A Fatal Combination: A Thymidylate Synthase Inhibitor with DNA Damaging Activity - Ligasová, Anna; Strunin, Dmytro; Friedecký, David; Adam, Tomáš; Koberna, Karel (PloS one, 2015)
Keywords: Abnormalities; Analysis; Biochemistry; Cancer; Cell cycle; Cell death; Cell division; Cell growth; Cell Line; Cell lines; Cell Proliferation - drug effects; Crosslinking; Cytotoxicity; Cytotoxins - metabolism; Cytotoxins - toxicity; Damage; Deoxyribonucleic acid; Deoxyuridine - analogs & derivatives; Deoxyuridine - metabolism; Deoxyuridine - toxicity; Dihydrofolate reductase; DNA; DNA - biosynthesis; DNA - genetics; DNA - metabolism; DNA Damage; DNA Replication - drug effects; Dose-Response Relationship, Drug; Enzyme Inhibitors - metabolism; Enzyme Inhibitors - toxicity; Herpes viruses; Humans; Inhibition; Intracellular Space - drug effects; Intracellular Space - metabolism; Kinases; Mass spectrometry; Medicine; Metabolism; Metabolites; Physiological aspects; S phase; S Phase - drug effects; Scientific imaging; Synthesis; Tetrahydrofolates - biosynthesis; Thymidine - metabolism; Thymidine - pharmacology; Thymidine monophosphate; Thymidine Monophosphate - metabolism; Thymidylate synthase; Thymidylate Synthase - antagonists & inhibitors; Toxicity; Hungary; Czech Republic