Single Oral Dose Pharmacokinetics of Decursin and Decursinol Angelate in Healthy Adult Men and Women
The ethanol extract of Angelica gigas Nakai (AGN) root has promising anti-cancer and other bioactivities in rodent models. It is currently believed that the pyranocoumarin isomers decursin (D) and decursinol angelate (DA) contribute to these activities. We and others have documented that D and DA we...
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| Published in | PloS one Vol. 10; no. 2; p. e0114992 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Public Library of Science
19.02.2015
Public Library of Science (PLoS) |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1932-6203 1932-6203 |
| DOI | 10.1371/journal.pone.0114992 |
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| Abstract | The ethanol extract of Angelica gigas Nakai (AGN) root has promising anti-cancer and other bioactivities in rodent models. It is currently believed that the pyranocoumarin isomers decursin (D) and decursinol angelate (DA) contribute to these activities. We and others have documented that D and DA were rapidly converted to decursinol (DOH) in rodents. However, our in vitro metabolism studies suggested that D and DA might be metabolized differently in humans. To test this hypothesis and address a key question for human translatability of animal model studies of D and DA or AGN extract, we conducted a single oral dose human pharmacokinetic study of D and DA delivered through an AGN-based dietary supplement Cogni.Q (purchased from Quality of Life Labs, Purchase, NY) in twenty healthy subjects, i.e., 10 men and 10 women, each consuming 119 mg D and 77 mg DA from 4 vegicaps. Analyses of plasma samples using UHPLC-MS/MS showed mean time to peak concentration (Tmax) of 2.1, 2.4 and 3.3 h and mean peak concentration (Cmax) of 5.3, 48.1 and 2,480 nmol/L for D, DA and DOH, respectively. The terminal elimination half-life (t1/2) for D and DA was similar (17.4 and 19.3 h) and each was much longer than that of DOH (7.4 h). The mean area under the curve (AUC0-48h) for D, DA and DOH was estimated as 37, 335 and 27,579 h∙nmol/L, respectively. Gender-wise, men absorbed the parent compounds faster and took shorter time to reach DOH peak concentration. The human data supported an extensive conversion of D and DA to DOH, even though they metabolized DA slightly slower than rodents. Therefore, the data generated in rodent models concerning anti-cancer efficacy, safety, tissue distribution and pharmacodynamic biomarkers will likely be relevant for human translation.
ClinicalTrials.gov NCT02114957. |
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| AbstractList | The ethanol extract of Angelica gigas Nakai (AGN) root has promising anti-cancer and other bioactivities in rodent models. It is currently believed that the pyranocoumarin isomers decursin (D) and decursinol angelate (DA) contribute to these activities. We and others have documented that D and DA were rapidly converted to decursinol (DOH) in rodents. However, our in vitro metabolism studies suggested that D and DA might be metabolized differently in humans. To test this hypothesis and address a key question for human translatability of animal model studies of D and DA or AGN extract, we conducted a single oral dose human pharmacokinetic study of D and DA delivered through an AGN-based dietary supplement Cogni.Q (purchased from Quality of Life Labs, Purchase, NY) in twenty healthy subjects, i.e., 10 men and 10 women, each consuming 119 mg D and 77 mg DA from 4 vegicaps. Analyses of plasma samples using UHPLC-MS/MS showed mean time to peak concentration (Tmax) of 2.1, 2.4 and 3.3 h and mean peak concentration (Cmax) of 5.3, 48.1 and 2,480 nmol/L for D, DA and DOH, respectively. The terminal elimination half-life (t1/2) for D and DA was similar (17.4 and 19.3 h) and each was much longer than that of DOH (7.4 h). The mean area under the curve (AUC0-48h) for D, DA and DOH was estimated as 37, 335 and 27,579 h∙nmol/L, respectively. Gender-wise, men absorbed the parent compounds faster and took shorter time to reach DOH peak concentration. The human data supported an extensive conversion of D and DA to DOH, even though they metabolized DA slightly slower than rodents. Therefore, the data generated in rodent models concerning anti-cancer efficacy, safety, tissue distribution and pharmacodynamic biomarkers will likely be relevant for human translation. Trial Registration ClinicalTrials.gov NCT02114957 The ethanol extract of Angelica gigas Nakai (AGN) root has promising anti-cancer and other bioactivities in rodent models. It is currently believed that the pyranocoumarin isomers decursin (D) and decursinol angelate (DA) contribute to these activities. We and others have documented that D and DA were rapidly converted to decursinol (DOH) in rodents. However, our in vitro metabolism studies suggested that D and DA might be metabolized differently in humans. To test this hypothesis and address a key question for human translatability of animal model studies of D and DA or AGN extract, we conducted a single oral dose human pharmacokinetic study of D and DA delivered through an AGN-based dietary supplement Cogni.Q (purchased from Quality of Life Labs, Purchase, NY) in twenty healthy subjects, i.e., 10 men and 10 women, each consuming 119 mg D and 77 mg DA from 4 vegicaps. Analyses of plasma samples using UHPLC-MS/MS showed mean time to peak concentration (Tmax) of 2.1, 2.4 and 3.3 h and mean peak concentration (Cmax) of 5.3, 48.1 and 2,480 nmol/L for D, DA and DOH, respectively. The terminal elimination half-life (t1/2) for D and DA was similar (17.4 and 19.3 h) and each was much longer than that of DOH (7.4 h). The mean area under the curve (AUC0-48h) for D, DA and DOH was estimated as 37, 335 and 27,579 h∙nmol/L, respectively. Gender-wise, men absorbed the parent compounds faster and took shorter time to reach DOH peak concentration. The human data supported an extensive conversion of D and DA to DOH, even though they metabolized DA slightly slower than rodents. Therefore, the data generated in rodent models concerning anti-cancer efficacy, safety, tissue distribution and pharmacodynamic biomarkers will likely be relevant for human translation. ClinicalTrials.gov NCT02114957. The ethanol extract of Angelica gigas Nakai (AGN) root has promising anti-cancer and other bioactivities in rodent models. It is currently believed that the pyranocoumarin isomers decursin (D) and decursinol angelate (DA) contribute to these activities. We and others have documented that D and DA were rapidly converted to decursinol (DOH) in rodents. However, our in vitro metabolism studies suggested that D and DA might be metabolized differently in humans. To test this hypothesis and address a key question for human translatability of animal model studies of D and DA or AGN extract, we conducted a single oral dose human pharmacokinetic study of D and DA delivered through an AGN-based dietary supplement Cogni.Q (purchased from Quality of Life Labs, Purchase, NY) in twenty healthy subjects, i.e., 10 men and 10 women, each consuming 119 mg D and 77 mg DA from 4 vegicaps. Analyses of plasma samples using UHPLC-MS/MS showed mean time to peak concentration (T.sub.max) of 2.1, 2.4 and 3.3 h and mean peak concentration (C.sub.max) of 5.3, 48.1 and 2,480 nmol/L for D, DA and DOH, respectively. The terminal elimination half-life (t.sub.1/2) for D and DA was similar (17.4 and 19.3 h) and each was much longer than that of DOH (7.4 h). The mean area under the curve (AUC.sub.0-48h) for D, DA and DOH was estimated as 37, 335 and 27,579 hânmol/L, respectively. Gender-wise, men absorbed the parent compounds faster and took shorter time to reach DOH peak concentration. The human data supported an extensive conversion of D and DA to DOH, even though they metabolized DA slightly slower than rodents. Therefore, the data generated in rodent models concerning anti-cancer efficacy, safety, tissue distribution and pharmacodynamic biomarkers will likely be relevant for human translation. The ethanol extract of Angelica gigas Nakai (AGN) root has promising anti-cancer and other bioactivities in rodent models. It is currently believed that the pyranocoumarin isomers decursin (D) and decursinol angelate (DA) contribute to these activities. We and others have documented that D and DA were rapidly converted to decursinol (DOH) in rodents. However, our in vitro metabolism studies suggested that D and DA might be metabolized differently in humans. To test this hypothesis and address a key question for human translatability of animal model studies of D and DA or AGN extract, we conducted a single oral dose human pharmacokinetic study of D and DA delivered through an AGN-based dietary supplement Cogni.Q (purchased from Quality of Life Labs, Purchase, NY) in twenty healthy subjects, i.e., 10 men and 10 women, each consuming 119 mg D and 77 mg DA from 4 vegicaps. Analyses of plasma samples using UHPLC-MS/MS showed mean time to peak concentration (T.sub.max) of 2.1, 2.4 and 3.3 h and mean peak concentration (C.sub.max) of 5.3, 48.1 and 2,480 nmol/L for D, DA and DOH, respectively. The terminal elimination half-life (t.sub.1/2) for D and DA was similar (17.4 and 19.3 h) and each was much longer than that of DOH (7.4 h). The mean area under the curve (AUC.sub.0-48h) for D, DA and DOH was estimated as 37, 335 and 27,579 hânmol/L, respectively. Gender-wise, men absorbed the parent compounds faster and took shorter time to reach DOH peak concentration. The human data supported an extensive conversion of D and DA to DOH, even though they metabolized DA slightly slower than rodents. Therefore, the data generated in rodent models concerning anti-cancer efficacy, safety, tissue distribution and pharmacodynamic biomarkers will likely be relevant for human translation. Trial Registration ClinicalTrials.gov NCT02114957 UnlabelledThe ethanol extract of Angelica gigas Nakai (AGN) root has promising anti-cancer and other bioactivities in rodent models. It is currently believed that the pyranocoumarin isomers decursin (D) and decursinol angelate (DA) contribute to these activities. We and others have documented that D and DA were rapidly converted to decursinol (DOH) in rodents. However, our in vitro metabolism studies suggested that D and DA might be metabolized differently in humans. To test this hypothesis and address a key question for human translatability of animal model studies of D and DA or AGN extract, we conducted a single oral dose human pharmacokinetic study of D and DA delivered through an AGN-based dietary supplement Cogni.Q (purchased from Quality of Life Labs, Purchase, NY) in twenty healthy subjects, i.e., 10 men and 10 women, each consuming 119 mg D and 77 mg DA from 4 vegicaps. Analyses of plasma samples using UHPLC-MS/MS showed mean time to peak concentration (Tmax) of 2.1, 2.4 and 3.3 h and mean peak concentration (Cmax) of 5.3, 48.1 and 2,480 nmol/L for D, DA and DOH, respectively. The terminal elimination half-life (t1/2) for D and DA was similar (17.4 and 19.3 h) and each was much longer than that of DOH (7.4 h). The mean area under the curve (AUC0-48h) for D, DA and DOH was estimated as 37, 335 and 27,579 h∙nmol/L, respectively. Gender-wise, men absorbed the parent compounds faster and took shorter time to reach DOH peak concentration. The human data supported an extensive conversion of D and DA to DOH, even though they metabolized DA slightly slower than rodents. Therefore, the data generated in rodent models concerning anti-cancer efficacy, safety, tissue distribution and pharmacodynamic biomarkers will likely be relevant for human translation.Trial registrationClinicalTrials.gov NCT02114957. The ethanol extract of Angelica gigas Nakai (AGN) root has promising anti-cancer and other bioactivities in rodent models. It is currently believed that the pyranocoumarin isomers decursin (D) and decursinol angelate (DA) contribute to these activities. We and others have documented that D and DA were rapidly converted to decursinol (DOH) in rodents. However, our in vitro metabolism studies suggested that D and DA might be metabolized differently in humans. To test this hypothesis and address a key question for human translatability of animal model studies of D and DA or AGN extract, we conducted a single oral dose human pharmacokinetic study of D and DA delivered through an AGN-based dietary supplement Cogni.Q (purchased from Quality of Life Labs, Purchase, NY) in twenty healthy subjects, i.e., 10 men and 10 women, each consuming 119 mg D and 77 mg DA from 4 vegicaps. Analyses of plasma samples using UHPLC-MS/MS showed mean time to peak concentration (Tmax) of 2.1, 2.4 and 3.3 h and mean peak concentration (Cmax) of 5.3, 48.1 and 2,480 nmol/L for D, DA and DOH, respectively. The terminal elimination half-life (t1/2) for D and DA was similar (17.4 and 19.3 h) and each was much longer than that of DOH (7.4 h). The mean area under the curve (AUC0-48h) for D, DA and DOH was estimated as 37, 335 and 27,579 h∙nmol/L, respectively. Gender-wise, men absorbed the parent compounds faster and took shorter time to reach DOH peak concentration. The human data supported an extensive conversion of D and DA to DOH, even though they metabolized DA slightly slower than rodents. Therefore, the data generated in rodent models concerning anti-cancer efficacy, safety, tissue distribution and pharmacodynamic biomarkers will likely be relevant for human translation.UNLABELLEDThe ethanol extract of Angelica gigas Nakai (AGN) root has promising anti-cancer and other bioactivities in rodent models. It is currently believed that the pyranocoumarin isomers decursin (D) and decursinol angelate (DA) contribute to these activities. We and others have documented that D and DA were rapidly converted to decursinol (DOH) in rodents. However, our in vitro metabolism studies suggested that D and DA might be metabolized differently in humans. To test this hypothesis and address a key question for human translatability of animal model studies of D and DA or AGN extract, we conducted a single oral dose human pharmacokinetic study of D and DA delivered through an AGN-based dietary supplement Cogni.Q (purchased from Quality of Life Labs, Purchase, NY) in twenty healthy subjects, i.e., 10 men and 10 women, each consuming 119 mg D and 77 mg DA from 4 vegicaps. Analyses of plasma samples using UHPLC-MS/MS showed mean time to peak concentration (Tmax) of 2.1, 2.4 and 3.3 h and mean peak concentration (Cmax) of 5.3, 48.1 and 2,480 nmol/L for D, DA and DOH, respectively. The terminal elimination half-life (t1/2) for D and DA was similar (17.4 and 19.3 h) and each was much longer than that of DOH (7.4 h). The mean area under the curve (AUC0-48h) for D, DA and DOH was estimated as 37, 335 and 27,579 h∙nmol/L, respectively. Gender-wise, men absorbed the parent compounds faster and took shorter time to reach DOH peak concentration. The human data supported an extensive conversion of D and DA to DOH, even though they metabolized DA slightly slower than rodents. Therefore, the data generated in rodent models concerning anti-cancer efficacy, safety, tissue distribution and pharmacodynamic biomarkers will likely be relevant for human translation.ClinicalTrials.gov NCT02114957.TRIAL REGISTRATIONClinicalTrials.gov NCT02114957. The ethanol extract of Angelica gigas Nakai (AGN) root has promising anti-cancer and other bioactivities in rodent models. It is currently believed that the pyranocoumarin isomers decursin (D) and decursinol angelate (DA) contribute to these activities. We and others have documented that D and DA were rapidly converted to decursinol (DOH) in rodents. However, our in vitro metabolism studies suggested that D and DA might be metabolized differently in humans. To test this hypothesis and address a key question for human translatability of animal model studies of D and DA or AGN extract, we conducted a single oral dose human pharmacokinetic study of D and DA delivered through an AGN-based dietary supplement Cogni.Q (purchased from Quality of Life Labs, Purchase, NY) in twenty healthy subjects, i.e., 10 men and 10 women, each consuming 119 mg D and 77 mg DA from 4 vegicaps. Analyses of plasma samples using UHPLC-MS/MS showed mean time to peak concentration ( T max ) of 2.1, 2.4 and 3.3 h and mean peak concentration ( C max ) of 5.3, 48.1 and 2,480 nmol/L for D, DA and DOH, respectively. The terminal elimination half-life ( t 1/2 ) for D and DA was similar (17.4 and 19.3 h) and each was much longer than that of DOH (7.4 h). The mean area under the curve (AUC 0-48h ) for D, DA and DOH was estimated as 37, 335 and 27,579 h∙nmol/L, respectively. Gender-wise, men absorbed the parent compounds faster and took shorter time to reach DOH peak concentration. The human data supported an extensive conversion of D and DA to DOH, even though they metabolized DA slightly slower than rodents. Therefore, the data generated in rodent models concerning anti-cancer efficacy, safety, tissue distribution and pharmacodynamic biomarkers will likely be relevant for human translation. The ethanol extract of Angelica gigas Nakai (AGN) root has promising anti-cancer and other bioactivities in rodent models. It is currently believed that the pyranocoumarin isomers decursin (D) and decursinol angelate (DA) contribute to these activities. We and others have documented that D and DA were rapidly converted to decursinol (DOH) in rodents. However, our in vitro metabolism studies suggested that D and DA might be metabolized differently in humans. To test this hypothesis and address a key question for human translatability of animal model studies of D and DA or AGN extract, we conducted a single oral dose human pharmacokinetic study of D and DA delivered through an AGN-based dietary supplement Cogni.Q (purchased from Quality of Life Labs, Purchase, NY) in twenty healthy subjects, i.e., 10 men and 10 women, each consuming 119 mg D and 77 mg DA from 4 vegicaps. Analyses of plasma samples using UHPLC-MS/MS showed mean time to peak concentration ( T max ) of 2.1, 2.4 and 3.3 h and mean peak concentration ( C max ) of 5.3, 48.1 and 2,480 nmol/L for D, DA and DOH, respectively. The terminal elimination half-life ( t 1/2 ) for D and DA was similar (17.4 and 19.3 h) and each was much longer than that of DOH (7.4 h). The mean area under the curve (AUC 0-48h ) for D, DA and DOH was estimated as 37, 335 and 27,579 h∙nmol/L, respectively. Gender-wise, men absorbed the parent compounds faster and took shorter time to reach DOH peak concentration. The human data supported an extensive conversion of D and DA to DOH, even though they metabolized DA slightly slower than rodents. Therefore, the data generated in rodent models concerning anti-cancer efficacy, safety, tissue distribution and pharmacodynamic biomarkers will likely be relevant for human translation. Trial Registration ClinicalTrials.gov NCT02114957 |
| Audience | Academic |
| Author | Chee, Wayne Li, Li Jiang, Cheng Xing, Chengguo Zhang, Jinhui Hale, Thomas W. Lü, Junxuan |
| AuthorAffiliation | 1 Department of Biomedical Sciences, Texas Tech University Health Sciences Center School of Pharmacy, Amarillo, Texas, United States of America University of Colorado Denver, UNITED STATES 3 Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota, United States of America 2 Clinical Research Unit, School of Medicine, Texas Tech University Health Sciences Center, Amarillo, Texas, United States of America |
| AuthorAffiliation_xml | – name: University of Colorado Denver, UNITED STATES – name: 1 Department of Biomedical Sciences, Texas Tech University Health Sciences Center School of Pharmacy, Amarillo, Texas, United States of America – name: 3 Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota, United States of America – name: 2 Clinical Research Unit, School of Medicine, Texas Tech University Health Sciences Center, Amarillo, Texas, United States of America |
| Author_xml | – sequence: 1 givenname: Jinhui surname: Zhang fullname: Zhang, Jinhui – sequence: 2 givenname: Li surname: Li fullname: Li, Li – sequence: 3 givenname: Thomas W. surname: Hale fullname: Hale, Thomas W. – sequence: 4 givenname: Wayne surname: Chee fullname: Chee, Wayne – sequence: 5 givenname: Chengguo surname: Xing fullname: Xing, Chengguo – sequence: 6 givenname: Cheng surname: Jiang fullname: Jiang, Cheng – sequence: 7 givenname: Junxuan surname: Lü fullname: Lü, Junxuan |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25695490$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/S0024-3205(03)00311-4 10.1002/ptr.3597 10.1002/ptr.2043 10.1200/JCO.2008.21.5798 10.1016/0003-2697(92)90225-V 10.2174/0929867043365189 10.1055/s-0033-1350796 10.1111/j.1476-5381.2009.00267.x 10.1158/0008-5472.1035.65.3 10.1002/ptr.3372 10.1002/mc.22230 10.1016/j.canlet.2009.02.012 10.1055/s-0031-1280384 10.2165/00003088-199325040-00005 10.1016/j.jep.2012.07.019 10.1142/S0192415X09006722 10.1186/bcr1790 10.1055/s-0032-1328202 10.1158/1538-7445.AM2013-LB-184 10.1055/s-0031-1298517 10.1211/jpp.59.6.0013 10.2174/187152012803833071 10.1158/0008-5472.CAN-05-1865 10.1158/1535-7163.MCT-06-0231 10.2174/138920011797470164 |
| ContentType | Journal Article |
| Copyright | COPYRIGHT 2015 Public Library of Science 2015 Zhang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2015 Zhang et al 2015 Zhang et al |
| Copyright_xml | – notice: COPYRIGHT 2015 Public Library of Science – notice: 2015 Zhang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2015 Zhang et al 2015 Zhang et al |
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| DOI | 10.1371/journal.pone.0114992 |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Article-2 ObjectType-Feature-1 content type line 23 Competing Interests: The authors confirm that Junxuan Lu, as co-author and corresponding author, is a PLOS ONE Editorial Board member (Academic Editor) and that this does not alter the authors' adherence to PLOS ONE Editorial policies and criteria, as detailed online in guide for authors. Conceived and designed the experiments: JL JZ TWH CX CJ. Performed the experiments: JZ LL WC JL. Analyzed the data: JZ LL JL TWH CJ. Contributed reagents/materials/analysis tools: CX CJ. Wrote the paper: JZ LL JL TWH. |
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| References | SH Son (ref29) 2011; 25 C Jiang (ref14) 2006; 66 JH Kim (ref9) 2003; 42 ref10 V Sharma (ref27) 2009; 157 A Chang (ref11) 2012; 26 SJ Park (ref6) 2012; 143 YK Tam (ref31) 1993; 25 L Li (ref5) 2013; 2013 L Li (ref16) 2012; 78 J Guo (ref13) 2007; 6 L Li (ref17) 2013; 79 J Zhang (ref2) 2012; 12 D Yim (ref12) 2005; 65 ref23 V Regitz-Zagrosek (ref24) 2012 PM LoRusso (ref32) 2009; 27 ref20 J Cohen (ref21) 1988 L Li (ref19) 2013; 79 GZ Xin (ref33) 2011; 12 ref28 YK Kim (ref35) 2007; 21 ref7 C Jiang (ref15) 2007; 9 HS Park (ref18) 2012; 78 ref4 ref3 SY Kang (ref25) 2007; 59 SD Sarker (ref1) 2004; 11 M Homma (ref34) 1992; 202 (ref22) 2014 SH Son (ref30) 2009; 280 SS Choi (ref26) 2003; 73 HJ Lee (ref8) 2009; 37 |
| References_xml | – volume: 73 start-page: 471 year: 2003 ident: ref26 article-title: Antinociceptive mechanisms of orally administered decursinol in the mouse publication-title: Life sciences doi: 10.1016/S0024-3205(03)00311-4 – volume: 26 start-page: 510 year: 2012 ident: ref11 article-title: The effect of herbal extract (EstroG-100) on pre-, peri- and post-menopausal women: a randomized double-blind, placebo-controlled study publication-title: Phytotherapy research: PTR doi: 10.1002/ptr.3597 – volume: 21 start-page: 288 year: 2007 ident: ref35 article-title: Antiproliferative effect of furanocoumarins from the root of Angelica dahurica on cultured human tumor cell lines publication-title: Phytotherapy research: PTR doi: 10.1002/ptr.2043 – volume: 27 start-page: 2586 year: 2009 ident: ref32 article-title: Phase 0 clinical trials: an answer to drug development stagnation? publication-title: Journal of clinical oncology: official journal of the American Society of Clinical Oncology doi: 10.1200/JCO.2008.21.5798 – ident: ref20 – volume: 202 start-page: 179 year: 1992 ident: ref34 article-title: A strategy for discovering biologically active compounds with high probability in traditional Chinese herb remedies: an application of saiboku-to in bronchial asthma publication-title: Analytical biochemistry doi: 10.1016/0003-2697(92)90225-V – volume: 11 start-page: 1479 year: 2004 ident: ref1 article-title: Natural medicine: the genus Angelica publication-title: Curr Med Chem doi: 10.2174/0929867043365189 – volume: 79 start-page: 1536 year: 2013 ident: ref19 article-title: In Vitro Metabolism of Pyranocoumarin Isomers Decursin and Decursinol Angelate by Liver Microsomes from Man and Rodents publication-title: Planta medica doi: 10.1055/s-0033-1350796 – volume: 157 start-page: 907 year: 2009 ident: ref27 article-title: To scale or not to scale: the principles of dose extrapolation publication-title: British journal of pharmacology doi: 10.1111/j.1476-5381.2009.00267.x – volume: 65 start-page: 1035 year: 2005 ident: ref12 article-title: A novel anticancer agent, decursin, induces G1 arrest and apoptosis in human prostate carcinoma cells publication-title: Cancer Research doi: 10.1158/0008-5472.1035.65.3 – volume: 42 start-page: 254 year: 2003 ident: ref9 article-title: A three month placebo-controlled clinical trial of INM 176 in the old aged subjects with memory impairment publication-title: Journal of Korean Neuropsychiatric Association – volume: 2013 start-page: 467245 year: 2013 ident: ref5 article-title: Decursin Isolated from Angelica gigas Nakai Rescues PC12 Cells from Amyloid beta-Protein-Induced Neurotoxicity through Nrf2-Mediated Upregulation of Heme Oxygenase-1: Potential Roles of MAPK publication-title: Evidence-based complementary and alternative medicine: eCAM – volume: 25 start-page: 959 year: 2011 ident: ref29 article-title: Decursin and Decursinol from Angelica gigas Inhibit the Lung Metastasis of Murine Colon Carcinoma publication-title: Phytother Res doi: 10.1002/ptr.3372 – ident: ref7 doi: 10.1002/mc.22230 – volume: 280 start-page: 86 year: 2009 ident: ref30 article-title: Decursin and decursinol inhibit VEGF-induced angiogenesis by blocking the activation of extracellular signal-regulated kinase and c-Jun N-terminal kinase publication-title: Cancer letters doi: 10.1016/j.canlet.2009.02.012 – volume: 78 start-page: 252 year: 2012 ident: ref16 article-title: Quantitative Determination of Decursin, Decursinol Angelate, and Decursinol in Mouse Plasma and Tumor Tissue Using Liquid-Liquid Extraction and HPLC publication-title: Planta Medica doi: 10.1055/s-0031-1280384 – year: 1988 ident: ref21 – volume: 25 start-page: 300 year: 1993 ident: ref31 article-title: Individual variation in first-pass metabolism publication-title: Clinical pharmacokinetics doi: 10.2165/00003088-199325040-00005 – volume: 143 start-page: 611 year: 2012 ident: ref6 article-title: The memory ameliorating effects of INM-176, an ethanolic extract of Angelica gigas, against scopolamine- or Abeta(1–42)-induced cognitive dysfunction in mice publication-title: J Ethnopharmacol doi: 10.1016/j.jep.2012.07.019 – volume: 37 start-page: 127 year: 2009 ident: ref8 article-title: In vivo anti-cancer activity of Korean Angelica gigas and its major pyranocoumarin decursin publication-title: Am J Chin Med doi: 10.1142/S0192415X09006722 – ident: ref4 – volume: 9 start-page: R77 year: 2007 ident: ref15 article-title: Decursin and decursinol angelate inhibit estrogen-stimulated and estrogen-independent growth and survival of breast cancer cells publication-title: Breast Cancer Res doi: 10.1186/bcr1790 – volume: 79 start-page: 275 year: 2013 ident: ref17 article-title: Single Oral Dose Pharmacokinetics of Decursin, Decursinol Angelate, and Decursinol in Rats publication-title: Planta Medica doi: 10.1055/s-0032-1328202 – ident: ref3 doi: 10.1158/1538-7445.AM2013-LB-184 – volume: 78 start-page: 909 year: 2012 ident: ref18 article-title: First-pass Metabolism of Decursin, a Bioactive Compound of Angelica gigas, in Rats publication-title: Planta Medica doi: 10.1055/s-0031-1298517 – ident: ref28 – ident: ref23 – year: 2014 ident: ref22 – volume: 59 start-page: 863 year: 2007 ident: ref25 article-title: Decursinol and decursin protect primary cultured rat cortical cells from glutamate-induced neurotoxicity publication-title: The Journal of pharmacy and pharmacology doi: 10.1211/jpp.59.6.0013 – volume: 12 start-page: 1239 year: 2012 ident: ref2 article-title: Anti-cancer and Other Bioactivities of Korean Angelica gigas Nakai (AGN) and Its Major Pyranocoumarin Compounds publication-title: Anti-cancer agents in medicinal chemistry doi: 10.2174/187152012803833071 – volume: 66 start-page: 453 year: 2006 ident: ref14 article-title: Potent antiandrogen and androgen receptor activities of an Angelica gigas-containing herbal formulation: Identification of decursin as a novel and active compound with implications for prevention and treatment of prostate cancer publication-title: Cancer Research doi: 10.1158/0008-5472.CAN-05-1865 – ident: ref10 – year: 2012 ident: ref24 – volume: 6 start-page: 907 year: 2007 ident: ref13 article-title: A novel class of pyranocoumarin anti-androgen receptor signaling compounds publication-title: Mol Cancer Ther doi: 10.1158/1535-7163.MCT-06-0231 – volume: 12 start-page: 809 year: 2011 ident: ref33 article-title: Strategies for integral metabolism profile of multiple compounds in herbal medicines: pharmacokinetics, metabolites characterization and metabolic interactions publication-title: Current drug metabolism doi: 10.2174/138920011797470164 |
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| SubjectTerms | Administration, Oral Adult Analysis Angelica gigas Animal models Anticancer properties Benzopyrans - administration & dosage Benzopyrans - pharmacokinetics Bioavailability Biomarkers Breast cancer Butyrates - administration & dosage Butyrates - pharmacokinetics Cancer Cell culture Cell cycle Clinical trials Diet Dietary supplements Drug dosages Ethanol Female Gender Health sciences Herbal medicine Humans Isomers Kinases Liver Male Men Metabolism Metabolites Pharmacodynamics Pharmacokinetics Pharmacology Pharmacy Physiological aspects Prostate Quality of Life Rodents Tandem Mass Spectrometry Women's health Womens health Young Adult |
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| Title | Single Oral Dose Pharmacokinetics of Decursin and Decursinol Angelate in Healthy Adult Men and Women |
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