Combination COX-2 inhibitor and metformin attenuate rate of joint replacement in osteoarthritis with diabetes: A nationwide, retrospective, matched-cohort study in Taiwan - Lu, Chieh-Hua; Chung, Chi-Hsiang; Lee, Chien-Hsing; Hsieh, Chang-Hsun; Hung, Yi-Jen; Lin, Fu-Huang; Tsao, Chang-Huei; Hsieh, Po-Shiuan; Chien, Wu-Chien (PloS one, 2018)
Keywords: Aged; Aged, 80 and over; Analysis; Antidiabetics; Arthritis; Arthroplasty, Replacement - statistics & numerical data; Biocompatibility; Biology and Life Sciences; Cohort analysis; Cohort Studies; COX-2 inhibitors; Cyclooxygenase 2 Inhibitors - administration & dosage; Cyclooxygenase-2; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - drug therapy; Dosage and administration; Drug Therapy, Combination; Female; Hazards; Health insurance; Humans; Hypoglycemic Agents - administration & dosage; Inflammation; Insulin resistance; Insurance; Joint replacement; Joint replacement surgery; Male; Medicine and Health Sciences; Metformin; Metformin - administration & dosage; Middle Aged; Osteoarthritis; Osteoarthritis - complications; Osteoarthritis - drug therapy; Osteoarthritis - surgery; Patients; People and Places; Proportional Hazards Models; Regression analysis; Retrospective Studies; Social Sciences; Subgroups; Surgery; Systematic review; Taiwan; Therapy; Type 2 diabetes; Urbanization; Taiwan