Estimating Temporal Causal Interaction between Spike Trains with Permutation and Transfer Entropy

• Published in: PloS one Vol. 8; no. 8; p. e70894
• Main Authors: Li, Zhaohui, Li, Xiaoli
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 05.08.2013; Public Library of Science (PLoS)
• Subjects: Action Potentials; Algorithms; Analysis; Biology; Causality; Coding; Computer Science; Computer Simulation; Cortex; Entropy; Estimation; Firing pattern; Firing rate; Information flow; Information management; Information theory; Methods; Models, Neurological; Nerve Net - cytology; Nerve Net - physiology; Neural coding; Neural networks; Neurons; Neurons - physiology; Permutations; Synapses; Time lag; Time series
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0070894

Estimating the causal interaction between neurons is very important for better understanding the functional connectivity in neuronal networks. We propose a method called normalized permutation transfer entropy (NPTE) to evaluate the temporal causal interaction between spike trains, which quantifies the fraction of ordinal information in a neuron that has presented in another one. The performance of this method is evaluated with the spike trains generated by an Izhikevich's neuronal model. Results show that the NPTE method can effectively estimate the causal interaction between two neurons without influence of data length. Considering both the precision of time delay estimated and the robustness of information flow estimated against neuronal firing rate, the NPTE method is superior to other information theoretic method including normalized transfer entropy, symbolic transfer entropy and permutation conditional mutual information. To test the performance of NPTE on analyzing simulated biophysically realistic synapses, an Izhikevich's cortical network that based on the neuronal model is employed. It is found that the NPTE method is able to characterize mutual interactions and identify spurious causality in a network of three neurons exactly. We conclude that the proposed method can obtain more reliable comparison of interactions between different pairs of neurons and is a promising tool to uncover more details on the neural coding.