Bone formation transcripts dominate the differential gene expression profile in an equine osteoporotic condition associated with pulmonary silicosis
Osteoporosis has been associated with pulmonary silicosis in California horses exposed to soils rich in cytotoxic silica dioxide crystals, a syndrome termed silicate associated osteoporosis (SAO). The causal mechanism for the development of osteoporosis is unknown. Osteoporotic lesions are primarily...
Saved in:
| Published in | PloS one Vol. 13; no. 6; p. e0197459 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Public Library of Science
01.06.2018
Public Library of Science (PLoS) |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1932-6203 1932-6203 |
| DOI | 10.1371/journal.pone.0197459 |
Cover
| Abstract | Osteoporosis has been associated with pulmonary silicosis in California horses exposed to soils rich in cytotoxic silica dioxide crystals, a syndrome termed silicate associated osteoporosis (SAO). The causal mechanism for the development of osteoporosis is unknown. Osteoporotic lesions are primarily located in bone marrow-rich sites such as ribs, scapula and pelvis. Gene transcription patterns within bone marrow and pulmonary lymph nodes of affected horses may offer clues to disease pathobiology. Bone marrow core and tracheobronchial lymph node tissue samples harvested postmortem from affected and unaffected horses were examined histologically and subjected to RNA sequencing (RNA-seq). Sequenced data were analyzed for differential gene expression and gene ontology. Metatranscriptomic and metagenomic assays evaluated samples for infectious agents. Thirteen of 17 differentially expressed transcripts in bone marrow were linked to bone and cartilage formation such as integrin binding bone sialoprotein (log2FC = 3.39, PFDR = 0.013) and chondroadherin (log2FC = 4.48, PFDR = 0.031). Equus caballus solute carrier family 9, subfamily A2 (log2FC = 3.77, PFDR = 0.0034) was one of the four differentially expressed transcripts linked to osteoclast activity. Osteoblasts were hyperplastic and hypertrophic in bone marrow from affected horses. Biological pathways associated with skeletal morphogenesis were significantly enriched in affected horses. The 30 differentially expressed genes in affected lymph nodes were associated with inflammatory responses. Evidence of infectious agents was not found. The SAO affected bone marrow molecular signature demonstrated increased transcription and heightened activation of osteoblasts. Increased osteoblastic activity could be part of the pathological mechanism for osteoporosis or a compensatory response to the accelerated osteolysis. Transcriptome data offer gene targets for inquiries into the role of osteocytes and osteoblasts in SAO pathogenesis. Viral or bacterial infectious etiology in SAO is less likely based on metatranscriptomic and metagenomic data but cannot be completely ruled out. |
|---|---|
| AbstractList | Osteoporosis has been associated with pulmonary silicosis in California horses exposed to soils rich in cytotoxic silica dioxide crystals, a syndrome termed silicate associated osteoporosis (SAO). The causal mechanism for the development of osteoporosis is unknown. Osteoporotic lesions are primarily located in bone marrow-rich sites such as ribs, scapula and pelvis. Gene transcription patterns within bone marrow and pulmonary lymph nodes of affected horses may offer clues to disease pathobiology. Bone marrow core and tracheobronchial lymph node tissue samples harvested postmortem from affected and unaffected horses were examined histologically and subjected to RNA sequencing (RNA-seq). Sequenced data were analyzed for differential gene expression and gene ontology. Metatranscriptomic and metagenomic assays evaluated samples for infectious agents. Thirteen of 17 differentially expressed transcripts in bone marrow were linked to bone and cartilage formation such as integrin binding bone sialoprotein (log.sub.2 FC = 3.39, P.sub.FDR = 0.013) and chondroadherin (log.sub.2 FC = 4.48, P.sub.FDR = 0.031). Equus caballus solute carrier family 9, subfamily A2 (log.sub.2 FC = 3.77, P.sub.FDR = 0.0034) was one of the four differentially expressed transcripts linked to osteoclast activity. Osteoblasts were hyperplastic and hypertrophic in bone marrow from affected horses. Biological pathways associated with skeletal morphogenesis were significantly enriched in affected horses. The 30 differentially expressed genes in affected lymph nodes were associated with inflammatory responses. Evidence of infectious agents was not found. The SAO affected bone marrow molecular signature demonstrated increased transcription and heightened activation of osteoblasts. Increased osteoblastic activity could be part of the pathological mechanism for osteoporosis or a compensatory response to the accelerated osteolysis. Transcriptome data offer gene targets for inquiries into the role of osteocytes and osteoblasts in SAO pathogenesis. Viral or bacterial infectious etiology in SAO is less likely based on metatranscriptomic and metagenomic data but cannot be completely ruled out. Osteoporosis has been associated with pulmonary silicosis in California horses exposed to soils rich in cytotoxic silica dioxide crystals, a syndrome termed silicate associated osteoporosis (SAO). The causal mechanism for the development of osteoporosis is unknown. Osteoporotic lesions are primarily located in bone marrow-rich sites such as ribs, scapula and pelvis. Gene transcription patterns within bone marrow and pulmonary lymph nodes of affected horses may offer clues to disease pathobiology. Bone marrow core and tracheobronchial lymph node tissue samples harvested postmortem from affected and unaffected horses were examined histologically and subjected to RNA sequencing (RNA-seq). Sequenced data were analyzed for differential gene expression and gene ontology. Metatranscriptomic and metagenomic assays evaluated samples for infectious agents. Thirteen of 17 differentially expressed transcripts in bone marrow were linked to bone and cartilage formation such as integrin binding bone sialoprotein (log2FC = 3.39, PFDR = 0.013) and chondroadherin (log2FC = 4.48, PFDR = 0.031). Equus caballus solute carrier family 9, subfamily A2 (log2FC = 3.77, PFDR = 0.0034) was one of the four differentially expressed transcripts linked to osteoclast activity. Osteoblasts were hyperplastic and hypertrophic in bone marrow from affected horses. Biological pathways associated with skeletal morphogenesis were significantly enriched in affected horses. The 30 differentially expressed genes in affected lymph nodes were associated with inflammatory responses. Evidence of infectious agents was not found. The SAO affected bone marrow molecular signature demonstrated increased transcription and heightened activation of osteoblasts. Increased osteoblastic activity could be part of the pathological mechanism for osteoporosis or a compensatory response to the accelerated osteolysis. Transcriptome data offer gene targets for inquiries into the role of osteocytes and osteoblasts in SAO pathogenesis. Viral or bacterial infectious etiology in SAO is less likely based on metatranscriptomic and metagenomic data but cannot be completely ruled out. Osteoporosis has been associated with pulmonary silicosis in California horses exposed to soils rich in cytotoxic silica dioxide crystals, a syndrome termed silicate associated osteoporosis (SAO). The causal mechanism for the development of osteoporosis is unknown. Osteoporotic lesions are primarily located in bone marrow-rich sites such as ribs, scapula and pelvis. Gene transcription patterns within bone marrow and pulmonary lymph nodes of affected horses may offer clues to disease pathobiology. Bone marrow core and tracheobronchial lymph node tissue samples harvested postmortem from affected and unaffected horses were examined histologically and subjected to RNA sequencing (RNA-seq). Sequenced data were analyzed for differential gene expression and gene ontology. Metatranscriptomic and metagenomic assays evaluated samples for infectious agents. Thirteen of 17 differentially expressed transcripts in bone marrow were linked to bone and cartilage formation such as integrin binding bone sialoprotein (log 2 FC = 3.39, P FDR = 0.013) and chondroadherin (log 2 FC = 4.48, P FDR = 0.031). Equus caballus solute carrier family 9, subfamily A2 (log 2 FC = 3.77, P FDR = 0.0034) was one of the four differentially expressed transcripts linked to osteoclast activity. Osteoblasts were hyperplastic and hypertrophic in bone marrow from affected horses. Biological pathways associated with skeletal morphogenesis were significantly enriched in affected horses. The 30 differentially expressed genes in affected lymph nodes were associated with inflammatory responses. Evidence of infectious agents was not found. The SAO affected bone marrow molecular signature demonstrated increased transcription and heightened activation of osteoblasts. Increased osteoblastic activity could be part of the pathological mechanism for osteoporosis or a compensatory response to the accelerated osteolysis. Transcriptome data offer gene targets for inquiries into the role of osteocytes and osteoblasts in SAO pathogenesis. Viral or bacterial infectious etiology in SAO is less likely based on metatranscriptomic and metagenomic data but cannot be completely ruled out. Osteoporosis has been associated with pulmonary silicosis in California horses exposed to soils rich in cytotoxic silica dioxide crystals, a syndrome termed silicate associated osteoporosis (SAO). The causal mechanism for the development of osteoporosis is unknown. Osteoporotic lesions are primarily located in bone marrow-rich sites such as ribs, scapula and pelvis. Gene transcription patterns within bone marrow and pulmonary lymph nodes of affected horses may offer clues to disease pathobiology. Bone marrow core and tracheobronchial lymph node tissue samples harvested postmortem from affected and unaffected horses were examined histologically and subjected to RNA sequencing (RNA-seq). Sequenced data were analyzed for differential gene expression and gene ontology. Metatranscriptomic and metagenomic assays evaluated samples for infectious agents. Thirteen of 17 differentially expressed transcripts in bone marrow were linked to bone and cartilage formation such as integrin binding bone sialoprotein (log2FC = 3.39, PFDR = 0.013) and chondroadherin (log2FC = 4.48, PFDR = 0.031). Equus caballus solute carrier family 9, subfamily A2 (log2FC = 3.77, PFDR = 0.0034) was one of the four differentially expressed transcripts linked to osteoclast activity. Osteoblasts were hyperplastic and hypertrophic in bone marrow from affected horses. Biological pathways associated with skeletal morphogenesis were significantly enriched in affected horses. The 30 differentially expressed genes in affected lymph nodes were associated with inflammatory responses. Evidence of infectious agents was not found. The SAO affected bone marrow molecular signature demonstrated increased transcription and heightened activation of osteoblasts. Increased osteoblastic activity could be part of the pathological mechanism for osteoporosis or a compensatory response to the accelerated osteolysis. Transcriptome data offer gene targets for inquiries into the role of osteocytes and osteoblasts in SAO pathogenesis. Viral or bacterial infectious etiology in SAO is less likely based on metatranscriptomic and metagenomic data but cannot be completely ruled out.Osteoporosis has been associated with pulmonary silicosis in California horses exposed to soils rich in cytotoxic silica dioxide crystals, a syndrome termed silicate associated osteoporosis (SAO). The causal mechanism for the development of osteoporosis is unknown. Osteoporotic lesions are primarily located in bone marrow-rich sites such as ribs, scapula and pelvis. Gene transcription patterns within bone marrow and pulmonary lymph nodes of affected horses may offer clues to disease pathobiology. Bone marrow core and tracheobronchial lymph node tissue samples harvested postmortem from affected and unaffected horses were examined histologically and subjected to RNA sequencing (RNA-seq). Sequenced data were analyzed for differential gene expression and gene ontology. Metatranscriptomic and metagenomic assays evaluated samples for infectious agents. Thirteen of 17 differentially expressed transcripts in bone marrow were linked to bone and cartilage formation such as integrin binding bone sialoprotein (log2FC = 3.39, PFDR = 0.013) and chondroadherin (log2FC = 4.48, PFDR = 0.031). Equus caballus solute carrier family 9, subfamily A2 (log2FC = 3.77, PFDR = 0.0034) was one of the four differentially expressed transcripts linked to osteoclast activity. Osteoblasts were hyperplastic and hypertrophic in bone marrow from affected horses. Biological pathways associated with skeletal morphogenesis were significantly enriched in affected horses. The 30 differentially expressed genes in affected lymph nodes were associated with inflammatory responses. Evidence of infectious agents was not found. The SAO affected bone marrow molecular signature demonstrated increased transcription and heightened activation of osteoblasts. Increased osteoblastic activity could be part of the pathological mechanism for osteoporosis or a compensatory response to the accelerated osteolysis. Transcriptome data offer gene targets for inquiries into the role of osteocytes and osteoblasts in SAO pathogenesis. Viral or bacterial infectious etiology in SAO is less likely based on metatranscriptomic and metagenomic data but cannot be completely ruled out. |
| Audience | Academic |
| Author | Katzman, Scott Zavodovskaya, Regina Finno, Carrie J. Murphy, Brian G. Britton, Monica Durbin-Johnson, Blythe Stover, Susan M. |
| AuthorAffiliation | 4 Department of Public Health Sciences, UC Davis School of Medicine, University of California, Davis, Davis, California, United States of America 3 Department of Surgical & Radiological Sciences, UC Davis School of Veterinary Medicine, University of California, Davis, California, United States of America 2 Department of Pathology, Microbiology and Immunology, UC Davis School of Veterinary Medicine, University of California, Davis, California, United States of America 1 Department of Anatomy, Physiology and Cell Biology, UC Davis School of Veterinary Medicine, University of California, Davis, California, United States of America 5 UC Davis Genome Center, Bioinformatics Core Facility, University of California, Davis, Davis, California, United States of America 6 Department of Population Health & Reproduction, UC Davis School of Veterinary Medicine, University of California, Davis, California, United States of America Augusta University, UNITED STATES |
| AuthorAffiliation_xml | – name: 2 Department of Pathology, Microbiology and Immunology, UC Davis School of Veterinary Medicine, University of California, Davis, California, United States of America – name: 5 UC Davis Genome Center, Bioinformatics Core Facility, University of California, Davis, Davis, California, United States of America – name: 3 Department of Surgical & Radiological Sciences, UC Davis School of Veterinary Medicine, University of California, Davis, California, United States of America – name: 6 Department of Population Health & Reproduction, UC Davis School of Veterinary Medicine, University of California, Davis, California, United States of America – name: 4 Department of Public Health Sciences, UC Davis School of Medicine, University of California, Davis, Davis, California, United States of America – name: Augusta University, UNITED STATES – name: 1 Department of Anatomy, Physiology and Cell Biology, UC Davis School of Veterinary Medicine, University of California, Davis, California, United States of America |
| Author_xml | – sequence: 1 givenname: Regina orcidid: 0000-0002-8433-3042 surname: Zavodovskaya fullname: Zavodovskaya, Regina – sequence: 2 givenname: Susan M. surname: Stover fullname: Stover, Susan M. – sequence: 3 givenname: Brian G. surname: Murphy fullname: Murphy, Brian G. – sequence: 4 givenname: Scott surname: Katzman fullname: Katzman, Scott – sequence: 5 givenname: Blythe surname: Durbin-Johnson fullname: Durbin-Johnson, Blythe – sequence: 6 givenname: Monica surname: Britton fullname: Britton, Monica – sequence: 7 givenname: Carrie J. surname: Finno fullname: Finno, Carrie J. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29856822$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNk1trHCEYhoeS0hzaf1BaoVDai93qODpjLwpp6CEQCPR0K46juwZHJ-q06f_oD66TnYTdEEqZixF93u_w6ndY7DnvVFE8RXCJcI3eXPgxOGGXQ95eQsTqirAHxQFiuFzQEuK9rfV-cRjjBYQEN5Q-KvZL1hDalOVB8ed9lgPtQy-S8Q6kIFyUwQwpgs73xomkQFor0BmtVVAuGWHBSmWRuhqCinFSDcFrYxUwDggH1OVo8rmPSfnBB5-MBNK7zlxnEDF6aXLYDvwyaQ2G0fbeifAbRGON9NHEx8VDLWxUT-b_UfH944dvJ58XZ-efTk-OzxaSsjItCCmlpG1XI1G1SkNSaVpRBFvCUINxjWWJBSWiVprWbd0RSEusa5FX2cAO4aPi-SbuYH3ks6GRl7BiBDUlhZk43RCdFxd8CKbPhXIvDL_e8GHFRcj9WcUZRqghNWsJ7XIVrGmprrL5MNdSacJyrHdztrHtVSezl0HYnaC7J86s-cr_5IQ1mNCp3FdzgOAvRxUT702UylrhlB_nuglpMn5UvLiD3t_dTK1EbsA47XNeOQXlx6RCsK5YjTO1vIfKX6f6fF9OTVe_K3i9I8hMUldpJcYY-enXL__Pnv_YZV9usWslbFpHb8fpWcVd8Nm207cW3zz7DFQbQAYfY1D6FkGQT9N1YxefpovP05Vlb-_IpEnXc5MdMfbf4r8uyi0Z |
| CitedBy_id | crossref_primary_10_3390_ani11040959 |
| Cites_doi | 10.1359/jbmr.2003.18.8.1506 10.1371/journal.pone.0056451 10.1164/ajrccm.157.5.9707141 10.1038/nrendo.2016.12 10.1378/chest.80.1_Supplement.82S 10.1210/en.2006-1704 10.1128/MCB.24.20.9248-9261.2004 10.1016/j.bone.2009.06.010 10.1080/03008200390181726 10.1016/S0092-8674(00)80258-5 10.1093/bioinformatics/btp616 10.1002/jbmr.5650080902 10.1016/j.rmed.2006.03.029 10.1016/j.ydbio.2008.01.001 10.1359/jbmr.1997.12.12.2040 10.2460/javma.232.11.1694 10.1006/geno.1996.0135 10.1080/15376510802354201 10.1073/pnas.95.7.3597 10.1007/s11914-009-0023-2 10.1111/vco.12279 10.1016/j.clim.2015.05.005 10.1002/jcb.10276 10.1145/2808719.2811442 10.1016/j.gene.2004.05.026 10.1189/jlb.0813462 10.1128/MCB.01077-15 10.1038/ng.166 10.1007/s00774-004-0504-4 10.1186/gb-2014-15-3-r46 10.1016/j.freeradbiomed.2016.10.009 10.1038/nm1270 10.1016/j.ydbio.2008.10.014 10.1016/j.cmet.2008.08.002 10.1128/JVI.02301-08 10.1177/0300985810385151 10.5578/tt.5721 10.1016/j.bone.2007.09.046 10.1038/ng.945 10.1074/jbc.272.13.8172 10.1093/bioinformatics/btl140 10.1084/jem.172.6.1665 10.1093/nar/gkv007 10.1111/j.1749-6632.2010.05389.x 10.1007/s00018-014-1778-x 10.1016/S0021-9258(17)44236-0 10.1186/s12864-017-4107-6 10.1016/0960-0760(95)00209-X 10.1093/bioinformatics/bts635 10.1016/S0092-8674(01)00622-5 10.1074/jbc.272.25.15959 10.1111/nyas.12043 10.1016/j.bbrc.2015.05.053 10.1080/03008200801913502 10.1196/annals.1402.023 10.1038/nature02079 10.1016/j.jmgm.2012.10.007 10.1042/bj3300549 10.1007/s002230010078 10.1074/jbc.M302112200 10.1359/jbmr.080907 10.1016/j.bbrc.2007.07.193 10.1016/j.bbrc.2007.03.108 10.1093/hmg/ddu551 10.1111/j.1749-6632.2009.05303.x 10.7717/peerj-cs.104 10.1007/s12199-016-0509-3 10.1002/art.34555 10.1038/sj.onc.1207676 |
| ContentType | Journal Article |
| Copyright | COPYRIGHT 2018 Public Library of Science 2018 Zavodovskaya et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2018 Zavodovskaya et al 2018 Zavodovskaya et al |
| Copyright_xml | – notice: COPYRIGHT 2018 Public Library of Science – notice: 2018 Zavodovskaya et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2018 Zavodovskaya et al 2018 Zavodovskaya et al |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM IOV ISR 3V. 7QG 7QL 7QO 7RV 7SN 7SS 7T5 7TG 7TM 7U9 7X2 7X7 7XB 88E 8AO 8C1 8FD 8FE 8FG 8FH 8FI 8FJ 8FK ABJCF ABUWG AEUYN AFKRA ARAPS ATCPS AZQEC BBNVY BENPR BGLVJ BHPHI C1K CCPQU D1I DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. KB. KB0 KL. L6V LK8 M0K M0S M1P M7N M7P M7S NAPCQ P5Z P62 P64 PATMY PDBOC PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PTHSS PYCSY RC3 7X8 5PM DOA |
| DOI | 10.1371/journal.pone.0197459 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Gale In Context: Opposing Viewpoints Gale In Context: Science ProQuest Central (Corporate) Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Biotechnology Research Abstracts ProQuest Nursing & Allied Health Database Ecology Abstracts Entomology Abstracts (Full archive) Immunology Abstracts Meteorological & Geoastrophysical Abstracts Nucleic Acids Abstracts Virology and AIDS Abstracts Agricultural Science Collection Proquest Health and Medical Complete ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Public Health Database Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Journals ProQuest Hospital Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Materials Science & Engineering Collection ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central Advanced Technologies & Aerospace Collection Agricultural & Environmental Science Collection ProQuest Central Essentials Biological Science Database ProQuest Central Technology collection Natural Science Collection Environmental Sciences and Pollution Management ProQuest One ProQuest Materials Science Collection ProQuest Central Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium ProQuest Health & Medical Complete (Alumni) Materials Science Database Nursing & Allied Health Database (Alumni Edition) Meteorological & Geoastrophysical Abstracts - Academic ProQuest Engineering Collection Biological Sciences Agriculture Science Database ProQuest Health & Medical Collection Medical Database Algology Mycology and Protozoology Abstracts (Microbiology C) ProQuest Biological Science Engineering Database Nursing & Allied Health Premium Advanced Technologies & Aerospace Database ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts Environmental Science Database Materials Science Collection ProQuest Central Premium ProQuest One Academic Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic ProQuest One Academic UKI Edition Engineering Collection Environmental Science Collection Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ - Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Agricultural Science Database Publicly Available Content Database ProQuest Central Student ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Meteorological & Geoastrophysical Abstracts Natural Science Collection Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) Engineering Collection Advanced Technologies & Aerospace Collection Engineering Database Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Agricultural Science Collection ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Environmental Science Collection Entomology Abstracts Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Environmental Science Database ProQuest Nursing & Allied Health Source (Alumni) Engineering Research Database ProQuest One Academic Meteorological & Geoastrophysical Abstracts - Academic ProQuest One Academic (New) Technology Collection Technology Research Database ProQuest One Academic Middle East (New) Materials Science Collection ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts ProQuest Engineering Collection Biotechnology Research Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Agricultural & Environmental Science Collection AIDS and Cancer Research Abstracts Materials Science Database ProQuest Materials Science Collection ProQuest Public Health ProQuest Nursing & Allied Health Source ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library Animal Behavior Abstracts Materials Science & Engineering Collection Immunology Abstracts ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE Agricultural Science Database MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Open Access Full Text url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 4 dbid: 8FG name: ProQuest Technology Collection url: https://search.proquest.com/technologycollection1 sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Sciences (General) Anatomy & Physiology Veterinary Medicine |
| DocumentTitleAlternate | Transcriptome profile in equine osteoporotic condition associated with pulmonary silicosis |
| EISSN | 1932-6203 |
| ExternalDocumentID | 2049518260 oai_doaj_org_article_93118579b56d46198b6f462001834f59 PMC5983561 A541074973 29856822 10_1371_journal_pone_0197459 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GeographicLocations | United States--US California |
| GeographicLocations_xml | – name: United States--US – name: California |
| GrantInformation_xml | – fundername: NCATS NIH HHS grantid: L40 TR001136 – fundername: NIH HHS grantid: K01 OD015134 – fundername: NIH HHS grantid: T32 OD011147 – fundername: ; grantid: SRGESAO 69240 – fundername: ; grantid: 1K01OD015134-01A1 – fundername: ; grantid: T32 OD 011147 – fundername: ; grantid: V431U81 – fundername: ; grantid: L40 TR001136 |
| GroupedDBID | --- 123 29O 2WC 53G 5VS 7RV 7X2 7X7 7XC 88E 8AO 8C1 8CJ 8FE 8FG 8FH 8FI 8FJ A8Z AAFWJ AAUCC AAWOE AAYXX ABDBF ABIVO ABJCF ABUWG ACGFO ACIHN ACIWK ACPRK ACUHS ADBBV ADRAZ AEAQA AENEX AEUYN AFKRA AFPKN AFRAH AHMBA ALIPV ALMA_UNASSIGNED_HOLDINGS AOIJS APEBS ARAPS ATCPS BAWUL BBNVY BCNDV BENPR BGLVJ BHPHI BKEYQ BPHCQ BVXVI BWKFM CCPQU CITATION CS3 D1I D1J D1K DIK DU5 E3Z EAP EAS EBD EMOBN ESX EX3 F5P FPL FYUFA GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE IAO IEA IGS IHR IHW INH INR IOV IPY ISE ISR ITC K6- KB. KQ8 L6V LK5 LK8 M0K M1P M48 M7P M7R M7S M~E NAPCQ O5R O5S OK1 OVT P2P P62 PATMY PDBOC PHGZM PHGZT PIMPY PQQKQ PROAC PSQYO PTHSS PV9 PYCSY RNS RPM RZL SV3 TR2 UKHRP WOQ WOW ~02 ~KM CGR CUY CVF ECM EIF IPNFZ NPM PJZUB PPXIY PQGLB RIG BBORY PMFND 3V. 7QG 7QL 7QO 7SN 7SS 7T5 7TG 7TM 7U9 7XB 8FD 8FK AZQEC C1K DWQXO FR3 GNUQQ H94 K9. KL. M7N P64 PKEHL PQEST PQUKI RC3 7X8 ESTFP PUEGO 5PM - 02 AAPBV ABPTK ADACO BBAFP KM |
| ID | FETCH-LOGICAL-c692t-552cc6bd71a4bef054f64610b59183373c23a65a7ef67b7d50623f7a7d5371d13 |
| IEDL.DBID | M48 |
| ISSN | 1932-6203 |
| IngestDate | Fri Nov 26 17:52:46 EST 2021 Wed Aug 27 01:29:08 EDT 2025 Thu Aug 21 18:04:29 EDT 2025 Mon Sep 08 05:18:33 EDT 2025 Fri Jul 25 11:19:12 EDT 2025 Tue Jun 17 21:14:25 EDT 2025 Tue Jun 10 20:30:34 EDT 2025 Fri Jun 27 03:31:11 EDT 2025 Fri Jun 27 03:47:43 EDT 2025 Thu May 22 21:22:38 EDT 2025 Mon Jul 21 05:49:28 EDT 2025 Thu Apr 24 23:05:56 EDT 2025 Tue Jul 01 03:51:53 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 6 |
| Language | English |
| License | This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Creative Commons Attribution License |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c692t-552cc6bd71a4bef054f64610b59183373c23a65a7ef67b7d50623f7a7d5371d13 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Competing Interests: The authors have declared that no competing interests exist. These authors also contributed equally to this work. |
| ORCID | 0000-0002-8433-3042 |
| OpenAccessLink | http://journals.scholarsportal.info/openUrl.xqy?doi=10.1371/journal.pone.0197459 |
| PMID | 29856822 |
| PQID | 2049518260 |
| PQPubID | 1436336 |
| PageCount | e0197459 |
| ParticipantIDs | plos_journals_2049518260 doaj_primary_oai_doaj_org_article_93118579b56d46198b6f462001834f59 pubmedcentral_primary_oai_pubmedcentral_nih_gov_5983561 proquest_miscellaneous_2049555898 proquest_journals_2049518260 gale_infotracmisc_A541074973 gale_infotracacademiconefile_A541074973 gale_incontextgauss_ISR_A541074973 gale_incontextgauss_IOV_A541074973 gale_healthsolutions_A541074973 pubmed_primary_29856822 crossref_primary_10_1371_journal_pone_0197459 crossref_citationtrail_10_1371_journal_pone_0197459 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2018-06-01 |
| PublicationDateYYYYMMDD | 2018-06-01 |
| PublicationDate_xml | – month: 06 year: 2018 text: 2018-06-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: San Francisco – name: San Francisco, CA USA |
| PublicationTitle | PloS one |
| PublicationTitleAlternate | PLoS One |
| PublicationYear | 2018 |
| Publisher | Public Library of Science Public Library of Science (PLoS) |
| Publisher_xml | – name: Public Library of Science – name: Public Library of Science (PLoS) |
| References | JD Anderson (ref3) 2008; 232 TN Perkins (ref74) 2015; 24 RA Battaglino (ref27) 2008; 42 M Jazayeri (ref43) 2015; 12 B Geering (ref52) 2014; 95 MJ Rock (ref34) 2008; 40 M Garcia-Carrasco (ref14) 2009; 11 VS Salazar (ref67) 2016; 12 AM Arens (ref1) 2011; 48 SJ Chen (ref12) 2015 RR McLean (ref15) 2009; 7 ref18 H Takayanagi (ref17) 2010; 1192 S Sheikh (ref10) 2014 MD Robinson (ref20) 2010; 26 K Ninomiya (ref28) 2007; 362 A Adriani (ref13) 2014; 56 K Nakashima (ref41) 2002; 108 R Masuyama (ref36) 2008; 8 Z Shen (ref48) 1998; 330 CW McIlwraith (ref79) 2017 F Guilak (ref35) 2010; 1192 NR Jorgensen (ref11) 2007; 101 Z Khavandgar (ref46) 2015; 72 H Li (ref59) 2008; 316 K Sonomoto (ref66) 2012; 64 M Chaplet (ref58) 2003; 18 T Komori (ref68) 1997; 89 MQ Hassan (ref31) 2004; 24 MT Yildizgoren (ref8) 2016; 21 T Tashima (ref29) 2015; 463 LW Fisher (ref61) 1983; 258 M Mizuno (ref63) 2000; 66 J Li (ref45) 2016; 36 Y Peng (ref39) 2013; 8 T Komori (ref69) 2002; 87 V Luu-The (ref51) 1995; 55 CR Maliszewski (ref55) 1990; 172 E Semik (ref77) 2017; 15 ref2 T Koga (ref38) 2005; 11 RN D'Souza (ref56) 1997; 12 E Nebot Valenzuela (ref6) 2016 K Vincent (ref42) 2013; 39 GS Stein (ref44) 2004; 23 CJ Finno (ref76) 2016; 101 ME Ritchie (ref21) 2015; 43 K Mizuta (ref50) 2007; 357 M Terasawa (ref71) 2004; 22 L Tessier (ref75) 2017; 18 MG Biswas (ref70) 1997; 272 SR Lamande (ref33) 2011; 43 Y Gao (ref40) 2004; 341 N Matsuo (ref64) 2008; 49 DE Wood (ref23) 2014; 15 ref25 A Dobin (ref19) 2013; 29 A Mantovani (ref53) 2013; 1285 JG Victoria (ref26) 2009; 83 E Balgairies (ref9) 1957; 38 SJ Choi (ref30) 2009; 325 M Koch (ref37) 2003; 278 J BF Lu (ref24) 2017; 3 G He (ref57) 2003; 44 X Li (ref72) 2009; 19 A Alexa (ref22) 2006; 22 BT Mossman (ref73) 1998; 157 H Yasuda (ref16) 1998; 95 VC Lui (ref47) 1996; 32 HY Zhou (ref49) 2007; 1116 V David (ref65) 2007; 148 S Seitz (ref5) 2009; 24 F Paic (ref32) 2009; 45 QQ Hoang (ref62) 2003; 425 RL Tallmadge (ref78) 2015; 160 MT Yildizgoren (ref7) 2014; 62 LW Schwartz (ref4) 1981; 80 RT Ingram (ref60) 1993; 8 A Basile (ref54) 1997; 272 |
| References_xml | – volume: 18 start-page: 1506 issue: 8 year: 2003 ident: ref58 article-title: Dentin matrix protein 1 is expressed in human lung cancer publication-title: Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research doi: 10.1359/jbmr.2003.18.8.1506 – volume: 8 start-page: e56451 issue: 2 year: 2013 ident: ref39 article-title: Characterization of Osterix protein stability and physiological role in osteoblast differentiation publication-title: PLoS One doi: 10.1371/journal.pone.0056451 – volume: 157 start-page: 1666 issue: 5 year: 1998 ident: ref73 article-title: Mechanisms in the pathogenesis of asbestosis and silicosis publication-title: American journal of respiratory and critical care medicine doi: 10.1164/ajrccm.157.5.9707141 – volume: 12 start-page: 203 issue: 4 year: 2016 ident: ref67 article-title: BMP signalling in skeletal development, disease and repair publication-title: Nat Rev Endocrinol doi: 10.1038/nrendo.2016.12 – volume: 80 start-page: 82 issue: 1 year: 1981 ident: ref4 article-title: Silicate pneumoconiosis and pulmonary fibrosis in horses from the Monterey-Carmel peninsula publication-title: Chest doi: 10.1378/chest.80.1_Supplement.82S – volume: 148 start-page: 2553 issue: 5 year: 2007 ident: ref65 article-title: Mechanical loading down-regulates peroxisome proliferator-activated receptor gamma in bone marrow stromal cells and favors osteoblastogenesis at the expense of adipogenesis publication-title: Endocrinology doi: 10.1210/en.2006-1704 – volume: 24 start-page: 9248 issue: 20 year: 2004 ident: ref31 article-title: Dlx3 transcriptional regulation of osteoblast differentiation: temporal recruitment of Msx2, Dlx3, and Dlx5 homeodomain proteins to chromatin of the osteocalcin gene publication-title: Mol Cell Biol doi: 10.1128/MCB.24.20.9248-9261.2004 – volume: 45 start-page: 682 issue: 4 year: 2009 ident: ref32 article-title: Identification of differentially expressed genes between osteoblasts and osteocytes publication-title: Bone doi: 10.1016/j.bone.2009.06.010 – volume: 44 start-page: 240 issue: Suppl 1 year: 2003 ident: ref57 article-title: Dentin matrix protein 1 initiates hydroxyapatite formation in vitro publication-title: Connect Tissue Res doi: 10.1080/03008200390181726 – year: 2015 ident: ref12 article-title: Chronic obstructive pulmonary disease is a strong independent risk factor for osteoporosis and pathologic fractures: a population-based cohort study publication-title: QJM: monthly journal of the Association of Physicians – volume: 89 start-page: 755 issue: 5 year: 1997 ident: ref68 article-title: Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts publication-title: Cell doi: 10.1016/S0092-8674(00)80258-5 – volume: 12 start-page: 197 issue: 3 year: 2015 ident: ref43 article-title: Evaluation of Mechanical and Chemical Stimulations on Osteocalcin and Runx2 Expression in Mesenchymal Stem Cells publication-title: Mol Cell Biomech – volume: 26 start-page: 139 issue: 1 year: 2010 ident: ref20 article-title: edgeR: a Bioconductor package for differential expression analysis of digital gene expression data publication-title: Bioinformatics doi: 10.1093/bioinformatics/btp616 – volume: 8 start-page: 1019 issue: 9 year: 1993 ident: ref60 article-title: Distribution of noncollagenous proteins in the matrix of adult human bone: evidence of anatomic and functional heterogeneity publication-title: Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research doi: 10.1002/jbmr.5650080902 – volume: 101 start-page: 177 issue: 1 year: 2007 ident: ref11 article-title: The prevalence of osteoporosis in patients with chronic obstructive pulmonary disease: a cross sectional study publication-title: Respiratory medicine doi: 10.1016/j.rmed.2006.03.029 – ident: ref2 – volume: 316 start-page: 458 issue: 2 year: 2008 ident: ref59 article-title: Expression and function of Dlx genes in the osteoblast lineage publication-title: Dev Biol doi: 10.1016/j.ydbio.2008.01.001 – volume: 12 start-page: 2040 issue: 12 year: 1997 ident: ref56 article-title: Gene expression patterns of murine dentin matrix protein 1 (Dmp1) and dentin sialophosphoprotein (DSPP) suggest distinct developmental functions in vivo publication-title: Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research doi: 10.1359/jbmr.1997.12.12.2040 – volume: 232 start-page: 1694 issue: 11 year: 2008 ident: ref3 article-title: Clinical and scintigraphic findings in horses with a bone fragility disorder: 16 cases (1980–2006) publication-title: Journal of the American Veterinary Medical Association doi: 10.2460/javma.232.11.1694 – volume: 32 start-page: 401 issue: 3 year: 1996 ident: ref47 article-title: The human alpha 2(XI) collagen gene (COL11A2): completion of coding information, identification of the promoter sequence, and precise localization within the major histocompatibility complex reveal overlap with the KE5 gene publication-title: Genomics doi: 10.1006/geno.1996.0135 – volume: 19 start-page: 51 issue: 1 year: 2009 ident: ref72 article-title: Silica-induced TNF-alpha and TGF-beta1 expression in RAW264.7 cells are dependent on Src-ERK/AP-1 pathways publication-title: Toxicol Mech Methods doi: 10.1080/15376510802354201 – volume: 95 start-page: 3597 issue: 7 year: 1998 ident: ref16 article-title: Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL publication-title: Proceedings of the National Academy of Sciences of the United States of America doi: 10.1073/pnas.95.7.3597 – volume: 7 start-page: 134 issue: 4 year: 2009 ident: ref15 article-title: Proinflammatory cytokines and osteoporosis publication-title: Curr Osteoporos Rep doi: 10.1007/s11914-009-0023-2 – volume: 15 start-page: 1370 issue: 4 year: 2017 ident: ref77 article-title: Transcriptome analysis of equine sarcoids publication-title: Vet Comp Oncol doi: 10.1111/vco.12279 – volume: 160 start-page: 261 issue: 2 year: 2015 ident: ref78 article-title: Bone marrow transcriptome and epigenome profiles of equine common variable immunodeficiency patients unveil block of B lymphocyte differentiation publication-title: Clin Immunol doi: 10.1016/j.clim.2015.05.005 – volume: 87 start-page: 1 issue: 1 year: 2002 ident: ref69 article-title: Runx2, a multifunctional transcription factor in skeletal development publication-title: J Cell Biochem doi: 10.1002/jcb.10276 – ident: ref25 doi: 10.1145/2808719.2811442 – volume: 341 start-page: 101 year: 2004 ident: ref40 article-title: Molecular cloning, structure, expression, and chromosomal localization of the human Osterix (SP7) gene publication-title: Gene doi: 10.1016/j.gene.2004.05.026 – volume: 95 start-page: 293 issue: 2 year: 2014 ident: ref52 article-title: DAPK2 positively regulates motility of neutrophils and eosinophils in response to intermediary chemoattractants publication-title: J Leukoc Biol doi: 10.1189/jlb.0813462 – volume: 36 start-page: 2282 issue: 17 year: 2016 ident: ref45 article-title: Smpd3 Expression in both Chondrocytes and Osteoblasts Is Required for Normal Endochondral Bone Development publication-title: Mol Cell Biol doi: 10.1128/MCB.01077-15 – volume: 40 start-page: 999 issue: 8 year: 2008 ident: ref34 article-title: Gain-of-function mutations in TRPV4 cause autosomal dominant brachyolmia publication-title: Nat Genet doi: 10.1038/ng.166 – volume: 22 start-page: 430 issue: 5 year: 2004 ident: ref71 article-title: Expression of dentin matrix protein 1 (DMP1) in nonmineralized tissues publication-title: Journal of bone and mineral metabolism doi: 10.1007/s00774-004-0504-4 – volume: 15 start-page: R46 issue: 3 year: 2014 ident: ref23 article-title: Kraken: ultrafast metagenomic sequence classification using exact alignments publication-title: Genome Biol doi: 10.1186/gb-2014-15-3-r46 – volume: 101 start-page: 261 year: 2016 ident: ref76 article-title: Transcriptome profiling of equine vitamin E deficient neuroaxonal dystrophy identifies upregulation of liver X receptor target genes publication-title: Free Radic Biol Med doi: 10.1016/j.freeradbiomed.2016.10.009 – volume: 11 start-page: 880 issue: 8 year: 2005 ident: ref38 article-title: NFAT and Osterix cooperatively regulate bone formation publication-title: Nat Med doi: 10.1038/nm1270 – volume: 325 start-page: 129 issue: 1 year: 2009 ident: ref30 article-title: In vivo impact of a 4 bp deletion mutation in the DLX3 gene on bone development publication-title: Dev Biol doi: 10.1016/j.ydbio.2008.10.014 – year: 2017 ident: ref79 article-title: Biomarkers for equine joint injury and osteoarthritis publication-title: Journal of orthopaedic research: official publication of the Orthopaedic Research Society – volume: 8 start-page: 257 issue: 3 year: 2008 ident: ref36 article-title: TRPV4-mediated calcium influx regulates terminal differentiation of osteoclasts publication-title: Cell Metab doi: 10.1016/j.cmet.2008.08.002 – year: 2016 ident: ref6 article-title: Epidemiology and pathology of Paget's disease of bone—a review publication-title: Wien Med Wochenschr – volume: 83 start-page: 4642 issue: 9 year: 2009 ident: ref26 article-title: Metagenomic analyses of viruses in stool samples from children with acute flaccid paralysis publication-title: J Virol doi: 10.1128/JVI.02301-08 – volume: 48 start-page: 593 issue: 3 year: 2011 ident: ref1 article-title: Osteoporosis associated with pulmonary silicosis in an equine bone fragility syndrome publication-title: Veterinary pathology doi: 10.1177/0300985810385151 – volume: 62 start-page: 98 issue: 1 year: 2014 ident: ref7 article-title: Osteoporosis: can it be related to silicosis? publication-title: Tuberk Toraks doi: 10.5578/tt.5721 – volume: 11 start-page: 486 issue: 8 year: 2009 ident: ref14 article-title: Osteoporosis in patients with systemic lupus erythematosus publication-title: The Israel Medical Association journal: IMAJ – volume: 42 start-page: 180 issue: 1 year: 2008 ident: ref27 article-title: NHA-oc/NHA2: a mitochondrial cation-proton antiporter selectively expressed in osteoclasts publication-title: Bone doi: 10.1016/j.bone.2007.09.046 – volume: 43 start-page: 1142 issue: 11 year: 2011 ident: ref33 article-title: Mutations in TRPV4 cause an inherited arthropathy of hands and feet publication-title: Nat Genet doi: 10.1038/ng.945 – volume: 272 start-page: 8172 issue: 13 year: 1997 ident: ref54 article-title: Characterization of the promoter for the human long pentraxin PTX3. Role of NF-kappaB in tumor necrosis factor-alpha and interleukin-1beta regulation publication-title: J Biol Chem doi: 10.1074/jbc.272.13.8172 – volume: 22 start-page: 1600 issue: 13 year: 2006 ident: ref22 article-title: Improved scoring of functional groups from gene expression data by decorrelating GO graph structure publication-title: Bioinformatics doi: 10.1093/bioinformatics/btl140 – volume: 172 start-page: 1665 issue: 6 year: 1990 ident: ref55 article-title: Expression cloning of a human Fc receptor for IgA publication-title: J Exp Med doi: 10.1084/jem.172.6.1665 – ident: ref18 doi: 10.1145/2808719.2811442 – volume: 43 start-page: e47 issue: 7 year: 2015 ident: ref21 article-title: limma powers differential expression analyses for RNA-sequencing and microarray studies publication-title: Nucleic Acids Res doi: 10.1093/nar/gkv007 – volume: 1192 start-page: 404 year: 2010 ident: ref35 article-title: Transient receptor potential vanilloid 4: The sixth sense of the musculoskeletal system? publication-title: Ann N Y Acad Sci doi: 10.1111/j.1749-6632.2010.05389.x – volume: 72 start-page: 959 issue: 5 year: 2015 ident: ref46 article-title: Sphingolipid metabolism and its role in the skeletal tissues publication-title: Cell Mol Life Sci doi: 10.1007/s00018-014-1778-x – volume: 258 start-page: 12723 issue: 20 year: 1983 ident: ref61 article-title: Matrix sialoprotein of developing bone publication-title: J Biol Chem doi: 10.1016/S0021-9258(17)44236-0 – volume: 18 start-page: 708 issue: 1 year: 2017 ident: ref75 article-title: Impaired response of the bronchial epithelium to inflammation characterizes severe equine asthma publication-title: BMC Genomics doi: 10.1186/s12864-017-4107-6 – volume: 55 start-page: 581 issue: 5–6 year: 1995 ident: ref51 article-title: Characteristics of human types 1, 2 and 3 17 beta-hydroxysteroid dehydrogenase activities: oxidation/reduction and inhibition publication-title: J Steroid Biochem Mol Biol doi: 10.1016/0960-0760(95)00209-X – volume: 29 start-page: 15 issue: 1 year: 2013 ident: ref19 article-title: STAR: ultrafast universal RNA-seq aligner publication-title: Bioinformatics doi: 10.1093/bioinformatics/bts635 – volume: 108 start-page: 17 issue: 1 year: 2002 ident: ref41 article-title: The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation publication-title: Cell doi: 10.1016/S0092-8674(01)00622-5 – year: 2014 ident: ref10 article-title: Factors associated with low bone mineral density in patients with cystic fibrosis publication-title: Journal of bone and mineral metabolism – volume: 56 start-page: 145 issue: 2 year: 2014 ident: ref13 article-title: Osteopenia and osteoporosis in patients with new diagnosis of inflammatory bowel disease publication-title: Panminerva medica – volume: 272 start-page: 15959 issue: 25 year: 1997 ident: ref70 article-title: Expression cloning and characterization of oxidative 17beta- and 3alpha-hydroxysteroid dehydrogenases from rat and human prostate publication-title: J Biol Chem doi: 10.1074/jbc.272.25.15959 – volume: 1285 start-page: 1 year: 2013 ident: ref53 article-title: The long pentraxin PTX3: a paradigm for humoral pattern recognition molecules publication-title: Ann N Y Acad Sci doi: 10.1111/nyas.12043 – volume: 463 start-page: 292 issue: 3 year: 2015 ident: ref29 article-title: Osteomodulin regulates diameter and alters shape of collagen fibrils publication-title: Biochemical and biophysical research communications doi: 10.1016/j.bbrc.2015.05.053 – volume: 49 start-page: 68 issue: 2 year: 2008 ident: ref64 article-title: Collagen XXIV (Col24a1) gene expression is a specific marker of osteoblast differentiation and bone formation publication-title: Connect Tissue Res doi: 10.1080/03008200801913502 – volume: 1116 start-page: 323 year: 2007 ident: ref49 article-title: Proteomic analysis of hydroxyapatite interaction proteins in bone publication-title: Ann N Y Acad Sci doi: 10.1196/annals.1402.023 – volume: 425 start-page: 977 issue: 6961 year: 2003 ident: ref62 article-title: Bone recognition mechanism of porcine osteocalcin from crystal structure publication-title: Nature doi: 10.1038/nature02079 – volume: 39 start-page: 108 year: 2013 ident: ref42 article-title: A structural and functional model for human bone sialoprotein publication-title: J Mol Graph Model doi: 10.1016/j.jmgm.2012.10.007 – volume: 330 start-page: 549 issue: Pt 1 year: 1998 ident: ref48 article-title: Chondroadherin expression changes in skeletal development publication-title: Biochem J doi: 10.1042/bj3300549 – volume: 66 start-page: 388 issue: 5 year: 2000 ident: ref63 article-title: Bone sialoprotein (BSP) is a crucial factor for the expression of osteoblastic phenotypes of bone marrow cells cultured on type I collagen matrix publication-title: Calcified tissue international doi: 10.1007/s002230010078 – volume: 278 start-page: 43236 issue: 44 year: 2003 ident: ref37 article-title: Collagen XXIV, a vertebrate fibrillar collagen with structural features of invertebrate collagens: selective expression in developing cornea and bone publication-title: J Biol Chem doi: 10.1074/jbc.M302112200 – volume: 24 start-page: 62 issue: 1 year: 2009 ident: ref5 article-title: Paget's disease of bone: histologic analysis of 754 patients publication-title: Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research doi: 10.1359/jbmr.080907 – volume: 38 start-page: 1112 issue: 11–12 year: 1957 ident: ref9 article-title: Spontaneous fractures of the ribs in silicotics publication-title: J Radiol Electrol Arch Electr Medicale – volume: 362 start-page: 460 issue: 2 year: 2007 ident: ref28 article-title: Osteoclastic activity induces osteomodulin expression in osteoblasts publication-title: Biochemical and biophysical research communications doi: 10.1016/j.bbrc.2007.07.193 – volume: 357 start-page: 126 issue: 1 year: 2007 ident: ref50 article-title: Molecular characterization of GDD1/TMEM16E, the gene product responsible for autosomal dominant gnathodiaphyseal dysplasia publication-title: Biochemical and biophysical research communications doi: 10.1016/j.bbrc.2007.03.108 – volume: 24 start-page: 1374 issue: 5 year: 2015 ident: ref74 article-title: Indications for distinct pathogenic mechanisms of asbestos and silica through gene expression profiling of the response of lung epithelial cells publication-title: Hum Mol Genet doi: 10.1093/hmg/ddu551 – volume: 1192 start-page: 117 year: 2010 ident: ref17 article-title: New immune connections in osteoclast formation publication-title: Ann N Y Acad Sci doi: 10.1111/j.1749-6632.2009.05303.x – volume: 3 start-page: e104 year: 2017 ident: ref24 article-title: Bracken: estimating species abundance in metagenomics data publication-title: PeerJ Computer Science doi: 10.7717/peerj-cs.104 – volume: 21 start-page: 149 issue: 3 year: 2016 ident: ref8 article-title: Evaluation of bone mineral density and 25-hydroxyvitamin D levels in subjects with silica exposure publication-title: Environ Health Prev Med doi: 10.1007/s12199-016-0509-3 – volume: 64 start-page: 3355 issue: 10 year: 2012 ident: ref66 article-title: Interleukin-1beta induces differentiation of human mesenchymal stem cells into osteoblasts via the Wnt-5a/receptor tyrosine kinase-like orphan receptor 2 pathway publication-title: Arthritis Rheum doi: 10.1002/art.34555 – volume: 23 start-page: 4315 issue: 24 year: 2004 ident: ref44 article-title: Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression publication-title: Oncogene doi: 10.1038/sj.onc.1207676 |
| SSID | ssj0053866 |
| Score | 2.2723463 |
| Snippet | Osteoporosis has been associated with pulmonary silicosis in California horses exposed to soils rich in cytotoxic silica dioxide crystals, a syndrome termed... |
| SourceID | plos doaj pubmedcentral proquest gale pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | e0197459 |
| SubjectTerms | Anatomy & physiology Animals Arthritis Autopsy Biocompatibility Biology and Life Sciences Biomedical materials Bone growth Bone marrow Bone Marrow Cells - metabolism Bone Marrow Cells - pathology Bone sialoprotein California Cartilage Crystals Cytokines Cytotoxicity Data processing Disease Etiology Gene expression Gene sequencing Genetic aspects Horse Diseases - genetics Horse Diseases - pathology Horses Horses - genetics Infectious diseases Inflammation Inflammation - genetics Inflammation - pathology Kinases Lesions Lymph nodes Lymph Nodes - metabolism Lymph Nodes - pathology Medicine and Health Sciences Molecular chains Morphogenesis Osteoblasts Osteoblasts - metabolism Osteoblasts - pathology Osteoclasts - metabolism Osteoclasts - pathology Osteocytes Osteogenesis Osteogenesis - genetics Osteolysis Osteoporosis Osteoporosis - genetics Pathogenesis Pelvis Physiology Ribonucleic acid RNA Scapula Sequence Analysis, RNA Silica Silicon dioxide Silicosis Transcription activation Transcription, Genetic Transcriptome - genetics Veterinary colleges Veterinary medicine |
| SummonAdditionalLinks | – databaseName: DOAJ - Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Nb9QwELXQnrggylcDBQxCAg5pN3Fsx8cWURUOIAFFvVmJY8NKUbI0iQT_gx_MTOxEG1SpHLjtrscrZ2Y8eZPMPBPyIjNGOVElseSOxfAtjwuTpDFSl1XWZtZ6ts8P4uw8e3_BL3aO-sKaME8P7BV3pFiCdEWq5KKC-SovhcsEVgLlLHN8bN1bq_WUTPkYDLtYiNAox2RyFOxyuG0bewigRmbITbpzIxr5-ueovNrWbXcV5Py7cnLnVnR6m9wKGJIe-7XvkRu2uUP2wi7t6KtAJf36Lvl9Akuhc4Mi7fHONMaJjlYtVsH0lgIEpNM5KbDfawo-Zan9GUpkGxrO9aabhhYNtT8GQKYUm0NaAO8tLIJCUl2NtV-0COa2FcVHvHQ71ODoxeUv2m1q8Lpu090j56dvv7w5i8M5DLERKu1jzlNjRFnJpMhK6wDkOYE07SVXYAQmmUlZIXghrROylBVfA6ZysoBPoPwqYffJqoHL3SdUpDbNc8eNw4dPzqgskSUy_FimcmVERNhkFG0CSTmelVHr8c2bhGTF61ijKXUwZUTiedbWk3RcI3-C9p5lkWJ7_AEcTwfH09c5XkSeordo3686Bwp9zDMsclWSReT5KIE0Gw3W8Xwrhq7T7z5-_Qehz58WQi-DkGtBHaYIvRNwTWj_heTBQhKChVkM76NvT1rpdAoZIscccw0zJ3-_evjZPIx_irV5jW2HIMN5rvKIPPDbY9ZsqnIuAINGRC42zkL1y5Fm831kOecKkgORPPwftnpEbgLQzX2J3wFZ9ZeDfQxgsi-fjHHjD0u5czg priority: 102 providerName: Directory of Open Access Journals – databaseName: Public Health Database dbid: 8C1 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1Lb9QwELZguXBBdAt0ocCAEI9D2ubh1wltK6qCBEhAq96ixLHLSkuybXYl-B_8YGYcb2hQBdw260lkezzjsf3NZ8aeZcZoJ6o4ktylET6pqDBxEhF1WWVtZm3H9vlBHB1n7075adhwawOscu0TvaOuGkN75LhIx1CeguG914vziG6NotPVcIXGdXYjRh9MhqkOeogH2rIQIV0ulfFu0M7OoqntDoY2MiOG0kvTkWft733zaDFv2qsCzz_xk5cmpMPb7FaIJGHaqX6DXbP1mG1Oa1xFf_sBz8FjO_2m-ZhtBBNu4WXgmX41ZuMTgsL4fFx4H47YN9nPfaw39DmNsKTJzLuWFqqGgDNLCxg1wvpqFXQRc8BhaMF-D6jaGsJV4DCroajBnq_w20D5JA3G-w3WGHAdXnm4GBRhhNgKaFcYFqs5djbVqp3NcaC2s_YOOz588-XgKApXN0RG6GQZcZ4YI8pKxkVWWodxoRPE7F5yjT4klalJ0kLwQlonZCkrvodhmJMF_kJNVXF6l41qbO4WA5HYRCnHjaP9Kmd0FsuSSIFsqpU2YsLStQZzE3jN6XqNee4P6ySubzqF5KT3POh9wqL-rUXH6_EP-X0aHL0ssXL7P5qLszwYea7TmKi1dMlFha3VqhQuE4RaU2nm6COPaWjlXYpr71vyKc8IF6tlOmFPvQQxc9QE_TkrVm2bv_148h9Cnz8NhF4EIddgd5gipFtgm0j_A8ntgST6FzMo3iJDWPdKm_-2RHxzbRxXFz_pi-mjBOerbbMKMpwrrSbsXmdLfc8mWnGBYeuEyYGVDbp-WFLPvnpidK5xPSHi-3-v1gN2E6Ne1eH9ttloebGyDzGyXJaPvPv4BeFGe_c priority: 102 providerName: ProQuest |
| Title | Bone formation transcripts dominate the differential gene expression profile in an equine osteoporotic condition associated with pulmonary silicosis |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/29856822 https://www.proquest.com/docview/2049518260 https://www.proquest.com/docview/2049555898 https://pubmed.ncbi.nlm.nih.gov/PMC5983561 https://doaj.org/article/93118579b56d46198b6f462001834f59 http://dx.doi.org/10.1371/journal.pone.0197459 |
| Volume | 13 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1fb9MwELe27oUXxPi3wigGIQEPmZo4tuMHhNZpZSAx0KCob1Hi2KNSlHRNK23fgw_MXeJEBBWNl6iNz1Z8vjvfJeffEfIq1FpZkfme5JZ58C_yEu0HHkKXZcaExjRon-fibBZ-mvP5DmlrtjoGVltDO6wnNVvlR9dXN-9B4d_VVRuk33Y6WpaFOQKXRYZc7ZI92JsEhmOfw-67Amh3_fUSvRZPBGPmDtP9a5TeZlVj-neWe7DMy2qbW_p3duUf29X0Hrnr_Ex63AjGPtkxxX2y7zS5om8c3PTbB-TXBB6FdocY6Rp3r9qWVDQrMVNmbSi4ibStpQI2Iacgd4aaa5dGW1BX-5suCpoU1FxtwHuleICkBN6W8BAUAu-szg-jiRMJk1F8DUyXmxyUIVnd0GqRg2RWi-ohmU1Pv5-cea5Wg6eFCtYe54HWIs2kn4SpseAIWoFQ7ilXYDSYZDpgieCJNFbIVGZ8DH6XlQn8AuZnPntEBgVM94BQEZggiizXFl9QWa1CX6aIAmSYipQWQ8LaRYm1AzLHehp5XH-dkxDQNDyOcSljt5RD4nW9lg2Qxy30E1zvjhZhuOsb5eoydlodK-YjlpZKuchgtipKhQ0FpqlFLLQ4yHOUlrg509oZk_iYh5gIqyQbkpc1BUJxFJjrc5lsqir--OXHfxB9u-gRvXZEtgR26MSdr4A54fr3KA97lGBQdK_5AGW75UoVBxBFcoxDx9CzlfftzS-6ZhwU8_cKU24cDeeRiobkcaMeHWcDFXEBfuqQyJ7i9FjfbykWP2skdK4ggBD-k1vZ_JTcAU83anL8DslgvdqYZ-BNrtMR2ZVzCdfoxMfr9MOI7E1Oz79ejOr3M6PagPwGiut7Gg |
| linkProvider | Scholars Portal |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3NbtQwELbKcoALolugC4UaxF8PKU0c2_EBoW2haukPErRVbyFx7LLSkmybXUHfg-fgGZlJnNCgCrj0tllPLMczHs_Y38wQ8jTUWlmR-Z7klnnwFHmJ9gMPU5dlxoTG1Nk-98XWYfj-mB_PkZ9NLAzCKhudWCnqrNB4Rg5OOpjyaAyvvZmcelg1Cm9XmxIatVjsmPNv4LKVr7ffAn-fBcHmu4ONLc9VFfC0UMHU4zzQWqSZ9JMwNRZMFisw6XjKFYg3k0wHLBE8kcYKmcqMr4GFYGUCv5j0M59Bv9fI9ZAxgRCyaKOFlIDuEMKF5wHpKycNq5MiN6tgSskQM6Je2P6qKgHtXtCbjIvyMkP3T7zmhQ1w8za55SxXOqxFbZ7MmbxPFoY5eO1fz-lzWmFJq0P6Ppl3KqOkL11e65U-6R8h9KaK_6V77kp_gfxYh3HTNoaSTnHzrFRZSbMCgTpTQ8FKpU0pF1BJYwpib6j57lC8OXWlx-kop0lOzekM-qYYv1KAf1HAiCn4_VkFT6OJk0iTUTyFppPZGJiLoypHY1gY5ai8Qw6vhKl3SS-Hz10kVAQmiCLLtcXzMatV6MsUkxAZpiKlxYCwhoOxdnnUsZzHOK4uByX4UzVDYuR77Pg-IF771qTOI_IP-nUUjpYWs4BXfxRnJ7FTKrFiPqbyUikXGXytilJhQ4EouYiFFjtZRtGK65DaVpfFQx4iDldJNiBPKgrMBJIj1OgkmZVlvP3h6D-IPn3sEL1wRLaA6dCJC--Ab0L-dyiXOpSgz3SneREXQjMrZfx75cObzeK4vPlx24ydInwwN8XM0XAeqWhA7tVrqZ3ZQEVcgJk8ILKzyjpT323JR1-qROxcgf8i_Pt_H9YyubF1sLcb727v7zwgN8Hijmqs4RLpTc9m5iFYtdP0UaVKKPl81brrF63Yt5E |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3NbtQwELbKIiEuiG6BLhRqEL-HtE0c2_EBoZaytBQKKrTqLSSOXVZakm2zK-h78DQ8HTOJExpUAZfeNuuJ5XhmPo_t-SHkYai1siLzPckt8-Ap8hLtBx6mLsuMCY2ps33uiq398M0hP5wjP5tYGHSrbDCxAuqs0HhGDpt0MOXRGF5btc4t4sPm8MXk2MMKUnjT2pTTqEVkx5x-g-1b-Xx7E3j9KAiGrz693PJchQFPCxVMPc4DrUWaST8JU2PBfLECE5CnXIGoM8l0wBLBE2mskKnM-BpYC1Ym8ItJP_MZ9HuJXJZMKnQnjIavm1UAcEQIF6oHpKtOMlYmRW5WwKySIWZHPbMUVhUD2nWhNxkX5XlG75--m2cWw-F1cs1ZsXS9Frt5MmfyPllYz2EH__WUPqaVX2l1YN8n8w4-SvrU5bh-1if9A3TDqWKB6Tt3vb9AfmzAuGkbT0mnuJBWsFbSrECnnamhYLHSpqwLwNOYggoYar47j96cujLkdJTTJKfmeAZ9U4xlKWCvUcCIqS7woh5pEyedJqN4Ik0nszEwF0dVjsagJOWovEH2L4SpN0kvh89dJFQEJogiy7XFszKrVejLFBMSGaYipcWAsIaDsXY51bG0xziuLgol7K1qhsTI99jxfUC89q1JnVPkH_QbKBwtLWYEr_4oTo5iBzCxYj6m9VIpFxl8rYpSYUOBHnMRCy12soyiFdfhtS2uxes8RJ9cJdmAPKgoMCtIjvp1lMzKMt5-f_AfRB_3OkRPHJEtYDp04kI94JuQ_x3KpQ4lYJvuNC-iIjSzUsa_UQDebJTj_Ob7bTN2iq6EuSlmjobzSEUDcqvWpXZmAxVxASbzgMiOlnWmvtuSj75USdm5gr2M8G__fVjL5AqgVvx2e3fnDrkKxndUux0ukd70ZGbugoE7Te9VSELJ54uGrl_VDbv7 |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Bone+formation+transcripts+dominate+the+differential+gene+expression+profile+in+an+equine+osteoporotic+condition+associated+with+pulmonary+silicosis&rft.jtitle=PloS+one&rft.au=Murphy%2C+Brian+G&rft.au=Britton%2C+Monica&rft.au=Zavodovskaya%2C+Regina&rft.au=Stover%2C+Susan+M&rft.date=2018-06-01&rft.pub=Public+Library+of+Science&rft.issn=1932-6203&rft.eissn=1932-6203&rft.volume=13&rft.issue=6&rft.spage=e0197459&rft_id=info:doi/10.1371%2Fjournal.pone.0197459&rft.externalDBID=n%2Fa&rft.externalDocID=A541074973 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1932-6203&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1932-6203&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1932-6203&client=summon |