Genetic algorithm-based personalized models of human cardiac action potential - Smirnov, Dmitrii; Pikunov, Andrey; Syunyaev, Roman; Deviatiiarov, Ruslan; Gusev, Oleg; Aras, Kedar; Gams, Anna; Koppel, Aaron; Efimov, Igor R. (PloS one, 2020)
Keywords: Action potential; Action Potentials - genetics; Action Potentials - physiology; Algorithms; Biology and Life Sciences; Cardiomyocytes; Convergence; Customization; Electrophysiology; Engineering and Technology; Gene Expression; Gene mapping; Genes; Genetic algorithms; Heart; Heart - physiology; Heart conduction system; Heart rate; Heart Transplantation; Heart Ventricles - metabolism; Humans; Mapping; Mathematical models; Medicine and Health Sciences; Messenger RNA; Methods; Models, Biological; Mutation; Myocytes, Cardiac - physiology; Noise levels; Novels; Organisms; Parameter modification; Patch-Clamp Techniques; Physical Sciences; Physics; Precision medicine; Research and Analysis Methods; Restitution; RNA; RNA-Seq; Signal to noise ratio; Simulation; Tissue Donors; Ventricle; Waveforms; Russia; United States--US