A novel neuroferritinopathy mouse model (FTL 498InsTC) shows progressive brain iron dysregulation, morphological signs of early neurodegeneration and motor coordination deficits - Maccarinelli, Federica; Pagani, Antonella; Cozzi, Anna; Codazzi, Franca; Di Giacomo, Giuseppina; Capoccia, Sara; Rapino, Stefania; Finazzi, Dario; Politi, Letterio Salvatore; Cirulli, Francesca; Giorgio, Marco; Cremona, Ottavio; et al. (Neurobiology of disease, 2015)
Keywords: Age Factors; Animals; Apoferritins - genetics; Apoferritins - metabolism; Brain - metabolism; Brain - pathology; Cell Death - genetics; Cells, Cultured; Disease Models, Animal; Disease Progression; DNA Damage - genetics; Female; Ferritin; Hippocampus - cytology; Humans; Iron; Iron Metabolism Disorders - complications; Iron Metabolism Disorders - etiology; Iron Metabolism Disorders - genetics; Iron Metabolism Disorders - pathology; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Models, Molecular; Neuroaxonal Dystrophies - complications; Neuroaxonal Dystrophies - genetics; Neuroaxonal Dystrophies - pathology; Neurodegenerative Diseases - etiology; Neurodegenerative disorder; Neuroferritinopathy; Neurology; Neurons - drug effects; Neurons - metabolism; Oxidative damage; Psychomotor Disorders - etiology; Neurodegenerative disorder; Tg; Oxidative damage; ROS; Ferritin; NF; Iron; FtH; WT; Neuroferritinopathy; FTL; neuroferritinopathy; ferritin light chain gene; ferritin light chain protein; reactive oxygen species; transgenic; wild type; ferritin heavy chain protein