Left Atrial Appendage Volume Increased in More Than Half of Patients with Cryptogenic Stroke
Ischemic strokes without a well-defined etiology are labeled as cryptogenic, and account for 30-40% of strokes in stroke registries. The left atrial appendage (LAA) is the most typical origin for intracardiac thrombus formation when associated with atrial fibrillation. Here, we examined whether incr...
Saved in:
| Published in | PloS one Vol. 8; no. 11; p. e79519 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Public Library of Science
04.11.2013
Public Library of Science (PLoS) |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1932-6203 1932-6203 |
| DOI | 10.1371/journal.pone.0079519 |
Cover
| Abstract | Ischemic strokes without a well-defined etiology are labeled as cryptogenic, and account for 30-40% of strokes in stroke registries. The left atrial appendage (LAA) is the most typical origin for intracardiac thrombus formation when associated with atrial fibrillation. Here, we examined whether increased LAA volume detected with cardiac computed tomography (cCT) constitutes a risk factor in cryptogenic stroke patients.
This study included 82 stroke/TIA patients (57 males; mean age, 58 years) with a diagnosis of cryptogenic stroke after extensive radiological and cardiological investigations. Cases were classified using the TOAST criteria modified by European Association of Echocardiography recommendations for defining cardiac sources of embolism. Forty age- and gender-matched control subjects without cardiovascular diseases were selected for pair-wise comparisons (21 males; mean age, 54 years). LAA volume adjusted for body surface area was measured three dimensionally by tracing the LAA borders on electrocardiogram-gated CT slices.
In control subjects, mean LAA volume was 3.4±1.1 mL/m(2). Mean+2SD, which was considered the upper limit for normal LAA volume was 5.6 mL/m(2). In paired Student t-test between the patient group and matched controls, LAA volume was 67% larger in cryptogenic stroke/TIA patients (5.7±2.0 mL/m(2) vs. 3.4±1.1 mL/m(2); P<0.001). Forty-five (55%) patients with cryptogenic stroke/TIA had enlarged LAA.
LAA is significantly enlarged in more than half of patients with cryptogenic stroke/TIA. LAA thrombosis may contribute to the pathogenesis of stroke in patients considered to have cryptogenic stroke after conventional evaluation. |
|---|---|
| AbstractList | Background Ischemic strokes without a well-defined etiology are labeled as cryptogenic, and account for 30-40% of strokes in stroke registries. The left atrial appendage (LAA) is the most typical origin for intracardiac thrombus formation when associated with atrial fibrillation. Here, we examined whether increased LAA volume detected with cardiac computed tomography (cCT) constitutes a risk factor in cryptogenic stroke patients. Methods This study included 82 stroke/TIA patients (57 males; mean age, 58 years) with a diagnosis of cryptogenic stroke after extensive radiological and cardiological investigations. Cases were classified using the TOAST criteria modified by European Association of Echocardiography recommendations for defining cardiac sources of embolism. Forty age- and gender-matched control subjects without cardiovascular diseases were selected for pair-wise comparisons (21 males; mean age, 54 years). LAA volume adjusted for body surface area was measured three dimensionally by tracing the LAA borders on electrocardiogram-gated CT slices. Results In control subjects, mean LAA volume was 3.4±1.1 mL/m.sup.2 . Mean+2SD, which was considered the upper limit for normal LAA volume was 5.6 mL/m.sup.2 . In paired Student t-test between the patient group and matched controls, LAA volume was 67% larger in cryptogenic stroke/TIA patients (5.7±2.0 mL/m.sup.2 vs. 3.4±1.1 mL/m.sup.2 ; P<0.001). Forty-five (55%) patients with cryptogenic stroke/TIA had enlarged LAA. Conclusion LAA is significantly enlarged in more than half of patients with cryptogenic stroke/TIA. LAA thrombosis may contribute to the pathogenesis of stroke in patients considered to have cryptogenic stroke after conventional evaluation. Ischemic strokes without a well-defined etiology are labeled as cryptogenic, and account for 30-40% of strokes in stroke registries. The left atrial appendage (LAA) is the most typical origin for intracardiac thrombus formation when associated with atrial fibrillation. Here, we examined whether increased LAA volume detected with cardiac computed tomography (cCT) constitutes a risk factor in cryptogenic stroke patients. This study included 82 stroke/TIA patients (57 males; mean age, 58 years) with a diagnosis of cryptogenic stroke after extensive radiological and cardiological investigations. Cases were classified using the TOAST criteria modified by European Association of Echocardiography recommendations for defining cardiac sources of embolism. Forty age- and gender-matched control subjects without cardiovascular diseases were selected for pair-wise comparisons (21 males; mean age, 54 years). LAA volume adjusted for body surface area was measured three dimensionally by tracing the LAA borders on electrocardiogram-gated CT slices. In control subjects, mean LAA volume was 3.4±1.1 mL/m(2). Mean+2SD, which was considered the upper limit for normal LAA volume was 5.6 mL/m(2). In paired Student t-test between the patient group and matched controls, LAA volume was 67% larger in cryptogenic stroke/TIA patients (5.7±2.0 mL/m(2) vs. 3.4±1.1 mL/m(2); P<0.001). Forty-five (55%) patients with cryptogenic stroke/TIA had enlarged LAA. LAA is significantly enlarged in more than half of patients with cryptogenic stroke/TIA. LAA thrombosis may contribute to the pathogenesis of stroke in patients considered to have cryptogenic stroke after conventional evaluation. Ischemic strokes without a well-defined etiology are labeled as cryptogenic, and account for 30-40% of strokes in stroke registries. The left atrial appendage (LAA) is the most typical origin for intracardiac thrombus formation when associated with atrial fibrillation. Here, we examined whether increased LAA volume detected with cardiac computed tomography (cCT) constitutes a risk factor in cryptogenic stroke patients. This study included 82 stroke/TIA patients (57 males; mean age, 58 years) with a diagnosis of cryptogenic stroke after extensive radiological and cardiological investigations. Cases were classified using the TOAST criteria modified by European Association of Echocardiography recommendations for defining cardiac sources of embolism. Forty age- and gender-matched control subjects without cardiovascular diseases were selected for pair-wise comparisons (21 males; mean age, 54 years). LAA volume adjusted for body surface area was measured three dimensionally by tracing the LAA borders on electrocardiogram-gated CT slices. In control subjects, mean LAA volume was 3.4±1.1 mL/m.sup.2 . Mean+2SD, which was considered the upper limit for normal LAA volume was 5.6 mL/m.sup.2 . In paired Student t-test between the patient group and matched controls, LAA volume was 67% larger in cryptogenic stroke/TIA patients (5.7±2.0 mL/m.sup.2 vs. 3.4±1.1 mL/m.sup.2 ; P<0.001). Forty-five (55%) patients with cryptogenic stroke/TIA had enlarged LAA. LAA is significantly enlarged in more than half of patients with cryptogenic stroke/TIA. LAA thrombosis may contribute to the pathogenesis of stroke in patients considered to have cryptogenic stroke after conventional evaluation. BACKGROUND: Ischemic strokes without a well-defined etiology are labeled as cryptogenic, and account for 30-40% of strokes in stroke registries. The left atrial appendage (LAA) is the most typical origin for intracardiac thrombus formation when associated with atrial fibrillation. Here, we examined whether increased LAA volume detected with cardiac computed tomography (cCT) constitutes a risk factor in cryptogenic stroke patients. METHODS: This study included 82 stroke/TIA patients (57 males; mean age, 58 years) with a diagnosis of cryptogenic stroke after extensive radiological and cardiological investigations. Cases were classified using the TOAST criteria modified by European Association of Echocardiography recommendations for defining cardiac sources of embolism. Forty age- and gender-matched control subjects without cardiovascular diseases were selected for pair-wise comparisons (21 males; mean age, 54 years). LAA volume adjusted for body surface area was measured three dimensionally by tracing the LAA borders on electrocardiogram-gated CT slices. RESULTS: In control subjects, mean LAA volume was 3.4±1.1 mL/m(2). Mean+2SD, which was considered the upper limit for normal LAA volume was 5.6 mL/m(2). In paired Student t-test between the patient group and matched controls, LAA volume was 67% larger in cryptogenic stroke/TIA patients (5.7±2.0 mL/m(2) vs. 3.4±1.1 mL/m(2); P<0.001). Forty-five (55%) patients with cryptogenic stroke/TIA had enlarged LAA. CONCLUSION: LAA is significantly enlarged in more than half of patients with cryptogenic stroke/TIA. LAA thrombosis may contribute to the pathogenesis of stroke in patients considered to have cryptogenic stroke after conventional evaluation. Ischemic strokes without a well-defined etiology are labeled as cryptogenic, and account for 30-40% of strokes in stroke registries. The left atrial appendage (LAA) is the most typical origin for intracardiac thrombus formation when associated with atrial fibrillation. Here, we examined whether increased LAA volume detected with cardiac computed tomography (cCT) constitutes a risk factor in cryptogenic stroke patients.BACKGROUNDIschemic strokes without a well-defined etiology are labeled as cryptogenic, and account for 30-40% of strokes in stroke registries. The left atrial appendage (LAA) is the most typical origin for intracardiac thrombus formation when associated with atrial fibrillation. Here, we examined whether increased LAA volume detected with cardiac computed tomography (cCT) constitutes a risk factor in cryptogenic stroke patients.This study included 82 stroke/TIA patients (57 males; mean age, 58 years) with a diagnosis of cryptogenic stroke after extensive radiological and cardiological investigations. Cases were classified using the TOAST criteria modified by European Association of Echocardiography recommendations for defining cardiac sources of embolism. Forty age- and gender-matched control subjects without cardiovascular diseases were selected for pair-wise comparisons (21 males; mean age, 54 years). LAA volume adjusted for body surface area was measured three dimensionally by tracing the LAA borders on electrocardiogram-gated CT slices.METHODSThis study included 82 stroke/TIA patients (57 males; mean age, 58 years) with a diagnosis of cryptogenic stroke after extensive radiological and cardiological investigations. Cases were classified using the TOAST criteria modified by European Association of Echocardiography recommendations for defining cardiac sources of embolism. Forty age- and gender-matched control subjects without cardiovascular diseases were selected for pair-wise comparisons (21 males; mean age, 54 years). LAA volume adjusted for body surface area was measured three dimensionally by tracing the LAA borders on electrocardiogram-gated CT slices.In control subjects, mean LAA volume was 3.4±1.1 mL/m(2). Mean+2SD, which was considered the upper limit for normal LAA volume was 5.6 mL/m(2). In paired Student t-test between the patient group and matched controls, LAA volume was 67% larger in cryptogenic stroke/TIA patients (5.7±2.0 mL/m(2) vs. 3.4±1.1 mL/m(2); P<0.001). Forty-five (55%) patients with cryptogenic stroke/TIA had enlarged LAA.RESULTSIn control subjects, mean LAA volume was 3.4±1.1 mL/m(2). Mean+2SD, which was considered the upper limit for normal LAA volume was 5.6 mL/m(2). In paired Student t-test between the patient group and matched controls, LAA volume was 67% larger in cryptogenic stroke/TIA patients (5.7±2.0 mL/m(2) vs. 3.4±1.1 mL/m(2); P<0.001). Forty-five (55%) patients with cryptogenic stroke/TIA had enlarged LAA.LAA is significantly enlarged in more than half of patients with cryptogenic stroke/TIA. LAA thrombosis may contribute to the pathogenesis of stroke in patients considered to have cryptogenic stroke after conventional evaluation.CONCLUSIONLAA is significantly enlarged in more than half of patients with cryptogenic stroke/TIA. LAA thrombosis may contribute to the pathogenesis of stroke in patients considered to have cryptogenic stroke after conventional evaluation. Background Ischemic strokes without a well-defined etiology are labeled as cryptogenic, and account for 30–40% of strokes in stroke registries. The left atrial appendage (LAA) is the most typical origin for intracardiac thrombus formation when associated with atrial fibrillation. Here, we examined whether increased LAA volume detected with cardiac computed tomography (cCT) constitutes a risk factor in cryptogenic stroke patients. Methods This study included 82 stroke/TIA patients (57 males; mean age, 58 years) with a diagnosis of cryptogenic stroke after extensive radiological and cardiological investigations. Cases were classified using the TOAST criteria modified by European Association of Echocardiography recommendations for defining cardiac sources of embolism. Forty age- and gender-matched control subjects without cardiovascular diseases were selected for pair-wise comparisons (21 males; mean age, 54 years). LAA volume adjusted for body surface area was measured three dimensionally by tracing the LAA borders on electrocardiogram-gated CT slices. Results In control subjects, mean LAA volume was 3.4±1.1 mL/m 2 . Mean+2SD, which was considered the upper limit for normal LAA volume was 5.6 mL/m 2 . In paired Student t-test between the patient group and matched controls, LAA volume was 67% larger in cryptogenic stroke/TIA patients (5.7±2.0 mL/m 2 vs. 3.4±1.1 mL/m 2 ; P <0.001). Forty-five (55%) patients with cryptogenic stroke/TIA had enlarged LAA. Conclusion LAA is significantly enlarged in more than half of patients with cryptogenic stroke/TIA. LAA thrombosis may contribute to the pathogenesis of stroke in patients considered to have cryptogenic stroke after conventional evaluation. Background Ischemic strokes without a well-defined etiology are labeled as cryptogenic, and account for 30–40% of strokes in stroke registries. The left atrial appendage (LAA) is the most typical origin for intracardiac thrombus formation when associated with atrial fibrillation. Here, we examined whether increased LAA volume detected with cardiac computed tomography (cCT) constitutes a risk factor in cryptogenic stroke patients. Methods This study included 82 stroke/TIA patients (57 males; mean age, 58 years) with a diagnosis of cryptogenic stroke after extensive radiological and cardiological investigations. Cases were classified using the TOAST criteria modified by European Association of Echocardiography recommendations for defining cardiac sources of embolism. Forty age- and gender-matched control subjects without cardiovascular diseases were selected for pair-wise comparisons (21 males; mean age, 54 years). LAA volume adjusted for body surface area was measured three dimensionally by tracing the LAA borders on electrocardiogram-gated CT slices. Results In control subjects, mean LAA volume was 3.4±1.1 mL/m2. Mean+2SD, which was considered the upper limit for normal LAA volume was 5.6 mL/m2. In paired Student t-test between the patient group and matched controls, LAA volume was 67% larger in cryptogenic stroke/TIA patients (5.7±2.0 mL/m2 vs. 3.4±1.1 mL/m2; P<0.001). Forty-five (55%) patients with cryptogenic stroke/TIA had enlarged LAA. Conclusion LAA is significantly enlarged in more than half of patients with cryptogenic stroke/TIA. LAA thrombosis may contribute to the pathogenesis of stroke in patients considered to have cryptogenic stroke after conventional evaluation. |
| Audience | Academic |
| Author | Tapiola, Tero Kärkkäinen, Satu Taina, Mikko Jäkälä, Pekka Vanninen, Ritva Sipola, Petri Hedman, Marja |
| AuthorAffiliation | 3 Heart Center, Kuopio University Hospital, Kuopio, Finland 6 Department of Neurology, North Kymi Hospital, Kouvola, Finland 1 Department of Clinical Radiology, Kuopio University Hospital, Kuopio, Finland 4 NeuroCenter, Kuopio University Hospital, Kuopio, Finland The University of Chicago, United States of America 2 Unit of Radiology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland 5 Unit of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland |
| AuthorAffiliation_xml | – name: 6 Department of Neurology, North Kymi Hospital, Kouvola, Finland – name: 2 Unit of Radiology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland – name: The University of Chicago, United States of America – name: 5 Unit of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland – name: 1 Department of Clinical Radiology, Kuopio University Hospital, Kuopio, Finland – name: 3 Heart Center, Kuopio University Hospital, Kuopio, Finland – name: 4 NeuroCenter, Kuopio University Hospital, Kuopio, Finland |
| Author_xml | – sequence: 1 givenname: Mikko surname: Taina fullname: Taina, Mikko – sequence: 2 givenname: Ritva surname: Vanninen fullname: Vanninen, Ritva – sequence: 3 givenname: Marja surname: Hedman fullname: Hedman, Marja – sequence: 4 givenname: Pekka surname: Jäkälä fullname: Jäkälä, Pekka – sequence: 5 givenname: Satu surname: Kärkkäinen fullname: Kärkkäinen, Satu – sequence: 6 givenname: Tero surname: Tapiola fullname: Tapiola, Tero – sequence: 7 givenname: Petri surname: Sipola fullname: Sipola, Petri |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/24223960$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNkl1v0zAUhiM0xD7gHyCIhITgoiX-SGJzgVRNwCoNDbGxKyTLcY5bD9cutsPYv8el3bROk5hykeTkOW_OeV_vFzvOOyiK56gaI9Kidxd-CE7a8TKXx1XV8hrxR8Ue4gSPGlyRnVvPu8V-jBdVVRPWNE-KXUwxJryp9oofx6BTOUnBSFtOlktwvZxBee7tsIBy6lQAGaEvjSu_-ADl2Vy68khaXXpdfpXJgEuxvDRpXh6Gq2XyM3BGlacp-J_wtHispY3wbHM_KL5_-nh2eDQ6Pvk8PZwcj1TDcRrpFhHV1UCkZtAzTfsKI0ow1tBDRVvMGgDUtA2GXjeMKt61rMrvHcNckZYcFC_Xukvro9gYEwWilFHU1JRnYromei8vxDKYhQxXwksj_hV8mAkZklEWBJaMK9TVvIOOckY5B91qWlcd6DwOZK16rTW4pby6lNbeCKJKrLK5HkGsshGbbHLfh82UQ7eAXmXngrRbw2x_cWYuZv63IAy1CJMs8GYjEPyvAWISCxMVWCsd-GG1b83qinBWZ_TVHfR-VzbUTObFjdM-_1etRMWEtozimpMmU-N7qHz1sDAqb6hNrm81vN1qyEyCP2kmhxjF9PTbw9mT82329S12DtKmecwHNRnv4jb44rbTNxZfH_sMvF8DKvgYA2ihTJIrnbyasf_Lkd5pflD8fwFCOSnK |
| CitedBy_id | crossref_primary_10_3389_fcvm_2022_968630 crossref_primary_10_1016_j_jstrokecerebrovasdis_2019_05_008 crossref_primary_10_18821_0023_2149_2018_96_5_389_396 crossref_primary_10_1056_NEJMcp1503946 crossref_primary_10_1371_journal_pone_0090903 crossref_primary_10_3390_jcm12206491 crossref_primary_10_1161_JAHA_123_030147 crossref_primary_10_1371_journal_pone_0120598 crossref_primary_10_1007_s10237_021_01454_4 crossref_primary_10_1093_europace_euz212 crossref_primary_10_1155_2022_9125224 crossref_primary_10_1371_journal_pone_0120910 crossref_primary_10_1007_s00380_018_1119_3 crossref_primary_10_1016_j_hrthm_2015_12_026 crossref_primary_10_1016_j_compbiomed_2022_105897 crossref_primary_10_4329_wjr_v15_i4_98 crossref_primary_10_1007_s10554_022_02779_6 crossref_primary_10_36660_abc_20190492 crossref_primary_10_1371_journal_pone_0101580 crossref_primary_10_1161_STROKEAHA_113_003720 crossref_primary_10_1371_journal_pone_0118822 crossref_primary_10_1371_journal_pone_0173703 crossref_primary_10_3389_fcvm_2021_753949 |
| Cites_doi | 10.1016/j.hrthm.2006.07.022 10.1212/01.wnl.0000325059.86313.31 10.1111/j.1540-8167.2010.01853.x 10.1161/STROKEAHA.113.001340 10.1111/j.1540-8167.2010.01854.x 10.1002/ana.10644 10.1056/NEJMoa1105575 10.1159/000200446 10.1016/S0735-1097(13)60279-X 10.1016/j.jns.2012.10.001 10.1056/NEJM198710223171717 10.1093/europace/eum227 10.1007/s10840-010-9485-5 10.1016/j.jstrokecerebrovasdis.2006.07.002 10.1002/ar.1092420411 10.1007/s10840-011-9638-1 10.1016/0140-6736(92)91658-U 10.1253/circj.70.971 10.1016/j.jacc.2012.04.032 10.1161/01.STR.24.1.35 10.1007/s10840-011-9591-z 10.1161/STROKEAHA.111.648725 10.1161/STROKEAHA.112.665844 10.1159/000350734 10.1007/s00330-006-0262-x 10.1016/j.ijcard.2008.11.055 10.1016/S1474-4422(03)00324-7 10.1161/01.STR.30.10.2019 10.1111/j.1540-8167.2008.01290.x 10.1186/1476-7120-7-15 10.1016/0003-4975(95)00887-X 10.1148/radiol.2513090794 10.1161/01.STR.28.12.2507 10.1161/STROKEAHA.112.654954 10.1161/STROKEAHA.107.513002 10.1016/j.amjcard.2010.05.014 10.1093/ejechocard/jeq045 10.1161/01.STR.20.12.1648 10.1161/01.CIR.47.1.144 10.1016/S0140-6736(96)07493-4 10.1503/cmaj.091688 |
| ContentType | Journal Article |
| Copyright | COPYRIGHT 2013 Public Library of Science 2013 Taina et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2013 Taina et al 2013 Taina et al |
| Copyright_xml | – notice: COPYRIGHT 2013 Public Library of Science – notice: 2013 Taina et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2013 Taina et al 2013 Taina et al |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM IOV ISR 3V. 7QG 7QL 7QO 7RV 7SN 7SS 7T5 7TG 7TM 7U9 7X2 7X7 7XB 88E 8AO 8C1 8FD 8FE 8FG 8FH 8FI 8FJ 8FK ABJCF ABUWG AEUYN AFKRA ARAPS ATCPS AZQEC BBNVY BENPR BGLVJ BHPHI C1K CCPQU D1I DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. KB. KB0 KL. L6V LK8 M0K M0S M1P M7N M7P M7S NAPCQ P5Z P62 P64 PATMY PDBOC PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PTHSS PYCSY RC3 7X8 5PM ADTOC UNPAY DOA |
| DOI | 10.1371/journal.pone.0079519 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Gale In Context: Opposing Viewpoints Gale In Context: Science ProQuest Central (Corporate) Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Biotechnology Research Abstracts Nursing & Allied Health Database Ecology Abstracts Entomology Abstracts (Full archive) Immunology Abstracts Meteorological & Geoastrophysical Abstracts Nucleic Acids Abstracts Virology and AIDS Abstracts Agricultural Science Collection Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Public Health Database Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection ProQuest Hospital Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Materials Science & Engineering Collection ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland Advanced Technologies & Aerospace Collection ProQuest Agricultural & Environmental Science Database ProQuest Central Essentials Biological Science Collection ProQuest Central Database Suite (ProQuest) Technology Collection Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Materials Science Collection ProQuest Central Korea Engineering Research Database Proquest Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Collection (ProQuest) ProQuest Health & Medical Complete (Alumni) Materials Science Database Nursing & Allied Health Database (Alumni Edition) Meteorological & Geoastrophysical Abstracts - Academic ProQuest Engineering Collection ProQuest Biological Science Collection Agriculture Science Database ProQuest Health & Medical Collection Medical Database Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Engineering Database ProQuest Nursing & Allied Health Premium Advanced Technologies & Aerospace Database ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts Environmental Science Database Materials Science Collection Proquest Central Premium ProQuest One Academic (New) Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic ProQuest One Academic UKI Edition Engineering Collection Environmental Science Collection Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) Unpaywall for CDI: Periodical Content Unpaywall DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Agricultural Science Database Publicly Available Content Database ProQuest Central Student ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Meteorological & Geoastrophysical Abstracts Natural Science Collection Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) Engineering Collection Advanced Technologies & Aerospace Collection Engineering Database Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Agricultural Science Collection ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Environmental Science Collection Entomology Abstracts Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Environmental Science Database ProQuest Nursing & Allied Health Source (Alumni) Engineering Research Database ProQuest One Academic Meteorological & Geoastrophysical Abstracts - Academic ProQuest One Academic (New) Technology Collection Technology Research Database ProQuest One Academic Middle East (New) Materials Science Collection ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts ProQuest Engineering Collection Biotechnology Research Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Agricultural & Environmental Science Collection AIDS and Cancer Research Abstracts Materials Science Database ProQuest Materials Science Collection ProQuest Public Health ProQuest Nursing & Allied Health Source ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library Animal Behavior Abstracts Materials Science & Engineering Collection Immunology Abstracts ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic Agricultural Science Database |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journal Collection url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 4 dbid: UNPAY name: Unpaywall url: https://proxy.k.utb.cz/login?url=https://unpaywall.org/ sourceTypes: Open Access Repository – sequence: 5 dbid: 8FG name: ProQuest Technology Collection url: https://search.proquest.com/technologycollection1 sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Sciences (General) Statistics Medicine |
| DocumentTitleAlternate | Enlarged Atrial Appendage in Cryptogenic Stroke |
| EISSN | 1932-6203 |
| ExternalDocumentID | 1448416549 oai_doaj_org_article_2a89c1b59beb498499ef7f450befde0e 10.1371/journal.pone.0079519 PMC3817123 3117409201 A478425936 24223960 10_1371_journal_pone_0079519 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GeographicLocations | Finland |
| GeographicLocations_xml | – name: Finland |
| GroupedDBID | --- 123 29O 2WC 53G 5VS 7RV 7X2 7X7 7XC 88E 8AO 8C1 8CJ 8FE 8FG 8FH 8FI 8FJ A8Z AAFWJ AAUCC AAWOE AAYXX ABDBF ABIVO ABJCF ABUWG ACGFO ACIHN ACIWK ACPRK ACUHS ADBBV ADRAZ AEAQA AENEX AEUYN AFKRA AFPKN AFRAH AHMBA ALMA_UNASSIGNED_HOLDINGS AOIJS APEBS ARAPS ATCPS BAWUL BBNVY BCNDV BENPR BGLVJ BHPHI BKEYQ BPHCQ BVXVI BWKFM CCPQU CITATION CS3 D1I D1J D1K DIK DU5 E3Z EAP EAS EBD EMOBN ESTFP ESX EX3 F5P FPL FYUFA GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE IAO IEA IGS IHR IHW INH INR IOV IPNFZ IPY ISE ISR ITC K6- KB. KQ8 L6V LK5 LK8 M0K M1P M48 M7P M7R M7S M~E NAPCQ O5R O5S OK1 OVT P2P P62 PATMY PDBOC PHGZM PHGZT PIMPY PJZUB PPXIY PQGLB PQQKQ PROAC PSQYO PTHSS PUEGO PYCSY RIG RNS RPM SV3 TR2 UKHRP WOQ WOW ~02 ~KM 3V. ALIPV BBORY CGR CUY CVF ECM EIF NPM PV9 RZL PMFND 7QG 7QL 7QO 7SN 7SS 7T5 7TG 7TM 7U9 7XB 8FD 8FK AZQEC C1K DWQXO FR3 GNUQQ H94 K9. KL. M7N P64 PKEHL PQEST PQUKI RC3 7X8 5PM ADTOC UNPAY - 02 AAPBV ABPTK ADACO BBAFP KM |
| ID | FETCH-LOGICAL-c692t-f713cb5e3af8ed8f4d0214322fede047286ee16762edf684c9b780676b829c373 |
| IEDL.DBID | M48 |
| ISSN | 1932-6203 |
| IngestDate | Fri Nov 26 17:14:06 EST 2021 Wed Aug 27 01:16:26 EDT 2025 Tue Aug 19 23:44:48 EDT 2025 Tue Sep 30 15:34:01 EDT 2025 Fri Sep 05 06:29:26 EDT 2025 Fri Jul 25 11:51:49 EDT 2025 Tue Jun 17 21:33:21 EDT 2025 Tue Jun 10 20:45:52 EDT 2025 Fri Jun 27 04:42:33 EDT 2025 Fri Jun 27 03:59:32 EDT 2025 Thu May 22 21:19:40 EDT 2025 Wed Feb 19 01:54:30 EST 2025 Thu Apr 24 23:03:33 EDT 2025 Wed Oct 01 03:57:20 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 11 |
| Language | English |
| License | This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. cc-by Creative Commons Attribution License |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c692t-f713cb5e3af8ed8f4d0214322fede047286ee16762edf684c9b780676b829c373 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Conceived and designed the experiments: MT RV MH PJ PS. Performed the experiments: MT RV MH PJ PS. Analyzed the data: MT RV MH PJ SK TT PS. Contributed reagents/materials/analysis tools: MT RV MH PJ SK TT PS. Wrote the manuscript: MT RV MH PJ SK TT PS. Competing Interests: The authors have declared that no competing interests exist. |
| OpenAccessLink | https://proxy.k.utb.cz/login?url=https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0079519&type=printable |
| PMID | 24223960 |
| PQID | 1448416549 |
| PQPubID | 1436336 |
| PageCount | e79519 |
| ParticipantIDs | plos_journals_1448416549 doaj_primary_oai_doaj_org_article_2a89c1b59beb498499ef7f450befde0e unpaywall_primary_10_1371_journal_pone_0079519 pubmedcentral_primary_oai_pubmedcentral_nih_gov_3817123 proquest_miscellaneous_1458503985 proquest_journals_1448416549 gale_infotracmisc_A478425936 gale_infotracacademiconefile_A478425936 gale_incontextgauss_ISR_A478425936 gale_incontextgauss_IOV_A478425936 gale_healthsolutions_A478425936 pubmed_primary_24223960 crossref_citationtrail_10_1371_journal_pone_0079519 crossref_primary_10_1371_journal_pone_0079519 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2013-11-04 |
| PublicationDateYYYYMMDD | 2013-11-04 |
| PublicationDate_xml | – month: 11 year: 2013 text: 2013-11-04 day: 04 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: San Francisco – name: San Francisco, USA |
| PublicationTitle | PloS one |
| PublicationTitleAlternate | PLoS One |
| PublicationYear | 2013 |
| Publisher | Public Library of Science Public Library of Science (PLoS) |
| Publisher_xml | – name: Public Library of Science – name: Public Library of Science (PLoS) |
| References | R Beinart (ref12) 2011; 22 T Rizos (ref22) 2012; 43 S Leschka (ref25) 2006; 16 G Ernst (ref29) 1995; 242 NH Pan (ref15) 2009; 20 L D'Olhaberriague (ref5) 1989; 20 S Nedios (ref28) 2011; 32 JM Ferro (ref4) 2003; 2 BK Whisenant (ref34) 2013; 61 TP Jr Graham (ref19) 1973; 47 PK Yip (ref3) 1997; 28 OY Bang (ref6) 2003; 54 AC Flint (ref40) 2012; 43 F Knebel (ref35) 2009; 7 G Manina (ref39) 2012 GC Jickling (ref7) 2012; 43 H Okuyama (ref11) 2006; 70 T Wolber (ref37); 16 P Amarenco (ref8) 2009; 27 M Pepi (ref18) 2010; 11 JL Blackshear (ref23) 1996; 61 HP Jr Adams (ref17) 1993; 24 RD Mosteller (ref20) 1987; 317 L Di Biase (ref14) 2012; 60 A Bouzas-Mosquera (ref10) 2011; 183 DJ Miller (ref9) 2013; 324 J Hur (ref36) 2009; 251 JS Healey (ref38) 2012; 366 CJ Murray (ref2) 1997; 349 M Anselmino (ref13) 2011; 22 DT Walker (ref31) 2012; 34 P Sipola (ref16) 2013; 35 MR Di Tullio (ref24) 1999; 30 EK Heist (ref32) 2006; 3 AH Tayal (ref41) 2008; 71 R Bonita (ref1) 1992; 339 JM Lacomis (ref26) 2007; 9 L Christiaens (ref27) 2010; 140 DJ Gladstone (ref42) 2008; 39 T Etgen (ref43) 2013; 44 LD Burrell (ref33) 2013 F Dion (ref21) 2010; 28 H Nakajima (ref30) 2010; 106 4686591 - Circulation. 1973 Jan;47(1):144-53 22871678 - Stroke. 2012 Oct;43(10):2689-94 19342838 - Cerebrovasc Dis. 2009;27 Suppl 1:97-103 18388334 - Stroke. 2008 May;39(5):e78-9; discussion e80 17074637 - Heart Rhythm. 2006 Nov;3(11):1313-8 22119857 - J Interv Card Electrophysiol. 2012 Aug;34(2):173-9 23817231 - Cerebrovasc Dis. 2013;35(6):521-30 8572814 - Ann Thorac Surg. 1996 Feb;61(2):755-9 16699752 - Eur Radiol. 2006 Sep;16(9):1964-72 19366905 - Radiology. 2009 Jun;251(3):683-90 1346420 - Lancet. 1992 Feb 8;339(8789):342-4 7486025 - Anat Rec. 1995 Aug;242(4):553-61 12891675 - Ann Neurol. 2003 Aug;54(2):227-34 10512901 - Stroke. 1999 Oct;30(10):2019-24 20662984 - J Cardiovasc Electrophysiol. 2011 Jan;22(1):10-5 22236222 - N Engl J Med. 2012 Jan 12;366(2):120-9 9142060 - Lancet. 1997 May 3;349(9061):1269-76 23827402 - Am J Cardiol. 2013 Oct 15;112(8):1148-52 16864927 - Circ J. 2006 Aug;70(8):971-6 20816132 - Am J Cardiol. 2010 Sep 15;106(6):885-92 22871679 - Stroke. 2012 Oct;43(10):2788-90 9412641 - Stroke. 1997 Dec;28(12):2507-12 12849239 - Lancet Neurol. 2003 Mar;2(3):177-88 19108909 - Int J Cardiol. 2010 Apr 15;140(2):189-96 3657876 - N Engl J Med. 1987 Oct 22;317(17):1098 20662985 - J Cardiovasc Electrophysiol. 2011 Jan;22(1):1-7 18803575 - J Cardiovasc Electrophysiol. 2009 Feb;20(2):153-8 22627989 - Stroke. 2012 Aug;43(8):2036-41 18815386 - Neurology. 2008 Nov 18;71(21):1696-701 22249917 - Intern Emerg Med. 2014 Feb;9(1):65-7 21667097 - J Interv Card Electrophysiol. 2011 Nov;32(2):87-94 23102659 - J Neurol Sci. 2013 Jan 15;324(1-2):57-61 20702884 - Eur J Echocardiogr. 2010 Jul;11(6):461-76 17942583 - Europace. 2007 Dec;9(12):1134-40 22858289 - J Am Coll Cardiol. 2012 Aug 7;60(6):531-8 19327171 - Cardiovasc Ultrasound. 2009;7:15 17689384 - J Stroke Cerebrovasc Dis. 2007 Jan-Feb;16(1):1-7 7678184 - Stroke. 1993 Jan;24(1):35-41 20454840 - J Interv Card Electrophysiol. 2010 Aug;28(2):101-7 23674523 - Stroke. 2013 Jul;44(7):2007-9 21609990 - CMAJ. 2011 Jul 12;183(10):E657-64 2688196 - Stroke. 1989 Dec;20(12):1648-52 |
| References_xml | – volume: 3 start-page: 1313 year: 2006 ident: ref32 article-title: Analysis of the left atrial appendage by magnetic resonance angiography in patients with atrial fibrillation publication-title: Heart Rhythm doi: 10.1016/j.hrthm.2006.07.022 – volume: 71 start-page: 1696 year: 2008 ident: ref41 article-title: Atrial fibrillation detected by mobile cardiac outpatient telemetry in cryptogenic TIA or stroke publication-title: Neurology doi: 10.1212/01.wnl.0000325059.86313.31 – volume: 22 start-page: 1 year: 2011 ident: ref13 article-title: Morphologic analysis of left atrial anatomy by magnetic resonance angiography in patients with atrial fibrillation: a large single center experience publication-title: J Cardiovasc Electrophysiol doi: 10.1111/j.1540-8167.2010.01853.x – volume: 44 start-page: 2007 year: 2013 ident: ref43 article-title: Insertable Cardiac Event Recorder in Detection of Atrial Fibrillation After Cryptogenic Stroke: An Audit Report publication-title: Stroke doi: 10.1161/STROKEAHA.113.001340 – volume: 22 start-page: 10 year: 2011 ident: ref12 article-title: Left atrial appendage dimensions predict the risk of stroke/TIA in patients with atrial fibrillation publication-title: J Cardiovasc Electrophysiol doi: 10.1111/j.1540-8167.2010.01854.x – volume: 54 start-page: 227 year: 2003 ident: ref6 article-title: Frequency and mechanisms of stroke recurrence after cryptogenic stroke publication-title: Ann Neurol doi: 10.1002/ana.10644 – volume: 366 start-page: 120 year: 2012 ident: ref38 article-title: Subclinical atrial fibrillation and the risk of stroke publication-title: N Engl J Med doi: 10.1056/NEJMoa1105575 – volume: 27 start-page: 97 year: 2009 ident: ref8 article-title: Underlying pathology of stroke of unknown cause (cryptogenic stroke) publication-title: Cerebrovasc Dis doi: 10.1159/000200446 – volume: 61 year: 2013 ident: ref34 article-title: Left atrial appendage volume as a predictor of embolic stroke in atrial fibrillation publication-title: J Am Coll Cardiol doi: 10.1016/S0735-1097(13)60279-X – year: 2012 ident: ref39 article-title: 96 hours ECG monitoring for patients with ischemic cryptogenic stroke or transient ischaemic attack. Intern Emerg Med – volume: 324 start-page: 57 year: 2013 ident: ref9 article-title: Outpatient cardiac telemetry detects a high rate of atrial fibrillation in cryptogenic stroke publication-title: J Neurol Sci doi: 10.1016/j.jns.2012.10.001 – volume: 317 start-page: 1098 year: 1987 ident: ref20 article-title: Simplified calculation of body-surface area publication-title: N Engl J Med doi: 10.1056/NEJM198710223171717 – volume: 9 start-page: 1134 year: 2007 ident: ref26 article-title: Dynamic multidimensional imaging of the human left atrial appendage publication-title: Europace doi: 10.1093/europace/eum227 – volume: 28 start-page: 101 year: 2010 ident: ref21 article-title: Unexpected low prevalence of atrial fibrillation in cryptogenic ischemic stroke: a prospective study publication-title: J Interv Card Electrophysiol doi: 10.1007/s10840-010-9485-5 – volume: 16 start-page: 1 ident: ref37 article-title: Should routine echocardiography be performed in all patients with stroke? publication-title: J Stroke Cerebrovasc Dis doi: 10.1016/j.jstrokecerebrovasdis.2006.07.002 – volume: 242 start-page: 553 year: 1995 ident: ref29 article-title: Morphology of left atrial appendage publication-title: Anat Rec doi: 10.1002/ar.1092420411 – volume: 34 start-page: 173 year: 2012 ident: ref31 article-title: 2912) Anatomical analysis of the left atrial appendage using segmented, three-dimensional cardiac CT: A comparison of patients with paroxysmal and persistent forms of atrial fibrillation publication-title: J Interv Card Electrophysiol doi: 10.1007/s10840-011-9638-1 – year: 2013 ident: ref33 article-title: Usefulness of left atrial appendage volume as a predictor of embolic stroke in patients with atrial bibrillation – volume: 339 start-page: 342 year: 1992 ident: ref1 article-title: Epidemiology of stroke publication-title: Lancet doi: 10.1016/0140-6736(92)91658-U – volume: 70 start-page: 971 year: 2006 ident: ref11 article-title: Higher levels of serum fibrin-monomer reflect hypercoagulable state and thrombus formation in the left atrial appendage in patients with acute ischemic stroke publication-title: Circ J doi: 10.1253/circj.70.971 – volume: 60 start-page: 531 year: 2012 ident: ref14 article-title: Does the left atrial appendage morphology correlate with the risk of stroke in patients with atrial fibrillation? Results from a multicenter study publication-title: J Am Coll Cardiol doi: 10.1016/j.jacc.2012.04.032 – volume: 24 start-page: 35 year: 1993 ident: ref17 article-title: Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment publication-title: Stroke doi: 10.1161/01.STR.24.1.35 – volume: 32 start-page: 87 year: 2011 ident: ref28 article-title: Characteristic changes of volume and three-dimensional structure of the left atrium in different forms of atrial fibrillation: predictive value after ablative treatment publication-title: J Interv Card Electrophysiol doi: 10.1007/s10840-011-9591-z – volume: 43 start-page: 2036 year: 2012 ident: ref7 article-title: Prediction of cardioembolic, arterial, and lacunar causes of cryptogenic stroke by gene expression and infarct location publication-title: Stroke doi: 10.1161/STROKEAHA.111.648725 – volume: 43 start-page: 2788 year: 2012 ident: ref40 article-title: Detection of paroxysmal atrial fibrillation by 30-day event monitoring in cryptogenic ischemic stroke: the Stroke and Monitoring for PAF in Real Time (SMART) Registry publication-title: Stroke doi: 10.1161/STROKEAHA.112.665844 – volume: 35 start-page: 521 year: 2013 ident: ref16 article-title: Computed tomography and echocardiography together reveal more high-risk findings than echocardiography alone in the diagnostics of stroke etiology publication-title: Cerebrovasc Dis doi: 10.1159/000350734 – volume: 16 start-page: 1964 year: 2006 ident: ref25 article-title: Optimal image reconstruction intervals for non-invasive coronary angiography with 64-slice CT publication-title: Eur Radiol doi: 10.1007/s00330-006-0262-x – volume: 140 start-page: 189 year: 2010 ident: ref27 article-title: Real three-dimensional assessment of left atrial and left atrial appendage volumes by 64-slice spiral computed tomography in individuals with or without cardiovascular disease publication-title: Int J Cardiol doi: 10.1016/j.ijcard.2008.11.055 – volume: 2 start-page: 177 year: 2003 ident: ref4 article-title: Cardioembolic stroke: An update publication-title: Lancet Neurol doi: 10.1016/S1474-4422(03)00324-7 – volume: 30 start-page: 2019 year: 1999 ident: ref24 article-title: Left atrial size and the risk of ischemic stroke in an ethnically mixed population publication-title: Stroke doi: 10.1161/01.STR.30.10.2019 – volume: 20 start-page: 153 year: 2009 ident: ref15 article-title: Dilated left atrium and pulmonary veins in patients with calcified coronary artery: A potential contributor to the genesis of atrial fibrillation publication-title: J Cardiovasc Electrophysiol doi: 10.1111/j.1540-8167.2008.01290.x – volume: 7 start-page: 15 year: 2009 ident: ref35 article-title: Transesophageal echocardiography in patients with cryptogenic cerebral ischemia publication-title: Cardiovasc Ultrasound doi: 10.1186/1476-7120-7-15 – volume: 61 start-page: 755 year: 1996 ident: ref23 article-title: Appendage obliteration to reduce stroke in cardiac surgical patients with atrial fibrillation publication-title: Ann Thorac Surg doi: 10.1016/0003-4975(95)00887-X – volume: 251 start-page: 683 year: 2009 ident: ref36 article-title: Left atrial appendage thrombi in stroke patients: detection with two-phase cardiac CT angiography versus transesophageal echocardiography publication-title: Radiology doi: 10.1148/radiol.2513090794 – volume: 28 start-page: 2507 year: 1997 ident: ref3 article-title: Subtypes of ischemic stroke. A hospital-based stroke registry in Taiwan (SCAN-IV) publication-title: Stroke doi: 10.1161/01.STR.28.12.2507 – volume: 43 start-page: 2689 year: 2012 ident: ref22 article-title: Continuous stroke unit electrocardiographic monitoring versus 24-hour holter electrocardiography for detection of paroxysmal atrial fibrillation after stroke publication-title: Stroke doi: 10.1161/STROKEAHA.112.654954 – volume: 39 start-page: 78 year: 2008 ident: ref42 article-title: EMBRACE Pilot Study Group. Detecting paroxysmal atrial fibrillation after ischemic stroke and transient ischemic attack: if you don’t look, you won’t find publication-title: Stroke doi: 10.1161/STROKEAHA.107.513002 – volume: 106 start-page: 885 year: 2010 ident: ref30 article-title: Analysis of the left atrial appendage by three-dimensional transesophageal echocardiography publication-title: Am J Cardiol doi: 10.1016/j.amjcard.2010.05.014 – volume: 11 start-page: 461 year: 2010 ident: ref18 article-title: Recommendations for echocardiography use in the diagnosis and management of cardiac sources of embolism: European Association of Echocardiography (EAE) (a registered branch of the ESC) publication-title: Eur J Echocardiogr doi: 10.1093/ejechocard/jeq045 – volume: 20 start-page: 1648 year: 1989 ident: ref5 article-title: A prospective study of atrial fibrillation and stroke publication-title: Stroke doi: 10.1161/01.STR.20.12.1648 – volume: 47 start-page: 144 year: 1973 ident: ref19 article-title: Right ventricular volume determinations in children. Normal values and observations with volume or pressure overload publication-title: Circulation doi: 10.1161/01.CIR.47.1.144 – volume: 349 start-page: 1269 year: 1997 ident: ref2 article-title: Mortality by cause for eight regions of the world: Global burden of disease study publication-title: Lancet doi: 10.1016/S0140-6736(96)07493-4 – volume: 183 start-page: 657 year: 2011 ident: ref10 article-title: Left atrial size and risk for all-cause mortality and ischemic stroke publication-title: CMAJ doi: 10.1503/cmaj.091688 – reference: 12891675 - Ann Neurol. 2003 Aug;54(2):227-34 – reference: 23674523 - Stroke. 2013 Jul;44(7):2007-9 – reference: 23102659 - J Neurol Sci. 2013 Jan 15;324(1-2):57-61 – reference: 21667097 - J Interv Card Electrophysiol. 2011 Nov;32(2):87-94 – reference: 9412641 - Stroke. 1997 Dec;28(12):2507-12 – reference: 4686591 - Circulation. 1973 Jan;47(1):144-53 – reference: 19108909 - Int J Cardiol. 2010 Apr 15;140(2):189-96 – reference: 18388334 - Stroke. 2008 May;39(5):e78-9; discussion e80 – reference: 22858289 - J Am Coll Cardiol. 2012 Aug 7;60(6):531-8 – reference: 17689384 - J Stroke Cerebrovasc Dis. 2007 Jan-Feb;16(1):1-7 – reference: 23827402 - Am J Cardiol. 2013 Oct 15;112(8):1148-52 – reference: 19342838 - Cerebrovasc Dis. 2009;27 Suppl 1:97-103 – reference: 22119857 - J Interv Card Electrophysiol. 2012 Aug;34(2):173-9 – reference: 17942583 - Europace. 2007 Dec;9(12):1134-40 – reference: 2688196 - Stroke. 1989 Dec;20(12):1648-52 – reference: 3657876 - N Engl J Med. 1987 Oct 22;317(17):1098 – reference: 1346420 - Lancet. 1992 Feb 8;339(8789):342-4 – reference: 22627989 - Stroke. 2012 Aug;43(8):2036-41 – reference: 7678184 - Stroke. 1993 Jan;24(1):35-41 – reference: 18803575 - J Cardiovasc Electrophysiol. 2009 Feb;20(2):153-8 – reference: 17074637 - Heart Rhythm. 2006 Nov;3(11):1313-8 – reference: 20454840 - J Interv Card Electrophysiol. 2010 Aug;28(2):101-7 – reference: 22236222 - N Engl J Med. 2012 Jan 12;366(2):120-9 – reference: 23817231 - Cerebrovasc Dis. 2013;35(6):521-30 – reference: 18815386 - Neurology. 2008 Nov 18;71(21):1696-701 – reference: 16864927 - Circ J. 2006 Aug;70(8):971-6 – reference: 19327171 - Cardiovasc Ultrasound. 2009;7:15 – reference: 22871679 - Stroke. 2012 Oct;43(10):2788-90 – reference: 8572814 - Ann Thorac Surg. 1996 Feb;61(2):755-9 – reference: 20662984 - J Cardiovasc Electrophysiol. 2011 Jan;22(1):10-5 – reference: 20816132 - Am J Cardiol. 2010 Sep 15;106(6):885-92 – reference: 7486025 - Anat Rec. 1995 Aug;242(4):553-61 – reference: 9142060 - Lancet. 1997 May 3;349(9061):1269-76 – reference: 21609990 - CMAJ. 2011 Jul 12;183(10):E657-64 – reference: 20662985 - J Cardiovasc Electrophysiol. 2011 Jan;22(1):1-7 – reference: 22871678 - Stroke. 2012 Oct;43(10):2689-94 – reference: 12849239 - Lancet Neurol. 2003 Mar;2(3):177-88 – reference: 16699752 - Eur Radiol. 2006 Sep;16(9):1964-72 – reference: 10512901 - Stroke. 1999 Oct;30(10):2019-24 – reference: 22249917 - Intern Emerg Med. 2014 Feb;9(1):65-7 – reference: 20702884 - Eur J Echocardiogr. 2010 Jul;11(6):461-76 – reference: 19366905 - Radiology. 2009 Jun;251(3):683-90 |
| SSID | ssj0053866 |
| Score | 2.2734954 |
| Snippet | Ischemic strokes without a well-defined etiology are labeled as cryptogenic, and account for 30-40% of strokes in stroke registries. The left atrial appendage... Background Ischemic strokes without a well-defined etiology are labeled as cryptogenic, and account for 30-40% of strokes in stroke registries. The left atrial... Background Ischemic strokes without a well-defined etiology are labeled as cryptogenic, and account for 30–40% of strokes in stroke registries. The left atrial... BACKGROUND: Ischemic strokes without a well-defined etiology are labeled as cryptogenic, and account for 30-40% of strokes in stroke registries. The left... Background Ischemic strokes without a well-defined etiology are labeled as cryptogenic, and account for 30–40% of strokes in stroke registries. The left atrial... |
| SourceID | plos doaj unpaywall pubmedcentral proquest gale pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | e79519 |
| SubjectTerms | Age Atherosclerosis Atrial Appendage - diagnostic imaging Atrial Appendage - pathology Cardiac arrhythmia Cardiovascular disease Cardiovascular diseases Cardiovascular system Case-Control Studies CAT scans Clinical medicine Computed tomography Contrast agents Development and progression Echocardiography EKG Electrocardiography Embolism Embolisms Etiology Female Fibrillation Flow velocity Health risks Heart Heart diseases Hospitals Humans Ischemia Male Males Medical imaging Medical research Medicine Middle Aged Neurology Organ Size Pathogenesis Patients Radiology Reproducibility of Results Risk factors Statistics Stroke Stroke - diagnostic imaging Stroke - pathology Stroke patients Surface area Thromboembolism Thrombosis Tomography, X-Ray Computed Ultrasonic imaging |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1ba9RAFB5kX_RFrLemFx1FUB_Sbm5zeaxiqeIF1EofhDBXu7gkYZNF-u89J5kNDRbaB9-WzMlCzv3MnPkOIS94knDc3Icylbk4524eQxiWsShS7YQ1trB4OfnTZ3Zymn84K84ujfrCnrABHnhg3GGqhDSJLqR2OpcCEnTnuc-LuXbeurlD7wthbFNMDT4YrJixcFEu48lhkMtBU1cOwbIhrZCTQNTj9Y9eedYs6_aqlPPfzsnb66pRF3_UcnkpLB3fI3dDPkmPhu_YIrdcdZ9sBYtt6asAK_36Afn50fmOqn5MB1UNzr4FX0IH90QXFaaPrbPwi2LzLcU9dXqulp7Wngb41Zbivi01q4umq0H1Foa23ar-7R6S0-N339-exGG2QmyYTLvYQ3FqdOEy5YWzwucWwdPAur0DruY8Fcy5hIGrdNYzkRupuYDIxrRIpcl49ojMKuDmNqF6XlitIU3QuIdktHI2VVoKm7FEgdgikm0YXZoAPI7zL5Zlf5rGoQAZeFWieMognojE41vNALxxDf0blOFIi7DZ_QNQpjIoU3mdMkXkKWpAOdxBHY2_PMo5HlfKjEXkeU-B0BkV9ub8Uuu2Ld9_-XEDom9fJ0QvA5GvgR1GhfsQ8E0IyTWh3JtQggMwk-Vt1NcNV1qo5nI8TIbKH97c6PDVy8_GZfxT7LerXL1GGigj55kURUQeDyo_chaSujSDwjcifGIME9ZPV6rFeY9cjnCQkCpF5GA0mxsJd-d_CHeX3ElxlgmeCeR7ZNat1m4fMspOP-mdx1__j3dI priority: 102 providerName: Directory of Open Access Journals – databaseName: ProQuest Technology Collection dbid: 8FG link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3db9MwELegSMALYuNjhQEGIQEP2Zpv5wmViVIQBcQ-tAekKLbPXUWVhCYV2n_PXeIGIibYa3yJ4vPd-T7s3zH2PHbdmJL7GKZG4AQxjBzchhNHhJ4EoZUONV1Onn2KpsfBh9Pw1CbcKnuscmMTG0OtC0U58n10_KlChuHM6_KHQ12jqLpqW2hcZddcDyWJbopP3m0sMepyFNnrcn7s7tvV2SuLHAgyG52LpLcdNaj9nW0elMuiusjx_Pv85I11XmbnP7Pl8o_NaXKb3bJeJR-3YrDFrkC-za7PbN18m21ZFa74S4sz_eoO-_YRTM3HTd8Ojt4oYHQ-B37S2CuOhoPOq4Pmi5zPihXwo7Ms59NsaXhh-JcWj7XilMjlB6vzsi5QFheKH9ar4jvcZceTt0cHU8c2W3BUlHi1YzBaVTIEPzMCtDCBJjQ1VHcDGghSUkQAboS2E7SJRKASGQvc6iIpvET5sX-PDXJk7A7jchRqKdFvkJRUUjID7WUyEdqP3CyRMGT-huepskjk1BBjmTbltRgjkpZtKa1UaldqyJzurbJF4vgP_Rtazo6WcLSbB8Vqnlq1TL1MJMqVIf6VDBKB4R-Y2AThSILBaeOvPiFhSNtLqZ01SMdBTPXLxI-G7FlDQVgaOR3WmWfrqkrffz65BNHh1x7RC0tkCmSHyuwFCZwTYXT1KHd7lGgRVG94h0R3w5Uq_a07-OZGnC8eftoN00fpAF4OxZpoMK4c-YkIh-x-K_0dZ9HL83yMhIcs7ulFj_X9kXxx1kCZEz4k-k5Dttdp0KUW98G_5_GQ3fSobQml_4NdNqhXa3iEzmMtHzcW4hftOG9i priority: 102 providerName: ProQuest – databaseName: Unpaywall dbid: UNPAY link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwELbK9gAXoLwaWMAgxOOQdPN2jktFtSBaKtqtWgkUxS-66ipZbbJC5cBvZyZxIgJFlAO31XpsxZ_t8YzH85mQZ7Hrxni4D25qpOwgViMbtuHEZqHHFZNChhKTk3f3osk0eHccHq-Rz20ujEEQfMR5UdaRfPxR5GrLILmFfEVN9NRx_dhtazgLEEIibDAZkuc14xCejFWYgHSFrEcYfxqQ9ene_vikiTR7duSNfJNO96eWettVzerf6e4BftlFhunv9yuvrvJFdv41m89_2rx2bpDvbbebOytnzqrijvj2CyPkf8PlJrluzF46blrZIGsqv0U2jGIp6UvDfv3qNvn0XumKjuvXRCjYyCqXoPLoUa1FKagzvEWvJJ3ldLdYKnp4muV0ks01LTTdb1hiS4rHy3R7eb6oClghM0EPqmVxpu6Q6c6bw-2JbZ6AsEWUeJWtwYcWPFR-ppmSTAcSOd5ACWklFRJdskgpNwKNrqSOWCASHjPYgCPOvET4sX-XDHIAYJNQPgol52DNcDzqEjxT0st4wqQfuVnClUX8dqRTYfjR8ZmOeVoH_WLwkxqsUkQ0NYhaxO5qLRp-kL_Iv8ZJ1Mkiu3f9BwxpaoYy9TKWCJeH8FU8SBg4pUrHOghHXGnoNnzqY5yCaZMq2-modBzEGFVN_MgiT2sJZPjI8QrRl2xVlunbD0eXEDr42BN6YYR0AXCIzKRtQJ9wxvUkhz1J0FOiV7yJU7ZFpQSnM8CYdxgAKMN2EV1c_KQrxkbxWmCuihXKgLc78hMWWuRes-Y6ZMH29Hzwzy0S91ZjD_p-ST47rQnWkbUSLDqLON26vdTg3v_XCg_INQ-fV8EwRTAkg2q5Ug_ByK34I6OqfgD1dKvp priority: 102 providerName: Unpaywall |
| Title | Left Atrial Appendage Volume Increased in More Than Half of Patients with Cryptogenic Stroke |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/24223960 https://www.proquest.com/docview/1448416549 https://www.proquest.com/docview/1458503985 https://pubmed.ncbi.nlm.nih.gov/PMC3817123 https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0079519&type=printable https://doaj.org/article/2a89c1b59beb498499ef7f450befde0e http://dx.doi.org/10.1371/journal.pone.0079519 |
| UnpaywallVersion | publishedVersion |
| Volume | 8 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVFSB databaseName: Free Full-Text Journals in Chemistry customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: HH5 dateStart: 20060101 isFulltext: true titleUrlDefault: http://abc-chemistry.org/ providerName: ABC ChemistRy – providerCode: PRVAFT databaseName: Open Access Digital Library customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: KQ8 dateStart: 20060101 isFulltext: true titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html providerName: Colorado Alliance of Research Libraries – providerCode: PRVAFT databaseName: Open Access Digital Library customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: KQ8 dateStart: 20061001 isFulltext: true titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html providerName: Colorado Alliance of Research Libraries – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journal Collection customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: DOA dateStart: 20060101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVEBS databaseName: EBSCOhost Academic Search Ultimate customDbUrl: https://search.ebscohost.com/login.aspx?authtype=ip,shib&custid=s3936755&profile=ehost&defaultdb=asn eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: ABDBF dateStart: 20080101 isFulltext: true titleUrlDefault: https://search.ebscohost.com/direct.asp?db=asn providerName: EBSCOhost – providerCode: PRVBFR databaseName: Free Medical Journals customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: DIK dateStart: 20060101 isFulltext: true titleUrlDefault: http://www.freemedicaljournals.com providerName: Flying Publisher – providerCode: PRVFQY databaseName: GFMER Free Medical Journals customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: GX1 dateStart: 20060101 isFulltext: true titleUrlDefault: http://www.gfmer.ch/Medical_journals/Free_medical.php providerName: Geneva Foundation for Medical Education and Research – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M~E dateStart: 20060101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVAQN databaseName: PubMed Central customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: RPM dateStart: 20060101 isFulltext: true titleUrlDefault: https://www.ncbi.nlm.nih.gov/pmc/ providerName: National Library of Medicine – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: http://www.proquest.com/pqcentral?accountid=15518 eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: BENPR dateStart: 20061201 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Health & Medical Collection customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 7X7 dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Technology Collection customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 8FG dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/technologycollection1 providerName: ProQuest – providerCode: PRVPQU databaseName: Public Health Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 8C1 dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/publichealth providerName: ProQuest – providerCode: PRVFZP databaseName: Scholars Portal Journals: Open Access customDbUrl: eissn: 1932-6203 dateEnd: 20250930 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M48 dateStart: 20061201 isFulltext: true titleUrlDefault: http://journals.scholarsportal.info providerName: Scholars Portal |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3db9MwELe27gFeEONrgVIMQnw8pGq-nQeEumljIFamQVGRkCI7sbeKKMmaVND_nrvEjYgooi9RFF8i53x3vvPZvyPkeWBZAS7uQ5jqS9MN5MiEaTg0mWcLyZI48RI8nHw28U-n7oeZN9sh60S7ZmC5MbTDelLTRTr8db16Cwr_pq7aEFjrl4ZFnkmEwganIXxRXJtYWgpTsLrOxi7Zg-nKRtE_c9tUAyh8ndBER8b07ZGjz9f968Od-auG-W-Nea9I83KTp_r3hssby6zgq588Tf-YzU5uk1vaDaXjRm72yY7M7pB9reglfaXRqF_fJd8_SlVRXlf3oLzAkrlggmhj1eg8Q6-zlAncUdyzS3Epnl7xVNFcUY3aWlJc7qXxYlVUOUjsPKZltch_yHtkenL85ejU1CUZzNgP7cpUENPGwpMOV0wmTLkJYq6BUVAykQg8yXwpLR8srEyUz9w4FAGDCdEXzA5jJ3Duk14G3DwgVIy8RAjwLgQuPcWCy8TmImSJ41s8FNIgzprRUazxyrFsRhrVSbgA4paGVxEOT6SHxyBm-1bR4HX8h_4Qx7ClRbTt-kG-uIy08kY2Z2FsCQ96JdyQQZAoVaBcbySkgt-Grj5BCYiao6utzYjGboBZztDxDfKspkDEjQy39FzyZVlG7z993YLo80WH6KUmUjmwI-b6GAX8EyJ5dSj7HUqwG3Gn-QDldc2VEoJAF3PQngtM6a9leHPz07YZP4rb9DKZL5EGos-REzLPIA8akW85C76g7UC8bJCgowwd1ndbsvlVDXiOKJLgYRlk2KrNVoP7cIuOPiI3baxwgpkCt0961WIpH4OfWYkB2Q1mAVzZkYXXk3cDsnd4PDm_GNQrN4PajsCz6eR8_O03CQGFiQ |
| linkProvider | Scholars Portal |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9NAEF6VIFEuiJZHDYUuCAQ9uI3f6wNCoVClNCmIplUOSMbr3W0jItvEjqr8KX4jM_bGYFFBL716x5Z3ZvbbmX18Q8iLwLICXNyHNNWXphvIrgnTcGgyz-aSiUR4Ai8nD4_8_on7ceyNV8jP5V0YPFa5xMQKqEWW4Br5LgT-uEMG6czb_IeJVaNwd3VZQqN2i0O5uICUrXhz8B7s-9K29z-M9vqmripgJn5ol6aCtCzhnnRixaRgyhVIGwZ-raSQyJ3IfCktH0BCCuUzNwl5wADTfc7sMHECB757g9x0na6LXP3BuEnwADt8X1_PcwJrV3vDTp6lEim6IZgJW9NfVSWgmQs6-TQrLgt0_z6vuTpP83hxEU-nf0yG-3fJHR3F0l7tdmtkRabr5NZQ79OvkzUNGQV9rXmtt--RrwOpStqr6oRQiH5lKgDM6GmFjxSACs_HS0EnKR1mM0lH53FK-_FU0UzRzzX_a0Fx4ZjuzRZ5mYHvTxJ6XM6y7_I-ObkWMzwgnRQUu0Eo73qCc4hTOC5iJTyWwo55yITjW3HIpUGcpc6jRDOfYwGOaVRt5wWQAdVqi9BSkbaUQczmrbxm_viP_Ds0ZyOLvN3Vg2x2FmkYiOyYhYnFPfgr7oYM0k2pAuV6XS4VdBt-dQudIaovwTboE_XcAPdLQ8c3yPNKArk7UjwcdBbPiyI6-HR6BaHjLy2hV1pIZaCOJNYXMqBPyAnWktxsSQICJa3mDXTdpVaK6PdYhTeX7nx587OmGT-KB_5Smc1RBvLYrhMyzyAPa-9vNAtRpe1A5m2QoDUuWqpvt6ST84o6HfkoIVYzyE4zgq5k3Ef_7scWWe2PhoNocHB0-JjctrFkCm49uJukU87m8gkEriV_WqEFJd-uG55-AYnxq-o |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3db9MwELdGkQYviI2PBQYzCAR7yNp8Jw8IlY2qZeuY2If6gBTi2N4qqiQ0qab-a_x13CVOIGKCvew1vkTx3fnnO9_5jpBXnmF4eLgPbqordNsTPR224UD3HZMJn8fc4Xg5eXzoDk_tTxNnskJ-1ndhMK2yxsQSqHka4xl5Fwx_jJCBO9OVKi3iaG_wPvuhYwcpjLTW7TQqFdkXy0tw3_J3oz2Q9WvTHHw82R3qqsOAHruBWegSXLSYOcKKpC-4L22OJcRAx6XgAuso-q4QhguAIbh0fTsOmOcDvrvMN4PY8iz47i1y27NsC9PJvEnj7AGOuK66qmd5Rldpxk6WJgLLdYNhE7S2wrJjQLMvdLJZml9l9P6du3lnkWTR8jKazf7YGAf3yT1l0dJ-pYJrZEUk62R1rGL262RNwUdO36oa19sPyNcDIQvaL3uGULCERcIB2OhZiZUUQAtz5QWn04SO07mgJxdRQofRTNJU0qOqFmxO8RCZ7s6XWZHCOpjG9LiYp9_FQ3J6I2J4RDoJMHaDUNZzOGNgszA80IpZJLgZscDnlmtEARMasWqeh7Gqgo7NOGZhGdrzwBuq2BaipEIlKY3ozVtZVQXkP_QfUJwNLdbwLh-k8_NQQUJoRn4QG8yBv2J24IPrKaQnbafHhIRpw69uoTKE1YXYBonCvu1h7DSwXI28LCmwjkeCK-I8WuR5OPp8dg2i4y8tojeKSKbAjjhSlzNgTlgfrEW52aIENIpbwxuoujVX8vD3uoU3a3W-evhFM4wfxeS_RKQLpAGftmcFvqORx5X2N5wFC9O0wAvXiNdaFy3Wt0eS6UVZRh1rU4LdppGdZgVdS7hP_j2PLbIKwBQejA73n5K7JnZPwSiEvUk6xXwhnoENW7DnJVhQ8u2m0ekXveCwJQ |
| linkToUnpaywall | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwELbK9gAXoLwaWMAgxOOQdPN2jktFtSBaKtqtWgkUxS-66ipZbbJC5cBvZyZxIgJFlAO31XpsxZ_t8YzH85mQZ7Hrxni4D25qpOwgViMbtuHEZqHHFZNChhKTk3f3osk0eHccHq-Rz20ujEEQfMR5UdaRfPxR5GrLILmFfEVN9NRx_dhtazgLEEIibDAZkuc14xCejFWYgHSFrEcYfxqQ9ene_vikiTR7duSNfJNO96eWettVzerf6e4BftlFhunv9yuvrvJFdv41m89_2rx2bpDvbbebOytnzqrijvj2CyPkf8PlJrluzF46blrZIGsqv0U2jGIp6UvDfv3qNvn0XumKjuvXRCjYyCqXoPLoUa1FKagzvEWvJJ3ldLdYKnp4muV0ks01LTTdb1hiS4rHy3R7eb6oClghM0EPqmVxpu6Q6c6bw-2JbZ6AsEWUeJWtwYcWPFR-ppmSTAcSOd5ACWklFRJdskgpNwKNrqSOWCASHjPYgCPOvET4sX-XDHIAYJNQPgol52DNcDzqEjxT0st4wqQfuVnClUX8dqRTYfjR8ZmOeVoH_WLwkxqsUkQ0NYhaxO5qLRp-kL_Iv8ZJ1Mkiu3f9BwxpaoYy9TKWCJeH8FU8SBg4pUrHOghHXGnoNnzqY5yCaZMq2-modBzEGFVN_MgiT2sJZPjI8QrRl2xVlunbD0eXEDr42BN6YYR0AXCIzKRtQJ9wxvUkhz1J0FOiV7yJU7ZFpQSnM8CYdxgAKMN2EV1c_KQrxkbxWmCuihXKgLc78hMWWuRes-Y6ZMH29Hzwzy0S91ZjD_p-ST47rQnWkbUSLDqLON26vdTg3v_XCg_INQ-fV8EwRTAkg2q5Ug_ByK34I6OqfgD1dKvp |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Left+atrial+appendage+volume+increased+in+more+than+half+of+patients+with+cryptogenic+stroke&rft.jtitle=PloS+one&rft.au=Taina%2C+Mikko&rft.au=Vanninen%2C+Ritva&rft.au=Hedman%2C+Marja&rft.au=J%C3%A4k%C3%A4l%C3%A4%2C+Pekka&rft.date=2013-11-04&rft.issn=1932-6203&rft.eissn=1932-6203&rft.volume=8&rft.issue=11&rft.spage=e79519&rft_id=info:doi/10.1371%2Fjournal.pone.0079519&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1932-6203&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1932-6203&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1932-6203&client=summon |