Docosahexaenoic acid inhibits the proliferation of Kras/TP53 double mutant pancreatic ductal adenocarcinoma cells through modulation of glutathione level and suppression of nucleotide synthesis - Hung, Wei-Chia; Lee, Der-Yen; Chiang, En-Pei Isabel; Syu, Jia-Ning; Chao, Che-Yi; Yang, Mei-Due; Tsai, Shu-Yao; Tang, Feng-Yao (PloS one, 2020)
Keywords: Acetylcysteine; Adenocarcinoma; Adenocarcinoma - drug therapy; Adenocarcinoma - metabolism; Animal tissues; Animals; Antibiotics; Antibodies; Anticancer properties; Apoptosis; Apoptosis - drug effects; Beta cells; Binding sites; Biology and Life Sciences; Biotechnology; Carcinoma, Pancreatic Ductal - drug therapy; Carcinoma, Pancreatic Ductal - metabolism; Care and treatment; Cell cycle; Cell death; Cell Line, Tumor; Cell proliferation; Cell Proliferation - drug effects; Cell survival; Consumption; Cyclin A; Cyclin B; Cyclin E; Cysteine; Deactivation; Development and progression; Docosahexaenoic acid; Docosahexaenoic Acids - pharmacology; Eicosapentaenoic acid; Ethanol; Fatty acids; Fatty Acids, Omega-3 - administration & dosage; Fatty Acids, Omega-3 - metabolism; Fish oils; Fish Oils - administration & dosage; G1 phase; Gemcitabine; Gene expression; Genetic aspects; Glucose metabolism; Glutathione; Glutathione - metabolism; Health aspects; Health risks; Homeostasis; Humans; Immunomodulators; Inactivation; K-Ras protein; Laboratories; Medicine and Health Sciences; Metabolism; Mice; Mice, Inbred NOD; Mice, SCID; Mode of action; Mutation; NADP; Nucleotides; Nutrition; Omega 3 fatty acids; Oxidative stress; Oxidative Stress - drug effects; p53 Protein; Pancreatic cancer; Pancreatic Neoplasms - drug therapy; Pancreatic Neoplasms - metabolism; Polyunsaturated fatty acids; Proteins; Proto-Oncogene Proteins p21(ras) - metabolism; Survival; Survival analysis; Synthesis; Tumor proteins; Tumor Suppressor Protein p53 - metabolism; Tumors; Xenografts; Xenotransplantation; China; Asia; Taiwan