Investigating Tissue Optical Properties and Texture Descriptors of the Retina in Patients with Multiple Sclerosis

• Published in: PloS one Vol. 10; no. 11; p. e0143711
• Main Authors: Varga, Boglárka Enikő, Gao, Wei, Laurik, Kornélia Lenke, Tátrai, Erika, Simó, Magdolna, Somfai, Gábor Márk, Cabrera DeBuc, Delia
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 30.11.2015; Public Library of Science (PLoS)
• Subjects: Adult; Analysis; Brain research; Care and treatment; Case-Control Studies; Central nervous system; Change detection; Coherence (Optics); Diagnosis; Diagnostic systems; Eye (anatomy); Female; Flow velocity; Fractals; Glaucoma; Humans; Image detection; Image processing; Image segmentation; Male; Medical imaging; Medical research; Medicine; Multiple sclerosis; Multiple Sclerosis - pathology; Neuritis; Neurodegeneration; Neurology; Ophthalmology; Optic neuritis; Optical Coherence Tomography; Optical properties; Optics; Patients; Reflectance; Retina; Retina - pathology; Risk factors; Segmentation; Statistical analysis; Texture; Tomography, Optical Coherence; Variance analysis; Hungary; Florida; United States > US
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0143711

To assess the differences in texture descriptors and optical properties of retinal tissue layers in patients with multiple sclerosis (MS) and to evaluate their usefulness in the detection of neurodegenerative changes using optical coherence tomography (OCT) image segmentation. 38 patients with MS were examined using Stratus OCT. The raw macular OCT data were exported and processed using OCTRIMA software. The enrolled eyes were divided into two groups, based on the presence of optic neuritis (ON) in the history (MSON+ group, n = 36 and MSON- group, n = 31). Data of 29 eyes of 24 healthy subjects (H) were used as controls. A total of seven intraretinal layers were segmented and thickness as well as optical parameters such as contrast, fractal dimension, layer index and total reflectance were measured. Mixed-model ANOVA analysis was used for statistical comparisons. Significant thinning of the retinal nerve fiber layer (RNFL), ganglion cell/inner plexiform layer complex (GCL+IPL) and ganglion cell complex (GCC, RNFL+GCL+IPL) was observed between study groups in all comparisons. Significant difference was found in contrast in the RNFL, GCL+IPL, GCC, inner nuclear layer (INL) and outer plexiform layer when comparing MSON+ to the other groups. Higher fractal dimension values were observed in GCL+IPL and INL layers when comparing H vs. MSON+ groups. A significant difference was found in layer index in the RNFL, GCL+IPL and GCC layers in all comparisons. A significant difference was observed in total reflectance in the RNFL, GCL+IPL and GCC layers between the three examination groups. Texture and optical properties of the retinal tissue undergo pronounced changes in MS even without optic neuritis. Our results may help to further improve the diagnostic efficacy of OCT in MS and neurodegeneration.