Passive Immunization with Phospho-Tau Antibodies Reduces Tau Pathology and Functional Deficits in Two Distinct Mouse Tauopathy Models - Sankaranarayanan, Sethu; Barten, Donna M.; Vana, Laurel; Devidze, Nino; Yang, Ling; Cadelina, Gregory; Hoque, Nina; DeCarr, Lynn; Keenan, Stefanie; Lin, Alan; Cao, Yang; Snyder, Bradley; et al. (PloS one, 2015)
Keywords: Age; Alzheimer Disease - chemically induced; Alzheimer Disease - immunology; Alzheimer Disease - pathology; Alzheimer Disease - therapy; Alzheimer's disease; Amyloid; Analysis; Animal models; Animals; Antibodies; Antibodies, Monoclonal - pharmacology; Brain; Cerebral Cortex - drug effects; Cerebral Cortex - immunology; Cerebral Cortex - pathology; Cerebrospinal fluid; Chief executive officers; Cognition Disorders - chemically induced; Cognition Disorders - immunology; Cognition Disorders - pathology; Cognition Disorders - therapy; Cognitive ability; Cortex (entorhinal); Disease Models, Animal; Exploratory Behavior - drug effects; Fibrils; Gene Expression Regulation; Generic drugs; Genetic engineering; Hippocampus; Hippocampus - drug effects; Hippocampus - immunology; Hippocampus - pathology; Immunization; Immunization, Passive; Immunotherapy; Injection; Male; Memory; Mice; Mice, Transgenic; Neurodegenerative diseases; Neurons - drug effects; Neurons - immunology; Neurons - pathology; Object recognition; Overexpression; Pathology; Pattern recognition; Phosphoproteins - pharmacology; Primary Cell Culture; Recombinant Proteins - administration & dosage; Recombinant Proteins - adverse effects; Rodents; Senile plaques; Signal Transduction; Tau protein; tau Proteins - antagonists & inhibitors; tau Proteins - genetics; tau Proteins - immunology; Therapeutic applications; Transgenic mice; Treatment Outcome