Asthma Is More Severe in Older Adults

Severe asthma occurs more often in older adult patients. We hypothesized that the greater risk for severe asthma in older individuals is due to aging, and is independent of asthma duration. This is a cross-sectional study of prospectively collected data from adult participants (N=1130; 454 with seve...

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Published inPloS one Vol. 10; no. 7; p. e0133490
Main Authors Zein, Joe G., Dweik, Raed A., Comhair, Suzy A., Bleecker, Eugene R., Moore, Wendy C., Peters, Stephen P., Busse, William W., Jarjour, Nizar N., Calhoun, William J., Castro, Mario, Chung, K. Fan, Fitzpatrick, Anne, Israel, Elliot, Teague, W. Gerald, Wenzel, Sally E., Love, Thomas E., Gaston, Benjamin M., Erzurum, Serpil C.
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 22.07.2015
Public Library of Science (PLoS)
Subjects
Adolescent
Adult
Adults
Age
Age Factors
Aged
Aging
Allergies
Asthma
Asthma - pathology
Asthma - physiopathology
Cross-Sectional Studies
Female
Genomics
Humans
Inflammation
Male
Middle Aged
Neutrophils
Older people
Outdoor air quality
Pediatrics
Precision medicine
Prospective Studies
Public health
Review boards
Risk
Severity of Illness Index
Signal transduction
Statistical analysis
Studies
Thorax
Womens health
Online AccessGet full text
ISSN1932-6203
1932-6203
DOI10.1371/journal.pone.0133490

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Abstract Severe asthma occurs more often in older adult patients. We hypothesized that the greater risk for severe asthma in older individuals is due to aging, and is independent of asthma duration. This is a cross-sectional study of prospectively collected data from adult participants (N=1130; 454 with severe asthma) enrolled from 2002 - 2011 in the Severe Asthma Research Program. The association between age and the probability of severe asthma, which was performed by applying a Locally Weighted Scatterplot Smoother, revealed an inflection point at age 45 for risk of severe asthma. The probability of severe asthma increased with each year of life until 45 years and thereafter increased at a much slower rate. Asthma duration also increased the probability of severe asthma but had less effect than aging. After adjustment for most comorbidities of aging and for asthma duration using logistic regression, asthmatics older than 45 maintained the greater probability of severe asthma [OR: 2.73 (95 CI: 1.96; 3.81)]. After 45, the age-related risk of severe asthma continued to increase in men, but not in women. Overall, the impact of age and asthma duration on risk for asthma severity in men and women is greatest over times of 18-45 years of age; age has a greater effect than asthma duration on risk of severe asthma.
AbstractList Severe asthma occurs more often in older adult patients. We hypothesized that the greater risk for severe asthma in older individuals is due to aging, and is independent of asthma duration. This is a cross-sectional study of prospectively collected data from adult participants (N=1130; 454 with severe asthma) enrolled from 2002 - 2011 in the Severe Asthma Research Program. The association between age and the probability of severe asthma, which was performed by applying a Locally Weighted Scatterplot Smoother, revealed an inflection point at age 45 for risk of severe asthma. The probability of severe asthma increased with each year of life until 45 years and thereafter increased at a much slower rate. Asthma duration also increased the probability of severe asthma but had less effect than aging. After adjustment for most comorbidities of aging and for asthma duration using logistic regression, asthmatics older than 45 maintained the greater probability of severe asthma [OR: 2.73 (95 CI: 1.96; 3.81)]. After 45, the age-related risk of severe asthma continued to increase in men, but not in women. Overall, the impact of age and asthma duration on risk for asthma severity in men and women is greatest over times of 18-45 years of age; age has a greater effect than asthma duration on risk of severe asthma.
BACKGROUNDSevere asthma occurs more often in older adult patients. We hypothesized that the greater risk for severe asthma in older individuals is due to aging, and is independent of asthma duration.METHODSThis is a cross-sectional study of prospectively collected data from adult participants (N=1130; 454 with severe asthma) enrolled from 2002 - 2011 in the Severe Asthma Research Program.RESULTSThe association between age and the probability of severe asthma, which was performed by applying a Locally Weighted Scatterplot Smoother, revealed an inflection point at age 45 for risk of severe asthma. The probability of severe asthma increased with each year of life until 45 years and thereafter increased at a much slower rate. Asthma duration also increased the probability of severe asthma but had less effect than aging. After adjustment for most comorbidities of aging and for asthma duration using logistic regression, asthmatics older than 45 maintained the greater probability of severe asthma [OR: 2.73 (95 CI: 1.96; 3.81)]. After 45, the age-related risk of severe asthma continued to increase in men, but not in women.CONCLUSIONSOverall, the impact of age and asthma duration on risk for asthma severity in men and women is greatest over times of 18-45 years of age; age has a greater effect than asthma duration on risk of severe asthma.
Background Severe asthma occurs more often in older adult patients. We hypothesized that the greater risk for severe asthma in older individuals is due to aging, and is independent of asthma duration. Methods This is a cross-sectional study of prospectively collected data from adult participants (N=1130; 454 with severe asthma) enrolled from 2002 - 2011 in the Severe Asthma Research Program. Results The association between age and the probability of severe asthma, which was performed by applying a Locally Weighted Scatterplot Smoother, revealed an inflection point at age 45 for risk of severe asthma. The probability of severe asthma increased with each year of life until 45 years and thereafter increased at a much slower rate. Asthma duration also increased the probability of severe asthma but had less effect than aging. After adjustment for most comorbidities of aging and for asthma duration using logistic regression, asthmatics older than 45 maintained the greater probability of severe asthma [OR: 2.73 (95 CI: 1.96; 3.81)]. After 45, the age-related risk of severe asthma continued to increase in men, but not in women. Conclusions Overall, the impact of age and asthma duration on risk for asthma severity in men and women is greatest over times of 18-45 years of age; age has a greater effect than asthma duration on risk of severe asthma.
Background Severe asthma occurs more often in older adult patients. We hypothesized that the greater risk for severe asthma in older individuals is due to aging, and is independent of asthma duration. Methods This is a cross-sectional study of prospectively collected data from adult participants (N=1130; 454 with severe asthma) enrolled from 2002 – 2011 in the Severe Asthma Research Program. Results The association between age and the probability of severe asthma, which was performed by applying a Locally Weighted Scatterplot Smoother, revealed an inflection point at age 45 for risk of severe asthma. The probability of severe asthma increased with each year of life until 45 years and thereafter increased at a much slower rate. Asthma duration also increased the probability of severe asthma but had less effect than aging. After adjustment for most comorbidities of aging and for asthma duration using logistic regression, asthmatics older than 45 maintained the greater probability of severe asthma [OR: 2.73 (95 CI: 1.96; 3.81)]. After 45, the age-related risk of severe asthma continued to increase in men, but not in women. Conclusions Overall, the impact of age and asthma duration on risk for asthma severity in men and women is greatest over times of 18-45 years of age; age has a greater effect than asthma duration on risk of severe asthma.
Severe asthma occurs more often in older adult patients. We hypothesized that the greater risk for severe asthma in older individuals is due to aging, and is independent of asthma duration. This is a cross-sectional study of prospectively collected data from adult participants (N=1130; 454 with severe asthma) enrolled from 2002 - 2011 in the Severe Asthma Research Program. The association between age and the probability of severe asthma, which was performed by applying a Locally Weighted Scatterplot Smoother, revealed an inflection point at age 45 for risk of severe asthma. The probability of severe asthma increased with each year of life until 45 years and thereafter increased at a much slower rate. Asthma duration also increased the probability of severe asthma but had less effect than aging. After adjustment for most comorbidities of aging and for asthma duration using logistic regression, asthmatics older than 45 maintained the greater probability of severe asthma [OR: 2.73 (95 CI: 1.96; 3.81)]. After 45, the age-related risk of severe asthma continued to increase in men, but not in women. Overall, the impact of age and asthma duration on risk for asthma severity in men and women is greatest over times of 18-45 years of age; age has a greater effect than asthma duration on risk of severe asthma.
Audience Academic
Author Gaston, Benjamin M.
Wenzel, Sally E.
Dweik, Raed A.
Castro, Mario
Fitzpatrick, Anne
Zein, Joe G.
Israel, Elliot
Peters, Stephen P.
Love, Thomas E.
Moore, Wendy C.
Busse, William W.
Erzurum, Serpil C.
Bleecker, Eugene R.
Calhoun, William J.
Jarjour, Nizar N.
Chung, K. Fan
Teague, W. Gerald
Comhair, Suzy A.
AuthorAffiliation 8 Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, United States of America
2 Department of Pathobiology, Cleveland Clinic, Cleveland, Ohio, United States of America
3 Center for Genomics and Personalized Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America
1 Respiratory Institute, Cleveland Clinic, Cleveland, Ohio, United States of America
6 Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America
9 Pulmonary Division, Harvard Medical School, Brigham and Women’s Hospital, Boston, Massachussets, United States of America
11 Asthma Institute, The University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
12 Department of Epidemiology and Biostatistics, Case Western Reserve University-MetroHealth Medical Center, Cleveland, Ohio, United States of America
4 Department of Medicine, The University of Wisconsin, School of Medicine and Public H
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/26200463$$D View this record in MEDLINE/PubMed
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2015 Zein et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
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– notice: 2015 Zein et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
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CorporateAuthor on behalf of The Severe Asthma Research Program
Severe Asthma Research Program
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DocumentTitleAlternate Asthma Is More Severe in Older Adults
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Membership of The Severe Asthma Research Program is provided in the Acknowledgments.
Conceived and designed the experiments: SCE JGZ. Performed the experiments: SAC ERB WWB WJC MC KFC RAD AF EI NNJ WCM SPP WGT SEW BMG SCE. Analyzed the data: JGZ SCE SAC. Contributed reagents/materials/analysis tools: SAC ERB WWB WJC MC KFC RAD AF EI NNJ WCM SPP WGT SEW BMG SCE. Wrote the paper: JGZ SCE. Supervised statistical analysis: TEL.
Competing Interests: The authors have declared that no competing interests exist.
These authors also contributed equally to this work.
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Snippet Severe asthma occurs more often in older adult patients. We hypothesized that the greater risk for severe asthma in older individuals is due to aging, and is...
Background Severe asthma occurs more often in older adult patients. We hypothesized that the greater risk for severe asthma in older individuals is due to...
BACKGROUNDSevere asthma occurs more often in older adult patients. We hypothesized that the greater risk for severe asthma in older individuals is due to...
BackgroundSevere asthma occurs more often in older adult patients. We hypothesized that the greater risk for severe asthma in older individuals is due to...
Background Severe asthma occurs more often in older adult patients. We hypothesized that the greater risk for severe asthma in older individuals is due to...
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StartPage e0133490
SubjectTerms Adolescent
Adult
Adults
Age
Age Factors
Aged
Aging
Allergies
Asthma
Asthma - pathology
Asthma - physiopathology
Cross-Sectional Studies
Female
Genomics
Humans
Inflammation
Male
Middle Aged
Neutrophils
Older people
Outdoor air quality
Pediatrics
Precision medicine
Prospective Studies
Public health
Review boards
Risk
Severity of Illness Index
Signal transduction
Statistical analysis
Studies
Thorax
Womens health
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Title Asthma Is More Severe in Older Adults
URI https://www.ncbi.nlm.nih.gov/pubmed/26200463
https://www.proquest.com/docview/1698024761
https://www.proquest.com/docview/1699490055
https://pubmed.ncbi.nlm.nih.gov/PMC4511639
https://doaj.org/article/e9683655ac7d4035a22756a5223f82b5
http://dx.doi.org/10.1371/journal.pone.0133490
Volume 10
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