DNA Prime/Adenovirus Boost Malaria Vaccine Encoding P. falciparum CSP and AMA1 Induces Sterile Protection Associated with Cell-Mediated Immunity - Chuang, Ilin; Sedegah, Martha; Cicatelli, Susan; Spring, Michele; Polhemus, Mark; Tamminga, Cindy; Patterson, Noelle; Guerrero, Melanie; Bennett, Jason W.; McGrath, Shannon; Ganeshan, Harini; Belmonte, Maria; et al. (PloS one, 2013)
Keywords: Acquired immune deficiency syndrome; Adenoviruses; Adenoviruses, Human - genetics; Adenoviruses, Human - immunology; Adolescent; Adult; Advertising executives; AIDS; Analysis; Animal models; Antibodies; Antigens; Antigens, Protozoan - genetics; Antigens, Protozoan - immunology; Aquatic insects; Biology; Bites (Injuries); CD8 antigen; CD8-Positive T-Lymphocytes - immunology; Cell-mediated immunity; Circumsporozoite protein; Control; Cytometry; Deoxyribonucleic acid; Diarrhea; DNA; Enzyme-linked immunosorbent assay; Expression vectors; Female; Flow cytometry; Genetic aspects; Health aspects; Humans; Immunity; Immunity, Cellular; Immunization; Insect bites; Interferon; Interferon-gamma - immunology; Leukocytes (mononuclear); Liver; Lymphocytes T; Malaria; Malaria vaccines; Malaria Vaccines - adverse effects; Malaria Vaccines - genetics; Malaria Vaccines - immunology; Malaria Vaccines - therapeutic use; Malaria, Falciparum - immunology; Malaria, Falciparum - parasitology; Malaria, Falciparum - prevention & control; Male; Medical research; Medicine; Membrane proteins; Membrane Proteins - genetics; Membrane Proteins - immunology; Middle Aged; Mosquitoes; Parasites; Peripheral blood mononuclear cells; Plasmids; Plasmodium falciparum; Plasmodium falciparum - genetics; Plasmodium falciparum - immunology; Protozoan Proteins - genetics; Protozoan Proteins - immunology; Replication; Serology; Sporozoites; Statistical analysis; T cells; Vaccination; Vaccines; Vaccines, DNA - adverse effects; Vaccines, DNA - genetics; Vaccines, DNA - immunology; Vaccines, DNA - therapeutic use; Vector-borne diseases; Wildlife conservation; Young Adult; γ-Interferon; United States--US; Maryland