A Novel Immunodominant CD8+ T Cell Response Restricted by a Common HLA-C Allele Targets a Conserved Region of Gag HIV-1 Clade CRF01_AE Infected Thais

CD8+ T cell responses play an important role in the control of HIV-1. The extensive sequence diversity of HIV-1 represents a critical hurdle to developing an effective HIV-1 vaccine, and it is likely that regional-specific vaccine strains will be required to overcome the diversity of the different H...

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Published inPloS one Vol. 6; no. 8; p. e23603
Main Authors Buranapraditkun, Supranee, Hempel, Ursula, Pitakpolrat, Patrawadee, Allgaier, Rachel L., Thantivorasit, Pattarawat, Lorenzen, Sven-Iver, Sirivichayakul, Sunee, Hildebrand, William H., Altfeld, Marcus, Brander, Christian, Walker, Bruce D., Phanuphak, Praphan, Hansasuta, Pokrath, Rowland-Jones, Sarah L., Allen, Todd M., Ruxrungtham, Kiat
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 22.08.2011
Public Library of Science (PLoS)
Subjects
Acquired immune deficiency syndrome
Adult
AIDS
AIDS vaccines
Alleles
Amino Acid Sequence
Antigenic determinants
Biology
CD8 antigen
CD8-Positive T-Lymphocytes - immunology
Conserved Sequence - genetics
Control
Cytotoxicity
Development and progression
Drug resistance
Enzyme-linked immunosorbent assay
Epidemiology
Epitopes
Female
gag Gene Products, Human Immunodeficiency Virus - chemistry
gag Gene Products, Human Immunodeficiency Virus - immunology
Glycoproteins
Health aspects
Histocompatibility antigen HLA
HIV
HIV Infections - genetics
HIV Infections - immunology
HIV tests
HIV-1
HLA antigens
HLA-C Antigens - genetics
Human immunodeficiency virus
Humans
Immunodominant Epitopes - chemistry
Immunodominant Epitopes - immunology
Immunology
Immunopathogenesis
Infection
Infections
Interferon
Laboratories
Lymphocytes
Lymphocytes T
Male
Medical research
Medicine
Molecular Sequence Data
Mutation - genetics
Peptides
Proteins
Regional development
T cells
Thailand
Trends
Vaccines
Thailand
Asia
United States > US
Massachusetts
Oklahoma
Bangkok Thailand
Online AccessGet full text
ISSN1932-6203
1932-6203
DOI10.1371/journal.pone.0023603

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Abstract CD8+ T cell responses play an important role in the control of HIV-1. The extensive sequence diversity of HIV-1 represents a critical hurdle to developing an effective HIV-1 vaccine, and it is likely that regional-specific vaccine strains will be required to overcome the diversity of the different HIV-1 clades distributed world-wide. Unfortunately, little is known about the CD8+ T cell responses against CRF01_AE, which is responsible for the majority of infections in Southeast Asia. To identify dominant CD8+ T cell responses recognized in HIV-1 clade CRF01_AE infected subjects we drew upon data from an immunological screen of 100 HIV-1 clade CRF01_AE infected subjects using IFN-gamma ELISpot to characterize a novel immunodominant CD8+ T cell response in HIV-1 Gag restricted by HLA-Cw*0102 (p24, (277)YSPVSILDI(285), YI9). Over 75% of Cw*0102+ve subjects targeted this epitope, representing the strongest response in more than a third of these individuals. This novel CD8 epitope was located in a highly conserved region of HIV-1 Gag known to contain immunodominant CD8 epitopes, which are restricted by HLA-B*57 and -B*27 in clade B infection. Nonetheless, viral escape in this epitope was frequently observed in Cw*0102+ve subjects, suggestive of strong selection pressure being exerted by this common CD8+ T cell response. As HLA-Cw*0102 is frequently expressed in the Thai population (allelic frequency of 16.8%), this immunodominant Cw*0102-restricted Gag epitope may represent an attractive candidate for vaccines specific to CRF01_AE and may help facilitate further studies of immunopathogenesis in this understudied HIV-1 clade.
AbstractList CD8+ T cell responses play an important role in the control of HIV-1. The extensive sequence diversity of HIV-1 represents a critical hurdle to developing an effective HIV-1 vaccine, and it is likely that regional-specific vaccine strains will be required to overcome the diversity of the different HIV-1 clades distributed world-wide. Unfortunately, little is known about the CD8+ T cell responses against CRF01_AE, which is responsible for the majority of infections in Southeast Asia. To identify dominant CD8+ T cell responses recognized in HIV-1 clade CRF01_AE infected subjects we drew upon data from an immunological screen of 100 HIV-1 clade CRF01_AE infected subjects using IFN-gamma ELISpot to characterize a novel immunodominant CD8+ T cell response in HIV-1 Gag restricted by HLA-Cw*0102 (p24, .sub.277 YSPVSILDI.sub.285, YI9). Over 75% of Cw*0102+ve subjects targeted this epitope, representing the strongest response in more than a third of these individuals. This novel CD8 epitope was located in a highly conserved region of HIV-1 Gag known to contain immunodominant CD8 epitopes, which are restricted by HLA-B*57 and -B*27 in clade B infection. Nonetheless, viral escape in this epitope was frequently observed in Cw*0102+ve subjects, suggestive of strong selection pressure being exerted by this common CD8+ T cell response. As HLA-Cw*0102 is frequently expressed in the Thai population (allelic frequency of 16.8%), this immunodominant Cw*0102-restricted Gag epitope may represent an attractive candidate for vaccines specific to CRF01_AE and may help facilitate further studies of immunopathogenesis in this understudied HIV-1 clade.
CD8+ T cell responses play an important role in the control of HIV-1. The extensive sequence diversity of HIV-1 represents a critical hurdle to developing an effective HIV-1 vaccine, and it is likely that regional-specific vaccine strains will be required to overcome the diversity of the different HIV-1 clades distributed world-wide. Unfortunately, little is known about the CD8+ T cell responses against CRF01_AE, which is responsible for the majority of infections in Southeast Asia.BACKGROUNDCD8+ T cell responses play an important role in the control of HIV-1. The extensive sequence diversity of HIV-1 represents a critical hurdle to developing an effective HIV-1 vaccine, and it is likely that regional-specific vaccine strains will be required to overcome the diversity of the different HIV-1 clades distributed world-wide. Unfortunately, little is known about the CD8+ T cell responses against CRF01_AE, which is responsible for the majority of infections in Southeast Asia.To identify dominant CD8+ T cell responses recognized in HIV-1 clade CRF01_AE infected subjects we drew upon data from an immunological screen of 100 HIV-1 clade CRF01_AE infected subjects using IFN-gamma ELISpot to characterize a novel immunodominant CD8+ T cell response in HIV-1 Gag restricted by HLA-Cw*0102 (p24, (277)YSPVSILDI(285), YI9). Over 75% of Cw*0102+ve subjects targeted this epitope, representing the strongest response in more than a third of these individuals. This novel CD8 epitope was located in a highly conserved region of HIV-1 Gag known to contain immunodominant CD8 epitopes, which are restricted by HLA-B*57 and -B*27 in clade B infection. Nonetheless, viral escape in this epitope was frequently observed in Cw*0102+ve subjects, suggestive of strong selection pressure being exerted by this common CD8+ T cell response.METHODOLOGY/PRINCIPAL FINDINGSTo identify dominant CD8+ T cell responses recognized in HIV-1 clade CRF01_AE infected subjects we drew upon data from an immunological screen of 100 HIV-1 clade CRF01_AE infected subjects using IFN-gamma ELISpot to characterize a novel immunodominant CD8+ T cell response in HIV-1 Gag restricted by HLA-Cw*0102 (p24, (277)YSPVSILDI(285), YI9). Over 75% of Cw*0102+ve subjects targeted this epitope, representing the strongest response in more than a third of these individuals. This novel CD8 epitope was located in a highly conserved region of HIV-1 Gag known to contain immunodominant CD8 epitopes, which are restricted by HLA-B*57 and -B*27 in clade B infection. Nonetheless, viral escape in this epitope was frequently observed in Cw*0102+ve subjects, suggestive of strong selection pressure being exerted by this common CD8+ T cell response.As HLA-Cw*0102 is frequently expressed in the Thai population (allelic frequency of 16.8%), this immunodominant Cw*0102-restricted Gag epitope may represent an attractive candidate for vaccines specific to CRF01_AE and may help facilitate further studies of immunopathogenesis in this understudied HIV-1 clade.CONCLUSIONS/SIGNIFICANCEAs HLA-Cw*0102 is frequently expressed in the Thai population (allelic frequency of 16.8%), this immunodominant Cw*0102-restricted Gag epitope may represent an attractive candidate for vaccines specific to CRF01_AE and may help facilitate further studies of immunopathogenesis in this understudied HIV-1 clade.
CD8+ T cell responses play an important role in the control of HIV-1. The extensive sequence diversity of HIV-1 represents a critical hurdle to developing an effective HIV-1 vaccine, and it is likely that regional-specific vaccine strains will be required to overcome the diversity of the different HIV-1 clades distributed world-wide. Unfortunately, little is known about the CD8+ T cell responses against CRF01_AE, which is responsible for the majority of infections in Southeast Asia. To identify dominant CD8+ T cell responses recognized in HIV-1 clade CRF01_AE infected subjects we drew upon data from an immunological screen of 100 HIV-1 clade CRF01_AE infected subjects using IFN-gamma ELISpot to characterize a novel immunodominant CD8+ T cell response in HIV-1 Gag restricted by HLA-Cw*0102 (p24, (277)YSPVSILDI(285), YI9). Over 75% of Cw*0102+ve subjects targeted this epitope, representing the strongest response in more than a third of these individuals. This novel CD8 epitope was located in a highly conserved region of HIV-1 Gag known to contain immunodominant CD8 epitopes, which are restricted by HLA-B*57 and -B*27 in clade B infection. Nonetheless, viral escape in this epitope was frequently observed in Cw*0102+ve subjects, suggestive of strong selection pressure being exerted by this common CD8+ T cell response. As HLA-Cw*0102 is frequently expressed in the Thai population (allelic frequency of 16.8%), this immunodominant Cw*0102-restricted Gag epitope may represent an attractive candidate for vaccines specific to CRF01_AE and may help facilitate further studies of immunopathogenesis in this understudied HIV-1 clade.
Background CD8+ T cell responses play an important role in the control of HIV-1. The extensive sequence diversity of HIV-1 represents a critical hurdle to developing an effective HIV-1 vaccine, and it is likely that regional-specific vaccine strains will be required to overcome the diversity of the different HIV-1 clades distributed world-wide. Unfortunately, little is known about the CD8+ T cell responses against CRF01_AE, which is responsible for the majority of infections in Southeast Asia. Methodology/Principal Findings To identify dominant CD8+ T cell responses recognized in HIV-1 clade CRF01_AE infected subjects we drew upon data from an immunological screen of 100 HIV-1 clade CRF01_AE infected subjects using IFN-gamma ELISpot to characterize a novel immunodominant CD8+ T cell response in HIV-1 Gag restricted by HLA-Cw*0102 (p24, .sub.277 YSPVSILDI.sub.285, YI9). Over 75% of Cw*0102+ve subjects targeted this epitope, representing the strongest response in more than a third of these individuals. This novel CD8 epitope was located in a highly conserved region of HIV-1 Gag known to contain immunodominant CD8 epitopes, which are restricted by HLA-B*57 and -B*27 in clade B infection. Nonetheless, viral escape in this epitope was frequently observed in Cw*0102+ve subjects, suggestive of strong selection pressure being exerted by this common CD8+ T cell response. Conclusions/Significance As HLA-Cw*0102 is frequently expressed in the Thai population (allelic frequency of 16.8%), this immunodominant Cw*0102-restricted Gag epitope may represent an attractive candidate for vaccines specific to CRF01_AE and may help facilitate further studies of immunopathogenesis in this understudied HIV-1 clade.
CD8+ T cell responses play an important role in the control of HIV-1. The extensive sequence diversity of HIV-1 represents a critical hurdle to developing an effective HIV-1 vaccine, and it is likely that regional-specific vaccine strains will be required to overcome the diversity of the different HIV-1 clades distributed world-wide. Unfortunately, little is known about the CD8+ T cell responses against CRF01_AE, which is responsible for the majority of infections in Southeast Asia.To identify dominant CD8+ T cell responses recognized in HIV-1 clade CRF01_AE infected subjects we drew upon data from an immunological screen of 100 HIV-1 clade CRF01_AE infected subjects using IFN-gamma ELISpot to characterize a novel immunodominant CD8+ T cell response in HIV-1 Gag restricted by HLA-Cw*0102 (p24, (277)YSPVSILDI(285), YI9). Over 75% of Cw*0102+ve subjects targeted this epitope, representing the strongest response in more than a third of these individuals. This novel CD8 epitope was located in a highly conserved region of HIV-1 Gag known to contain immunodominant CD8 epitopes, which are restricted by HLA-B*57 and -B*27 in clade B infection. Nonetheless, viral escape in this epitope was frequently observed in Cw*0102+ve subjects, suggestive of strong selection pressure being exerted by this common CD8+ T cell response.As HLA-Cw*0102 is frequently expressed in the Thai population (allelic frequency of 16.8%), this immunodominant Cw*0102-restricted Gag epitope may represent an attractive candidate for vaccines specific to CRF01_AE and may help facilitate further studies of immunopathogenesis in this understudied HIV-1 clade.
Background CD8+ T cell responses play an important role in the control of HIV-1. The extensive sequence diversity of HIV-1 represents a critical hurdle to developing an effective HIV-1 vaccine, and it is likely that regional-specific vaccine strains will be required to overcome the diversity of the different HIV-1 clades distributed world-wide. Unfortunately, little is known about the CD8+ T cell responses against CRF01_AE, which is responsible for the majority of infections in Southeast Asia. Methodology/Principal Findings To identify dominant CD8+ T cell responses recognized in HIV-1 clade CRF01_AE infected subjects we drew upon data from an immunological screen of 100 HIV-1 clade CRF01_AE infected subjects using IFN-gamma ELISpot to characterize a novel immunodominant CD8+ T cell response in HIV-1 Gag restricted by HLA-Cw*0102 (p24, 277 YSPVSILDI 285 , YI9). Over 75% of Cw*0102+ve subjects targeted this epitope, representing the strongest response in more than a third of these individuals. This novel CD8 epitope was located in a highly conserved region of HIV-1 Gag known to contain immunodominant CD8 epitopes, which are restricted by HLA-B*57 and -B*27 in clade B infection. Nonetheless, viral escape in this epitope was frequently observed in Cw*0102+ve subjects, suggestive of strong selection pressure being exerted by this common CD8+ T cell response. Conclusions/Significance As HLA-Cw*0102 is frequently expressed in the Thai population (allelic frequency of 16.8%), this immunodominant Cw*0102-restricted Gag epitope may represent an attractive candidate for vaccines specific to CRF01_AE and may help facilitate further studies of immunopathogenesis in this understudied HIV-1 clade.
Background CD8+ T cell responses play an important role in the control of HIV-1. The extensive sequence diversity of HIV-1 represents a critical hurdle to developing an effective HIV-1 vaccine, and it is likely that regional-specific vaccine strains will be required to overcome the diversity of the different HIV-1 clades distributed world-wide. Unfortunately, little is known about the CD8+ T cell responses against CRF01_AE, which is responsible for the majority of infections in Southeast Asia. Methodology/Principal Findings To identify dominant CD8+ T cell responses recognized in HIV-1 clade CRF01_AE infected subjects we drew upon data from an immunological screen of 100 HIV-1 clade CRF01_AE infected subjects using IFN-gamma ELISpot to characterize a novel immunodominant CD8+ T cell response in HIV-1 Gag restricted by HLA-Cw*0102 (p24, 277YSPVSILDI285, YI9). Over 75% of Cw*0102+ve subjects targeted this epitope, representing the strongest response in more than a third of these individuals. This novel CD8 epitope was located in a highly conserved region of HIV-1 Gag known to contain immunodominant CD8 epitopes, which are restricted by HLA-B*57 and -B*27 in clade B infection. Nonetheless, viral escape in this epitope was frequently observed in Cw*0102+ve subjects, suggestive of strong selection pressure being exerted by this common CD8+ T cell response. Conclusions/Significance As HLA-Cw*0102 is frequently expressed in the Thai population (allelic frequency of 16.8%), this immunodominant Cw*0102-restricted Gag epitope may represent an attractive candidate for vaccines specific to CRF01_AE and may help facilitate further studies of immunopathogenesis in this understudied HIV-1 clade.
Audience Academic
Author Thantivorasit, Pattarawat
Hansasuta, Pokrath
Hildebrand, William H.
Ruxrungtham, Kiat
Buranapraditkun, Supranee
Brander, Christian
Sirivichayakul, Sunee
Walker, Bruce D.
Hempel, Ursula
Allgaier, Rachel L.
Phanuphak, Praphan
Rowland-Jones, Sarah L.
Allen, Todd M.
Lorenzen, Sven-Iver
Pitakpolrat, Patrawadee
Altfeld, Marcus
AuthorAffiliation 3 Department of Microbiology and Immunology, Health Sciences Center, University of Oklahoma, Oklahoma City, Oklahoma, United States of America
6 Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
7 Medical Research Council, Human Immunology Unit, Weather all Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
5 Thai Red Cross AIDS Research Center, Bangkok, Thailand
2 Ragon Institute of MGH, MIT and Harvard, Boston, Massachusetts, United States of America
1 Vaccine and Cellular Immunology Laboratory, Chulalongkorn Medical Research Center (ChulaMRC), and Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
4 AIDS Research Institute IrsiCaixa - HIVACAT, Hospital Germans Trias i Pujol, Badalona, and Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain
8 Interdisciplinary Program of Medical Microbiology, Graduate School, Chulalongkorn University, Bangkok, Thailand
Karoli
AuthorAffiliation_xml – name: 7 Medical Research Council, Human Immunology Unit, Weather all Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
– name: 2 Ragon Institute of MGH, MIT and Harvard, Boston, Massachusetts, United States of America
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– name: Karolinska Institutet, Sweden
– name: 3 Department of Microbiology and Immunology, Health Sciences Center, University of Oklahoma, Oklahoma City, Oklahoma, United States of America
– name: 5 Thai Red Cross AIDS Research Center, Bangkok, Thailand
– name: 6 Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
– name: 1 Vaccine and Cellular Immunology Laboratory, Chulalongkorn Medical Research Center (ChulaMRC), and Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
– name: 8 Interdisciplinary Program of Medical Microbiology, Graduate School, Chulalongkorn University, Bangkok, Thailand
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/21887282$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1038/nm0297-212
10.1038/nm0496-405
10.1038/34929
10.1089/088922201750236988
10.1038/ni0304-233
10.1097/00002030-200203290-00005
10.1086/508748
10.1038/nm992
10.1097/01.aids.0000299410.37152.17
10.1097/01.aids.0000247564.73009.bc
10.1128/JVI.77.9.5439-5450.2003
10.1186/1742-4690-5-68
10.1016/S0140-6736(08)61591-3
10.1128/JVI.00114-09
10.1097/00002030-200100005-00005
10.1038/nm0297-205
10.1128/JVI.01277-07
10.1038/nri1959
10.1016/j.cub.2005.04.050
10.1016/S1074-7613(00)80065-5
10.1089/aid.2006.22.1271
10.1128/JVI.68.7.4650-4655.1994
10.1128/JVI.00619-10
10.1097/01.aids.0000299409.29528.23
10.1128/JVI.01543-07
10.1038/354453a0
10.1126/science.1143767
10.1086/524845
10.1128/JVI.68.9.6103-6110.1994
10.1056/NEJMra066267
10.1086/428404
10.1586/14760584.6.6.879
10.1371/journal.pmed.0030403
10.1097/00002030-200205030-00015
10.1056/NEJM200009073431006
10.1128/JVI.76.17.8757-8768.2002
10.1086/521123
10.1073/pnas.050567397
10.1073/pnas.94.5.1890
10.1128/JVI.78.3.1324-1332.2004
10.1056/NEJM199803263381301
10.1128/JVI.00182-09
10.1038/ng.486
10.1126/science.1070441
10.1128/JVI.02356-07
ContentType Journal Article
Copyright COPYRIGHT 2011 Public Library of Science
2011 Buranapraditkun et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Buranapraditkun et al. 2011
Copyright_xml – notice: COPYRIGHT 2011 Public Library of Science
– notice: 2011 Buranapraditkun et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: Buranapraditkun et al. 2011
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Conceived and designed the experiments: SB UH BW TA KR. Performed the experiments: SB UH PP RA PT SL SS WH. Analyzed the data: SB UH WH MA CB BW TA KR. Contributed reagents/materials/analysis tools: PP PH SR. Wrote the paper: SB UH TA KR.
These authors also contributed equally to this work.
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References K Ljungberg (ref8) 2007; 6
P Wirachsilp (ref23) 2007; 38
K Yusim (ref46) 2002; 76
KA Lau (ref45) 2007; 9
KL Collins (ref38) 1998; 391
SP Buchbinder (ref43) 2008; 372
B Larder (ref3) 2001; 15
A Schneidewind (ref35) 2007; 81
P Borrow (ref4) 1994; 68
V Sanchez-Merino (ref31) 2008; 197
NM Flynn (ref40) 2005; 191
J Hemelaar (ref24) 2006; 20
MI Johnston (ref9) 2007; 356
PJ Goulder (ref17) 1997; 3
M Altfeld (ref32) 2006; 3
W Kantakamalakul (ref27) 2006; 22
F Prugnolle (ref12) 2005; 15
R Rangsin (ref25) 2007; 21
RA Koup (ref5) 1994; 68
MM Addo (ref47) 2002; 16
GB Cohen (ref39) 1999; 10
Y Liu (ref16) 2007; 81
AJ Leslie (ref19) 2004; 10
DR Burton (ref42) 2004; 5
KE Nelson (ref26) 2007; 21
R Thomas (ref21) 2009; 41
A Schneidewind (ref30) 2008; 82
RE Phillips (ref14) 1991; 354
A Specht (ref37) 2010; 84
NL Letvin (ref10) 2006; 6
H Streeck (ref33) 2009; 83
UK Von Schwedler (ref18) 2003; 77
J Fellay (ref20) 2007; 317
J Klein (ref11) 2000; 343
DA Price (ref6) 1997; 94
FJ Palella Jr (ref1) 1998; 338
P Pitisuttithum (ref41) 2006; 194
BT Korber (ref44) 2009; 83
P Borrow (ref7) 1997; 3
A Matucci (ref22) 2008; 5
RA Kaslow (ref36) 1996; 2
KB Bond (ref29) 2001; 17
SA Migueles (ref34) 2000; 97
B Ojikutu (ref2) 2007; 196
B Gaschen (ref15) 2002; 296
K Fukada (ref28) 2002; 16
Y Yokomaku (ref13) 2004; 78
17053344 - AIDS. 2006 Oct 24;20(16):W13-23
17209771 - AIDS Res Hum Retroviruses. 2006 Dec;22(12):1271-82
12692245 - J Virol. 2003 May;77(9):5439-50
14770175 - Nat Med. 2004 Mar;10(3):282-9
10974135 - N Engl J Med. 2000 Sep 7;343(10):702-9
11816171 - AIDS. 2001;15 Suppl 5:S27-34
8207839 - J Virol. 1994 Jul;68(7):4650-5
18032938 - AIDS. 2007 Nov;21 Suppl 6:S47-54
9018241 - Nat Med. 1997 Feb;3(2):212-7
18377348 - Expert Rev Vaccines. 2007 Dec;6(6):879-82
19439471 - J Virol. 2009 Sep;83(17):8300-14
18219365 - AIDS Rev. 2007 Oct-Dec;9(4):218-29
15688278 - J Infect Dis. 2005 Mar 1;191(5):654-65
18032937 - AIDS. 2007 Nov;21 Suppl 6:S39-46
9018240 - Nat Med. 1997 Feb;3(2):205-11
18673537 - Retrovirology. 2008;5:68
15936272 - Curr Biol. 2005 Jun 7;15(11):1022-7
19458000 - J Virol. 2009 Aug;83(15):7641-8
14985706 - Nat Immunol. 2004 Mar;5(3):233-6
18041297 - Southeast Asian J Trop Med Public Health. 2007 Sep;38(5):814-27
17507706 - N Engl J Med. 2007 May 17;356(20):2073-81
18177249 - J Infect Dis. 2008 Jan 15;197(2):300-8
19012954 - Lancet. 2008 Nov 29;372(9653):1881-93
11953475 - AIDS. 2002 May 3;16(7):1071-3
17109337 - J Infect Dis. 2006 Dec 15;194(12):1661-71
18181692 - J Infect Dis. 2007 Dec 1;196 Suppl 3:S445-8
9450757 - Nature. 1998 Jan 22;391(6665):397-401
8057491 - J Virol. 1994 Sep;68(9):6103-10
17641165 - Science. 2007 Aug 17;317(5840):944-7
17728222 - J Virol. 2007 Nov;81(22):12179-88
20463068 - J Virol. 2010 Jul;84(14):7300-11
11429111 - AIDS Res Hum Retroviruses. 2001 May 20;17(8):703-17
1721107 - Nature. 1991 Dec 12;354(6353):453-9
17804494 - J Virol. 2007 Nov;81(22):12382-93
18385228 - J Virol. 2008 Jun;82(11):5594-605
17124514 - Nat Rev Immunol. 2006 Dec;6(12):930-9
19935663 - Nat Genet. 2009 Dec;41(12):1290-4
10403641 - Immunity. 1999 Jun;10(6):661-71
17076553 - PLoS Med. 2006 Oct;3(10):e403
11964526 - AIDS. 2002 Mar 29;16(5):701-11
8597949 - Nat Med. 1996 Apr;2(4):405-11
9050875 - Proc Natl Acad Sci U S A. 1997 Mar 4;94(5):1890-5
9516219 - N Engl J Med. 1998 Mar 26;338(13):853-60
12089434 - Science. 2002 Jun 28;296(5577):2354-60
12163596 - J Virol. 2002 Sep;76(17):8757-68
10694578 - Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2709-14
14722287 - J Virol. 2004 Feb;78(3):1324-32
References_xml – volume: 3
  start-page: 212
  year: 1997
  ident: ref17
  article-title: Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS.
  publication-title: Nat Med
  doi: 10.1038/nm0297-212
– volume: 2
  start-page: 405
  year: 1996
  ident: ref36
  article-title: Influence of combinations of human major histocompatibility complex genes on the course of HIV-1 infection.
  publication-title: Nat Med
  doi: 10.1038/nm0496-405
– volume: 391
  start-page: 397
  year: 1998
  ident: ref38
  article-title: HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes.
  publication-title: Nature
  doi: 10.1038/34929
– volume: 17
  start-page: 703
  year: 2001
  ident: ref29
  article-title: An HLA-directed molecular and bioinformatics approach identifies new HLA-A11 HIV-1 subtype E cytotoxic T lymphocyte epitopes in HIV-1-infected Thais.
  publication-title: AIDS Res Hum Retroviruses
  doi: 10.1089/088922201750236988
– volume: 5
  start-page: 233
  year: 2004
  ident: ref42
  article-title: HIV vaccine design and the neutralizing antibody problem.
  publication-title: Nat Immunol
  doi: 10.1038/ni0304-233
– volume: 16
  start-page: 701
  year: 2002
  ident: ref28
  article-title: Cytotoxic T-cell recognition of HIV-1 cross-clade and clade-specific epitopes in HIV-1-infected Thai and Japanese patients.
  publication-title: AIDS
  doi: 10.1097/00002030-200203290-00005
– volume: 194
  start-page: 1661
  year: 2006
  ident: ref41
  article-title: Randomized, double-blind, placebo-controlled efficacy trial of a bivalent recombinant glycoprotein 120 HIV-1 vaccine among injection drug users in Bangkok, Thailand.
  publication-title: J Infect Dis
  doi: 10.1086/508748
– volume: 10
  start-page: 282
  year: 2004
  ident: ref19
  article-title: HIV evolution: CTL escape mutation and reversion after transmission.
  publication-title: Nat Med
  doi: 10.1038/nm992
– volume: 21
  start-page: S47
  year: 2007
  ident: ref26
  article-title: Survival of blood donors and their spouses with HIV-1 subtype E (CRF01 A_E) infection in northern Thailand, 1992–2007.
  publication-title: AIDS
  doi: 10.1097/01.aids.0000299410.37152.17
– volume: 20
  start-page: W13
  year: 2006
  ident: ref24
  article-title: Global and regional distribution of HIV-1 genetic subtypes and recombinants in 2004.
  publication-title: AIDS
  doi: 10.1097/01.aids.0000247564.73009.bc
– volume: 77
  start-page: 5439
  year: 2003
  ident: ref18
  article-title: Functional surfaces of the human immunodeficiency virus type 1 capsid protein.
  publication-title: J Virol
  doi: 10.1128/JVI.77.9.5439-5450.2003
– volume: 9
  start-page: 218
  year: 2007
  ident: ref45
  article-title: Emerging trends of HIV epidemiology in Asia.
  publication-title: AIDS Rev
– volume: 5
  start-page: 68
  year: 2008
  ident: ref22
  article-title: HLA-C increases HIV-1 infectivity and is associated with gp120.
  publication-title: Retrovirology
  doi: 10.1186/1742-4690-5-68
– volume: 372
  start-page: 1881
  year: 2008
  ident: ref43
  article-title: Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial.
  publication-title: Lancet
  doi: 10.1016/S0140-6736(08)61591-3
– volume: 83
  start-page: 8300
  year: 2009
  ident: ref44
  article-title: T cell Vaccine Strategies for HIV, the Virus With a Thousand Faces.
  publication-title: J Virol
  doi: 10.1128/JVI.00114-09
– volume: 15
  start-page: S27
  year: 2001
  ident: ref3
  article-title: Mechanisms of HIV-1 drug resistance.
  publication-title: AIDS
  doi: 10.1097/00002030-200100005-00005
– volume: 3
  start-page: 205
  year: 1997
  ident: ref7
  article-title: Antiviral pressure exerted by HIV-1-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus.
  publication-title: Nat Med
  doi: 10.1038/nm0297-205
– volume: 81
  start-page: 12179
  year: 2007
  ident: ref16
  article-title: Evolution of human immunodeficiency virus type 1 cytotoxic T-lymphocyte epitopes: fitness-balanced escape.
  publication-title: J Virol
  doi: 10.1128/JVI.01277-07
– volume: 6
  start-page: 930
  year: 2006
  ident: ref10
  article-title: Progress and obstacles in the development of an AIDS vaccine.
  publication-title: Nat Rev Immunol
  doi: 10.1038/nri1959
– volume: 15
  start-page: 1022
  year: 2005
  ident: ref12
  article-title: Pathogen-driven selection and worldwide HLA class I diversity.
  publication-title: Curr Biol
  doi: 10.1016/j.cub.2005.04.050
– volume: 10
  start-page: 661
  year: 1999
  ident: ref39
  article-title: The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells.
  publication-title: Immunity
  doi: 10.1016/S1074-7613(00)80065-5
– volume: 22
  start-page: 1271
  year: 2006
  ident: ref27
  article-title: Identification of a novel HIV type 1 CRF01_AE cytotoxic T lymphocyte (CTL) epitope restricted by an HLA-Cw0602 allele and a novel HLA-A0206/peptide restriction.
  publication-title: AIDS Res Hum Retroviruses
  doi: 10.1089/aid.2006.22.1271
– volume: 68
  start-page: 4650
  year: 1994
  ident: ref5
  article-title: Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome.
  publication-title: J Virol
  doi: 10.1128/JVI.68.7.4650-4655.1994
– volume: 84
  start-page: 7300
  year: 2010
  ident: ref37
  article-title: Counteraction of HLA-C-mediated immune control of HIV-1 by Nef.
  publication-title: J Virol
  doi: 10.1128/JVI.00619-10
– volume: 21
  start-page: S39
  year: 2007
  ident: ref25
  article-title: The natural history of HIV-1 subtype E infection in young men in Thailand with up to 14 years of follow-up.
  publication-title: AIDS
  doi: 10.1097/01.aids.0000299409.29528.23
– volume: 81
  start-page: 12382
  year: 2007
  ident: ref35
  article-title: Escape from the dominant HLA-B27-restricted cytotoxic T-lymphocyte response in Gag is associated with a dramatic reduction in human immunodeficiency virus type 1 replication.
  publication-title: J Virol
  doi: 10.1128/JVI.01543-07
– volume: 354
  start-page: 453
  year: 1991
  ident: ref14
  article-title: Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition.
  publication-title: Nature
  doi: 10.1038/354453a0
– volume: 317
  start-page: 944
  year: 2007
  ident: ref20
  article-title: A whole-genome association study of major determinants for host control of HIV-1.
  publication-title: Science
  doi: 10.1126/science.1143767
– volume: 197
  start-page: 300
  year: 2008
  ident: ref31
  article-title: Identification and characterization of HIV-1 CD8+ T cell escape variants with impaired fitness.
  publication-title: J Infect Dis
  doi: 10.1086/524845
– volume: 68
  start-page: 6103
  year: 1994
  ident: ref4
  article-title: Virus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection.
  publication-title: J Virol
  doi: 10.1128/JVI.68.9.6103-6110.1994
– volume: 356
  start-page: 2073
  year: 2007
  ident: ref9
  article-title: An HIV vaccine-evolving concepts.
  publication-title: N Engl J Med
  doi: 10.1056/NEJMra066267
– volume: 191
  start-page: 654
  year: 2005
  ident: ref40
  article-title: Placebo-controlled phase 3 trial of a recombinant glycoprotein 120 vaccine to prevent HIV-1 infection.
  publication-title: J Infect Dis
  doi: 10.1086/428404
– volume: 6
  start-page: 879
  year: 2007
  ident: ref8
  article-title: HIV vaccine development: the myth of Sisyphus modernized?
  publication-title: Expert Rev Vaccines
  doi: 10.1586/14760584.6.6.879
– volume: 3
  start-page: e403
  year: 2006
  ident: ref32
  article-title: HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8(+) T Cell Response against HIV-1.
  publication-title: PLoS Med
  doi: 10.1371/journal.pmed.0030403
– volume: 16
  start-page: 1071
  year: 2002
  ident: ref47
  article-title: HIV-1 Vpu represents a minor target for cytotoxic T lymphocytes in HIV-1-infection.
  publication-title: AIDS
  doi: 10.1097/00002030-200205030-00015
– volume: 343
  start-page: 702
  year: 2000
  ident: ref11
  article-title: The HLA system. First of two parts.
  publication-title: N Engl J Med
  doi: 10.1056/NEJM200009073431006
– volume: 76
  start-page: 8757
  year: 2002
  ident: ref46
  article-title: Clustering patterns of cytotoxic T-lymphocyte epitopes in human immunodeficiency virus type 1 (HIV-1) proteins reveal imprints of immune evasion on HIV-1 global variation.
  publication-title: J Virol
  doi: 10.1128/JVI.76.17.8757-8768.2002
– volume: 196
  start-page: S445
  year: 2007
  ident: ref2
  article-title: Introduction: the realities of antiretroviral therapy rollout: overcoming challenges to successful programmatic implementation.
  publication-title: J Infect Dis
  doi: 10.1086/521123
– volume: 97
  start-page: 2709
  year: 2000
  ident: ref34
  article-title: HLA B*5701 is highly associated with restriction of virus replication in a subgroup of HIV-infected long term nonprogressors.
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.050567397
– volume: 94
  start-page: 1890
  year: 1997
  ident: ref6
  article-title: Positive selection of HIV-1 cytotoxic T lymphocyte escape variants during primary infection.
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.94.5.1890
– volume: 78
  start-page: 1324
  year: 2004
  ident: ref13
  article-title: Impaired processing and presentation of cytotoxic-T-lymphocyte (CTL) epitopes are major escape mechanisms from CTL immune pressure in human immunodeficiency virus type 1 infection.
  publication-title: J Virol
  doi: 10.1128/JVI.78.3.1324-1332.2004
– volume: 38
  start-page: 814
  year: 2007
  ident: ref23
  article-title: Surveillance of subtype and genetic variation of the circulating strains of HIV-1 in Thailand.
  publication-title: Southeast Asian J Trop Med Public Health
– volume: 338
  start-page: 853
  year: 1998
  ident: ref1
  article-title: Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators.
  publication-title: N Engl J Med
  doi: 10.1056/NEJM199803263381301
– volume: 83
  start-page: 7641
  year: 2009
  ident: ref33
  article-title: Human immunodeficiency virus type 1-specific CD8+ T-cell responses during primary infection are major determinants of the viral set point and loss of CD4+ T cells.
  publication-title: J Virol
  doi: 10.1128/JVI.00182-09
– volume: 41
  start-page: 1290
  year: 2009
  ident: ref21
  article-title: HLA-C cell surface expression and control of HIV/AIDS correlate with a variant upstream of HLA-C.
  publication-title: Nat Genet
  doi: 10.1038/ng.486
– volume: 296
  start-page: 2354
  year: 2002
  ident: ref15
  article-title: Diversity considerations in HIV-1 vaccine selection.
  publication-title: Science
  doi: 10.1126/science.1070441
– volume: 82
  start-page: 5594
  year: 2008
  ident: ref30
  article-title: Structural and Functional Constraints Limit Options for CTL Escape in the Immunodominant HLA-B27 Restricted Epitope in HIV-1 Capsid.
  publication-title: J Virol
  doi: 10.1128/JVI.02356-07
– reference: 8207839 - J Virol. 1994 Jul;68(7):4650-5
– reference: 15936272 - Curr Biol. 2005 Jun 7;15(11):1022-7
– reference: 19458000 - J Virol. 2009 Aug;83(15):7641-8
– reference: 12089434 - Science. 2002 Jun 28;296(5577):2354-60
– reference: 12163596 - J Virol. 2002 Sep;76(17):8757-68
– reference: 9018241 - Nat Med. 1997 Feb;3(2):212-7
– reference: 17209771 - AIDS Res Hum Retroviruses. 2006 Dec;22(12):1271-82
– reference: 18219365 - AIDS Rev. 2007 Oct-Dec;9(4):218-29
– reference: 10694578 - Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2709-14
– reference: 14722287 - J Virol. 2004 Feb;78(3):1324-32
– reference: 18041297 - Southeast Asian J Trop Med Public Health. 2007 Sep;38(5):814-27
– reference: 18673537 - Retrovirology. 2008;5:68
– reference: 17728222 - J Virol. 2007 Nov;81(22):12179-88
– reference: 18377348 - Expert Rev Vaccines. 2007 Dec;6(6):879-82
– reference: 9018240 - Nat Med. 1997 Feb;3(2):205-11
– reference: 17507706 - N Engl J Med. 2007 May 17;356(20):2073-81
– reference: 18032937 - AIDS. 2007 Nov;21 Suppl 6:S39-46
– reference: 18385228 - J Virol. 2008 Jun;82(11):5594-605
– reference: 18177249 - J Infect Dis. 2008 Jan 15;197(2):300-8
– reference: 14770175 - Nat Med. 2004 Mar;10(3):282-9
– reference: 9050875 - Proc Natl Acad Sci U S A. 1997 Mar 4;94(5):1890-5
– reference: 17076553 - PLoS Med. 2006 Oct;3(10):e403
– reference: 11429111 - AIDS Res Hum Retroviruses. 2001 May 20;17(8):703-17
– reference: 19935663 - Nat Genet. 2009 Dec;41(12):1290-4
– reference: 10974135 - N Engl J Med. 2000 Sep 7;343(10):702-9
– reference: 12692245 - J Virol. 2003 May;77(9):5439-50
– reference: 1721107 - Nature. 1991 Dec 12;354(6353):453-9
– reference: 9450757 - Nature. 1998 Jan 22;391(6665):397-401
– reference: 17124514 - Nat Rev Immunol. 2006 Dec;6(12):930-9
– reference: 8057491 - J Virol. 1994 Sep;68(9):6103-10
– reference: 10403641 - Immunity. 1999 Jun;10(6):661-71
– reference: 20463068 - J Virol. 2010 Jul;84(14):7300-11
– reference: 15688278 - J Infect Dis. 2005 Mar 1;191(5):654-65
– reference: 11816171 - AIDS. 2001;15 Suppl 5:S27-34
– reference: 11953475 - AIDS. 2002 May 3;16(7):1071-3
– reference: 17641165 - Science. 2007 Aug 17;317(5840):944-7
– reference: 9516219 - N Engl J Med. 1998 Mar 26;338(13):853-60
– reference: 17804494 - J Virol. 2007 Nov;81(22):12382-93
– reference: 19439471 - J Virol. 2009 Sep;83(17):8300-14
– reference: 17053344 - AIDS. 2006 Oct 24;20(16):W13-23
– reference: 19012954 - Lancet. 2008 Nov 29;372(9653):1881-93
– reference: 18032938 - AIDS. 2007 Nov;21 Suppl 6:S47-54
– reference: 11964526 - AIDS. 2002 Mar 29;16(5):701-11
– reference: 14985706 - Nat Immunol. 2004 Mar;5(3):233-6
– reference: 8597949 - Nat Med. 1996 Apr;2(4):405-11
– reference: 17109337 - J Infect Dis. 2006 Dec 15;194(12):1661-71
– reference: 18181692 - J Infect Dis. 2007 Dec 1;196 Suppl 3:S445-8
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Snippet CD8+ T cell responses play an important role in the control of HIV-1. The extensive sequence diversity of HIV-1 represents a critical hurdle to developing an...
Background CD8+ T cell responses play an important role in the control of HIV-1. The extensive sequence diversity of HIV-1 represents a critical hurdle to...
Background CD8+ T cell responses play an important role in the control of HIV-1. The extensive sequence diversity of HIV-1 represents a critical hurdle to...
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StartPage e23603
SubjectTerms Acquired immune deficiency syndrome
Adult
AIDS
AIDS vaccines
Alleles
Amino Acid Sequence
Antigenic determinants
Biology
CD8 antigen
CD8-Positive T-Lymphocytes - immunology
Conserved Sequence - genetics
Control
Cytotoxicity
Development and progression
Drug resistance
Enzyme-linked immunosorbent assay
Epidemiology
Epitopes
Female
gag Gene Products, Human Immunodeficiency Virus - chemistry
gag Gene Products, Human Immunodeficiency Virus - immunology
Glycoproteins
Health aspects
Histocompatibility antigen HLA
HIV
HIV Infections - genetics
HIV Infections - immunology
HIV tests
HIV-1
HLA antigens
HLA-C Antigens - genetics
Human immunodeficiency virus
Humans
Immunodominant Epitopes - chemistry
Immunodominant Epitopes - immunology
Immunology
Immunopathogenesis
Infection
Infections
Interferon
Laboratories
Lymphocytes
Lymphocytes T
Male
Medical research
Medicine
Molecular Sequence Data
Mutation - genetics
Peptides
Proteins
Regional development
T cells
Thailand
Trends
Vaccines
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Title A Novel Immunodominant CD8+ T Cell Response Restricted by a Common HLA-C Allele Targets a Conserved Region of Gag HIV-1 Clade CRF01_AE Infected Thais
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