A Bayesian gene network reveals insight into the JAK-STAT pathway in systemic lupus erythematosus - Li, Yupeng; Higgs, Richard E.; Hoffman, Robert W.; Dow, Ernst R.; Liu, Xiong; Petri, Michelle; Wallace, Daniel J.; Dörner, Thomas; Eastwood, Brian J.; Miller, Bradley B.; Liu, Yushi (PloS one, 2019)
Keywords: Abnormalities; Adaptive immunity; Algorithms; Analysis; Autoimmune diseases; Bayes Theorem; Bayesian analysis; Biology and Life Sciences; Biomarkers; Cancer; Chronic conditions; Clinical trials; Clinical Trials, Phase III as Topic; Computer and Information Sciences; Computer Simulation; Data Mining; Datasets as Topic; Drug therapy; Endoplasmic reticulum; Gene expression; Gene Expression Profiling; Gene loci; Gene Regulatory Networks - immunology; Genes; Genomics; Humans; Immune response; Inflammatory diseases; Interferon regulatory factor 1; Interferon regulatory factor 7; Janus kinase 2; Janus Kinase 2 - immunology; Janus Kinase 2 - metabolism; Linear Models; Lupus; Lupus erythematosus; Lupus Erythematosus, Systemic - drug therapy; Lupus Erythematosus, Systemic - genetics; Lupus Erythematosus, Systemic - immunology; Medicine and Health Sciences; Methods; Models, Genetic; Natural language processing; Network topologies; Oligonucleotide Array Sequence Analysis; Organs; Pathogenesis; Pharmaceutical industry; Random variables; Randomized Controlled Trials as Topic; Ribonucleic acid; RNA; Signal Transduction - drug effects; Signal Transduction - genetics; Signal Transduction - immunology; Social networks; Stat1 protein; STAT1 Transcription Factor - immunology; STAT1 Transcription Factor - metabolism; Stat2 protein; STAT2 Transcription Factor - immunology; STAT2 Transcription Factor - metabolism; Success; Systemic lupus erythematosus; Therapeutic applications; United States; Los Angeles California; California; United States--US; Indianapolis Indiana