Influence of molecular weight of chemically sulfated citrus pectin fractions on their antithrombotic and bleeding effects - Cipriani, Thales R; Gracher, Ana Helena P; de Souza, Lauro M; Fonseca, Roberto J C; Belmiro, Celso L R; Gorin, Philip A J; Sassaki, Guilherme L; Iacomini, Marcello (Thrombosis and haemostasis, 2009)
Keywords: Animals; Anticoagulants - chemistry; Anticoagulants - isolation & purification; Anticoagulants - pharmacology; Anticoagulants - toxicity; Blood Coagulation - drug effects; Citrus sinensis - chemistry; Disease Models, Animal; Dose-Response Relationship, Drug; Factor Xa Inhibitors; Female; Fibrinolytic Agents - chemistry; Fibrinolytic Agents - isolation & purification; Fibrinolytic Agents - pharmacology; Fibrinolytic Agents - toxicity; Hemorrhage - chemically induced; Humans; Male; Molecular Weight; Pectins - chemistry; Pectins - isolation & purification; Pectins - pharmacology; Pectins - toxicity; Platelet Aggregation - drug effects; Rats; Rats, Wistar; Structure-Activity Relationship; Sulfates - chemistry; Sulfates - isolation & purification; Sulfates - pharmacology; Sulfates - toxicity; Thrombin - antagonists & inhibitors; Venous Thrombosis - blood; Venous Thrombosis - prevention & control