Social isolation is linked to classical risk factors of Alzheimer’s disease-related dementias

Alzheimer’s disease and related dementias is a major public health burden–compounding over upcoming years due to longevity. Recently, clinical evidence hinted at the experience of social isolation in expediting dementia onset. In 502,506 UK Biobank participants and 30,097 participants from the Canad...

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Published inPloS one Vol. 18; no. 2; p. e0280471
Main Authors Shafighi, Kimia, Villeneuve, Sylvia, Rosa Neto, Pedro, Badhwar, AmanPreet, Poirier, Judes, Sharma, Vaibhav, Medina, Yasser Iturria, Silveira, Patricia P., Dube, Laurette, Glahn, David, Bzdok, Danilo
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 01.02.2023
Public Library of Science (PLoS)
Subjects
Alzheimer Disease - epidemiology
Alzheimer Disease - etiology
Alzheimer Disease - prevention & control
Alzheimer's disease
Biology and Life Sciences
Canada - epidemiology
Complications and side effects
COVID-19
Dementia disorders
Deprivation
Diabetes
Diagnosis
Health risks
Humans
Loneliness
Longitudinal Studies
Medicine and Health Sciences
Mental health
Neurodegenerative diseases
Public health
Risk analysis
Risk Factors
Social interactions
Social Isolation
Social support
Canada
United Kingdom > UK
Online AccessGet full text
ISSN1932-6203
1932-6203
DOI10.1371/journal.pone.0280471

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Abstract Alzheimer’s disease and related dementias is a major public health burden–compounding over upcoming years due to longevity. Recently, clinical evidence hinted at the experience of social isolation in expediting dementia onset. In 502,506 UK Biobank participants and 30,097 participants from the Canadian Longitudinal Study of Aging, we revisited traditional risk factors for developing dementia in the context of loneliness and lacking social support. Across these measures of subjective and objective social deprivation, we have identified strong links between individuals’ social capital and various indicators of Alzheimer’s disease and related dementias risk, which replicated across both population cohorts. The quality and quantity of daily social encounters had deep connections with key aetiopathological factors, which represent 1) personal habits and lifestyle factors, 2) physical health, 3) mental health, and 4) societal and external factors. Our population-scale assessment suggest that social lifestyle determinants are linked to most neurodegeneration risk factors, highlighting them as promising targets for preventive clinical action.
AbstractList Alzheimer's disease and related dementias is a major public health burden-compounding over upcoming years due to longevity. Recently, clinical evidence hinted at the experience of social isolation in expediting dementia onset. In 502,506 UK Biobank participants and 30,097 participants from the Canadian Longitudinal Study of Aging, we revisited traditional risk factors for developing dementia in the context of loneliness and lacking social support. Across these measures of subjective and objective social deprivation, we have identified strong links between individuals' social capital and various indicators of Alzheimer's disease and related dementias risk, which replicated across both population cohorts. The quality and quantity of daily social encounters had deep connections with key aetiopathological factors, which represent 1) personal habits and lifestyle factors, 2) physical health, 3) mental health, and 4) societal and external factors. Our population-scale assessment suggest that social lifestyle determinants are linked to most neurodegeneration risk factors, highlighting them as promising targets for preventive clinical action.Alzheimer's disease and related dementias is a major public health burden-compounding over upcoming years due to longevity. Recently, clinical evidence hinted at the experience of social isolation in expediting dementia onset. In 502,506 UK Biobank participants and 30,097 participants from the Canadian Longitudinal Study of Aging, we revisited traditional risk factors for developing dementia in the context of loneliness and lacking social support. Across these measures of subjective and objective social deprivation, we have identified strong links between individuals' social capital and various indicators of Alzheimer's disease and related dementias risk, which replicated across both population cohorts. The quality and quantity of daily social encounters had deep connections with key aetiopathological factors, which represent 1) personal habits and lifestyle factors, 2) physical health, 3) mental health, and 4) societal and external factors. Our population-scale assessment suggest that social lifestyle determinants are linked to most neurodegeneration risk factors, highlighting them as promising targets for preventive clinical action.
Alzheimer’s disease and related dementias is a major public health burden–compounding over upcoming years due to longevity. Recently, clinical evidence hinted at the experience of social isolation in expediting dementia onset. In 502,506 UK Biobank participants and 30,097 participants from the Canadian Longitudinal Study of Aging, we revisited traditional risk factors for developing dementia in the context of loneliness and lacking social support. Across these measures of subjective and objective social deprivation, we have identified strong links between individuals’ social capital and various indicators of Alzheimer’s disease and related dementias risk, which replicated across both population cohorts. The quality and quantity of daily social encounters had deep connections with key aetiopathological factors, which represent 1) personal habits and lifestyle factors, 2) physical health, 3) mental health, and 4) societal and external factors. Our population-scale assessment suggest that social lifestyle determinants are linked to most neurodegeneration risk factors, highlighting them as promising targets for preventive clinical action.
Audience Academic
Author Bzdok, Danilo
Medina, Yasser Iturria
Villeneuve, Sylvia
Sharma, Vaibhav
Glahn, David
Shafighi, Kimia
Rosa Neto, Pedro
Silveira, Patricia P.
Poirier, Judes
Badhwar, AmanPreet
Dube, Laurette
AuthorAffiliation 6 Le Centre Intégré Universitaire de Santé et de Services Sociaux (CIUSSS) de l’Ouest-de-l’Île-de-Montréal, Montréal, Canada
15 Department of Psychiatry, Harvard Medical School, Boston, MA, United States of America
Clinca Geriatrica, ITALY
16 School of Computer Science, McGill University, Montreal, Canada
5 Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, Alzheimer’s Disease Research Unit, Montreal, Canada
4 Douglas Mental Health University Institute, Studies on Prevention of Alzheimer’s Disease (StoP-AD) Centre, Montreal, Quebec, Canada
7 Department of Neurology and Neurosurgery, Psychiatry and Pharmacology and Therapeutics, McGill University, Montreal, Canada
8 Département de Pharmacologie et Physiologie & Institut de Génie Biomédical, Faculté de Médecine, Université de Montréal, Montréal, Canada
13 Desautels Faculty of Management, McGill Center for the Convergence of Health and Economics, McGill University, Montreal, QC, Canada
11 Neurology and N
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/36724157$$D View this record in MEDLINE/PubMed
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Copyright Copyright: © 2023 Shafighi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
COPYRIGHT 2023 Public Library of Science
2023 Shafighi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
2023 Shafighi et al 2023 Shafighi et al
2023 Shafighi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
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– notice: 2023 Shafighi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: 2023 Shafighi et al 2023 Shafighi et al
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License Copyright: © 2023 Shafighi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Snippet Alzheimer’s disease and related dementias is a major public health burden–compounding over upcoming years due to longevity. Recently, clinical evidence hinted...
Alzheimer's disease and related dementias is a major public health burden-compounding over upcoming years due to longevity. Recently, clinical evidence hinted...
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SubjectTerms Alzheimer Disease - epidemiology
Alzheimer Disease - etiology
Alzheimer Disease - prevention & control
Alzheimer's disease
Biology and Life Sciences
Canada - epidemiology
Complications and side effects
COVID-19
Dementia disorders
Deprivation
Diabetes
Diagnosis
Health risks
Humans
Loneliness
Longitudinal Studies
Medicine and Health Sciences
Mental health
Neurodegenerative diseases
Public health
Risk analysis
Risk Factors
Social interactions
Social Isolation
Social support
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Title Social isolation is linked to classical risk factors of Alzheimer’s disease-related dementias
URI https://www.ncbi.nlm.nih.gov/pubmed/36724157
https://www.proquest.com/docview/2771621203
https://www.proquest.com/docview/2771635892
https://pubmed.ncbi.nlm.nih.gov/PMC9891507
https://doaj.org/article/1f92ecf8631e4e6fbd563d9e093ed3f3
http://dx.doi.org/10.1371/journal.pone.0280471
Volume 18
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