMAG prototype system centered at the optic nerve head (ONH) (Carl Zeiss Meditec Inc, Dublin, CA). Microvascular images were generated from the OMAG dataset by detecting the differences in OCT signal between consecutive B-scans. The pre-laminar layer (preLC) was isolated by a semi-automatic segmentation program. Optic disc perfusion, quantified as flux, vessel area density, and normalized flux (flux normalized by the vessel area) within the ONH. Glaucomatous eyes had significantly lower optic disc perfusion in preLC in all three perfusion metrics (p<0.0001) compared to normal eyes. The visual field (VF) mean deviation (MD) and pattern standard deviation (PSD) were similar between the POAG and NTG groups, and no differences in optic disc perfusion were observed between POAG and NTG. Univariate analysis revealed significant correlation between optic disc perfusion and VF MD, VF PSD, and rim area in both POAG and NTG groups (p≤0.0288). However, normalized optic disc perfusion was correlated with some structural measures (retinal nerve fiber layer thickness and ONH cup/disc ratio) only in POAG eyes. Optic disc perfusion detected with OMAG was significantly reduced in POAG and NTG groups compared to normal controls, but no difference was seen between POAG and NTG groups with similar levels of VF damage. Disc perfusion was significantly correlated with VF MD, VF PSD, and rim area in glaucomatous eyes. Vascular changes at the optic disc as measured using OMAG may provide useful information for diagnosis and monitoring of glaucoma.
Audience Academic
Author Bojikian, Karine D.
Chen, Philip P.
Gupta, Divakar
Chen, Chieh-Li
Wen, Joanne C.
Mudumbai, Raghu C.
Xin, Chen
Zhang, Qinqin
Wang, Ruikang K.
Johnstone, Murray A.
AuthorAffiliation 2 Department of Bioengineering, University of Washington, Seattle, Washington, United States of America
Massachusetts Eye & Ear Infirmary, Harvard Medical School, UNITED STATES
1 Department of Ophthalmology, University of Washington, Seattle, Washington, United States of America
3 Department of Ophthalmology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China
AuthorAffiliation_xml – name: 2 Department of Bioengineering, University of Washington, Seattle, Washington, United States of America
– name: 1 Department of Ophthalmology, University of Washington, Seattle, Washington, United States of America
– name: 3 Department of Ophthalmology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China
– name: Massachusetts Eye & Ear Infirmary, Harvard Medical School, UNITED STATES
Author_xml – sequence: 1
  givenname: Karine D.
  surname: Bojikian
  fullname: Bojikian, Karine D.
– sequence: 2
  givenname: Chieh-Li
  surname: Chen
  fullname: Chen, Chieh-Li
– sequence: 3
  givenname: Joanne C.
  surname: Wen
  fullname: Wen, Joanne C.
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  givenname: Qinqin
  surname: Zhang
  fullname: Zhang, Qinqin
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  givenname: Chen
  surname: Xin
  fullname: Xin, Chen
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  givenname: Divakar
  surname: Gupta
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  givenname: Philip P.
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/27149261$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1016/j.coph.2012.10.001
10.1117/1.JBO.20.10.100901
10.1186/1878-5085-4-14
10.1088/0031-9155/59/22/6693
10.1001/archopht.1991.01080080050026
10.1016/0002-9394(84)90505-1
10.1097/IJG.0b013e3181e666a1
10.1136/bjo.61.2.126
10.1016/j.ophtha.2014.01.021
10.1111/j.1395-3907.2004.00269.x
10.1117/1.JBO.19.8.086020
10.1016/S0161-6420(86)33697-2
10.1117/1.JBO.20.6.066008
10.1097/01.ijg.0000212264.96864.3e
10.1016/S1350-9462(02)00008-3
10.1136/bjo.2005.081224
10.1034/j.1600-0420.2003.00073.x
10.1001/archopht.1990.01070070091042
10.1007/s10384-006-0375-4
10.1364/BOE.4.001214
10.1097/IJG.0b013e31820719f6
10.1007/s10384-003-0071-6
10.1364/OL.35.001467
10.1016/S0002-9394(14)77781-5
10.1007/s10384-004-0072-0
10.1117/1.JBO.17.11.116018
10.1177/112067210901900410
10.1097/01.ijg.0000176932.06606.6e
10.1097/IJG.0b013e318193c45c
10.1097/ICU.0b013e3282f3919b
10.1155/2012/509783
10.1167/iovs.06-0024
10.1136/bjo.78.6.449
10.1016/S0002-9394(14)73703-1
10.1001/archophthalmol.2011.117
10.1016/S0161-6420(02)01247-2
10.1001/archopht.1985.01050080057020
10.1136/bjo.79.8.732
10.1016/0002-9394(88)90118-3
10.1001/archopht.1982.01030040052005
10.1001/archopht.1995.01100070092031
10.1136/bjo.2008.150276
10.1136/bjo.67.12.818
10.1016/0002-9394(86)90596-9
10.1117/1.3642638
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– notice: 2016 Bojikian et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
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Conceived and designed the experiments: KDB CLC JCW QZ CX DG RCM MAJ RKW PPC. Performed the experiments: KDB CLC JW DG. Analyzed the data: KDB, CHC. Contributed reagents/materials/analysis tools: KDB CLC JCW QZ CX DG RCM MAJ RKW PPC. Wrote the paper: KDB CLC JCW QZ CX DG RCM MAJ RKW PPC.
Competing Interests: The authors have read the journal's policy and have the following competing interests: CLC, QZ, and RKW received research support from Carl Zeiss Meditec, Inc.; MAJ is a consultant for Healonics, Sensimed, Ivantis, Cascade Ophthalmics, and receives royalties from intellectual property owned by Allergan; RKW has significant financial interest in the intellectual property of OMAG technology, owned by Oregon Health & Science University; KDB, JCW, CX, DG, RCM, and PPC: None. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.
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References N Kurita (ref16) 2006; 50
A Sommer (ref6) 2011; 129
O Thonginnetra (ref42) 2010; 19
J Caprioli (ref38) 1985; 103
A Sommer (ref3) 1991; 109
P Fazio (ref39) 1990; 108
I Leibovitch (ref18) 2005; 14
L An (ref21) 2011; 16
LA Yannuzzi (ref36) 1986; 93
Y Yamazaki (ref34) 1995; 79
K Yaoeda (ref23) 2003; 81
CJ Liu (ref47) 2002; 109
S Yousefi (ref27) 2014; 59
M Motolko (ref40) 1982; 100
J Flammer (ref10) 2013; 4
SM Drance (ref12) 1988; 105
RA Lewis (ref45) 1983; 96
P Hamard (ref33) 1994; 78
MC Leske (ref2) 1995; 113
T Tokunaga (ref17) 2004; 48
MB Shields (ref8) 2012; 21
X Yin (ref28) 2014; 19
Y Wang (ref37) 2009; 93
RA Hitchings (ref44) 1983; 67
I Stalmans (ref35) 2009; 19
R Reif (ref29) 2012; 2012
HA Quigley (ref1) 2006; 90
P Gasser (ref11) 1991; 111
Q Zhang (ref24) 2015; 20
RA Hitchings (ref32) 1977; 61
A Zhang (ref25) 2015; 20
BE Klein (ref4) 1992; 99
J Caprioli (ref43) 1984; 97
K Huber (ref14) 2004; 82
AF Frangi (ref30); 1496
S Yousefi (ref26) 2013; 4
MB Shields (ref7) 2008; 19
RK Wang (ref20) 2010; 35
L An (ref22) 2012; 17
Y Shiose (ref5) 1991; 35
M Mozaffarieh (ref31) 2013; 13
A Oettli (ref15) 2011; 20
J Flammer (ref9) 2002; 21
J Suzuki (ref19) 2004; 48
W-W Su (ref13) 2006; 47
Y Jia (ref48) 2014; 121
D King (ref41) 1986; 101
S Ishibashi (ref46) 2006; 15
References_xml – volume: 1496
  start-page: 130
  ident: ref30
  article-title: MICCAI 1998, LNCS
– volume: 13
  start-page: 43
  year: 2013
  ident: ref31
  article-title: New insights in the pathogenesis and treatment of normal tension glaucoma
  publication-title: Curr Opin Pharmacol
  doi: 10.1016/j.coph.2012.10.001
– volume: 20
  start-page: 100901
  issue: 10
  year: 2015
  ident: ref25
  article-title: Methods and algorithms for optical coherence tomography-based angiography: a review and comparison
  publication-title: J Biomed Opt
  doi: 10.1117/1.JBO.20.10.100901
– volume: 4
  start-page: 14
  year: 2013
  ident: ref10
  article-title: The primary vascular dysregulation syndrome: implications for eye diseases
  publication-title: EPMA J
  doi: 10.1186/1878-5085-4-14
– volume: 59
  start-page: 6693
  year: 2014
  ident: ref27
  article-title: Simultaneous estimation of bidirectional particle flow and relative flux using MUSIC-OCT: phantom studies
  publication-title: Physics in medicine and biology
  doi: 10.1088/0031-9155/59/22/6693
– volume: 109
  start-page: 1090
  year: 1991
  ident: ref3
  article-title: Relationship between intraocular pressure and primary open angle glaucoma among white and black Americans. The Baltimore Eye Survey
  publication-title: Arch Ophthalmol
  doi: 10.1001/archopht.1991.01080080050026
– volume: 97
  start-page: 730
  issue: 6
  year: 1984
  ident: ref43
  article-title: Comparison of visual field defects in the low-tension glaucomas with those in the high-tension glaucomas
  publication-title: Am J Ophthalmol
  doi: 10.1016/0002-9394(84)90505-1
– volume: 20
  start-page: 303
  issue: 5
  year: 2011
  ident: ref15
  article-title: Rigidity of retinal vessel in untreated eyes of normal tension primary open-angle glaucoma patients
  publication-title: J Glaucoma
  doi: 10.1097/IJG.0b013e3181e666a1
– volume: 61
  start-page: 126
  year: 1977
  ident: ref32
  article-title: Fluorescein angiography in chronic simple and low-tension glaucoma
  publication-title: Br J Ophthalmol
  doi: 10.1136/bjo.61.2.126
– volume: 121
  start-page: 1322
  year: 2014
  ident: ref48
  article-title: Optical coherence tomography angiography of optic disc perfusion in glaucoma
  publication-title: Ophthalmology
  doi: 10.1016/j.ophtha.2014.01.021
– volume: 82
  start-page: 426
  issue: 4
  year: 2004
  ident: ref14
  article-title: Comparison of colour Doppler imaging and retinal scanning laser fluorescein angiography in healthy volunteers and normal pressure glaucoma patients
  publication-title: Acta Ophthalmol Scand
  doi: 10.1111/j.1395-3907.2004.00269.x
– volume: 19
  start-page: 086020
  year: 2014
  ident: ref28
  article-title: User-guided segmentation for volumetric retinal optical coherence tomography images
  publication-title: J Biomed Opt
  doi: 10.1117/1.JBO.19.8.086020
– volume: 99
  start-page: 1499
  issue: 10
  year: 1992
  ident: ref4
  article-title: Prevalence of glaucoma
  publication-title: The Beaver Dam Eye Study. Ophthalmology
– volume: 93
  start-page: 611
  issue: 5
  year: 1986
  ident: ref36
  article-title: Fluorescein angiography complication survey
  publication-title: Ophthalmology
  doi: 10.1016/S0161-6420(86)33697-2
– volume: 20
  start-page: 066008
  year: 2015
  ident: ref24
  article-title: Wide-field imaging of retinal vasculature using optical coherence tomography-based microangiography provided by motion tracking
  publication-title: J Biomed Opt
  doi: 10.1117/1.JBO.20.6.066008
– volume: 15
  start-page: 354
  year: 2006
  ident: ref46
  article-title: Effect of latanoprost on the diurnal variations in the intraocular and ocular perfusion pressure in normal tension glaucoma
  publication-title: J Glaucoma
  doi: 10.1097/01.ijg.0000212264.96864.3e
– volume: 21
  start-page: 359
  year: 2002
  ident: ref9
  article-title: The impact of ocular blood flow in glaucoma
  publication-title: Prog Retin Eye Res
  doi: 10.1016/S1350-9462(02)00008-3
– volume: 90
  start-page: 262
  year: 2006
  ident: ref1
  article-title: The number of people with glaucoma worldwide in 2010 and 2020
  publication-title: Br J Ophthalmol
  doi: 10.1136/bjo.2005.081224
– volume: 81
  start-page: 253
  issue: 3
  year: 2003
  ident: ref23
  article-title: Relationship between optic nerve head microcirculation and visual field loss in glaucoma
  publication-title: Acta Ophthalmol Scand
  doi: 10.1034/j.1600-0420.2003.00073.x
– volume: 108
  start-page: 705
  issue: 5
  year: 1990
  ident: ref39
  article-title: Optic disc topography in patients with low-tension and primary open angle glaucoma
  publication-title: Arch Ophthalmol
  doi: 10.1001/archopht.1990.01070070091042
– volume: 50
  start-page: 547
  year: 2006
  ident: ref16
  article-title: No apparent association between ocular perfusion pressure and visual field damage in normal-tension glaucoma patients
  publication-title: Jpn J Ophthalmol
  doi: 10.1007/s10384-006-0375-4
– volume: 4
  start-page: 1214
  year: 2013
  ident: ref26
  article-title: Super-resolution spectral estimation of optical micro-angiography for quantifying blood flow within microcirculatory tissue beds in vivo
  publication-title: Biomedical Optics Express
  doi: 10.1364/BOE.4.001214
– volume: 21
  start-page: 141
  issue: 3
  year: 2012
  ident: ref8
  article-title: The glaucomatous process and the evolving definition of glaucoma
  publication-title: J Glaucoma
  doi: 10.1097/IJG.0b013e31820719f6
– volume: 48
  start-page: 380
  year: 2004
  ident: ref17
  article-title: Association between nocturnal blood pressure reduction and progression of visual field defect in patients with primary open-angle glaucoma and normal-tension glaucoma
  publication-title: Jpn J Ophthalmol
  doi: 10.1007/s10384-003-0071-6
– volume: 35
  start-page: 1467
  year: 2010
  ident: ref20
  article-title: Depth-resolved imaging of capillary networks in retina and choroid using ultrahigh sensitive optical microangiography
  publication-title: Opt Lett
  doi: 10.1364/OL.35.001467
– volume: 96
  start-page: 148
  issue: 2
  year: 1983
  ident: ref45
  article-title: Optic disk and visual field correlations in primary open-angle and low-tension glaucoma
  publication-title: Am J Ophthalmol
  doi: 10.1016/S0002-9394(14)77781-5
– volume: 48
  start-page: 340
  year: 2004
  ident: ref19
  article-title: Visual field damage in normal-tension glaucoma patients with or without ischemic changes in cerebral magnetic resonance imaging
  publication-title: Jpn J Ophthalmol
  doi: 10.1007/s10384-004-0072-0
– volume: 17
  start-page: 116018
  issue: 11
  year: 2012
  ident: ref22
  article-title: Optical microangiography provides correlation between microstructure and microvasculature of optic nerve head in human subjects
  publication-title: J Biomed Opt
  doi: 10.1117/1.JBO.17.11.116018
– volume: 19
  start-page: 580
  issue: 4
  year: 2009
  ident: ref35
  article-title: Color Doppler imaging and ocular pulse amplitude in glaucomatous and healthy eyes
  publication-title: Eur J Ophthalmol
  doi: 10.1177/112067210901900410
– volume: 14
  start-page: 384
  year: 2005
  ident: ref18
  article-title: C-reactive protein levels in normal tension glaucoma
  publication-title: J Glaucoma
  doi: 10.1097/01.ijg.0000176932.06606.6e
– volume: 19
  start-page: 151
  issue: 3
  year: 2010
  ident: ref42
  article-title: Normal versus high tension glaucoma: a comparison of functional and structural defects
  publication-title: J Glaucoma
  doi: 10.1097/IJG.0b013e318193c45c
– volume: 19
  start-page: 85
  issue: 2
  year: 2008
  ident: ref7
  article-title: Normal-tension glaucoma: is it different from primary open-angle glaucoma?
  publication-title: Curr Opin Ophthalmol
  doi: 10.1097/ICU.0b013e3282f3919b
– volume: 2012
  start-page: 509783
  year: 2012
  ident: ref29
  article-title: Quantifying optical microangiography images obtained from a spectral domain optical coherence tomography system
  publication-title: Int J Biomed Imaging
  doi: 10.1155/2012/509783
– volume: 47
  start-page: 3390
  issue: 8
  year: 2006
  ident: ref13
  article-title: Abnormal flow-mediated vasodilation in normal-tension glaucoma using a noninvasive determination for peripheral endothelial dysfunction
  publication-title: Invest Ophthalmol Vis Sci
  doi: 10.1167/iovs.06-0024
– volume: 78
  start-page: 449
  year: 1994
  ident: ref33
  article-title: Optic nerve head blood flow using a laser Doppler velocimeter and haemorheology in primary open angle glaucoma and normal pressure glaucoma
  publication-title: Br J Ophthalmol
  doi: 10.1136/bjo.78.6.449
– volume: 111
  start-page: 585
  issue: 5
  year: 1991
  ident: ref11
  article-title: Blood-cell velocity in the nailfold capillaries of patients with normal-tension and high-tension glaucoma
  publication-title: Am J Ophthalmol
  doi: 10.1016/S0002-9394(14)73703-1
– volume: 129
  start-page: 785
  issue: 6
  year: 2011
  ident: ref6
  article-title: Ocular hypertension and normal-tension glaucoma: time for banishment and burial
  publication-title: Arch Ophthalmol
  doi: 10.1001/archophthalmol.2011.117
– volume: 109
  start-page: 2241
  year: 2002
  ident: ref47
  article-title: Changes in intraocular pressure and ocular perfusion pressure after latanoprost 0.005% or brimonidine tartrate 0.2% in normal-tension glaucoma patients
  publication-title: Ophthalmology
  doi: 10.1016/S0161-6420(02)01247-2
– volume: 103
  start-page: 1145
  issue: 8
  year: 1985
  ident: ref38
  article-title: Comparison of the optic nerve head in high- and low tension glaucoma
  publication-title: Arch Ophthalmol
  doi: 10.1001/archopht.1985.01050080057020
– volume: 79
  start-page: 732
  issue: 8
  year: 1995
  ident: ref34
  article-title: Comparison of flow velocity of ophthalmic artery between primary open angle glaucoma and normal tension glaucoma
  publication-title: Br J Ophthalmol
  doi: 10.1136/bjo.79.8.732
– volume: 105
  start-page: 35
  issue: 1
  year: 1988
  ident: ref12
  article-title: Response of blood flow to warm and cold in normal and low-tension glaucoma patients
  publication-title: Am J Ophthalmol
  doi: 10.1016/0002-9394(88)90118-3
– volume: 100
  start-page: 1074
  issue: 7
  year: 1982
  ident: ref40
  article-title: Visual field defects in low-tension glaucoma. Comparison of defects in low-tension glaucoma and chronic open angle glaucoma,”
  publication-title: Arch Ophthalmol
  doi: 10.1001/archopht.1982.01030040052005
– volume: 113
  start-page: 918
  year: 1995
  ident: ref2
  article-title: Risk factors for open-angle glaucoma. The Barbados Eye Study
  publication-title: Arch Ophthalmol
  doi: 10.1001/archopht.1995.01100070092031
– volume: 93
  start-page: 634
  year: 2009
  ident: ref37
  article-title: Measurement of total blood flow in the normal human retina using Doppler Fourier-domain optical coherence tomography
  publication-title: Br J Ophthalmol
  doi: 10.1136/bjo.2008.150276
– volume: 67
  start-page: 818
  issue: 12
  year: 1983
  ident: ref44
  article-title: A comparative study of visual field defects seen in patients with low-tension glaucoma and chronic simple glaucoma
  publication-title: Br Ophthalmol
  doi: 10.1136/bjo.67.12.818
– volume: 35
  start-page: 133
  issue: 2
  year: 1991
  ident: ref5
  article-title: Epidemiology of glaucoma in Japan—a nationwide glaucoma survey
  publication-title: Jpn J Ophthalmol
– volume: 101
  start-page: 204
  issue: 2
  year: 1986
  ident: ref41
  article-title: Comparison of visual field defects in normaltension glaucoma and high-tension glaucoma,”
  publication-title: Am J Ophthalmol
  doi: 10.1016/0002-9394(86)90596-9
– volume: 16
  start-page: 106013
  year: 2011
  ident: ref21
  article-title: Using ultrahigh sensitive optical microangiography to achieve comprehensive depth resolved microvasculature mapping for human retina
  publication-title: J Biomed Opt
  doi: 10.1117/1.3642638
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Snippet To investigate optic disc perfusion differences in normal, primary open-angle glaucoma (POAG), and normal tension glaucoma (NTG) eyes using optical...
Purpose To investigate optic disc perfusion differences in normal, primary open-angle glaucoma (POAG), and normal tension glaucoma (NTG) eyes using optical...
PURPOSE:To investigate optic disc perfusion differences in normal, primary open-angle glaucoma (POAG), and normal tension glaucoma (NTG) eyes using optical...
Purpose To investigate optic disc perfusion differences in normal, primary open-angle glaucoma (POAG), and normal tension glaucoma (NTG) eyes using optical...
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SubjectTerms Analysis
Angiography
Angiography - methods
Bioengineering
Biology and Life Sciences
Care and treatment
Case-Control Studies
Cataracts
Correlation analysis
Defects
Development and progression
Diagnosis
Eye
Eye (anatomy)
Flow velocity
Fluctuations
Fluorescein angiography
Flux
Glaucoma
Glaucoma, Open-Angle - diagnostic imaging
Glaucoma, Open-Angle - physiopathology
Humans
Image processing
Image segmentation
Intraocular pressure
Investigations
Low Tension Glaucoma - diagnostic imaging
Low Tension Glaucoma - physiopathology
Medical imaging
Medicine and Health Sciences
Microvasculature
Migraine
Observational studies
Optic Disk - blood supply
Optic nerve
Optical Coherence Tomography
Optics
Perfusion
Research and Analysis Methods
Retina
Risk factors
Tension
Thickness
Tomography
Tomography, Optical Coherence - methods
Visual field
Visual fields
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Title Optic Disc Perfusion in Primary Open Angle and Normal Tension Glaucoma Eyes Using Optical Coherence Tomography-Based Microangiography
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