Cisplatin Induces a Mitochondrial-ROS Response That Contributes to Cytotoxicity Depending on Mitochondrial Redox Status and Bioenergetic Functions - Marullo, Rossella; Werner, Erica; Degtyareva, Natalya; Moore, Bryn; Altavilla, Giuseppe; Ramalingam, Suresh S.; Doetsch, Paul W. (PloS one, 2013)
Keywords: Adducts; Animals; Anticancer properties; Antineoplastic Agents - pharmacology; Antitumor agents; Apoptosis; Apoptosis - drug effects; Baking yeast; Biochemistry; Biocompatibility; Blockage; Cancer; Cancer research; Cancer treatment; Cell death; Cell Line, Tumor; Cell Nucleus - drug effects; Cell Nucleus - metabolism; Chemotherapy; Cisplatin; Cisplatin - pharmacology; Cytotoxicity; Damage; Deoxyribonucleic acid; DNA; DNA - chemistry; DNA - metabolism; DNA adducts; DNA Adducts - chemistry; DNA biosynthesis; DNA Damage; DNA Repair - drug effects; DNA replication; Drug development; Drug dosages; Drug efficacy; Exposure; Hematology; Humans; Kinases; Medical prognosis; Medical research; Mice; Mitochondria; Mitochondria - drug effects; Mitochondria - metabolism; Mitochondrial DNA; Oncology; Oxidation-Reduction; Oxidative stress; Pathogenesis; Phosphorylation; Protein biosynthesis; Protein synthesis; Reactive Oxygen Species - agonists; Reactive Oxygen Species - metabolism; Saccharomyces cerevisiae; Saccharomyces cerevisiae - drug effects; Saccharomyces cerevisiae - genetics; Saccharomyces cerevisiae - metabolism; Signal transduction; Stress response; Studies; Survival analysis; Tissues; Toxicity; Transcription; Transcription (Genetics); Tumor cell lines; Tumors; Yeast; Atlanta Georgia; Georgia; United States--US; Pennsylvania