Physiologic Status Monitoring via the Gastrointestinal Tract

• Published in: PloS one Vol. 10; no. 11; p. e0141666
• Main Authors: Traverso, G., Ciccarelli, G., Schwartz, S., Hughes, T., Boettcher, T., Barman, R., Langer, R., Swiston, A.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 18.11.2015; Public Library of Science (PLoS)
• Subjects: Acoustics; Adults; Algorithms; Analysis; Animals; Athletes; Bioengineering; Cancer; Chemical engineering; Children; Dermatitis; Duodenum; Endoscopy; Esophagus; Feasibility studies; Female; First responders; Gastroenterology; Gastrointestinal system; Gastrointestinal tract; Health aspects; Heart rate; Heart Rate - physiology; Humans; Intensive care; Irritation; Laboratories; Medical equipment; Medical research; Microphones; Monitoring; Monitoring, Ambulatory - instrumentation; Monitoring, Ambulatory - methods; Physiology; Respiratory Rate - physiology; Signal processing; Skin; Stomach; Swine; Telemedicine; Telemedicine - instrumentation; Vital signs; Wireless Technology - instrumentation; United States > US; Massachusetts
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0141666

Reliable, real-time heart and respiratory rates are key vital signs used in evaluating the physiological status in many clinical and non-clinical settings. Measuring these vital signs generally requires superficial attachment of physically or logistically obtrusive sensors to subjects that may result in skin irritation or adversely influence subject performance. Given the broad acceptance of ingestible electronics, we developed an approach that enables vital sign monitoring internally from the gastrointestinal tract. Here we report initial proof-of-concept large animal (porcine) experiments and a robust processing algorithm that demonstrates the feasibility of this approach. Implementing vital sign monitoring as a stand-alone technology or in conjunction with other ingestible devices has the capacity to significantly aid telemedicine, optimize performance monitoring of athletes, military service members, and first-responders, as well as provide a facile method for rapid clinical evaluation and triage.