Genome-Wide Association Study of Copy Number Variants Suggests LTBP1 and FGD4 Are Important for Alcohol Drinking

Alcohol dependence (AD) is a complex disorder characterized by psychiatric and physiological dependence on alcohol. AD is reflected by regular alcohol drinking, which is highly inheritable. In this study, to identify susceptibility genes associated with alcohol drinking, we performed a genome-wide a...

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Published inPloS one Vol. 7; no. 1; p. e30860
Main Authors Pei, Yu-Fang, Zhang, Lei, Yang, Tie-Lin, Han, Yingying, Hai, Rong, Ran, Shu, Tian, Qing, Shen, Hui, Li, Jian, Zhu, Xue-Zhen, Luo, Xingguang, Deng, Hong-Wen
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 25.01.2012
Public Library of Science (PLoS)
Subjects
Adult
Advertising executives
Alcohol
Alcohol Drinking - genetics
Alcohol use
Alcoholic beverages
Alcoholism
Alcohols
Asian Continental Ancestry Group - genetics
Biology
Cdc42 protein
Clustering
Copy number
Crohn's disease
Crohns disease
Dehydrogenases
Disease susceptibility
DNA Copy Number Variations - genetics
Drinking
Drinking (Alcoholic beverages)
Drinking behavior
Drug dependence
European Continental Ancestry Group - genetics
Female
Gene expression
Genes
Genetic aspects
Genome-wide association studies
Genome-Wide Association Study
Genomes
Genomics
Genotyping
Genotyping Techniques
Growth factors
Hormone replacement therapy
Humans
Laboratories
Latent TGF-beta Binding Proteins - genetics
Male
Medicine
Metabolism
Microfilament Proteins - genetics
Middle Aged
Physiological aspects
Polymorphism, Single Nucleotide - genetics
Protein transport
Psychopharmacology
Science
Studies
Transforming growth factor-b1
Trends
White people
γ-Aminobutyric acid A receptors
Louisiana
United States > US
China
Online AccessGet full text
ISSN1932-6203
1932-6203
DOI10.1371/journal.pone.0030860

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Abstract Alcohol dependence (AD) is a complex disorder characterized by psychiatric and physiological dependence on alcohol. AD is reflected by regular alcohol drinking, which is highly inheritable. In this study, to identify susceptibility genes associated with alcohol drinking, we performed a genome-wide association study of copy number variants (CNVs) in 2,286 Caucasian subjects with Affymetrix SNP6.0 genotyping array. We replicated our findings in 1,627 Chinese subjects with the same genotyping array. We identified two CNVs, CNV207 (combined p-value 1.91E-03) and CNV1836 (combined p-value 3.05E-03) that were associated with alcohol drinking. CNV207 and CNV1836 are located at the downstream of genes LTBP1 (870 kb) and FGD4 (400 kb), respectively. LTBP1, by interacting TGFB1, may down-regulate enzymes directly participating in alcohol metabolism. FGD4 plays a role in clustering and trafficking GABA(A) receptor and subsequently influence alcohol drinking through activating CDC42. Our results provide suggestive evidence that the newly identified CNV regions and relevant genes may contribute to the genetic mechanism of alcohol dependence.
AbstractList Alcohol dependence (AD) is a complex disorder characterized by psychiatric and physiological dependence on alcohol. AD is reflected by regular alcohol drinking, which is highly inheritable. In this study, to identify susceptibility genes associated with alcohol drinking, we performed a genome-wide association study of copy number variants (CNVs) in 2,286 Caucasian subjects with Affymetrix SNP6.0 genotyping array. We replicated our findings in 1,627 Chinese subjects with the same genotyping array. We identified two CNVs, CNV207 (combined p-value 1.91E-03) and CNV1836 (combined p-value 3.05E-03) that were associated with alcohol drinking. CNV207 and CNV1836 are located at the downstream of genes LTBP1 (870 kb) and FGD4 (400 kb), respectively. LTBP1, by interacting TGFB1, may down-regulate enzymes directly participating in alcohol metabolism. FGD4 plays a role in clustering and trafficking GABA(A) receptor and subsequently influence alcohol drinking through activating CDC42. Our results provide suggestive evidence that the newly identified CNV regions and relevant genes may contribute to the genetic mechanism of alcohol dependence.Alcohol dependence (AD) is a complex disorder characterized by psychiatric and physiological dependence on alcohol. AD is reflected by regular alcohol drinking, which is highly inheritable. In this study, to identify susceptibility genes associated with alcohol drinking, we performed a genome-wide association study of copy number variants (CNVs) in 2,286 Caucasian subjects with Affymetrix SNP6.0 genotyping array. We replicated our findings in 1,627 Chinese subjects with the same genotyping array. We identified two CNVs, CNV207 (combined p-value 1.91E-03) and CNV1836 (combined p-value 3.05E-03) that were associated with alcohol drinking. CNV207 and CNV1836 are located at the downstream of genes LTBP1 (870 kb) and FGD4 (400 kb), respectively. LTBP1, by interacting TGFB1, may down-regulate enzymes directly participating in alcohol metabolism. FGD4 plays a role in clustering and trafficking GABA(A) receptor and subsequently influence alcohol drinking through activating CDC42. Our results provide suggestive evidence that the newly identified CNV regions and relevant genes may contribute to the genetic mechanism of alcohol dependence.
Alcohol dependence (AD) is a complex disorder characterized by psychiatric and physiological dependence on alcohol. AD is reflected by regular alcohol drinking, which is highly inheritable. In this study, to identify susceptibility genes associated with alcohol drinking, we performed a genome-wide association study of copy number variants (CNVs) in 2,286 Caucasian subjects with Affymetrix SNP6.0 genotyping array. We replicated our findings in 1,627 Chinese subjects with the same genotyping array. We identified two CNVs, CNV207 (combined p-value 1.91E-03) and CNV1836 (combined p-value 3.05E-03) that were associated with alcohol drinking. CNV207 and CNV1836 are located at the downstream of genes LTBP1 (870 kb) and FGD4 (400 kb), respectively. LTBP1, by interacting TGFB1, may down-regulate enzymes directly participating in alcohol metabolism. FGD4 plays a role in clustering and trafficking GABA.sub.A receptor and subsequently influence alcohol drinking through activating CDC42. Our results provide suggestive evidence that the newly identified CNV regions and relevant genes may contribute to the genetic mechanism of alcohol dependence.
Alcohol dependence (AD) is a complex disorder characterized by psychiatric and physiological dependence on alcohol. AD is reflected by regular alcohol drinking, which is highly inheritable. In this study, to identify susceptibility genes associated with alcohol drinking, we performed a genome-wide association study of copy number variants (CNVs) in 2,286 Caucasian subjects with Affymetrix SNP6.0 genotyping array. We replicated our findings in 1,627 Chinese subjects with the same genotyping array. We identified two CNVs, CNV207 (combined p-value 1.91E-03) and CNV1836 (combined p-value 3.05E-03) that were associated with alcohol drinking. CNV207 and CNV1836 are located at the downstream of genes LTBP1 (870 kb) and FGD4 (400 kb), respectively. LTBP1, by interacting TGFB1, may down-regulate enzymes directly participating in alcohol metabolism. FGD4 plays a role in clustering and trafficking GABAA receptor and subsequently influence alcohol drinking through activating CDC42. Our results provide suggestive evidence that the newly identified CNV regions and relevant genes may contribute to the genetic mechanism of alcohol dependence.
Alcohol dependence (AD) is a complex disorder characterized by psychiatric and physiological dependence on alcohol. AD is reflected by regular alcohol drinking, which is highly inheritable. In this study, to identify susceptibility genes associated with alcohol drinking, we performed a genome-wide association study of copy number variants (CNVs) in 2,286 Caucasian subjects with Affymetrix SNP6.0 genotyping array. We replicated our findings in 1,627 Chinese subjects with the same genotyping array. We identified two CNVs, CNV207 (combined p-value 1.91E-03) and CNV1836 (combined p-value 3.05E-03) that were associated with alcohol drinking. CNV207 and CNV1836 are located at the downstream of genes LTBP1 (870 kb) and FGD4 (400 kb), respectively. LTBP1, by interacting TGFB1, may down-regulate enzymes directly participating in alcohol metabolism. FGD4 plays a role in clustering and trafficking GABA(A) receptor and subsequently influence alcohol drinking through activating CDC42. Our results provide suggestive evidence that the newly identified CNV regions and relevant genes may contribute to the genetic mechanism of alcohol dependence.
Audience Academic
Author Han, Yingying
Ran, Shu
Deng, Hong-Wen
Hai, Rong
Luo, Xingguang
Shen, Hui
Zhu, Xue-Zhen
Yang, Tie-Lin
Zhang, Lei
Pei, Yu-Fang
Li, Jian
Tian, Qing
AuthorAffiliation 1 Center of System Biomedical Sciences, University of Shanghai for Science and Technology, Shanghai, People's Republic of China
FuWai Hospital, Chinese Academy of Medical Sciences, China
2 School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, People's Republic of China
3 The Affiliated Hospital of Inner Mongolia Medical College Huhhot, Inner Mongolia, People's Republic of China
4 Department of Biostatistics, Tulane University, New Orleans, Louisiana, United States of America
6 Laboratory of Molecular and Statistical Genetics and Key Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education, College of Life Sciences, Hunan Normal University, Changsha, People's Republic of China
5 Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, United States of America
AuthorAffiliation_xml – name: 5 Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, United States of America
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/22295116$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1121/1.2839140
10.1080/07853890310001276
10.1038/ng.237
10.1038/sj.mp.4001811
10.1158/0008-5472.CAN-07-2144
10.1038/nature07953
10.1038/ng.345
10.1038/ng.162
10.1126/science.1138659
10.1126/science.1101160
10.1371/journal.pgen.0020020
10.1002/gepi.1370170722
10.1001/jama.1992.03490140085040
10.1038/ng.350
10.1086/383283
10.1111/j.1530-0277.1998.tb05913.x
10.1111/j.1572-0241.2004.40304.x
10.1007/s002130050685
10.1016/j.biopsych.2009.05.018
10.1111/j.1530-0277.2002.tb02443.x
10.1001/archpsyc.1997.01830140090015
10.1038/nrg1767
10.1016/S0140-6736(04)17104-3
10.1038/ng1847
10.1086/506371
10.1086/504113
10.1016/j.tcb.2006.08.006
10.1016/j.jhep.2009.12.003
10.1126/science.1155174
10.1126/science.1136678
10.1016/S0166-2236(00)01627-1
10.1038/ng1696
10.1097/01.ALC.0000134221.32773.69
10.1038/ng1754
10.1073/pnas.1017288108
10.1016/S0376-8716(01)00156-9
10.1093/hmg/ddl426
10.1101/gr.3677206
10.1016/j.biopsych.2011.02.028
10.1038/nature05329
10.1186/1471-2156-6-S1-S128
10.1093/hmg/ddl057
10.1371/journal.pgen.0010049
10.1176/ajp.156.1.34
10.1038/nature07239
10.1091/mbc.11.12.4295
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2012 Pei et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
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DocumentTitleAlternate CNV-Based GWAS for Alcohol Drinking
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Conceived and designed the experiments: Y-FP H-WD. Performed the experiments: LZ T-LY YYH RH SR HS X-ZZ. Analyzed the data: Y-FP QT JL. Contributed reagents/materials/analysis tools: XL. Wrote the paper: Y-FP.
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References R Redon (ref19) 2006; 444
JR Lupski (ref26) 2005; 1
KS Kendler (ref3) 1997; 54
S Repping (ref23) 2006; 38
BE Stranger (ref44) 2007; 315
A Gualandris (ref38) 2000; 11
CN Henrichsen (ref48) 2009; 41
AJ Ridley (ref42) 2006; 16
JL Freeman (ref25) 2006; 16
X Luo (ref15) 2006; 78
P Ibanez (ref29) 2004; 364
DQ Nguyen (ref22) 2006; 2
X Zhu (ref12) 2005; 6
JT Glessner (ref30) 2009; 459
G Schumann (ref6) 0; 108
JB Whitfield (ref8) 2004; 28
PR Buckland (ref20) 2003; 35
J Sebat (ref16) 2007; 316
M Kneussel (ref41) 2000; 23
E Gonzalez (ref31) 2005; 307
HJ Edenberg (ref13) 2004; 74
T Foroud (ref11) 1998; 22
J Gelernter (ref14) 2006; 15
CA Prescott (ref1) 2006; 11
KS Kendler (ref2) 1992; 268
SL Liu (ref46); 6
B Xu (ref17) 2008; 40
JD Grant (ref7) 2009; 66
IS Consortium (ref28) 2008; 455
(ref34) 2010
BS Saltzman (ref39) 2008; 68
KA Fisher (ref36) 2008; 123
M Economou (ref49) 2004; 99
T Walsh (ref27) 2008; 320
S D'Alfonso (ref9) 1999; 17
L Zuo (ref37)
L Feuk (ref24) 2006; 15 Spec No 1
AC Heath (ref5); 70
A Berney (ref32) 2002; 65
L Feuk (ref18) 2006; 7
CA Prescott (ref4) 1999; 156
P Cahan (ref47) 2009; 41
AC Grobin (ref43) 1998; 139
AL Price (ref35) 2006; 38
JM Korn (ref33) 2008; 40
G Merla (ref45) 2006; 79
DM Dick (ref10) 2002; 26
L Ciuclan (ref40); 52
SA McCarroll (ref21) 2006; 38
15637236 - Science. 2005 Mar 4;307(5714):1434-40
9040286 - Arch Gen Psychiatry. 1997 Feb;54(2):178-84
18511947 - Nat Genet. 2008 Jul;40(7):880-5
16809666 - Genome Res. 2006 Aug;16(8):949-61
9892295 - Am J Psychiatry. 1999 Jan;156(1):34-40
21789208 - PLoS One. 2011;6(7):e22035
12394277 - Alcohol Clin Exp Res. 2002 Oct;26(10):1453-60
16651370 - Hum Mol Genet. 2006 Apr 15;15 Spec No 1:R57-66
9768538 - Psychopharmacology (Berl). 1998 Sep;139(1-2):2-19
11102524 - Mol Biol Cell. 2000 Dec;11(12):4295-308
20129692 - J Hepatol. 2010 Mar;52(3):407-16
9884148 - Alcohol Clin Exp Res. 1998 Dec;22(9):2035-42
16468122 - Nat Genet. 2006 Jan;38(1):86-92
17085484 - Hum Mol Genet. 2006 Dec 15;15(24):3498-507
16949823 - Trends Cell Biol. 2006 Oct;16(10):522-9
18369103 - Science. 2008 Apr 25;320(5875):539-43
16534506 - Mol Psychiatry. 2006 Jun;11(6):603-11
19576574 - Biol Psychiatry. 2009 Oct 15;66(8):795-800
16685648 - Am J Hum Genet. 2006 Jun;78(6):973-87
11772476 - Drug Alcohol Depend. 2002 Jan 1;65(2):149-58
15451225 - Lancet. 2004 Sep 25-Oct 1;364(9440):1169-71
16501575 - Nat Genet. 2006 Apr;38(4):463-7
16451586 - BMC Genet. 2005;6 Suppl 1:S128
15024690 - Am J Hum Genet. 2004 Apr;74(4):705-14
18668038 - Nature. 2008 Sep 11;455(7210):237-41
21471458 - Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):7119-24
19270705 - Nat Genet. 2009 Apr;41(4):424-9
12952017 - Ann Med. 2003;35(5):308-15
19404257 - Nature. 2009 May 28;459(7246):569-73
17363630 - Science. 2007 Apr 20;316(5823):445-9
10941193 - Trends Neurosci. 2000 Sep;23(9):429-35
16482228 - PLoS Genet. 2006 Feb;2(2):e20
16444292 - PLoS Genet. 2005 Dec;1(6):e49
18281501 - Cancer Res. 2008 Feb 15;68(4):1236-44
18776909 - Nat Genet. 2008 Oct;40(10):1253-60
16862161 - Nat Genet. 2006 Aug;38(8):904-9
19270704 - Nat Genet. 2009 Apr;41(4):430-7
17122850 - Nature. 2006 Nov 23;444(7118):444-54
15571588 - Am J Gastroenterol. 2004 Dec;99(12):2393-404
16418744 - Nat Rev Genet. 2006 Feb;7(2):85-97
17289997 - Science. 2007 Feb 9;315(5813):848-53
21529783 - Biol Psychiatry. 2011 Sep 15;70(6):513-8
15318113 - Alcohol Clin Exp Res. 2004 Aug;28(8):1153-60
21956439 - Neuropsychopharmacology. 2012 Jan;37(2):557-66
16826523 - Am J Hum Genet. 2006 Aug;79(2):332-41
18396995 - J Acoust Soc Am. 2008 Apr;123(4):1862-5
1404711 - JAMA. 1992 Oct 14;268(14):1877-82
10597424 - Genet Epidemiol. 1999;17 Suppl 1:S127-31
References_xml – volume: 123
  start-page: 1862
  year: 2008
  ident: ref36
  article-title: Modeling the acoustic radiation force in microfluidic chambers.
  publication-title: J Acoust Soc Am
  doi: 10.1121/1.2839140
– volume: 35
  start-page: 308
  year: 2003
  ident: ref20
  article-title: Polymorphically duplicated genes: their relevance to phenotypic variation in humans.
  publication-title: Ann Med
  doi: 10.1080/07853890310001276
– volume: 40
  start-page: 1253
  year: 2008
  ident: ref33
  article-title: Integrated genotype calling and association analysis of SNPs, common copy number polymorphisms and rare CNVs.
  publication-title: Nat Genet
  doi: 10.1038/ng.237
– volume: 11
  start-page: 603
  year: 2006
  ident: ref1
  article-title: Genomewide linkage study in the Irish affected sib pair study of alcohol dependence: evidence for a susceptibility region for symptoms of alcohol dependence on chromosome 4.
  publication-title: Mol Psychiatry
  doi: 10.1038/sj.mp.4001811
– volume: 68
  start-page: 1236
  year: 2008
  ident: ref39
  article-title: Association of genetic variation in the transforming growth factor beta-1 gene with serum levels and risk of colorectal neoplasia.
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-07-2144
– volume: 459
  start-page: 569
  year: 2009
  ident: ref30
  article-title: Autism genome-wide copy number variation reveals ubiquitin and neuronal genes.
  publication-title: Nature
  doi: 10.1038/nature07953
– volume: 41
  start-page: 424
  year: 2009
  ident: ref48
  article-title: Segmental copy number variation shapes tissue transcriptomes.
  publication-title: Nat Genet
  doi: 10.1038/ng.345
– volume: 40
  start-page: 880
  year: 2008
  ident: ref17
  article-title: Strong association of de novo copy number mutations with sporadic schizophrenia.
  publication-title: Nat Genet
  doi: 10.1038/ng.162
– volume: 316
  start-page: 445
  year: 2007
  ident: ref16
  article-title: Strong association of de novo copy number mutations with autism.
  publication-title: Science
  doi: 10.1126/science.1138659
– volume: 307
  start-page: 1434
  year: 2005
  ident: ref31
  article-title: The influence of CCL3L1 gene-containing segmental duplications on HIV-1/AIDS susceptibility.
  publication-title: Science
  doi: 10.1126/science.1101160
– volume: 2
  start-page: e20
  year: 2006
  ident: ref22
  article-title: Bias of selection on human copy-number variants.
  publication-title: PLoS Genet
  doi: 10.1371/journal.pgen.0020020
– volume: 6
  start-page: e22035
  ident: ref46
  article-title: Copy Number Variation in CNP267 Region May Be Associated with Hip Bone Size.
  publication-title: PLoS One
– volume: 17
  start-page: S127
  year: 1999
  ident: ref9
  article-title: Nonparametric linkage analysis of alcohol dependence with chromosome 1 and 7 markers.
  publication-title: Genet Epidemiol
  doi: 10.1002/gepi.1370170722
– volume: 268
  start-page: 1877
  year: 1992
  ident: ref2
  article-title: A population-based twin study of alcoholism in women.
  publication-title: Jama
  doi: 10.1001/jama.1992.03490140085040
– volume: 41
  start-page: 430
  year: 2009
  ident: ref47
  article-title: The impact of copy number variation on local gene expression in mouse hematopoietic stem and progenitor cells.
  publication-title: Nat Genet
  doi: 10.1038/ng.350
– volume: 74
  start-page: 705
  year: 2004
  ident: ref13
  article-title: Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations.
  publication-title: Am J Hum Genet
  doi: 10.1086/383283
– volume: 22
  start-page: 2035
  year: 1998
  ident: ref11
  article-title: Linkage of an alcoholism-related severity phenotype to chromosome 16.
  publication-title: Alcohol Clin Exp Res
  doi: 10.1111/j.1530-0277.1998.tb05913.x
– ident: ref37
  article-title: Genome-Wide Association Study of Alcohol Dependence Implicates KIAA0040 on Chromosome 1q.
  publication-title: Neuropsychopharmacology
– volume: 99
  start-page: 2393
  year: 2004
  ident: ref49
  article-title: Differential effects of NOD2 variants on Crohn's disease risk and phenotype in diverse populations: a metaanalysis.
  publication-title: Am J Gastroenterol
  doi: 10.1111/j.1572-0241.2004.40304.x
– volume: 139
  start-page: 2
  year: 1998
  ident: ref43
  article-title: The role of GABA(A) receptors in the acute and chronic effects of ethanol.
  publication-title: Psychopharmacology (Berl)
  doi: 10.1007/s002130050685
– volume: 66
  start-page: 795
  year: 2009
  ident: ref7
  article-title: Alcohol consumption indices of genetic risk for alcohol dependence.
  publication-title: Biol Psychiatry
  doi: 10.1016/j.biopsych.2009.05.018
– volume: 26
  start-page: 1453
  year: 2002
  ident: ref10
  article-title: Suggestive linkage on chromosome 1 for a quantitative alcohol-related phenotype.
  publication-title: Alcohol Clin Exp Res
  doi: 10.1111/j.1530-0277.2002.tb02443.x
– volume: 54
  start-page: 178
  year: 1997
  ident: ref3
  article-title: Temperance board registration for alcohol abuse in a national sample of Swedish male twins, born 1902 to 1949.
  publication-title: Arch Gen Psychiatry
  doi: 10.1001/archpsyc.1997.01830140090015
– volume: 7
  start-page: 85
  year: 2006
  ident: ref18
  article-title: Structural variation in the human genome.
  publication-title: Nat Rev Genet
  doi: 10.1038/nrg1767
– volume: 364
  start-page: 1169
  year: 2004
  ident: ref29
  article-title: Causal relation between alpha-synuclein gene duplication and familial Parkinson's disease.
  publication-title: Lancet
  doi: 10.1016/S0140-6736(04)17104-3
– volume: 38
  start-page: 904
  year: 2006
  ident: ref35
  article-title: Principal components analysis corrects for stratification in genome-wide association studies.
  publication-title: Nat Genet
  doi: 10.1038/ng1847
– volume: 79
  start-page: 332
  year: 2006
  ident: ref45
  article-title: Submicroscopic deletion in patients with Williams-Beuren syndrome influences expression levels of the nonhemizygous flanking genes.
  publication-title: Am J Hum Genet
  doi: 10.1086/506371
– volume: 78
  start-page: 973
  year: 2006
  ident: ref15
  article-title: Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependence.
  publication-title: Am J Hum Genet
  doi: 10.1086/504113
– volume: 16
  start-page: 522
  year: 2006
  ident: ref42
  article-title: Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking.
  publication-title: Trends Cell Biol
  doi: 10.1016/j.tcb.2006.08.006
– volume: 52
  start-page: 407
  ident: ref40
  article-title: TGF-beta enhances alcohol dependent hepatocyte damage via down-regulation of alcohol dehydrogenase I.
  publication-title: J Hepatol
  doi: 10.1016/j.jhep.2009.12.003
– volume: 320
  start-page: 539
  year: 2008
  ident: ref27
  article-title: Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophrenia.
  publication-title: Science
  doi: 10.1126/science.1155174
– volume: 315
  start-page: 848
  year: 2007
  ident: ref44
  article-title: Relative impact of nucleotide and copy number variation on gene expression phenotypes.
  publication-title: Science
  doi: 10.1126/science.1136678
– volume: 23
  start-page: 429
  year: 2000
  ident: ref41
  article-title: Clustering of inhibitory neurotransmitter receptors at developing postsynaptic sites: the membrane activation model.
  publication-title: Trends Neurosci
  doi: 10.1016/S0166-2236(00)01627-1
– volume: 38
  start-page: 86
  year: 2006
  ident: ref21
  article-title: Common deletion polymorphisms in the human genome.
  publication-title: Nat Genet
  doi: 10.1038/ng1696
– volume: 28
  start-page: 1153
  year: 2004
  ident: ref8
  article-title: The genetics of alcohol intake and of alcohol dependence.
  publication-title: Alcohol Clin Exp Res
  doi: 10.1097/01.ALC.0000134221.32773.69
– volume: 38
  start-page: 463
  year: 2006
  ident: ref23
  article-title: High mutation rates have driven extensive structural polymorphism among human Y chromosomes.
  publication-title: Nat Genet
  doi: 10.1038/ng1754
– volume: 108
  start-page: 7119
  year: 0
  ident: ref6
  article-title: Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption.
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1017288108
– volume: 65
  start-page: 149
  year: 2002
  ident: ref32
  article-title: Diagnostic interview for genetic studies (DIGS): inter-rater and test-retest reliability of alcohol and drug diagnoses.
  publication-title: Drug Alcohol Depend
  doi: 10.1016/S0376-8716(01)00156-9
– volume: 15
  start-page: 3498
  year: 2006
  ident: ref14
  article-title: Haplotype spanning TTC12 and ANKK1, flanked by the DRD2 and NCAM1 loci, is strongly associated to nicotine dependence in two distinct American populations.
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/ddl426
– volume: 16
  start-page: 949
  year: 2006
  ident: ref25
  article-title: Copy number variation: new insights in genome diversity.
  publication-title: Genome Res
  doi: 10.1101/gr.3677206
– volume: 70
  start-page: 513
  ident: ref5
  article-title: A quantitative-trait genome-wide association study of alcoholism risk in the community: findings and implications.
  publication-title: Biol Psychiatry
  doi: 10.1016/j.biopsych.2011.02.028
– volume: 444
  start-page: 444
  year: 2006
  ident: ref19
  article-title: Global variation in copy number in the human genome.
  publication-title: Nature
  doi: 10.1038/nature05329
– volume: 6
  start-page: S128
  year: 2005
  ident: ref12
  article-title: A genome-wide linkage and association study using COGA data.
  publication-title: BMC Genet
  doi: 10.1186/1471-2156-6-S1-S128
– year: 2010
  ident: ref34
  article-title: R: A language and environment for statistical computing.
– volume: 15 Spec No 1
  start-page: R57
  year: 2006
  ident: ref24
  article-title: Structural variants: changing the landscape of chromosomes and design of disease studies.
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/ddl057
– volume: 1
  start-page: e49
  year: 2005
  ident: ref26
  article-title: Genomic disorders: molecular mechanisms for rearrangements and conveyed phenotypes.
  publication-title: PLoS Genet
  doi: 10.1371/journal.pgen.0010049
– volume: 156
  start-page: 34
  year: 1999
  ident: ref4
  article-title: Genetic and environmental contributions to alcohol abuse and dependence in a population-based sample of male twins.
  publication-title: Am J Psychiatry
  doi: 10.1176/ajp.156.1.34
– volume: 455
  start-page: 237
  year: 2008
  ident: ref28
  article-title: Rare chromosomal deletions and duplications increase risk of schizophrenia.
  publication-title: Nature
  doi: 10.1038/nature07239
– volume: 11
  start-page: 4295
  year: 2000
  ident: ref38
  article-title: The latent transforming growth factor-beta-binding protein-1 promotes in vitro differentiation of embryonic stem cells into endothelium.
  publication-title: Mol Biol Cell
  doi: 10.1091/mbc.11.12.4295
– reference: 18369103 - Science. 2008 Apr 25;320(5875):539-43
– reference: 17363630 - Science. 2007 Apr 20;316(5823):445-9
– reference: 9884148 - Alcohol Clin Exp Res. 1998 Dec;22(9):2035-42
– reference: 18668038 - Nature. 2008 Sep 11;455(7210):237-41
– reference: 16468122 - Nat Genet. 2006 Jan;38(1):86-92
– reference: 16418744 - Nat Rev Genet. 2006 Feb;7(2):85-97
– reference: 17085484 - Hum Mol Genet. 2006 Dec 15;15(24):3498-507
– reference: 19404257 - Nature. 2009 May 28;459(7246):569-73
– reference: 21529783 - Biol Psychiatry. 2011 Sep 15;70(6):513-8
– reference: 16482228 - PLoS Genet. 2006 Feb;2(2):e20
– reference: 15318113 - Alcohol Clin Exp Res. 2004 Aug;28(8):1153-60
– reference: 10941193 - Trends Neurosci. 2000 Sep;23(9):429-35
– reference: 16444292 - PLoS Genet. 2005 Dec;1(6):e49
– reference: 19270704 - Nat Genet. 2009 Apr;41(4):430-7
– reference: 16826523 - Am J Hum Genet. 2006 Aug;79(2):332-41
– reference: 12394277 - Alcohol Clin Exp Res. 2002 Oct;26(10):1453-60
– reference: 16809666 - Genome Res. 2006 Aug;16(8):949-61
– reference: 9768538 - Psychopharmacology (Berl). 1998 Sep;139(1-2):2-19
– reference: 21471458 - Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):7119-24
– reference: 21956439 - Neuropsychopharmacology. 2012 Jan;37(2):557-66
– reference: 21789208 - PLoS One. 2011;6(7):e22035
– reference: 11772476 - Drug Alcohol Depend. 2002 Jan 1;65(2):149-58
– reference: 19576574 - Biol Psychiatry. 2009 Oct 15;66(8):795-800
– reference: 15571588 - Am J Gastroenterol. 2004 Dec;99(12):2393-404
– reference: 16501575 - Nat Genet. 2006 Apr;38(4):463-7
– reference: 19270705 - Nat Genet. 2009 Apr;41(4):424-9
– reference: 16685648 - Am J Hum Genet. 2006 Jun;78(6):973-87
– reference: 17289997 - Science. 2007 Feb 9;315(5813):848-53
– reference: 18511947 - Nat Genet. 2008 Jul;40(7):880-5
– reference: 1404711 - JAMA. 1992 Oct 14;268(14):1877-82
– reference: 16949823 - Trends Cell Biol. 2006 Oct;16(10):522-9
– reference: 16451586 - BMC Genet. 2005;6 Suppl 1:S128
– reference: 18776909 - Nat Genet. 2008 Oct;40(10):1253-60
– reference: 15637236 - Science. 2005 Mar 4;307(5714):1434-40
– reference: 15451225 - Lancet. 2004 Sep 25-Oct 1;364(9440):1169-71
– reference: 16651370 - Hum Mol Genet. 2006 Apr 15;15 Spec No 1:R57-66
– reference: 9040286 - Arch Gen Psychiatry. 1997 Feb;54(2):178-84
– reference: 15024690 - Am J Hum Genet. 2004 Apr;74(4):705-14
– reference: 10597424 - Genet Epidemiol. 1999;17 Suppl 1:S127-31
– reference: 18281501 - Cancer Res. 2008 Feb 15;68(4):1236-44
– reference: 17122850 - Nature. 2006 Nov 23;444(7118):444-54
– reference: 11102524 - Mol Biol Cell. 2000 Dec;11(12):4295-308
– reference: 16862161 - Nat Genet. 2006 Aug;38(8):904-9
– reference: 16534506 - Mol Psychiatry. 2006 Jun;11(6):603-11
– reference: 12952017 - Ann Med. 2003;35(5):308-15
– reference: 18396995 - J Acoust Soc Am. 2008 Apr;123(4):1862-5
– reference: 20129692 - J Hepatol. 2010 Mar;52(3):407-16
– reference: 9892295 - Am J Psychiatry. 1999 Jan;156(1):34-40
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Snippet Alcohol dependence (AD) is a complex disorder characterized by psychiatric and physiological dependence on alcohol. AD is reflected by regular alcohol...
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doaj
pubmedcentral
proquest
gale
pubmed
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SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
StartPage e30860
SubjectTerms Adult
Advertising executives
Alcohol
Alcohol Drinking - genetics
Alcohol use
Alcoholic beverages
Alcoholism
Alcohols
Asian Continental Ancestry Group - genetics
Biology
Cdc42 protein
Clustering
Copy number
Crohn's disease
Crohns disease
Dehydrogenases
Disease susceptibility
DNA Copy Number Variations - genetics
Drinking
Drinking (Alcoholic beverages)
Drinking behavior
Drug dependence
European Continental Ancestry Group - genetics
Female
Gene expression
Genes
Genetic aspects
Genome-wide association studies
Genome-Wide Association Study
Genomes
Genomics
Genotyping
Genotyping Techniques
Growth factors
Hormone replacement therapy
Humans
Laboratories
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Title Genome-Wide Association Study of Copy Number Variants Suggests LTBP1 and FGD4 Are Important for Alcohol Drinking
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