Physiologic Status Monitoring via the Gastrointestinal Tract
Reliable, real-time heart and respiratory rates are key vital signs used in evaluating the physiological status in many clinical and non-clinical settings. Measuring these vital signs generally requires superficial attachment of physically or logistically obtrusive sensors to subjects that may resul...
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| Published in | PloS one Vol. 10; no. 11; p. e0141666 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Public Library of Science
18.11.2015
Public Library of Science (PLoS) |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1932-6203 1932-6203 |
| DOI | 10.1371/journal.pone.0141666 |
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| Abstract | Reliable, real-time heart and respiratory rates are key vital signs used in evaluating the physiological status in many clinical and non-clinical settings. Measuring these vital signs generally requires superficial attachment of physically or logistically obtrusive sensors to subjects that may result in skin irritation or adversely influence subject performance. Given the broad acceptance of ingestible electronics, we developed an approach that enables vital sign monitoring internally from the gastrointestinal tract. Here we report initial proof-of-concept large animal (porcine) experiments and a robust processing algorithm that demonstrates the feasibility of this approach. Implementing vital sign monitoring as a stand-alone technology or in conjunction with other ingestible devices has the capacity to significantly aid telemedicine, optimize performance monitoring of athletes, military service members, and first-responders, as well as provide a facile method for rapid clinical evaluation and triage. |
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| AbstractList | Reliable, real-time heart and respiratory rates are key vital signs used in evaluating the physiological status in many clinical and non-clinical settings. Measuring these vital signs generally requires superficial attachment of physically or logistically obtrusive sensors to subjects that may result in skin irritation or adversely influence subject performance. Given the broad acceptance of ingestible electronics, we developed an approach that enables vital sign monitoring internally from the gastrointestinal tract. Here we report initial proof-of-concept large animal (porcine) experiments and a robust processing algorithm that demonstrates the feasibility of this approach. Implementing vital sign monitoring as a stand-alone technology or in conjunction with other ingestible devices has the capacity to significantly aid telemedicine, optimize performance monitoring of athletes, military service members, and first-responders, as well as provide a facile method for rapid clinical evaluation and triage. Reliable, real-time heart and respiratory rates are key vital signs used in evaluating the physiological status in many clinical and non-clinical settings. Measuring these vital signs generally requires superficial attachment of physically or logistically obtrusive sensors to subjects that may result in skin irritation or adversely influence subject performance. Given the broad acceptance of ingestible electronics, we developed an approach that enables vital sign monitoring internally from the gastrointestinal tract. Here we report initial proof-of-concept large animal (porcine) experiments and a robust processing algorithm that demonstrates the feasibility of this approach. Implementing vital sign monitoring as a stand-alone technology or in conjunction with other ingestible devices has the capacity to significantly aid telemedicine, optimize performance monitoring of athletes, military service members, and first-responders, as well as provide a facile method for rapid clinical evaluation and triage.Reliable, real-time heart and respiratory rates are key vital signs used in evaluating the physiological status in many clinical and non-clinical settings. Measuring these vital signs generally requires superficial attachment of physically or logistically obtrusive sensors to subjects that may result in skin irritation or adversely influence subject performance. Given the broad acceptance of ingestible electronics, we developed an approach that enables vital sign monitoring internally from the gastrointestinal tract. Here we report initial proof-of-concept large animal (porcine) experiments and a robust processing algorithm that demonstrates the feasibility of this approach. Implementing vital sign monitoring as a stand-alone technology or in conjunction with other ingestible devices has the capacity to significantly aid telemedicine, optimize performance monitoring of athletes, military service members, and first-responders, as well as provide a facile method for rapid clinical evaluation and triage. |
| Audience | Academic |
| Author | Schwartz, S. Barman, R. Swiston, A. Hughes, T. Langer, R. Boettcher, T. Traverso, G. Ciccarelli, G. |
| AuthorAffiliation | 1 Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States of America 2 Department of Chemical Engineering and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, United States of America 3 Bioengineering Systems and Technologies, Massachusetts Institute of Technology Lincoln Laboratory, Lexington, MA, 02420, United States of America Radboud University Nijmegen, NETHERLANDS |
| AuthorAffiliation_xml | – name: 1 Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States of America – name: 2 Department of Chemical Engineering and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, United States of America – name: 3 Bioengineering Systems and Technologies, Massachusetts Institute of Technology Lincoln Laboratory, Lexington, MA, 02420, United States of America – name: Radboud University Nijmegen, NETHERLANDS |
| Author_xml | – sequence: 1 givenname: G. surname: Traverso fullname: Traverso, G. – sequence: 2 givenname: G. surname: Ciccarelli fullname: Ciccarelli, G. – sequence: 3 givenname: S. surname: Schwartz fullname: Schwartz, S. – sequence: 4 givenname: T. surname: Hughes fullname: Hughes, T. – sequence: 5 givenname: T. surname: Boettcher fullname: Boettcher, T. – sequence: 6 givenname: R. surname: Barman fullname: Barman, R. – sequence: 7 givenname: R. surname: Langer fullname: Langer, R. – sequence: 8 givenname: A. surname: Swiston fullname: Swiston, A. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26580216$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1136/emj.2007.054965 10.1007/s00134-010-2006-2 10.1111/cod.12137 10.1016/j.jtherbio.2004.08.020 10.1111/j.1742-481X.2011.00915.x 10.1097/00005768-199803000-00020 10.3109/03091902.2012.684831 10.1088/0967-3334/32/11/S04 10.7205/MILMED.172.6.592 10.1007/s10620-009-0899-9 10.7205/MILMED-D-12-00538 10.1109/ISSPIT.2008.4775670 10.1097/00003246-198510000-00009 10.1093/cvr/5.3.358 10.1016/j.gie.2013.06.026 |
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| Copyright | COPYRIGHT 2015 Public Library of Science 2015 Traverso et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2015 Traverso et al 2015 Traverso et al |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Competing Interests: The authors have declared that no competing interests exist. Conceived and designed the experiments: GT AS TH. Performed the experiments: GT AS TB RB. Analyzed the data: GC AS TH SS. Contributed reagents/materials/analysis tools: GC GT RL AS. Wrote the paper: GC GT SS AS RL. |
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| Title | Physiologic Status Monitoring via the Gastrointestinal Tract |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/26580216 https://www.proquest.com/docview/1734286388 https://www.proquest.com/docview/1735905352 https://pubmed.ncbi.nlm.nih.gov/PMC4651338 https://doaj.org/article/4c25feac306443828389f6edb985f82f http://dx.doi.org/10.1371/journal.pone.0141666 |
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