Evaluation of alternately combining HPV viral load and 16/18 genotyping in secondary screening algorithms
Correlation with HPV viral load and worsening cervical lesions had been reported, but its potential for triage after primary HPV screening has not been adequately explored, especially when combined with HPV-16/18 genotyping. To evaluate combinations of human papillomavirus (HPV) viral load and genot...
Saved in:
| Published in | PloS one Vol. 14; no. 7; p. e0220200 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Public Library of Science
26.07.2019
Public Library of Science (PLoS) |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1932-6203 1932-6203 |
| DOI | 10.1371/journal.pone.0220200 |
Cover
| Abstract | Correlation with HPV viral load and worsening cervical lesions had been reported, but its potential for triage after primary HPV screening has not been adequately explored, especially when combined with HPV-16/18 genotyping.
To evaluate combinations of human papillomavirus (HPV) viral load and genotyping for HPV-16/18 as secondary screening strategies.
The Shenzhen Cervical Cancer Screening Trial Ⅱ (SHENCCAST Ⅱ) database was re-analyzed to explore new screening algorithms using the results of Hybrid Capture 2 (HC2), Mass Array Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass spectrometry System (MALDI-TOF-MS) and the ThinPrep cytologic test (TCT) obtained by endocervical sampling.
Compared with the recommended screening strategy of genotyping HPV-16/18 plus reflex to cytology, using viral load (10 RLU/CO as threshold) plus reflex to cytology resulted in less cytology but had a significantly higher sensitivity for cervical intraepithelial neoplasia 2+ (CIN2+)/CIN3+ without considerable changes in specificity and referral rates. Both of the strategy of using viral load ≥10 RLU/CO as cut-point for immediate colposcopy followed by triage genotyping HPV-16/18 for the other positive (≥1<10 RLU/CO) and the strategy of referring HPV-16/18 positives for immediate colposcopy followed by triage viral load (10 RLU/CO as threshold) for non-HPV-16/18 positives had comparable screening efficacy with algorithims that contain cytology.
Primary HPV screening with triage of HPV-positive women by a combination of viral load and genotyping for HPV-16/18 provides good balance between sensitivity and specificity, the number of tests required, and referral rates. |
|---|---|
| AbstractList | Correlation with HPV viral load and worsening cervical lesions had been reported, but its potential for triage after primary HPV screening has not been adequately explored, especially when combined with HPV-16/18 genotyping.BACKGROUNDCorrelation with HPV viral load and worsening cervical lesions had been reported, but its potential for triage after primary HPV screening has not been adequately explored, especially when combined with HPV-16/18 genotyping.To evaluate combinations of human papillomavirus (HPV) viral load and genotyping for HPV-16/18 as secondary screening strategies.OBJECTIVETo evaluate combinations of human papillomavirus (HPV) viral load and genotyping for HPV-16/18 as secondary screening strategies.The Shenzhen Cervical Cancer Screening Trial Ⅱ (SHENCCAST Ⅱ) database was re-analyzed to explore new screening algorithms using the results of Hybrid Capture 2 (HC2), Mass Array Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass spectrometry System (MALDI-TOF-MS) and the ThinPrep cytologic test (TCT) obtained by endocervical sampling.METHODSThe Shenzhen Cervical Cancer Screening Trial Ⅱ (SHENCCAST Ⅱ) database was re-analyzed to explore new screening algorithms using the results of Hybrid Capture 2 (HC2), Mass Array Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass spectrometry System (MALDI-TOF-MS) and the ThinPrep cytologic test (TCT) obtained by endocervical sampling.Compared with the recommended screening strategy of genotyping HPV-16/18 plus reflex to cytology, using viral load (10 RLU/CO as threshold) plus reflex to cytology resulted in less cytology but had a significantly higher sensitivity for cervical intraepithelial neoplasia 2+ (CIN2+)/CIN3+ without considerable changes in specificity and referral rates. Both of the strategy of using viral load ≥10 RLU/CO as cut-point for immediate colposcopy followed by triage genotyping HPV-16/18 for the other positive (≥1<10 RLU/CO) and the strategy of referring HPV-16/18 positives for immediate colposcopy followed by triage viral load (10 RLU/CO as threshold) for non-HPV-16/18 positives had comparable screening efficacy with algorithims that contain cytology.RESULTSCompared with the recommended screening strategy of genotyping HPV-16/18 plus reflex to cytology, using viral load (10 RLU/CO as threshold) plus reflex to cytology resulted in less cytology but had a significantly higher sensitivity for cervical intraepithelial neoplasia 2+ (CIN2+)/CIN3+ without considerable changes in specificity and referral rates. Both of the strategy of using viral load ≥10 RLU/CO as cut-point for immediate colposcopy followed by triage genotyping HPV-16/18 for the other positive (≥1<10 RLU/CO) and the strategy of referring HPV-16/18 positives for immediate colposcopy followed by triage viral load (10 RLU/CO as threshold) for non-HPV-16/18 positives had comparable screening efficacy with algorithims that contain cytology.Primary HPV screening with triage of HPV-positive women by a combination of viral load and genotyping for HPV-16/18 provides good balance between sensitivity and specificity, the number of tests required, and referral rates.CONCLUSIONSPrimary HPV screening with triage of HPV-positive women by a combination of viral load and genotyping for HPV-16/18 provides good balance between sensitivity and specificity, the number of tests required, and referral rates. Background Correlation with HPV viral load and worsening cervical lesions had been reported, but its potential for triage after primary HPV screening has not been adequately explored, especially when combined with HPV-16/18 genotyping. Objective To evaluate combinations of human papillomavirus (HPV) viral load and genotyping for HPV-16/18 as secondary screening strategies. Methods The Shenzhen Cervical Cancer Screening Trial Ⅱ (SHENCCAST Ⅱ) database was re-analyzed to explore new screening algorithms using the results of Hybrid Capture 2 (HC2), Mass Array Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass spectrometry System (MALDI-TOF-MS) and the ThinPrep cytologic test (TCT) obtained by endocervical sampling. Results Compared with the recommended screening strategy of genotyping HPV-16/18 plus reflex to cytology, using viral load (10 RLU/CO as threshold) plus reflex to cytology resulted in less cytology but had a significantly higher sensitivity for cervical intraepithelial neoplasia 2+ (CIN2+)/CIN3+ without considerable changes in specificity and referral rates. Both of the strategy of using viral load ≥10 RLU/CO as cut-point for immediate colposcopy followed by triage genotyping HPV-16/18 for the other positive (≥1<10 RLU/CO) and the strategy of referring HPV-16/18 positives for immediate colposcopy followed by triage viral load (10 RLU/CO as threshold) for non-HPV-16/18 positives had comparable screening efficacy with algorithims that contain cytology. Conclusions Primary HPV screening with triage of HPV-positive women by a combination of viral load and genotyping for HPV-16/18 provides good balance between sensitivity and specificity, the number of tests required, and referral rates. Correlation with HPV viral load and worsening cervical lesions had been reported, but its potential for triage after primary HPV screening has not been adequately explored, especially when combined with HPV-16/18 genotyping. To evaluate combinations of human papillomavirus (HPV) viral load and genotyping for HPV-16/18 as secondary screening strategies. The Shenzhen Cervical Cancer Screening Trial II (SHENCCAST II) database was re-analyzed to explore new screening algorithms using the results of Hybrid Capture 2 (HC2), Mass Array Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass spectrometry System (MALDI-TOF-MS) and the ThinPrep cytologic test (TCT) obtained by endocervical sampling. Compared with the recommended screening strategy of genotyping HPV-16/18 plus reflex to cytology, using viral load (10 RLU/CO as threshold) plus reflex to cytology resulted in less cytology but had a significantly higher sensitivity for cervical intraepithelial neoplasia 2+ (CIN2+)/CIN3+ without considerable changes in specificity and referral rates. Both of the strategy of using viral load [greater than or equal to]10 RLU/CO as cut-point for immediate colposcopy followed by triage genotyping HPV-16/18 for the other positive ([greater than or equal to]1<10 RLU/CO) and the strategy of referring HPV-16/18 positives for immediate colposcopy followed by triage viral load (10 RLU/CO as threshold) for non-HPV-16/18 positives had comparable screening efficacy with algorithims that contain cytology. Primary HPV screening with triage of HPV-positive women by a combination of viral load and genotyping for HPV-16/18 provides good balance between sensitivity and specificity, the number of tests required, and referral rates. Background Correlation with HPV viral load and worsening cervical lesions had been reported, but its potential for triage after primary HPV screening has not been adequately explored, especially when combined with HPV-16/18 genotyping. Objective To evaluate combinations of human papillomavirus (HPV) viral load and genotyping for HPV-16/18 as secondary screening strategies. Methods The Shenzhen Cervical Cancer Screening Trial Ⅱ (SHENCCAST Ⅱ) database was re-analyzed to explore new screening algorithms using the results of Hybrid Capture 2 (HC2), Mass Array Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass spectrometry System (MALDI-TOF-MS) and the ThinPrep cytologic test (TCT) obtained by endocervical sampling. Results Compared with the recommended screening strategy of genotyping HPV-16/18 plus reflex to cytology, using viral load (10 RLU/CO as threshold) plus reflex to cytology resulted in less cytology but had a significantly higher sensitivity for cervical intraepithelial neoplasia 2+ (CIN2+)/CIN3+ without considerable changes in specificity and referral rates. Both of the strategy of using viral load ≥10 RLU/CO as cut-point for immediate colposcopy followed by triage genotyping HPV-16/18 for the other positive (≥1<10 RLU/CO) and the strategy of referring HPV-16/18 positives for immediate colposcopy followed by triage viral load (10 RLU/CO as threshold) for non-HPV-16/18 positives had comparable screening efficacy with algorithims that contain cytology. Conclusions Primary HPV screening with triage of HPV-positive women by a combination of viral load and genotyping for HPV-16/18 provides good balance between sensitivity and specificity, the number of tests required, and referral rates. Background Correlation with HPV viral load and worsening cervical lesions had been reported, but its potential for triage after primary HPV screening has not been adequately explored, especially when combined with HPV-16/18 genotyping. Objective To evaluate combinations of human papillomavirus (HPV) viral load and genotyping for HPV-16/18 as secondary screening strategies. Methods The Shenzhen Cervical Cancer Screening Trial II (SHENCCAST II) database was re-analyzed to explore new screening algorithms using the results of Hybrid Capture 2 (HC2), Mass Array Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass spectrometry System (MALDI-TOF-MS) and the ThinPrep cytologic test (TCT) obtained by endocervical sampling. Results Compared with the recommended screening strategy of genotyping HPV-16/18 plus reflex to cytology, using viral load (10 RLU/CO as threshold) plus reflex to cytology resulted in less cytology but had a significantly higher sensitivity for cervical intraepithelial neoplasia 2+ (CIN2+)/CIN3+ without considerable changes in specificity and referral rates. Both of the strategy of using viral load [greater than or equal to]10 RLU/CO as cut-point for immediate colposcopy followed by triage genotyping HPV-16/18 for the other positive ([greater than or equal to]1<10 RLU/CO) and the strategy of referring HPV-16/18 positives for immediate colposcopy followed by triage viral load (10 RLU/CO as threshold) for non-HPV-16/18 positives had comparable screening efficacy with algorithims that contain cytology. Conclusions Primary HPV screening with triage of HPV-positive women by a combination of viral load and genotyping for HPV-16/18 provides good balance between sensitivity and specificity, the number of tests required, and referral rates. Correlation with HPV viral load and worsening cervical lesions had been reported, but its potential for triage after primary HPV screening has not been adequately explored, especially when combined with HPV-16/18 genotyping. To evaluate combinations of human papillomavirus (HPV) viral load and genotyping for HPV-16/18 as secondary screening strategies. The Shenzhen Cervical Cancer Screening Trial Ⅱ (SHENCCAST Ⅱ) database was re-analyzed to explore new screening algorithms using the results of Hybrid Capture 2 (HC2), Mass Array Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass spectrometry System (MALDI-TOF-MS) and the ThinPrep cytologic test (TCT) obtained by endocervical sampling. Compared with the recommended screening strategy of genotyping HPV-16/18 plus reflex to cytology, using viral load (10 RLU/CO as threshold) plus reflex to cytology resulted in less cytology but had a significantly higher sensitivity for cervical intraepithelial neoplasia 2+ (CIN2+)/CIN3+ without considerable changes in specificity and referral rates. Both of the strategy of using viral load ≥10 RLU/CO as cut-point for immediate colposcopy followed by triage genotyping HPV-16/18 for the other positive (≥1<10 RLU/CO) and the strategy of referring HPV-16/18 positives for immediate colposcopy followed by triage viral load (10 RLU/CO as threshold) for non-HPV-16/18 positives had comparable screening efficacy with algorithims that contain cytology. Primary HPV screening with triage of HPV-positive women by a combination of viral load and genotyping for HPV-16/18 provides good balance between sensitivity and specificity, the number of tests required, and referral rates. BackgroundCorrelation with HPV viral load and worsening cervical lesions had been reported, but its potential for triage after primary HPV screening has not been adequately explored, especially when combined with HPV-16/18 genotyping.ObjectiveTo evaluate combinations of human papillomavirus (HPV) viral load and genotyping for HPV-16/18 as secondary screening strategies.MethodsThe Shenzhen Cervical Cancer Screening Trial Ⅱ (SHENCCAST Ⅱ) database was re-analyzed to explore new screening algorithms using the results of Hybrid Capture 2 (HC2), Mass Array Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass spectrometry System (MALDI-TOF-MS) and the ThinPrep cytologic test (TCT) obtained by endocervical sampling.ResultsCompared with the recommended screening strategy of genotyping HPV-16/18 plus reflex to cytology, using viral load (10 RLU/CO as threshold) plus reflex to cytology resulted in less cytology but had a significantly higher sensitivity for cervical intraepithelial neoplasia 2+ (CIN2+)/CIN3+ without considerable changes in specificity and referral rates. Both of the strategy of using viral load ≥10 RLU/CO as cut-point for immediate colposcopy followed by triage genotyping HPV-16/18 for the other positive (≥1<10 RLU/CO) and the strategy of referring HPV-16/18 positives for immediate colposcopy followed by triage viral load (10 RLU/CO as threshold) for non-HPV-16/18 positives had comparable screening efficacy with algorithims that contain cytology.ConclusionsPrimary HPV screening with triage of HPV-positive women by a combination of viral load and genotyping for HPV-16/18 provides good balance between sensitivity and specificity, the number of tests required, and referral rates. |
| Audience | Academic |
| Author | Luo, Hongxue Belinson, Jerome L. Du, Hui Wu, Ruifang |
| AuthorAffiliation | 5 Preventive Oncology International, Cleveland Heights, OH, United States of America 2 Department of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen, PR China 3 Shenzhen Key Laboratory on Technology for Early Diagnosis of Major Gynecological diseases, Shenzhen, PR China 1 Department of Obstetrics and Gynecology, Peking University People’ Hospital, Beijing, PR China 4 Gynecologic Oncology Division, Women’s Health Institute, Cleveland Clinic, Cleveland, OH, United States of America Bharathidasan University, INDIA |
| AuthorAffiliation_xml | – name: 4 Gynecologic Oncology Division, Women’s Health Institute, Cleveland Clinic, Cleveland, OH, United States of America – name: 3 Shenzhen Key Laboratory on Technology for Early Diagnosis of Major Gynecological diseases, Shenzhen, PR China – name: 1 Department of Obstetrics and Gynecology, Peking University People’ Hospital, Beijing, PR China – name: 2 Department of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen, PR China – name: 5 Preventive Oncology International, Cleveland Heights, OH, United States of America – name: Bharathidasan University, INDIA |
| Author_xml | – sequence: 1 givenname: Hongxue surname: Luo fullname: Luo, Hongxue – sequence: 2 givenname: Hui surname: Du fullname: Du, Hui – sequence: 3 givenname: Jerome L. surname: Belinson fullname: Belinson, Jerome L. – sequence: 4 givenname: Ruifang orcidid: 0000-0002-4231-0774 surname: Wu fullname: Wu, Ruifang |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31348794$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNk11r2zAUhs3oWD-2fzA2w2BsF0n1YcnyLgaldGug0LGP3grZOnZUFCmz7Gz595OTtMSljOILm-PnfXX0Huk4OXDeQZK8xmiKaY5Pb33fOmWny1ieIkIQQehZcoQLSiacIHqw932YHIdwixCjgvMXySHFNBN5kR0l5mKlbK86413q61TZDqJrB3adVn5RGmdck15-u0lXplU2tV7pVDmdYn6KRdqA8916OTDGpQEq77Rq12moWoCNVNnGt6abL8LL5HmtbIBXu_dJ8uvLxc_zy8nV9dfZ-dnVpOIF6SYM17REBRG8KAEQ1SWui4xmDOWVVkywOgONNaOMcgyCAsOKVDERXWaFEDU9Sd5ufZfWB7lLKUhCeMYKLASLxGxLaK9u5bI1i9iz9MrITcG3jVRtZyoLMucZJbTkNcnrrGRFoRESRNQoi8tryKMX23r1bqnWf5S194YYyWFQdy3IYVByN6io-7zrsi8XoCtwXavsqJnxH2fmsvEryTlHqBgMPuwMWv-7h9DJhQkVWKsc-H6zX5bzIuMD-u4B-ngqO6pRcePG1T6uWw2m8oxFHyLyfKCmj1Dx0bAwcfxQm1gfCT6OBJHp4G_XqD4EOfvx_ens9c2Yfb_HziGe3Hnwth9OchiDb_aTvo_47g5EINsCVetDaKF-6gQ_PZBVpttcpJiIsf8X_wM1gS1W |
| CitedBy_id | crossref_primary_10_3390_ijms24021320 crossref_primary_10_1002_cncy_22920 crossref_primary_10_3390_cancers13164149 crossref_primary_10_1371_journal_pone_0232107 crossref_primary_10_1016_j_gocm_2020_10_005 crossref_primary_10_1371_journal_pone_0232117 crossref_primary_10_1186_s12985_022_01908_w crossref_primary_10_1186_s13027_022_00440_4 crossref_primary_10_1002_ijc_34283 crossref_primary_10_1007_s11033_022_07955_4 crossref_primary_10_1002_cyto_a_24349 crossref_primary_10_3389_fpubh_2022_1010066 crossref_primary_10_1002_ijc_35190 crossref_primary_10_1111_1471_0528_16631 |
| Cites_doi | 10.1093/annonc/mdt538 10.1097/LGT.0000000000000243 10.1016/j.vaccine.2012.06.095 10.1097/LGT.0000000000000277 10.1158/1055-9965.EPI-05-0240 10.1002/ijc.28723 10.1016/S1470-2045(12)70568-5 10.1002/ijc.26056 10.1097/LGT.0b013e31824f48c8 10.1002/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F 10.1016/S1470-2045(11)70188-7 10.1016/S1473-3099(07)70158-5 10.1002/ijc.27650 10.1586/14737140.2014.856273 10.1371/journal.pone.0107573 10.1002/ijc.26202 10.1097/IGC.0b013e318286a95d 10.1016/j.ajog.2012.11.020 10.1093/jjco/hyu112 10.1016/S0140-6736(13)62218-7 |
| ContentType | Journal Article |
| Copyright | COPYRIGHT 2019 Public Library of Science 2019 Luo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2019 Luo et al 2019 Luo et al |
| Copyright_xml | – notice: COPYRIGHT 2019 Public Library of Science – notice: 2019 Luo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2019 Luo et al 2019 Luo et al |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM IOV ISR 3V. 7QG 7QL 7QO 7RV 7SN 7SS 7T5 7TG 7TM 7U9 7X2 7X7 7XB 88E 8AO 8C1 8FD 8FE 8FG 8FH 8FI 8FJ 8FK ABJCF ABUWG AEUYN AFKRA ARAPS ATCPS AZQEC BBNVY BENPR BGLVJ BHPHI C1K CCPQU D1I DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. KB. KB0 KL. L6V LK8 M0K M0S M1P M7N M7P M7S NAPCQ P5Z P62 P64 PATMY PDBOC PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PTHSS PYCSY RC3 7X8 5PM ADTOC UNPAY DOA |
| DOI | 10.1371/journal.pone.0220200 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Gale In Context: Opposing Viewpoints Gale In Context: Science ProQuest Central (Corporate) Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Biotechnology Research Abstracts Nursing & Allied Health Database Ecology Abstracts Entomology Abstracts (Full archive) Immunology Abstracts Meteorological & Geoastrophysical Abstracts Nucleic Acids Abstracts Virology and AIDS Abstracts Agricultural Science Collection Health & Medical Collection (Proquest) ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Public Health Database Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Journals Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Materials Science & Engineering Collection ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland Advanced Technologies & Computer Science Collection ProQuest Agricultural & Environmental Science & Pollution Managment ProQuest Central Essentials Biological Science Database ProQuest Central Technology Collection (via ProQuest SciTech Premium Collection) Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Materials Science Collection ProQuest Central Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Materials Science Database Nursing & Allied Health Database (Alumni Edition) Meteorological & Geoastrophysical Abstracts - Academic ProQuest Engineering Collection Biological Sciences Agricultural Science Database Health & Medical Collection (Alumni Edition) Medical Database Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Engineering Database Nursing & Allied Health Premium Advanced Technologies & Aerospace Collection ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts Environmental Science Database Materials Science Collection ProQuest Central Premium ProQuest One Academic Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic ProQuest One Academic UKI Edition Engineering collection Environmental Science Collection Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) Unpaywall for CDI: Periodical Content Unpaywall DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Agricultural Science Database Publicly Available Content Database ProQuest Central Student ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Meteorological & Geoastrophysical Abstracts Natural Science Collection Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) Engineering Collection Advanced Technologies & Aerospace Collection Engineering Database Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Agricultural Science Collection ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Environmental Science Collection Entomology Abstracts Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Environmental Science Database ProQuest Nursing & Allied Health Source (Alumni) Engineering Research Database ProQuest One Academic Meteorological & Geoastrophysical Abstracts - Academic ProQuest One Academic (New) Technology Collection Technology Research Database ProQuest One Academic Middle East (New) Materials Science Collection ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts ProQuest Engineering Collection Biotechnology Research Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Agricultural & Environmental Science Collection AIDS and Cancer Research Abstracts Materials Science Database ProQuest Materials Science Collection ProQuest Public Health ProQuest Nursing & Allied Health Source ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library Animal Behavior Abstracts Materials Science & Engineering Collection Immunology Abstracts ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic Agricultural Science Database MEDLINE |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 4 dbid: UNPAY name: Unpaywall url: https://proxy.k.utb.cz/login?url=https://unpaywall.org/ sourceTypes: Open Access Repository – sequence: 5 dbid: 8FG name: ProQuest Technology Collection url: https://search.proquest.com/technologycollection1 sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Sciences (General) |
| DocumentTitleAlternate | HPV viral load and 16/18 genotyping in secondary screening algorithms |
| EISSN | 1932-6203 |
| ExternalDocumentID | 2264591885 oai_doaj_org_article_764323b6f27f4b599d00828f04536de7 10.1371/journal.pone.0220200 PMC6660090 A594628775 31348794 10_1371_journal_pone_0220200 |
| Genre | Research Support, Non-U.S. Gov't Journal Article Comparative Study |
| GeographicLocations | United States--US China Ohio |
| GeographicLocations_xml | – name: China – name: United States--US – name: Ohio |
| GroupedDBID | --- 123 29O 2WC 53G 5VS 7RV 7X2 7X7 7XC 88E 8AO 8C1 8CJ 8FE 8FG 8FH 8FI 8FJ A8Z AAFWJ AAUCC AAWOE AAYXX ABDBF ABIVO ABJCF ABUWG ACGFO ACIHN ACIWK ACPRK ACUHS ADBBV AEAQA AENEX AEUYN AFKRA AFPKN AFRAH AHMBA ALMA_UNASSIGNED_HOLDINGS AOIJS APEBS ARAPS ATCPS BAWUL BBNVY BCNDV BENPR BGLVJ BHPHI BKEYQ BPHCQ BVXVI BWKFM CCPQU CITATION CS3 D1I D1J D1K DIK DU5 E3Z EAP EAS EBD EMOBN ESTFP ESX EX3 F5P FPL FYUFA GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE IAO IEA IGS IHR IHW INH INR IOV IPY ISE ISR ITC K6- KB. KQ8 L6V LK5 LK8 M0K M1P M48 M7P M7R M7S M~E NAPCQ O5R O5S OK1 OVT P2P P62 PATMY PDBOC PHGZM PHGZT PIMPY PJZUB PPXIY PQGLB PQQKQ PROAC PSQYO PTHSS PUEGO PV9 PYCSY RNS RPM RZL SV3 TR2 UKHRP WOQ WOW ~02 ~KM 3V. ADRAZ ALIPV BBORY CGR CUY CVF ECM EIF IPNFZ NPM RIG 7QG 7QL 7QO 7SN 7SS 7T5 7TG 7TM 7U9 7XB 8FD 8FK AZQEC C1K DWQXO FR3 GNUQQ H94 K9. KL. M7N P64 PKEHL PQEST PQUKI RC3 7X8 5PM ADTOC UNPAY AAPBV ABPTK |
| ID | FETCH-LOGICAL-c692t-51f3b092869bee03db1f9434507cda585f4ed1d535361e83e51a2c137db4988f3 |
| IEDL.DBID | M48 |
| ISSN | 1932-6203 |
| IngestDate | Sun Nov 05 00:20:41 EDT 2023 Fri Oct 03 12:44:22 EDT 2025 Sun Oct 26 03:35:06 EDT 2025 Tue Sep 30 16:57:35 EDT 2025 Sat Sep 27 21:42:52 EDT 2025 Tue Oct 07 09:16:29 EDT 2025 Mon Oct 20 21:54:04 EDT 2025 Mon Oct 20 16:47:38 EDT 2025 Thu Oct 16 14:27:04 EDT 2025 Thu Oct 16 14:24:01 EDT 2025 Thu May 22 21:20:34 EDT 2025 Wed Feb 19 02:30:16 EST 2025 Wed Oct 01 02:12:53 EDT 2025 Thu Apr 24 23:12:39 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 7 |
| Language | English |
| License | This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. cc-by Creative Commons Attribution License |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c692t-51f3b092869bee03db1f9434507cda585f4ed1d535361e83e51a2c137db4988f3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Article-2 ObjectType-Feature-1 content type line 23 Competing Interests: The authors have declared that no competing interests exist. |
| ORCID | 0000-0002-4231-0774 |
| OpenAccessLink | http://journals.scholarsportal.info/openUrl.xqy?doi=10.1371/journal.pone.0220200 |
| PMID | 31348794 |
| PQID | 2264591885 |
| PQPubID | 1436336 |
| ParticipantIDs | plos_journals_2264591885 doaj_primary_oai_doaj_org_article_764323b6f27f4b599d00828f04536de7 unpaywall_primary_10_1371_journal_pone_0220200 pubmedcentral_primary_oai_pubmedcentral_nih_gov_6660090 proquest_miscellaneous_2265769460 proquest_journals_2264591885 gale_infotracmisc_A594628775 gale_infotracacademiconefile_A594628775 gale_incontextgauss_ISR_A594628775 gale_incontextgauss_IOV_A594628775 gale_healthsolutions_A594628775 pubmed_primary_31348794 crossref_primary_10_1371_journal_pone_0220200 crossref_citationtrail_10_1371_journal_pone_0220200 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2019-07-26 |
| PublicationDateYYYYMMDD | 2019-07-26 |
| PublicationDate_xml | – month: 07 year: 2019 text: 2019-07-26 day: 26 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: San Francisco – name: San Francisco, CA USA |
| PublicationTitle | PloS one |
| PublicationTitleAlternate | PLoS One |
| PublicationYear | 2019 |
| Publisher | Public Library of Science Public Library of Science (PLoS) |
| Publisher_xml | – name: Public Library of Science – name: Public Library of Science (PLoS) |
| References | HT Tsai (ref19) 2005; 14 JM Walboomers (ref2) 1999; 189 PK Chan (ref22) 2014; 9 KU Petry (ref25) 2011; 121 H Luo (ref15) 2017; 21 AT Hesselink (ref26) 2014; 135 G Ronco (ref3) 2014; 383 N. Wentzensen (ref9) 2013; 14 PE Castle (ref14) 2011; 12 JL Belinson (ref16) 2011; 135 M Arbyn (ref4) 2012; 30 MG Dijkstra (ref6) 2014; 25 RP Bosgraaf (ref7) 2014; 14 S de Sanjose (ref8) 2007; 7 M Arbyn (ref5) 2012; 131 HH Zur (ref1) 1977; 78 JL Belinson (ref17) 2012; 130 TC Wright Jr (ref10) 2017; 144 Y Wu (ref20) 2006; 35 R Wu (ref18) 2012; 16 JT Cox (ref13) 2013; 208 WK Huh (ref12) 2015; 125 SS Xiao (ref24) 2016; 20 DC Rijkaart (ref11) 2012; 130 SM Wang (ref21) 2013; 23 Y Azuma (ref23) 2014; 44 |
| References_xml | – volume: 25 start-page: 927 issue: 5 year: 2014 ident: ref6 article-title: Cervical cancer screening: on the way to a shift from cytology to full molecular screening publication-title: Ann Oncol doi: 10.1093/annonc/mdt538 – volume: 20 start-page: 327 year: 2016 ident: ref24 article-title: Analysis of Human Papillomavirus Infection in 16,320 Patients From a Gynecology Clinic in Central South China publication-title: J Low Genit Tract Dis doi: 10.1097/LGT.0000000000000243 – volume: 30 start-page: F88 issue: Suppl 5 year: 2012 ident: ref4 article-title: Evidence Regarding Human Papillomavirus Testing in Secondary Prevention of Cervical Cancer publication-title: Vaccine doi: 10.1016/j.vaccine.2012.06.095 – volume: 21 start-page: 12 year: 2017 ident: ref15 article-title: Evaluation of Viral Load as a Triage Strategy With Primary High-Risk Human Papillomavirus Cervical Cancer Screening publication-title: J Low Genit Tract Dis doi: 10.1097/LGT.0000000000000277 – volume: 125 start-page: 330 year: 2015 ident: ref12 article-title: Use of primary high-risk human papillomavirus testing for cervical cancer screening: Interim clinical guidance publication-title: ObstetGynecol – volume: 144 start-page: 51 year: 2017 ident: ref10 article-title: Triaging HPV-positive women with p16/Ki-67 dual-stained cytology: Results from a sub-study nested into the ATHENA trial publication-title: GynecolOncol – volume: 14 start-page: 2544 issue: 11 year: 2005 ident: ref19 article-title: Association between quantitative high-risk human papillomavirus DNA load and cervical intraepithelial neoplasm risk publication-title: Cancer Epidemiol Biomarkers Prev doi: 10.1158/1055-9965.EPI-05-0240 – volume: 135 start-page: 790 year: 2011 ident: ref16 article-title: A Population-Based Clinical Trial Comparing Endocervical High-Risk HPV Testing Using Hybrid Capture 2 and CervistaFrom the SHENCCAST II Study publication-title: Am J ClinPathol – volume: 135 start-page: 880 year: 2014 ident: ref26 article-title: Methylation marker analysis of self-sampled cervico-vaginal lavage specimens to triage high-risk HPV-positive women for colposcopy publication-title: Int J Cancer doi: 10.1002/ijc.28723 – volume: 14 start-page: 107 year: 2013 ident: ref9 article-title: Triage of HPV-positive women in cervical cancer screening publication-title: Lancet Oncol doi: 10.1016/S1470-2045(12)70568-5 – volume: 78 start-page: 1 year: 1977 ident: ref1 article-title: Human papillomaviruses and their possible role in squamous cell carcinomas publication-title: Curr Top MicrobiolImmunol – volume: 130 start-page: 602 year: 2012 ident: ref11 article-title: Evaluation of 14 triage strategies for HPV DNA-positive women in population-based cervical screening publication-title: Int J Cancer doi: 10.1002/ijc.26056 – volume: 16 start-page: 416 year: 2012 ident: ref18 article-title: Secondary screening after primary self-sampling for human papillomavirus from SHENCCAST II publication-title: J Low Genit Tract Dis doi: 10.1097/LGT.0b013e31824f48c8 – volume: 35 start-page: 264 year: 2006 ident: ref20 article-title: Associations of high-risk HPV types and viral load with cervical cancer in China publication-title: J ClinVirol – volume: 189 start-page: 12 year: 1999 ident: ref2 article-title: Human papillomavirus is a necessary cause of invasive cervical cancer worldwide publication-title: J Pathol doi: 10.1002/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F – volume: 12 start-page: 880 year: 2011 ident: ref14 article-title: Performance of carcinogenic human papillomavirus (HPV) testing and HPV16 or HPV18 genotyping for cervical cancer screening of women aged 25 years and older: a subanalysis of the ATHENA study publication-title: Lancet Oncol doi: 10.1016/S1470-2045(11)70188-7 – volume: 7 start-page: 453 year: 2007 ident: ref8 article-title: Worldwide prevalence and genotype distribution of cervical human papillomavirus DNA in women with normal cytology: a meta-analysis publication-title: Lancet Infect Dis doi: 10.1016/S1473-3099(07)70158-5 – volume: 131 start-page: 1969 issue: 9 year: 2012 ident: ref5 article-title: EUROGIN 2011 roadmap on prevention and treatment of HPV-related disease publication-title: Int J Cancer doi: 10.1002/ijc.27650 – volume: 14 start-page: 75 year: 2014 ident: ref7 article-title: The current position and the future perspectives of cervical cancer screening publication-title: Expert Rev Anticancer Ther doi: 10.1586/14737140.2014.856273 – volume: 9 start-page: e107573 year: 2014 ident: ref22 article-title: Meta-Analysis on Prevalence and Attribution of Human Papillomavirus Types 52 and 58 in Cervical Neoplasia Worldwide publication-title: PLoS One doi: 10.1371/journal.pone.0107573 – volume: 130 start-page: 1855 year: 2012 ident: ref17 article-title: Improved sensitivity of vaginal self-collection and high-risk human papillomavirus testing publication-title: Int J Cancer doi: 10.1002/ijc.26202 – volume: 23 start-page: 716 year: 2013 ident: ref21 article-title: Six-year regression and progression of cervical lesions of different human papillomavirus viral loads in varied histological diagnoses publication-title: Int J Gynecol Cancer doi: 10.1097/IGC.0b013e318286a95d – volume: 121 start-page: 505 issue: 3 year: 2011 ident: ref25 article-title: Triaging Pap cytology negative, HPV positive cervical cancer screening results with p16/Ki-67 Dual-stained cytology publication-title: GynecolOncol – volume: 208 start-page: 184.e1 year: 2013 ident: ref13 article-title: Comparison of cervical cancer screening strategies incorporating different combinations of cytology, HPV testing, and genotyping for HPV 16/18: Results from the ATHENA HPV study publication-title: Am J ObstetGynecol doi: 10.1016/j.ajog.2012.11.020 – volume: 44 start-page: 910 year: 2014 ident: ref23 article-title: Human papillomavirus genotype distribution in cervical intraepithelial neoplasia grade 2/3 and invasive cervical cancer in Japanese women publication-title: Jpn J ClinOncol doi: 10.1093/jjco/hyu112 – volume: 383 start-page: 524 issue: 9916 year: 2014 ident: ref3 article-title: Efficacy of HPV-based screening for prevention of invasive cervical cancer: follow-up of four European randomised controlled trials publication-title: Lancet doi: 10.1016/S0140-6736(13)62218-7 |
| SSID | ssj0053866 |
| Score | 2.3748612 |
| Snippet | Correlation with HPV viral load and worsening cervical lesions had been reported, but its potential for triage after primary HPV screening has not been... Background Correlation with HPV viral load and worsening cervical lesions had been reported, but its potential for triage after primary HPV screening has not... BackgroundCorrelation with HPV viral load and worsening cervical lesions had been reported, but its potential for triage after primary HPV screening has not... Background Correlation with HPV viral load and worsening cervical lesions had been reported, but its potential for triage after primary HPV screening has not... |
| SourceID | plos doaj unpaywall pubmedcentral proquest gale pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | e0220200 |
| SubjectTerms | Adult Algorithms Antiretroviral drugs Biology and Life Sciences Biomarkers Cancer Cancer screening Cellular biology Cervical cancer Cervical Intraepithelial Neoplasia - virology Cervix dysplasia Colposcopy Cytology Diagnosis DNA, Viral - analysis Feasibility Studies Female Genetic aspects Genotyping Genotyping Techniques Gynecology Health screening Human papillomavirus Human papillomavirus 16 - genetics Human papillomavirus 16 - physiology Human papillomavirus 18 - genetics Human papillomavirus 18 - physiology Humans Ionization Ions Laboratories Laser arrays Lesions Load distribution Mass spectrometry Mass spectroscopy Medical screening Medicine and Health Sciences Middle Aged Obstetrics Oncology Papillomavirus Papillomavirus infections Papillomavirus Infections - diagnosis Physical Sciences Research and Analysis Methods Risk factors Scientific imaging Sensitivity Sensitivity and Specificity Spectroscopy Strategy Triage Viral Load Womens health |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Nb9QwELXQXuCCKF_dUsAgJOCQ7TqOHftYUKsFiQ8BrXqLnNhuVwrJarMrtP-emcQbbUSl9sA1njjKm_FkRvF7JuSNdQXXYppE1nofJcqZSGtvI5ZDrZ96nWqDBOcvX-XsLPl8IS52jvrCPWGdPHAH3FEKn8yY59LHqU9yobVtVdc8lCJcWtfyyKdKb5upLgfDKpYyEOV4yo6CXyaLunIT5JbGyGjb-RC1ev19Vh4tyrq5ruT8d-fk3XW1MJs_pix3PkunD8j9UE_S4-499sgdVz0ke2HFNvRdkJV-_4jMT3phb1p72v4mr6DSLDcUoi5vD4qgs-_nFLf9lrSsjaWmspTJI6YoarmuNkiuovOKNthGW7PcUMg60AnjZVNe1sv56up385icnZ78-jiLwkELUSF1vIoE8zyf6lhJnTs35TZnHnXjoFYsrIGGwifOMis4QM6c4k4wExeArM0TrZTnT8ioAmj3CTV4Tq4shExym8jCKAGuc0Xic5hBTd2Y8C3qWRFUyPEwjDJrf62l0I10wGXoqyz4akyi_q5Fp8Jxg_0HdGhvixra7QWIrCxEVnZTZI3JSwyHrCOk9pkgOxYaCb1pKsbkdWuBOhoVbtS5NOumyT59O7-F0c8fA6O3wcjXAEdhAjkC3gn1uQaWhwNLyAbFYHgfg3eLSpMhUVpophTeuQ3o64df9cM4KW6-q1y9bm2gK4UnAK5Pu_jvkeWMQ8urkzFJBytjAP1wpJpftTLm0DhDgQ9zTvo1dCvnHvwP5z4j96D0Rf5eFMtDMlot1-45lJer_EWbSf4CqRR3-Q priority: 102 providerName: Directory of Open Access Journals – databaseName: ProQuest Central dbid: BENPR link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3fb9MwELZG9wAviPFrhQEGIQEPaZs4duIHhDbUqSBRpsGmvUVObHeVQlKaVqj_PXepExYxwV7ji9t857vcxb7vCHmtTcYkH4We1tZ6YWyUJ6XVnp9CrB9ZGUmFBc5fpmJyFn6-4Bc7ZNrUwuCxysYn1o5alxl-Ix9iwSeXfhzzD4ufHnaNwt3VpoWGcq0V9PuaYuwW2Q2QGatHdo_G05PTxjeDdQvhCuhY5A-dvgaLsjADrDkNsNLtyguq5vFvvXVvkZfVdaHo3ycqb6-Lhdr8Unl-5XV1fI_cdXEmPdwujD2yY4r7ZM9ZckXfOrrpdw_IfNwSftPS0nr7vIAINN9QQCatG0jQyck5xePAOc1LpakqNPXF0I8pcryuNlh0RecFrTC91mq5oeCNIEPGyyqfAY6ryx_VQ3J2PP7-ceK5BgxeJmSw8rhvWTqSQSxkasyI6dS3yCcHMWSmFSQaNjTa15xxJnwTM8N9FWSArE5DGceWPSK9AqDdJ1Rh_1yRcRGmOhSZinkqrMlCm8IM8cj0CWtQTzLHTo5NMvKk3nKLIEvZApegrhKnqz7x2rsWW3aO_8gfoUJbWeTWri-Uy1niTDWJIEgLGPy9ILJhyqXUNc-fheCXCW2iPnmByyHZFqq2HiI55BILfaOI98mrWgL5NQo8wDNT66pKPn09v4HQt9OO0BsnZEuAI1OuaAKeCXm7OpIHHUnwEllneB8Xb4NKlfyxJ7izWdDXD79sh3FSPJRXmHJdy0C2Cr8AuD7erv8WWeYzSIVl2CdRxzI60HdHivllTW8OCTUE_jDnoLWhGyn3yb-f4ym5A8EuVux5gTggvdVybZ5BQLlKnzsv8Rvzg3dU priority: 102 providerName: ProQuest – databaseName: Unpaywall dbid: UNPAY link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3Pb9MwFLZGd4ALMH6tMMAgJOCQtoljJz4WtKkgMSag0zigyIntrSIkVdMKlQN_O-8lbkRgiHHgVsWfneSz_fJe7feZkCfaZEzyUehpba0XxkZ5Ulrt-Sn4-pGVkVSY4PzmUEym4esTfrJFPm1yYRyDECPmZVWv5OOPsjBDx-QQ9Yqa1dOBzyJ_U2MwB9AA80ZR-rJWHMJ_xpaYgHSJbAsOrnqPbE8Pj8Yfm5XmwBPBiLl0uj-11Plc1ar-re3u4ZOd55j-vr_y8qqYq_VXlec_fbwOrpHvm9du9qx8HqyW6SD79osi5H_j5Tq56txeOm5a2SFbprhBdpxhqegzp379_CaZ7bf647S0tF7NL8AhztcUJkdan2dBJ0fHFHcn5zQvlaaq0NQXQz-mKDkLd0fMrKAVRvtaLdYUjCME7HhZ5aflYrY8-1LdItOD_Q8vJ547D8LLhAyWHvctS0cyiIVMjRkxnfoW5e3Apc20grjHhkb7mjPOhG9iZrivggzI0Gko49iy26RXABu7hCo8zldkXISpDkWmYp4Ka7LQptBCPDJ9wjbdnmROLB3P7MiTegUwgqCpIS5BehNHb594ba15IxbyF_wLHFEtFqW-6wvQv4nr1yQCnzFg8HhBZMOUS6lr2UELvjgT2kR98hDHY9LkzbYGKxlziXnHUcT75HGNQLmPAvcTnapVVSWv3h5fAPT-XQf01IFsCXRkyuVwwDvh8Osg9zpIMFpZp3gXx--GlSrBfG4u_TjGmpsZdX7xo7YYG8U9goUpVzUGgme4A_B6p5mALbPMZxCZy7BPos7U7FDfLSlmZ7XaOsT3EIdAm4N2El-oc-_-a4V75Ap445hS6AVij_SWi5W5Dx7vMn3g7NYPoZ6wQg priority: 102 providerName: Unpaywall |
| Title | Evaluation of alternately combining HPV viral load and 16/18 genotyping in secondary screening algorithms |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/31348794 https://www.proquest.com/docview/2264591885 https://www.proquest.com/docview/2265769460 https://pubmed.ncbi.nlm.nih.gov/PMC6660090 https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0220200&type=printable https://doaj.org/article/764323b6f27f4b599d00828f04536de7 http://dx.doi.org/10.1371/journal.pone.0220200 |
| UnpaywallVersion | publishedVersion |
| Volume | 14 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVFSB databaseName: Free Full-Text Journals in Chemistry customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: HH5 dateStart: 20060101 isFulltext: true titleUrlDefault: http://abc-chemistry.org/ providerName: ABC ChemistRy – providerCode: PRVAFT databaseName: Open Access Digital Library customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: KQ8 dateStart: 20060101 isFulltext: true titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html providerName: Colorado Alliance of Research Libraries – providerCode: PRVAFT databaseName: Open Access Digital Library customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: KQ8 dateStart: 20061001 isFulltext: true titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html providerName: Colorado Alliance of Research Libraries – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: DOA dateStart: 20060101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVEBS databaseName: EBSCOhost Academic Search Ultimate customDbUrl: https://search.ebscohost.com/login.aspx?authtype=ip,shib&custid=s3936755&profile=ehost&defaultdb=asn eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: ABDBF dateStart: 20080101 isFulltext: true titleUrlDefault: https://search.ebscohost.com/direct.asp?db=asn providerName: EBSCOhost – providerCode: PRVEBS databaseName: EBSCOhost Food Science Source customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: A8Z dateStart: 20080101 isFulltext: true titleUrlDefault: https://search.ebscohost.com/login.aspx?authtype=ip,uid&profile=ehost&defaultdb=fsr providerName: EBSCOhost – providerCode: PRVBFR databaseName: Free Medical Journals customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: DIK dateStart: 20060101 isFulltext: true titleUrlDefault: http://www.freemedicaljournals.com providerName: Flying Publisher – providerCode: PRVFQY databaseName: GFMER Free Medical Journals customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: GX1 dateStart: 20060101 isFulltext: true titleUrlDefault: http://www.gfmer.ch/Medical_journals/Free_medical.php providerName: Geneva Foundation for Medical Education and Research – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M~E dateStart: 20060101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVAQN databaseName: PubMed Central customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: RPM dateStart: 20060101 isFulltext: true titleUrlDefault: https://www.ncbi.nlm.nih.gov/pmc/ providerName: National Library of Medicine – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 7X7 dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: http://www.proquest.com/pqcentral?accountid=15518 eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: BENPR dateStart: 20061201 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Technology Collection customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 8FG dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/technologycollection1 providerName: ProQuest – providerCode: PRVPQU databaseName: Public Health Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 8C1 dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/publichealth providerName: ProQuest – providerCode: PRVFZP databaseName: Scholars Portal Journals: Open Access customDbUrl: eissn: 1932-6203 dateEnd: 20250930 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M48 dateStart: 20061201 isFulltext: true titleUrlDefault: http://journals.scholarsportal.info providerName: Scholars Portal |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3db9MwELe27gFeEONrhVEMQgIeUpo6duIHhLqppSCtVINO5SlyYrurFJKuaQX977lL04iIAXvJg312k_Odfdfz_Y6Ql9rETPKO52htreMFRjlSWu24Edj6vpW-VJjgfDYSw4n3acqne2QXaC8ZmF_r2mE9qckyaf-82rwHhX9XVG3w3d2g9iJLTRszRxH8cnHlYGkpDMGWdTb2yQEcXxLrO5x5VagBFF6IMqfub5PVzqwC2r_awBuLJMuvs07_vGR5a50u1OaHSpLfTrDBXXKnND1pbysrh2TPpPfIYancOX1dIlC_uU_m_QoDnGaWFhH1FIzSZENBQKOipgQdji8o3hBOaJIpTVWqqSveugFF2NfVBvOw6DylOXrcWi03FDYocJqxWSUz4Nrq8nv-gEwG_a-nQ6esyeDEQnZXDnctizqyGwgZGdNhOnItQsyBWRlrBb6H9Yx2NWecCdcEzHBXdWPgrI48GQSWPSSNFFh7RKjCkroi5sKLtCdiFfBIWBN7NoIZgo5pErbjehiXgOVYNyMJiyicD47LlnEhrlVYrlWTONWoxRaw4z_0J7igFS3CbRcN2XIWltob-mC3dRm8Xte3XsSl1AX0nwV7mAlt_CZ5huIQbnNXq00j7HGJub--z5vkRUGBkBsp3umZqXWehx8_X9yA6Mt5jehVSWQzYEesyjwK-CaE8qpRHtcoYeOIa91HKLw7ruQh5lRz6QYBjtwJ9PXdz6tunBTv6aUmWxc04MDCLwBfH23lv-Iscxl4x9JrEr-mGTXW13vS-WWBeA4-NvgCMGe70qEbLe7jf3_HE3Ib7F9M4nO64pg0Vsu1eQo25ipqkX1_6sMzOHXxOfjQIgcn_dH4vFX8a9Mq9hBom4zGvW-_AC1VhOY |
| linkProvider | Scholars Portal |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3db9MwELdGeRgviPG1wmAGgYCHtE0cO_EDQgM2tewDBNvUt-DEdlcpJKVpNfWf4m_kLk3DIibYy17ji9vcnX-5i_27I-SFNgmTvOc7Wlvr-KFRjpRWO24MsX5gZSAVEpwPj0T_xP805MM18mvFhcFjlStMLIFa5wl-I-8i4ZNLNwz5u8lPB7tG4e7qqoXG0i32zeIcUrbi7eAj2Pel5-3tHn_oO1VXAScR0ps53LUs7kkvFDI2psd07FoskgaBUaIVRM_WN9rVnHEmXBMyw13lJS4LdOzLMLQM5r1BbvoMsATWTzCsEzzADiEqeh4L3G7lDZ1JnpkOMlo95NFdeP2VXQLqd0FrkubFZYHu3-c11-fZRC3OVZpeeBnu3SG3qyiW7izdboOsmewu2ahwoqCvq2LWb-6R8W5dTpzmlpab8xnEt-mCgt7jsj0F7X85pXjYOKVprjRVmaau6LohxQqyswVSuug4owUm71pNFxSwDvJvvKzSEVhpdvajuE9OrsUQD0grA9VuEqqwO69IuPBj7YtEhTwW1iS-jWGGsGfahK20HiVV7XNswZFG5YZeADnQUnER2iqqbNUmTn3XZFn74z_y79GgtSxW7i4v5NNRVAFBFEAI6DH4e15g_ZhLqcsqghZCaya0CdpkG90hWtJga_yJdrhEGnEQ8DZ5Xkpg9Y4MjweN1LwoosHn0ysIffvaEHpVCdkc1JGoipIBz4RVwRqSWw1JwKCkMbyJzrvSShH9Wa1w58qhLx9-Vg_jpHjkLzP5vJSBXBh-AfT6cOn_tWaZyyDRln6bBI2V0VB9cyQbn5XF0yFdh7QC5uzUa-hKxn307-fYJuv948OD6GBwtP-Y3IKwGrmBjie2SGs2nZsnELrO4qclXlDy_boB6jcwBazD |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3db9MwELfGkIAXxPhaYTCDQMBD2iaO7fgBocE2bQzGxNjUt-DEdlcpJGVpNfVf46_jLk3DIibYy17ji1vfnX--i--DkBfGpkzxfugZ45wXRlZ7Sjnj-QnY-tIpqTQmOH_eFztH4ccBHyyRX4tcGAyrXGBiBdSmSPEbeQ8TPrnyo4j3XB0WcbC5_W7808MOUnjTuminMVeRPTs7A_etfLu7CbJ-GQTbW98-7Hh1hwEvFSqYeNx3LOmrIBIqsbbPTOI7LJgGRlJqNFjSLrTGN5xxJnwbMct9HaQ-kyYJVRQ5BvNeI9clg_XCXpKDxtkDHBGiTtVj0u_VmtEdF7ntYnZrgDl1547CqmNAcy4sj7OivMjo_Tt28-Y0H-vZmc6ycwfj9h1yu7Zo6cZcBVfIks3vkpUaM0r6ui5s_eYeGW01pcVp4Wh1UZ-DrZvNKMggqVpV0J2DY4qBxxnNCm2ozg31Rc-PKFaTncwwvYuOclqiI2_06YwC7oEvjo91NgQpTU5-lPfJ0ZUI4gFZzoG1q4Rq7NQrUi7CxIQi1RFPhLNp6BKYIerbDmELrsdpXQcd23FkcXW5J8EfmjMuRlnFtaw6xGveGs_rgPyH_j0KtKHFKt7Vg-J0GNegEEswBwMGfy-QLky4UqaqKOjAzGbCWNkh66gO8TwltsGieIMrTCmWknfI84oCK3nkuCeGelqW8e6X40sQHX5tEb2qiVwB7Eh1nZ4Ba8IKYS3KtRYl4FHaGl5F5V1wpYz_7Fx4c6HQFw8_a4ZxUgz_y20xrWjAL4ZfAL4-nOt_w1nmM3C6VdghsrUzWqxvj-Sjk6qQOrju4GLAnN1mD11KuI_-vY51cgOgKf60u7_3mNwCCxvTBL1ArJHlyenUPgErdpI8reCCku9XjU-_AZ7csQY |
| linkToUnpaywall | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3Pb9MwFLZGd4ALMH6tMMAgJOCQtoljJz4WtKkgMSag0zigyIntrSIkVdMKlQN_O-8lbkRgiHHgVsWfneSz_fJe7feZkCfaZEzyUehpba0XxkZ5Ulrt-Sn4-pGVkVSY4PzmUEym4esTfrJFPm1yYRyDECPmZVWv5OOPsjBDx-QQ9Yqa1dOBzyJ_U2MwB9AA80ZR-rJWHMJ_xpaYgHSJbAsOrnqPbE8Pj8Yfm5XmwBPBiLl0uj-11Plc1ar-re3u4ZOd55j-vr_y8qqYq_VXlec_fbwOrpHvm9du9qx8HqyW6SD79osi5H_j5Tq56txeOm5a2SFbprhBdpxhqegzp379_CaZ7bf647S0tF7NL8AhztcUJkdan2dBJ0fHFHcn5zQvlaaq0NQXQz-mKDkLd0fMrKAVRvtaLdYUjCME7HhZ5aflYrY8-1LdItOD_Q8vJ547D8LLhAyWHvctS0cyiIVMjRkxnfoW5e3Apc20grjHhkb7mjPOhG9iZrivggzI0Gko49iy26RXABu7hCo8zldkXISpDkWmYp4Ka7LQptBCPDJ9wjbdnmROLB3P7MiTegUwgqCpIS5BehNHb594ba15IxbyF_wLHFEtFqW-6wvQv4nr1yQCnzFg8HhBZMOUS6lr2UELvjgT2kR98hDHY9LkzbYGKxlziXnHUcT75HGNQLmPAvcTnapVVSWv3h5fAPT-XQf01IFsCXRkyuVwwDvh8Osg9zpIMFpZp3gXx--GlSrBfG4u_TjGmpsZdX7xo7YYG8U9goUpVzUGgme4A_B6p5mALbPMZxCZy7BPos7U7FDfLSlmZ7XaOsT3EIdAm4N2El-oc-_-a4V75Ap445hS6AVij_SWi5W5Dx7vMn3g7NYPoZ6wQg |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Evaluation+of+alternately+combining+HPV+viral+load+and+16%2F18+genotyping+in+secondary+screening+algorithms&rft.jtitle=PloS+one&rft.au=Luo%2C+Hongxue&rft.au=Du%2C+Hui&rft.au=Belinson%2C+Jerome+L&rft.au=Wu%2C+Ruifang&rft.date=2019-07-26&rft.pub=Public+Library+of+Science&rft.eissn=1932-6203&rft.volume=14&rft.issue=7&rft.spage=e0220200&rft_id=info:doi/10.1371%2Fjournal.pone.0220200&rft.externalDBID=HAS_PDF_LINK |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1932-6203&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1932-6203&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1932-6203&client=summon |