Alpha-Adducin Gly460Trp Polymorphism and Hypertension Risk: A Meta-Analysis of 22 Studies Including 14303 Cases and 15961 Controls

• Published in: PloS one Vol. 5; no. 9; p. e13057
• Main Authors: Liu, Kuo, Liu, Jielin, Huang, Yan, Liu, Ya, Lou, Yuqing, Wang, Zuoguang, Zhang, Hong, Yan, Shan, Li, Zhizhong, Wen, Shaojun
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 28.09.2010; Public Library of Science (PLoS)
• Subjects: Adducin; Alleles; Asian Continental Ancestry Group - genetics; Biological effects; Blood Pressure; Calmodulin-Binding Proteins - genetics; Cardiovascular Disorders/Hypertension; Case-Control Studies; Environmental effects; Environmental factors; European Continental Ancestry Group - genetics; Gene polymorphism; Genes; Genetic aspects; Genetic engineering; Genetic polymorphisms; Genetic Predisposition to Disease; Genetics and Genomics/Genetics of Disease; Genetics and Genomics/Medical Genetics; Genotype & phenotype; Heart; Heterogeneity; Humans; Hypertension; Hypertension - genetics; Hypertension - physiopathology; Medical ethics; Medical research; Meta-analysis; Mutation, Missense; Polymorphism; Polymorphism, Genetic; Population; Risk analysis; Risk Factors; Sensitivity analysis; Statistical analysis; Studies; Beijing China; China
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0013057

No clear consensus has been reached on the alpha-adducin polymorphism (Gly460Trp) and essential hypertension risk. We performed a meta-analysis in an effort to systematically summarize the possible association. Studies were identified by searching MEDLINE and EMBASE databases complemented with perusal of bibliographies of retrieved articles and correspondence with original authors. The fixed-effects model and the random-effects model were applied for dichotomous outcomes to combine the results of the individual studies. We selected 22 studies that met the inclusion criteria including a total of 14303 hypertensive patients and 15961 normotensive controls. Overall, the 460Trp allele showed no statistically significant association with hypertension risk compared to Gly460 allele (P = 0.69, OR = 1.02, 95% CI 0.94-1.10, P(heterogeneity)<0.0001) in all subjects. Meta-analysis under other genetic contrasts still did not reveal any significant association in all subjects, Caucasians, East Asians and others. The results were similar but heterogeneity did not persist when sensitivity analyses were limited to these studies. Our meta-analysis failed to provide evidence for the genetic association of α-adducin gene Gly460Trp polymorphism with hypertension. Further studies investigating the effect of genetic networks, environmental factors, individual biological characteristics and their mutual interactions are needed to elucidate the possible mechanism for hypertension in humans.