Roles of Insulin Receptor Substrates (IRS) in renal function and renal hemodynamics
We have reported previously that renal hemodynamic abnormalities exist in the prediabetic stage of type II diabetic rats. At this prediabetic stage these rats have hyperinsulinemia, insulin resistance and metabolic syndrome. It is well known that insulin resistance is frequently associated with rena...
Saved in:
| Published in | PLOS ONE Vol. 15; no. 12; p. e0242332 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Public Library of Science (PLoS)
03.12.2020
Public Library of Science |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1932-6203 1932-6203 |
| DOI | 10.1371/journal.pone.0242332 |
Cover
| Abstract | We have reported previously that renal hemodynamic abnormalities exist in the prediabetic stage of type II diabetic rats. At this prediabetic stage these rats have hyperinsulinemia, insulin resistance and metabolic syndrome. It is well known that insulin resistance is frequently associated with renal abnormalities, but the mechanism underlying this association has remained speculative. Although insulin is known to modify renal hemodynamics, little is known about the roles of insulin receptor substrates (IRS1, IRS2) in the renal actions of insulin. To address this issue, the effects of insulin on renal function and renal hemodynamics were investigated in C57BL/6 (WT: wild type), insulin receptor substrate 1- knockout (
IRS1–/–
), and IRS2-knockout (
IRS2–/–
) mice. IRS2–/–mice had elevated glucose level as expected. 24-h urine collections and serum creatinine revealed that creatinine clearance did not significantly differ between these groups. Albuminuria was found in
IRS1–/–
and
IRS2–/–
groups. We examined the effects on the IRS during the administration of Losartan, which is widely used for diabetic nephropathy. After the administration of Losartan the IRS displayed improved renal hemodynamics. Moreover, the subjects were also given Pioglitazone, which improves insulin resistance. Losartan significantly reduced albuminuria in both groups. Pioglitazone also showed similar results. We assessed the autoregulatory responses of the total renal blood flow (RBF), the superficial (SBF) and the deep renal cortical blood flow (DBF) with stepwise reductions of renal perfusion pressure (RPP), which was induced by a manual clamp on the abdominal aorta. During the clamp induced reductions of the RPP by 10 to 20mm HG, RBF, SBF and the DBF fell significantly more in the IRS1 and IRS2 than in the WT mice. Furthermore micropuncture studies showded that compared to the WT tubuloglomerular feedback (TGF) responses of the stop flow pressure (P
sf
) were reduced in both the
IRS1 -/-
and
IRS2 -/-
. The results of the IRS1 and IRS2 mice displayed the pressence of hemodynamic abnormalities. Losartan and Pioglitazone have shown the potential to improve these abnormalities. In conclusion the results indicate that IRS plays a major role in the stimulation of renal functions and renal hemodynamics in type type II diabetes. |
|---|---|
| AbstractList | We have reported previously that renal hemodynamic abnormalities exist in the prediabetic stage of type II diabetic rats. At this prediabetic stage these rats have hyperinsulinemia, insulin resistance and metabolic syndrome. It is well known that insulin resistance is frequently associated with renal abnormalities, but the mechanism underlying this association has remained speculative. Although insulin is known to modify renal hemodynamics, little is known about the roles of insulin receptor substrates (IRS1, IRS2) in the renal actions of insulin. To address this issue, the effects of insulin on renal function and renal hemodynamics were investigated in C57BL/6 (WT: wild type), insulin receptor substrate 1- knockout (IRS1-/-), and IRS2-knockout (IRS2-/-) mice. IRS2-/-mice had elevated glucose level as expected. 24-h urine collections and serum creatinine revealed that creatinine clearance did not significantly differ between these groups. Albuminuria was found in IRS1-/-and IRS2-/-groups. We examined the effects on the IRS during the administration of Losartan, which is widely used for diabetic nephropathy. After the administration of Losartan the IRS displayed improved renal hemodynamics. Moreover, the subjects were also given Pioglitazone, which improves insulin resistance. Losartan significantly reduced albuminuria in both groups. Pioglitazone also showed similar results. We assessed the autoregulatory responses of the total renal blood flow (RBF), the superficial (SBF) and the deep renal cortical blood flow (DBF) with stepwise reductions of renal perfusion pressure (RPP), which was induced by a manual clamp on the abdominal aorta. During the clamp induced reductions of the RPP by 10 to 20mm HG, RBF, SBF and the DBF fell significantly more in the IRS1 and IRS2 than in the WT mice. Furthermore micropuncture studies showded that compared to the WT tubuloglomerular feedback (TGF) responses of the stop flow pressure (Psf) were reduced in both the IRS1 -/- and IRS2 -/-. The results of the IRS1 and IRS2 mice displayed the pressence of hemodynamic abnormalities. Losartan and Pioglitazone have shown the potential to improve these abnormalities. In conclusion the results indicate that IRS plays a major role in the stimulation of renal functions and renal hemodynamics in type type II diabetes. We have reported previously that renal hemodynamic abnormalities exist in the prediabetic stage of type II diabetic rats. At this prediabetic stage these rats have hyperinsulinemia, insulin resistance and metabolic syndrome. It is well known that insulin resistance is frequently associated with renal abnormalities, but the mechanism underlying this association has remained speculative. Although insulin is known to modify renal hemodynamics, little is known about the roles of insulin receptor substrates (IRS1, IRS2) in the renal actions of insulin. To address this issue, the effects of insulin on renal function and renal hemodynamics were investigated in C57BL/6 (WT: wild type), insulin receptor substrate 1- knockout (IRS1-/-), and IRS2-knockout (IRS2-/-) mice. IRS2-/-mice had elevated glucose level as expected. 24-h urine collections and serum creatinine revealed that creatinine clearance did not significantly differ between these groups. Albuminuria was found in IRS1-/-and IRS2-/-groups. We examined the effects on the IRS during the administration of Losartan, which is widely used for diabetic nephropathy. After the administration of Losartan the IRS displayed improved renal hemodynamics. Moreover, the subjects were also given Pioglitazone, which improves insulin resistance. Losartan significantly reduced albuminuria in both groups. Pioglitazone also showed similar results. We assessed the autoregulatory responses of the total renal blood flow (RBF), the superficial (SBF) and the deep renal cortical blood flow (DBF) with stepwise reductions of renal perfusion pressure (RPP), which was induced by a manual clamp on the abdominal aorta. During the clamp induced reductions of the RPP by 10 to 20mm HG, RBF, SBF and the DBF fell significantly more in the IRS1 and IRS2 than in the WT mice. Furthermore micropuncture studies showded that compared to the WT tubuloglomerular feedback (TGF) responses of the stop flow pressure (P.sub.sf) were reduced in both the IRS1 -/- and IRS2 -/-. The results of the IRS1 and IRS2 mice displayed the pressence of hemodynamic abnormalities. Losartan and Pioglitazone have shown the potential to improve these abnormalities. In conclusion the results indicate that IRS plays a major role in the stimulation of renal functions and renal hemodynamics in type type II diabetes. We have reported previously that renal hemodynamic abnormalities exist in the prediabetic stage of type II diabetic rats. At this prediabetic stage these rats have hyperinsulinemia, insulin resistance and metabolic syndrome. It is well known that insulin resistance is frequently associated with renal abnormalities, but the mechanism underlying this association has remained speculative. Although insulin is known to modify renal hemodynamics, little is known about the roles of insulin receptor substrates (IRS1, IRS2) in the renal actions of insulin. To address this issue, the effects of insulin on renal function and renal hemodynamics were investigated in C57BL/6 (WT: wild type), insulin receptor substrate 1- knockout (IRS1-/-), and IRS2-knockout (IRS2-/-) mice. IRS2-/-mice had elevated glucose level as expected. 24-h urine collections and serum creatinine revealed that creatinine clearance did not significantly differ between these groups. Albuminuria was found in IRS1-/-and IRS2-/-groups. We examined the effects on the IRS during the administration of Losartan, which is widely used for diabetic nephropathy. After the administration of Losartan the IRS displayed improved renal hemodynamics. Moreover, the subjects were also given Pioglitazone, which improves insulin resistance. Losartan significantly reduced albuminuria in both groups. Pioglitazone also showed similar results. We assessed the autoregulatory responses of the total renal blood flow (RBF), the superficial (SBF) and the deep renal cortical blood flow (DBF) with stepwise reductions of renal perfusion pressure (RPP), which was induced by a manual clamp on the abdominal aorta. During the clamp induced reductions of the RPP by 10 to 20mm HG, RBF, SBF and the DBF fell significantly more in the IRS1 and IRS2 than in the WT mice. Furthermore micropuncture studies showded that compared to the WT tubuloglomerular feedback (TGF) responses of the stop flow pressure (Psf) were reduced in both the IRS1 -/- and IRS2 -/-. The results of the IRS1 and IRS2 mice displayed the pressence of hemodynamic abnormalities. Losartan and Pioglitazone have shown the potential to improve these abnormalities. In conclusion the results indicate that IRS plays a major role in the stimulation of renal functions and renal hemodynamics in type type II diabetes.We have reported previously that renal hemodynamic abnormalities exist in the prediabetic stage of type II diabetic rats. At this prediabetic stage these rats have hyperinsulinemia, insulin resistance and metabolic syndrome. It is well known that insulin resistance is frequently associated with renal abnormalities, but the mechanism underlying this association has remained speculative. Although insulin is known to modify renal hemodynamics, little is known about the roles of insulin receptor substrates (IRS1, IRS2) in the renal actions of insulin. To address this issue, the effects of insulin on renal function and renal hemodynamics were investigated in C57BL/6 (WT: wild type), insulin receptor substrate 1- knockout (IRS1-/-), and IRS2-knockout (IRS2-/-) mice. IRS2-/-mice had elevated glucose level as expected. 24-h urine collections and serum creatinine revealed that creatinine clearance did not significantly differ between these groups. Albuminuria was found in IRS1-/-and IRS2-/-groups. We examined the effects on the IRS during the administration of Losartan, which is widely used for diabetic nephropathy. After the administration of Losartan the IRS displayed improved renal hemodynamics. Moreover, the subjects were also given Pioglitazone, which improves insulin resistance. Losartan significantly reduced albuminuria in both groups. Pioglitazone also showed similar results. We assessed the autoregulatory responses of the total renal blood flow (RBF), the superficial (SBF) and the deep renal cortical blood flow (DBF) with stepwise reductions of renal perfusion pressure (RPP), which was induced by a manual clamp on the abdominal aorta. During the clamp induced reductions of the RPP by 10 to 20mm HG, RBF, SBF and the DBF fell significantly more in the IRS1 and IRS2 than in the WT mice. Furthermore micropuncture studies showded that compared to the WT tubuloglomerular feedback (TGF) responses of the stop flow pressure (Psf) were reduced in both the IRS1 -/- and IRS2 -/-. The results of the IRS1 and IRS2 mice displayed the pressence of hemodynamic abnormalities. Losartan and Pioglitazone have shown the potential to improve these abnormalities. In conclusion the results indicate that IRS plays a major role in the stimulation of renal functions and renal hemodynamics in type type II diabetes. We have reported previously that renal hemodynamic abnormalities exist in the prediabetic stage of type II diabetic rats. At this prediabetic stage these rats have hyperinsulinemia, insulin resistance and metabolic syndrome. It is well known that insulin resistance is frequently associated with renal abnormalities, but the mechanism underlying this association has remained speculative. Although insulin is known to modify renal hemodynamics, little is known about the roles of insulin receptor substrates (IRS1, IRS2) in the renal actions of insulin. To address this issue, the effects of insulin on renal function and renal hemodynamics were investigated in C57BL/6 (WT: wild type), insulin receptor substrate 1- knockout ( IRS1–/– ), and IRS2-knockout ( IRS2–/– ) mice. IRS2–/–mice had elevated glucose level as expected. 24-h urine collections and serum creatinine revealed that creatinine clearance did not significantly differ between these groups. Albuminuria was found in IRS1–/– and IRS2–/– groups. We examined the effects on the IRS during the administration of Losartan, which is widely used for diabetic nephropathy. After the administration of Losartan the IRS displayed improved renal hemodynamics. Moreover, the subjects were also given Pioglitazone, which improves insulin resistance. Losartan significantly reduced albuminuria in both groups. Pioglitazone also showed similar results. We assessed the autoregulatory responses of the total renal blood flow (RBF), the superficial (SBF) and the deep renal cortical blood flow (DBF) with stepwise reductions of renal perfusion pressure (RPP), which was induced by a manual clamp on the abdominal aorta. During the clamp induced reductions of the RPP by 10 to 20mm HG, RBF, SBF and the DBF fell significantly more in the IRS1 and IRS2 than in the WT mice. Furthermore micropuncture studies showded that compared to the WT tubuloglomerular feedback (TGF) responses of the stop flow pressure (P sf ) were reduced in both the IRS1 -/- and IRS2 -/- . The results of the IRS1 and IRS2 mice displayed the pressence of hemodynamic abnormalities. Losartan and Pioglitazone have shown the potential to improve these abnormalities. In conclusion the results indicate that IRS plays a major role in the stimulation of renal functions and renal hemodynamics in type type II diabetes. |
| Audience | Academic |
| Author | Takashi Shigematsu Seiji Hashimoto Toshio Mochizuki Tomochika Maoka Takao Koike Tetsuya Kawata |
| AuthorAffiliation | 1 Department of Nephrology, Kinan Hospital, Tanabe, Wakayama Prefecture, Japan 4 Department of Nephrology, Wakayama Medical University, Wakayama, Wakayama Prefecture, Japan University Medical Center Utrecht, NETHERLANDS 2 NTT East Japan Sapporo Hospital Department of Nephrology, Chuou-ku, Sapporo, Japan 3 Hokkaido University Graduate School of Medicine, Internal Medicine II, Kita-ku, Sapporo, Japan |
| AuthorAffiliation_xml | – name: University Medical Center Utrecht, NETHERLANDS – name: 2 NTT East Japan Sapporo Hospital Department of Nephrology, Chuou-ku, Sapporo, Japan – name: 3 Hokkaido University Graduate School of Medicine, Internal Medicine II, Kita-ku, Sapporo, Japan – name: 4 Department of Nephrology, Wakayama Medical University, Wakayama, Wakayama Prefecture, Japan – name: 1 Department of Nephrology, Kinan Hospital, Tanabe, Wakayama Prefecture, Japan |
| Author_xml | – sequence: 1 givenname: Seiji orcidid: 0000-0002-6404-9503 surname: Hashimoto fullname: Hashimoto, Seiji – sequence: 2 givenname: Tomochika surname: Maoka fullname: Maoka, Tomochika – sequence: 3 givenname: Tetsuya surname: Kawata fullname: Kawata, Tetsuya – sequence: 4 givenname: Toshio orcidid: 0000-0002-3820-3191 surname: Mochizuki fullname: Mochizuki, Toshio – sequence: 5 givenname: Takao surname: Koike fullname: Koike, Takao – sequence: 6 givenname: Takashi surname: Shigematsu fullname: Shigematsu, Takashi |
| BackLink | https://cir.nii.ac.jp/crid/1871709542506746752$$DView record in CiNii https://www.ncbi.nlm.nih.gov/pubmed/33270683$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNU9tq3DAQNSWlSdP8QWkN7UP6sFvdLNl9KITQy0KgsNs-C1kabRS00sayW_L3lbNOyIZAi8AyM-ccnZmRXhYHIQYoitcYzTEV-ONVHLqg_Hybw3NEGKGUPCuOcEPJjBNEDx78HxYnKbkWsYpigSr0ojjMaIF4TY-K1TJ6SGW05SKkwbtQLkHDto9duRra1Heqz-nTxXL1oczJDvKppR2C7l0MpQpmCl3CJpqboDZOp1fFc6t8gpNpPy5-ff3y8_z77OLHt8X52cVM87ruZ6xFwComaGtrxbMhKwxHpAYGtsWKNKLC1rS8acBYIurGgAHeYI4E100F9Lh4u9Pd-pjk1JIkCeNc8KbiPCMWO4SJ6kpuO7dR3Y2MysnbQOzWUnW90x4kQ8poi2tWt5o1WCgjKFDGMQEFqsJZq9ppDWGrbv4o7-8FMZLjVO4syHEqcppK5n2eXA7tBoyGkJvq98zsZ4K7lOv4WwqBGUYoC5xOAl28HiD1cuOSBu9VgDjc1is4rmk9enz3CPp0VybUWuXCXbAxn6tHUXnGGeWCZnBGzZ9A5WUgDzlXaF2O7xHePCz0vsK7y5YBbAfQXUypA_u_Dfz0iKZdr8b7lw05_y_y-x05OJd54xfXIr-DpmKkQlzk5lWE_gUNggii |
| CitedBy_id | crossref_primary_10_3390_molecules26072074 crossref_primary_10_2215_CJN_0000000000000159 crossref_primary_10_1038_s41392_023_01400_z crossref_primary_10_2147_PRBM_S375722 crossref_primary_10_4239_wjd_v12_i5_556 crossref_primary_10_1210_clinem_dgac735 crossref_primary_10_47836_mjmhs_18_s21_7 crossref_primary_10_3390_ijms241814209 crossref_primary_10_1002_jcb_30294 |
| Cites_doi | 10.1056/NEJM195110042451402 10.1152/ajpregu.00582.2011 10.1007/s00125-012-2644-8 10.1159/000443746 10.1073/pnas.75.10.5173 10.1369/jhc.4A6590.2005 10.1172/JCI119752 10.2337/diabetes.49.11.1880 10.1038/36116 10.1681/ASN.V5101761 10.2337/diab.32.1.35 10.1046/j.1523-1755.2002.00529.x 10.1111/j.1523-1755.2004.00582.x 10.1038/352073a0 10.1111/1744-9987.12378 10.1681/ASN.2005010106 10.1161/01.HYP.0000078490.59735.6E 10.1172/JCI18212 10.1111/j.1523-1755.2004.00574.x 10.1038/377173a0 10.1161/01.HYP.0000125142.41703.64 10.1210/jc.2002-021716 10.1681/ASN.2006050459 10.1038/372182a0 10.1152/ajprenal.00074.2008 10.1016/j.diabres.2011.05.032 10.1053/j.ajkd.2008.12.031 10.1161/01.HYP.28.1.127 10.1152/ajprenal.00381.2005 10.1111/j.1559-4564.2006.05795.x 10.1677/joe.1.06290 10.1111/j.1365-201X.2004.01318.x 10.1016/j.dsx.2015.02.008 10.1248/bpb.30.1610 10.1056/NEJM197001222820402 |
| ContentType | Journal Article |
| Copyright | COPYRIGHT 2020 Public Library of Science 2020 Hashimoto et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2020 Hashimoto et al 2020 Hashimoto et al |
| Copyright_xml | – notice: COPYRIGHT 2020 Public Library of Science – notice: 2020 Hashimoto et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2020 Hashimoto et al 2020 Hashimoto et al |
| DBID | RYH AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7QG 7QL 7QO 7RV 7SN 7SS 7T5 7TG 7TM 7U9 7X2 7X7 7XB 88E 8AO 8C1 8FD 8FE 8FG 8FH 8FI 8FJ 8FK ABJCF ABUWG AEUYN AFKRA ARAPS ATCPS AZQEC BBNVY BENPR BGLVJ BHPHI C1K CCPQU D1I DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. KB. KB0 KL. L6V LK8 M0K M0S M1P M7N M7P M7S NAPCQ P5Z P62 P64 PATMY PDBOC PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PTHSS PYCSY RC3 7X8 5PM ADTOC UNPAY DOA |
| DOI | 10.1371/journal.pone.0242332 |
| DatabaseName | CiNii Complete CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Biotechnology Research Abstracts Nursing & Allied Health Database Ecology Abstracts Entomology Abstracts (Full archive) Immunology Abstracts Meteorological & Geoastrophysical Abstracts Nucleic Acids Abstracts Virology and AIDS Abstracts Agricultural Science Collection Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Proquest Public Health Database Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Journals ProQuest Hospital Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Materials Science & Engineering Collection ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central Advanced Technologies & Computer Science Collection Agricultural & Environmental Science Collection ProQuest Central Essentials Biological Science Collection ProQuest Central Technology Collection Natural Science Collection Environmental Sciences and Pollution Management ProQuest One ProQuest Materials Science Collection ProQuest Central Engineering Research Database Proquest Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Materials Science Database Nursing & Allied Health Database (Alumni Edition) Meteorological & Geoastrophysical Abstracts - Academic ProQuest Engineering Collection Biological Sciences Agricultural Science Database ProQuest Health & Medical Collection Medical Database Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Engineering Database Nursing & Allied Health Premium Advanced Technologies & Aerospace Database ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts Environmental Science Database Materials Science Collection ProQuest Central Premium ProQuest One Academic (New) Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic ProQuest One Academic UKI Edition Engineering Collection Environmental Science Collection Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) Unpaywall for CDI: Periodical Content Unpaywall DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Agricultural Science Database Publicly Available Content Database ProQuest Central Student ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Meteorological & Geoastrophysical Abstracts Natural Science Collection Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) Engineering Collection Advanced Technologies & Aerospace Collection Engineering Database Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Agricultural Science Collection ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Environmental Science Collection Entomology Abstracts Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Environmental Science Database ProQuest Nursing & Allied Health Source (Alumni) Engineering Research Database ProQuest One Academic Meteorological & Geoastrophysical Abstracts - Academic ProQuest One Academic (New) Technology Collection Technology Research Database ProQuest One Academic Middle East (New) Materials Science Collection ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts ProQuest Engineering Collection Biotechnology Research Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Agricultural & Environmental Science Collection AIDS and Cancer Research Abstracts Materials Science Database ProQuest Materials Science Collection ProQuest Public Health ProQuest Nursing & Allied Health Source ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library Animal Behavior Abstracts Materials Science & Engineering Collection Immunology Abstracts ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | Agricultural Science Database MEDLINE - Academic CrossRef MEDLINE |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 4 dbid: UNPAY name: Unpaywall url: https://proxy.k.utb.cz/login?url=https://unpaywall.org/ sourceTypes: Open Access Repository – sequence: 5 dbid: 8FG name: ProQuest Technology Collection url: https://search.proquest.com/technologycollection1 sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Sciences (General) |
| DocumentTitleAlternate | Insulin Receptor Substrates (IRS) in renal function and hemodynamics |
| EISSN | 1932-6203 |
| ExternalDocumentID | 2466769566 oai_doaj_org_article_40adcf1848bc4917ad73e34612eaea51 10.1371/journal.pone.0242332 PMC7714100 A643673246 33270683 10_1371_journal_pone_0242332 |
| Genre | Journal Article |
| GeographicLocations | Japan United States--US |
| GeographicLocations_xml | – name: Japan – name: United States--US |
| GroupedDBID | --- 123 29O 2WC 53G 5VS 7RV 7X2 7X7 7XC 88E 8AO 8C1 8CJ 8FE 8FG 8FH 8FI 8FJ A8Z AAFWJ AAUCC AAWOE ABDBF ABIVO ABJCF ABUWG ACGFO ACIHN ACIWK ACPRK ACUHS ADBBV AEAQA AENEX AEUYN AFKRA AFPKN AFRAH AHMBA ALIPV ALMA_UNASSIGNED_HOLDINGS AOIJS APEBS ARAPS ATCPS BAWUL BBNVY BBORY BCNDV BENPR BGLVJ BHPHI BKEYQ BPHCQ BVXVI BWKFM CCPQU CS3 D1I D1J D1K DIK DU5 E3Z EAP EAS EBD EMOBN ESX EX3 F5P FPL FYUFA GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE IAO IEA IGS IHR IHW INH INR IOV IPY ISE ISR ITC K6- KB. KQ8 L6V LK5 LK8 M0K M1P M48 M7P M7R M7S M~E NAPCQ O5R O5S OK1 OVT P2P P62 PATMY PDBOC PHGZM PHGZT PIMPY PQQKQ PROAC PSQYO PTHSS PV9 PYCSY RNS RPM RYH RZL SV3 TR2 UKHRP WOQ WOW ~02 ~KM AAYXX CITATION ESTFP PJZUB PPXIY PQGLB PUEGO 3V. ADRAZ CGR CUY CVF ECM EIF IPNFZ NPM RIG 7QG 7QL 7QO 7SN 7SS 7T5 7TG 7TM 7U9 7XB 8FD 8FK AZQEC C1K DWQXO FR3 GNUQQ H94 K9. KL. M7N P64 PKEHL PQEST PQUKI RC3 7X8 5PM ADTOC UNPAY AAPBV ABPTK |
| ID | FETCH-LOGICAL-c688t-4b0e45473bf8a6270f7d6028e4efb1a29751fdb699edf2789dede6916076c95e3 |
| IEDL.DBID | M48 |
| ISSN | 1932-6203 |
| IngestDate | Sun Sep 03 00:14:41 EDT 2023 Tue Oct 14 19:05:24 EDT 2025 Sun Oct 26 04:06:20 EDT 2025 Tue Sep 30 16:47:29 EDT 2025 Mon Sep 08 10:55:42 EDT 2025 Tue Oct 07 09:07:51 EDT 2025 Mon Oct 20 22:08:42 EDT 2025 Mon Oct 20 16:37:44 EDT 2025 Wed Feb 19 02:29:42 EST 2025 Thu Apr 24 23:12:58 EDT 2025 Wed Oct 01 03:11:19 EDT 2025 Thu Jun 26 22:44:21 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 12 |
| Language | English |
| License | This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. cc-by Creative Commons Attribution License |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c688t-4b0e45473bf8a6270f7d6028e4efb1a29751fdb699edf2789dede6916076c95e3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Current address: Fourth Department of Internal Medicine, Tokyo Women's Medical University, Tokyo, Japan Competing Interests: The authors have declared that no competing interests exist. |
| ORCID | 0000-0002-6404-9503 0000-0002-3820-3191 |
| OpenAccessLink | http://journals.scholarsportal.info/openUrl.xqy?doi=10.1371/journal.pone.0242332 |
| PMID | 33270683 |
| PQID | 2466769566 |
| PQPubID | 1436336 |
| ParticipantIDs | plos_journals_2466769566 doaj_primary_oai_doaj_org_article_40adcf1848bc4917ad73e34612eaea51 unpaywall_primary_10_1371_journal_pone_0242332 pubmedcentral_primary_oai_pubmedcentral_nih_gov_7714100 proquest_miscellaneous_2467618381 proquest_journals_2466769566 gale_infotracmisc_A643673246 gale_infotracacademiconefile_A643673246 pubmed_primary_33270683 crossref_primary_10_1371_journal_pone_0242332 crossref_citationtrail_10_1371_journal_pone_0242332 nii_cinii_1871709542506746752 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2020-12-03 |
| PublicationDateYYYYMMDD | 2020-12-03 |
| PublicationDate_xml | – month: 12 year: 2020 text: 2020-12-03 day: 03 |
| PublicationDecade | 2020 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: San Francisco – name: San Francisco, CA USA |
| PublicationTitle | PLOS ONE |
| PublicationTitleAlternate | PLoS One |
| PublicationYear | 2020 |
| Publisher | Public Library of Science (PLoS) Public Library of Science |
| Publisher_xml | – name: Public Library of Science (PLoS) – name: Public Library of Science |
| References | O Marsenic (pone.0242332.ref020) 2009; 53 K Iseki (pone.0242332.ref010) 2004; 65 PA Sarafidis (pone.0242332.ref028) 2006; 1 MH Clough (pone.0242332.ref029) 2005; 53 S Hashimoto (pone.0242332.ref015) 2004; 181 G Licata (pone.0242332.ref022) 2002; 62 S Zafiriou (pone.0242332.ref032) 2004; 65 I Masakane (pone.0242332.ref002) 2015; 19 RK Dubey (pone.0242332.ref037) 1993; 265 XJ Sun (pone.0242332.ref004) 1991; 352 CG Zubrod (pone.0242332.ref008) 1951; 245 H. Tamemoto (pone.0242332.ref006) 1994; 372 M Kurella (pone.0242332.ref012) 2005; 16 N Kubota (pone.0242332.ref014) 2000; 49 L Pihl (pone.0242332.ref024) 2012; 303 F Folli (pone.0242332.ref033) 1997; 100 DJ Withers (pone.0242332.ref007) 1998; 391 DR Dengel (pone.0242332.ref023) 1996; 28 R Bataller (pone.0242332.ref035) 2003; 112 R Rabkin (pone.0242332.ref019) 1970; 282 S Hashimoto (pone.0242332.ref016) 2006; 290 RA DeFronzo (pone.0242332.ref027) 1978; 75 MA Marini (pone.0242332.ref026) 2003; 88 T Asano (pone.0242332.ref003) 2007; 30 V Vallon (pone.0242332.ref025) 1995; 5 L Petrica (pone.0242332.ref031) 2011; 94 KD Copps (pone.0242332.ref018) 2012; 55 M Furuhashi (pone.0242332.ref036) 2003; 42 DT Chan (pone.0242332.ref013) 2017; 32 CM Rebholz (pone.0242332.ref011) 2015; 42 RA DeFronzo (pone.0242332.ref009) 1983; 32 T Shiuchi (pone.0242332.ref034) 2004; 43 T Nakagawa (pone.0242332.ref021) 2007; 18 J Ahmad (pone.0242332.ref001) 2015; 9 XJ Sun (pone.0242332.ref005) 1995; 377 S Hashimoto (pone.0242332.ref017) 2009; 296 F Sentinelli (pone.0242332.ref030) 2006; 188 |
| References_xml | – volume: 245 start-page: 518 year: 1951 ident: pone.0242332.ref008 article-title: Amelioration of diabetes and striking rarity of acidosis in patients with Kimmelstiel-Wilson lesions publication-title: N Engl J Med doi: 10.1056/NEJM195110042451402 – volume: 303 start-page: R39 year: 2012 ident: pone.0242332.ref024 article-title: Insulin induces the correlation between renal blood flow and glomerular filtration rate in diabetes: implications for mechanisms causing hyperfiltration publication-title: Am J Physiol Regul Integr Comp Physiol doi: 10.1152/ajpregu.00582.2011 – volume: 55 start-page: 2565 year: 2012 ident: pone.0242332.ref018 article-title: Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2 publication-title: Diabetologia doi: 10.1007/s00125-012-2644-8 – volume: 42 start-page: 427 year: 2015 ident: pone.0242332.ref011 article-title: Dietary Acid Load and Incident Chronic Kidney Disease: Results from the ARIC Study publication-title: Am J Nephrol doi: 10.1159/000443746 – volume: 75 start-page: 5173 year: 1978 ident: pone.0242332.ref027 article-title: Influence of hyperinsulinemia, hyperglycemia, and the route of glucose administration on splanchnic glucose exchange publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.75.10.5173 – volume: 53 start-page: 603 year: 2005 ident: pone.0242332.ref029 article-title: Attenuation of accumulation of neointimal lipid by pioglitazone in mice genetically deficient in insulin receptor substrate-2 and apolipoprotein E publication-title: J Histochem Cytochem doi: 10.1369/jhc.4A6590.2005 – volume: 100 start-page: 2158 year: 1997 ident: pone.0242332.ref033 article-title: Angiotensin II inhibits insulin signaling in aortic smooth muscle cells at multiple levels. A potential role for serine phosphorylation in insulin/angiotensin II crosstalk publication-title: J Clin Invest doi: 10.1172/JCI119752 – volume: 49 start-page: 1880 year: 2000 ident: pone.0242332.ref014 article-title: Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia publication-title: Diabetes doi: 10.2337/diabetes.49.11.1880 – volume: 391 start-page: 900 year: 1998 ident: pone.0242332.ref007 article-title: Disruption of IRS-2 causes type 2 diabetes in mice publication-title: Nature doi: 10.1038/36116 – volume: 5 start-page: 1761 year: 1995 ident: pone.0242332.ref025 article-title: Renal hemodynamics and plasma and kidney angiotensin II in established diabetes mellitus in rats: effect of sodium and salt restriction publication-title: J Am Soc Nephrol doi: 10.1681/ASN.V5101761 – volume: 32 start-page: 35 year: 1983 ident: pone.0242332.ref009 article-title: Regulation of splanchnic and peripheral glucose uptake by insulin and hyperglycemia in man publication-title: Diabetes doi: 10.2337/diab.32.1.35 – volume: 62 start-page: 1005 year: 2002 ident: pone.0242332.ref022 article-title: Insulin resistance and glomerular hemodynamics in essential hypertension publication-title: Kidney Int doi: 10.1046/j.1523-1755.2002.00529.x – volume: 65 start-page: 1870 year: 2004 ident: pone.0242332.ref010 article-title: Body mass index and the risk of development of end-stage renal disease in a screened cohort publication-title: Kidney Int doi: 10.1111/j.1523-1755.2004.00582.x – volume: 352 start-page: 73 year: 1991 ident: pone.0242332.ref004 article-title: Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein publication-title: Nature doi: 10.1038/352073a0 – volume: 19 start-page: 540 year: 2015 ident: pone.0242332.ref002 article-title: An Overview of Regular Dialysis Treatment in Japan (As of 31 December 2013) publication-title: Ther Apher Dial doi: 10.1111/1744-9987.12378 – volume: 32 start-page: 1274 year: 2017 ident: pone.0242332.ref013 article-title: Insulin resistance and vascular dysfunction in chronic kidney disease: mechanisms and therapeutic interventions publication-title: Nephrol Dial Transplant – volume: 16 start-page: 2134 year: 2005 ident: pone.0242332.ref012 article-title: Metabolic syndrome and the risk for chronic kidney disease among nondiabetic adults publication-title: J Am Soc Nephrol doi: 10.1681/ASN.2005010106 – volume: 42 start-page: 76 year: 2003 ident: pone.0242332.ref036 article-title: Blockade of the renin-angiotensin system increases adiponectin concentrations in patients with essential hypertension publication-title: Hypertension doi: 10.1161/01.HYP.0000078490.59735.6E – volume: 112 start-page: 1383 year: 2003 ident: pone.0242332.ref035 article-title: NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis publication-title: J Clin Invest doi: 10.1172/JCI18212 – volume: 65 start-page: 1647 year: 2004 ident: pone.0242332.ref032 article-title: Pioglitazone increases renal tubular cell albumin uptake but limits proinflammatory and fibrotic responses publication-title: Kidney Int doi: 10.1111/j.1523-1755.2004.00574.x – volume: 377 start-page: 173 year: 1995 ident: pone.0242332.ref005 article-title: Role of IRS-2 in insulin and cytokine signalling publication-title: Nature doi: 10.1038/377173a0 – volume: 43 start-page: 1003 year: 2004 ident: pone.0242332.ref034 article-title: Angiotensin II type-1 receptor blocker valsartan enhances insulin sensitivity in skeletal muscles of diabetic mice publication-title: Hypertension doi: 10.1161/01.HYP.0000125142.41703.64 – volume: 88 start-page: 3368 year: 2003 ident: pone.0242332.ref026 article-title: The Arg972 variant in insulin receptor substrate-1 is associated with an atherogenic profile in offspring of type 2 diabetic patients publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2002-021716 – volume: 18 start-page: 539 year: 2007 ident: pone.0242332.ref021 article-title: Diabetic endothelial nitric oxide synthase knockout mice develop advanced diabetic nephropathy publication-title: J Am Soc Nephrol doi: 10.1681/ASN.2006050459 – volume: 372 start-page: 182 year: 1994 ident: pone.0242332.ref006 article-title: Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1 publication-title: Nature doi: 10.1038/372182a0 – volume: 296 start-page: F598 year: 2009 ident: pone.0242332.ref017 article-title: Abnormal autoregulation and tubuloglomerular feedback in prediabetic and diabetic OLETF rats publication-title: Am J Physiol Renal Physiol doi: 10.1152/ajprenal.00074.2008 – volume: 94 start-page: 22 year: 2011 ident: pone.0242332.ref031 article-title: Pioglitazone delays proximal tubule dysfunction and improves cerebral vessel endothelial dysfunction in normoalbuminuric people with type 2 diabetes mellitus publication-title: Diabetes Res Clin Pract doi: 10.1016/j.diabres.2011.05.032 – volume: 53 start-page: 875 year: 2009 ident: pone.0242332.ref020 article-title: Glucose control by the kidney: an emerging target in diabetes publication-title: Am J Kidney Dis doi: 10.1053/j.ajkd.2008.12.031 – volume: 265 start-page: R726 year: 1993 ident: pone.0242332.ref037 article-title: Pioglitazone attenuates hypertension and inhibits growth of renal arteriolar smooth muscle in rats publication-title: Am J Physiol – volume: 28 start-page: 127 year: 1996 ident: pone.0242332.ref023 article-title: Insulin resistance, elevated glomerular filtration fraction, and renal injury publication-title: Hypertension doi: 10.1161/01.HYP.28.1.127 – volume: 290 start-page: F888 year: 2006 ident: pone.0242332.ref016 article-title: Reduced autoregulatory effectiveness in adenosine 1 receptor-deficient mice publication-title: Am J Physiol Renal Physiol doi: 10.1152/ajprenal.00381.2005 – volume: 1 start-page: 334 year: 2006 ident: pone.0242332.ref028 article-title: Insulin resistance, hyperinsulinemia, and hypertension: an epidemiologic approach publication-title: J Cardiometab Syndr doi: 10.1111/j.1559-4564.2006.05795.x – volume: 188 start-page: 271 year: 2006 ident: pone.0242332.ref030 article-title: The G972R variant of the insulin receptor substrate-1 gene impairs insulin signaling and cell differentiation in 3T3L1 adipocytes; treatment with a PPARgamma agonist restores normal cell signaling and differentiation publication-title: J Endocrinol doi: 10.1677/joe.1.06290 – volume: 181 start-page: 455 year: 2004 ident: pone.0242332.ref015 article-title: Compensation of proximal tubule malabsorption in AQP1-deficient mice without TGF-mediated reduction of GFR publication-title: Acta Physiol Scand doi: 10.1111/j.1365-201X.2004.01318.x – volume: 9 start-page: 343 year: 2015 ident: pone.0242332.ref001 article-title: Management of diabetic nephropathy: Recent progress and future perspective publication-title: Diabetes Metab Syndr doi: 10.1016/j.dsx.2015.02.008 – volume: 30 start-page: 1610 year: 2007 ident: pone.0242332.ref003 article-title: Role of phosphatidylinositol 3-kinase activation on insulin action and its alteration in diabetic conditions publication-title: Biol Pharm Bull doi: 10.1248/bpb.30.1610 – volume: 282 start-page: 182 year: 1970 ident: pone.0242332.ref019 article-title: Effect of renal disease on renal uptake and excretion of insulin in man publication-title: N Engl J Med doi: 10.1056/NEJM197001222820402 |
| SSID | ssib045317050 ssib045318062 ssib045324867 ssib045316197 ssib045319074 ssib045319085 ssib045319086 ssib045316121 ssib045318733 ssib045316049 ssib045317797 ssib045315901 ssib045318737 ssib045317988 ssj0053866 |
| Score | 2.3977766 |
| Snippet | We have reported previously that renal hemodynamic abnormalities exist in the prediabetic stage of type II diabetic rats. At this prediabetic stage these rats... |
| SourceID | plos doaj unpaywall pubmedcentral proquest gale pubmed crossref nii |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | e0242332 |
| SubjectTerms | Abnormalities Albuminuria Albuminuria - blood Albuminuria - genetics Analysis Animals Aorta Biology and Life Sciences Blood Blood flow Blood Glucose Blood Glucose - genetics Creatinine Creatinine - blood Diabetes Diabetes mellitus Diabetes Mellitus, Type 2 Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - pathology Diabetic Nephropathies Diabetic Nephropathies - blood Diabetic Nephropathies - genetics Diabetic Nephropathies - pathology Diabetic nephropathy Dosage and administration Engineering and Technology Experiments Genetic engineering Hemodynamic Monitoring Hemodynamic Monitoring - methods Hemodynamics Hospitals Hyperinsulinemia Hyperinsulinism Hyperinsulinism - blood Hyperinsulinism - genetics Hyperinsulinism - pathology Insulin Insulin - blood Insulin receptor substrate 1 Insulin Receptor Substrate Proteins Insulin Receptor Substrate Proteins - genetics Insulin receptors Insulin Resistance Insulin Resistance - genetics Internal medicine Kidney Kidney - blood supply Kidney - metabolism Kidney - pathology Kidney function tests Laboratory animals Losartan Male Measurement Medicine Medicine and Health Sciences Metabolic disorders Metabolic syndrome Metabolism Methods Mice Mice, Knockout Nephrology Nephropathy Perfusion Pioglitazone Prediabetic State Prediabetic State - blood Prediabetic State - genetics Prediabetic State - pathology Q R Rats Receptors Renal Circulation Renal Circulation - genetics Renal function Research Article Science Signal Transduction Signal Transduction - genetics Structure Substrates University graduates Urine Veins & arteries |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELagF7ggWh4NtCiVkKCHbJ31KzkW1KpFgkNLpd4ixx6rKy3JqrsrxL9nJvFGjahUDr3sIbaTeGbs-SY785mxj9zlyiknMmUCz2QpQ2at0pkCx2ti4A-Oaoe__9BnV_Lbtbq-c9QX5YT19MC94I4kt94FjEOK2kmMLaw3AoRExwwWbFc8PeVFuQmm-j0YV7HWsVBOmPwo6mWyaBuYkFcSYjpyRB1f_7ArP21mMyI7nbfL-4Dnv_mTz9bNwv75befzO87p9CV7EVFletzPZps9gWaHbcd1u0w_R3Lpw1fs8oIYnNI2pOd9FnqKwBEWGHmntId0XLU44Pzi8jDFxlug-5LzIwWmtvHx0g38an1_mv3yNbs6Pfn59SyLBytkThfFKpM1ByLyEnUorJ4aHozXCDRAQqhzS8W2efC1LkvwgUplPXjQJXHRaVcqEG_YVoOi3GVpDoi3uA9KGStLRD8-t8Jzr62FwtYiYWIj5cpF1nE6_GJedX-lGYw-ehFVpJsq6iZh2TBq0bNuPND_Cylw6Euc2d0FtKQqWlL1kCUl7BOpv6KVja_obCxQwOcQR1Z1jOBNGwSgOmF7o564It2oeR8NCKdLvzlGpAZxLO6NCAzQLSl8210yrc1MlhWOoUxjRNZ454253d98MDTTQylBroF23fUxGrfnAqfxtrfOQRooIMN1gbowI7sdiWvc0sxuOqpxYygPmCdsMlj4fynk3WMo5D17PqWvG5Q8JPbY1up2DfsIAVf1h261_wXnKVgy priority: 102 providerName: Directory of Open Access Journals – databaseName: ProQuest Central dbid: BENPR link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1Lb9QwELbarQRcEC2PprQoSEjQQ7ZJHNvJAaEWtWqRukJbKvUWOX7QlZYk3YcQ_56ZxAlEVMBlD7GziWfG48_xzDeEvAlVxBRTNGDChkGSJTaQkvGAGRUWyMBvFeYOX074-XXy6YbdbJBJlwuDYZWdT2wcta4UfiM_ipMmGhPQx4f6LsCqUXi62pXQkK60gn7fUIxtkq0YmbFGZOvkdPJ52vlmmN2cuwQ6KqIjp69xXZVmjKsVpfFggWp4_HtvvVnOZkiCOq-W9wHSP-MqH67LWv74Lufz3xatsyfksUOb_nFrHttkw5Q75MGlO0_fIdtuai_9d45_-vApuZoiyZNfWf-iDVT3AVuaGjbnPrqZhs4WbriYXh360Lgw-AhcH1HHviy1u3RrvlW6LXi_fEauz06_fDwPXO2FQPE0XQVJERrk-qKFTSWPRWiF5oBFTGJsEUnMx42sLniWGW0xm1YbbXiGdHVcZczQ52RUglR3iR8ZgGShtowJmWQAkHQkqQ41l9KksqAeoZ3Ac-WIybE-xjxvTtsEbFBaaeWoptypySNBf1fdEnP8o_8J6rLvi7TazYVq8TV3szRPQqmVhU1vWqgENrJSC2poAijQSCNZ5JG3aAk5Tn54RSVdDgM8B2m08mPAd1wARuUe2R_0hEmrBs0HYEswXPyNYNMqAOqC-wTsACsXg7fdRSvrRrLMf5k__HNnefc3v-6b8aEYQ1eaat30ERw8eArDeNEaai8NEJAIeQq6EAMTHohr2FLObhs2ciEwVDj0yLg39v9SyN7fx_GSPIrx0wZGDtF9Mlot1uYA8N-qeOUm9U9b3lko priority: 102 providerName: ProQuest – databaseName: Unpaywall dbid: UNPAY link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwELba7QEuQHl1oUVBQkAPSZ04tpPjgqhaJCrUslI5oMixHXXFNlntZoXKgd_OTOJEBIqAA5fVKn7EHk_G38QzXwh5RnXINdfM57KgfpzGha8UFz63mubIwF9ozB1-dyKOpvHbc36-QT51uTBOguAjzqtVc5KPf6rSHjhJHiBfUXt6GoRMhl2LYAGVAtxxGIueN4xD-GasxgSkTbIlOED1EdmanryffGxPmiNfRJS5dLrf9TTYrhpW_952b5azGVKiwviug6e_RlneWJcLdfVFzec_bGGHt8m3bvJt5MrnYF3ngf76Ey_kf5POHXLLgV9v0vayTTZseZdsO_Oy8l46Duz9e-TsFImmvKrwjttgeQ_wrV3U1dJDU9dQ6kKD49OzfQ8Klxb7xT0a9cxTpXGXLuxlZa5KdTnTq_tkevjmw-sj333_wdciSWo_zqlFvjGWF4kSkaSFNALwkI1tkYcKc4LDwuQiTa0pMKPXWGNFipR5QqfcsgdkVMK8d4gXWoCF1BScSxWnANJMqJihRihlE5WzMWHdMmfakaPjNzrmWXPiJ8FJakWUoSAzJ8gx8ftWi5Yc5A_1X6EG9XWR2ru5ACuZuRXMYqqMLsDxTnIdgzOtjGSWxYBErbKKh2PyAvUvQwMEQ9TK5VHAfXDxswlgTCEBJ4sx2R3UBMOhB8V7oMEwXfwNwXGWALfBhAN-gd2Tw2h3ULu6mawyaIMB0eAAQM-dvl9f_LQvxptiHF9pq3VTRwrYRRKYxsP28eilAQKSVCSwFnLw4AzENSwpZxcNI7qUGK5MxyToH7G_WpBH_9rgMbkZ4QsXjGdiu2RUL9d2D1BpnT9xtuU7SieO7Q priority: 102 providerName: Unpaywall |
| Title | Roles of Insulin Receptor Substrates (IRS) in renal function and renal hemodynamics |
| URI | https://cir.nii.ac.jp/crid/1871709542506746752 https://www.ncbi.nlm.nih.gov/pubmed/33270683 https://www.proquest.com/docview/2466769566 https://www.proquest.com/docview/2467618381 https://pubmed.ncbi.nlm.nih.gov/PMC7714100 https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0242332&type=printable https://doaj.org/article/40adcf1848bc4917ad73e34612eaea51 http://dx.doi.org/10.1371/journal.pone.0242332 |
| UnpaywallVersion | publishedVersion |
| Volume | 15 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVFSB databaseName: Free Full-Text Journals in Chemistry customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: HH5 dateStart: 20060101 isFulltext: true titleUrlDefault: http://abc-chemistry.org/ providerName: ABC ChemistRy – providerCode: PRVAFT databaseName: Open Access Digital Library customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: KQ8 dateStart: 20060101 isFulltext: true titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html providerName: Colorado Alliance of Research Libraries – providerCode: PRVAFT databaseName: Open Access Digital Library customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: KQ8 dateStart: 20061001 isFulltext: true titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html providerName: Colorado Alliance of Research Libraries – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: DOA dateStart: 20060101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVEBS databaseName: Academic Search Ultimate customDbUrl: https://search.ebscohost.com/login.aspx?authtype=ip,shib&custid=s3936755&profile=ehost&defaultdb=asn eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: ABDBF dateStart: 20080101 isFulltext: true titleUrlDefault: https://search.ebscohost.com/direct.asp?db=asn providerName: EBSCOhost – providerCode: PRVEBS databaseName: EBSCOhost Food Science Source customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: A8Z dateStart: 20080101 isFulltext: true titleUrlDefault: https://search.ebscohost.com/login.aspx?authtype=ip,uid&profile=ehost&defaultdb=fsr providerName: EBSCOhost – providerCode: PRVBFR databaseName: Free Medical Journals customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: DIK dateStart: 20060101 isFulltext: true titleUrlDefault: http://www.freemedicaljournals.com providerName: Flying Publisher – providerCode: PRVFQY databaseName: GFMER Free Medical Journals customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: GX1 dateStart: 20060101 isFulltext: true titleUrlDefault: http://www.gfmer.ch/Medical_journals/Free_medical.php providerName: Geneva Foundation for Medical Education and Research – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M~E dateStart: 20060101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVAQN databaseName: PubMed Central (Free e-resource, activated by CARLI) customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: RPM dateStart: 20060101 isFulltext: true titleUrlDefault: https://www.ncbi.nlm.nih.gov/pmc/ providerName: National Library of Medicine – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 7X7 dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: http://www.proquest.com/pqcentral?accountid=15518 eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: BENPR dateStart: 20061201 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Proquest Public Health Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 8C1 dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/publichealth providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Technology Collection customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 8FG dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/technologycollection1 providerName: ProQuest – providerCode: PRVFZP databaseName: Scholars Portal Journals: Open Access customDbUrl: eissn: 1932-6203 dateEnd: 20250930 omitProxy: true ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M48 dateStart: 20061201 isFulltext: true titleUrlDefault: http://journals.scholarsportal.info providerName: Scholars Portal |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1bb9MwFLZ2kYAXxAZsha0KEhLsIVUyx3bygFA3rWxIraaOSuUpcnxhlbqk60Wwf885iRsR0Qle8uBLHJ-L_Tm2v0PI-0CFTDFFfSZs4EdJZH0pGfeZUUGGDPxW4d3h_oBfjqKvYzbeIuuYrU6Ai41LO4wnNZpPO7_uHz6Dw38qozaIcF2pMyty08E5h1IYlHdhrkowmEM_qvcVwLs5dxfoHqvZmKBKHv96tN7OJxMkQZ0Wi02A9O9zlU9X-Uw-_JTT6R-TVu8Fee7QptetzGOPbJl8nzzpu_30fbLnXHvhfXT80ycvyc0QSZ68wnpX1UF1D7ClmcHi3MNhpqSzhQpXw5sTDzLnBpvA-RF17Mlcu6Rbc1foKuD94hUZ9S6-nV_6LvaCr3gcL_0oCwxyfdHMxpKfisAKzQGLmMjYLJR4Hze0OuNJYrTF27TaaMMTpKvjKmGGviY7OUj1kHihAUgWaMuYkFECAEmHkupAcylNLDPaInQt8FQ5YnKMjzFNy902AQuUSlopqil1amoRv641q4g5_lH-DHVZl0Va7TKhmP9InZemUSC1srDojTMVwUJWakENjQAFGmkkC1vkA1pCiuYIn6iku8MA7SCNVtoFfMcFYFTeIkeNkuC0qpF9DLYE3cVnCItWAVAXhk_ADjBzMfjaQ7SydU8WKdTBw8gAvuHNa8vbnP2uzsZG8QxdbopVWUZwGMFj6MZBZai1NEBAIuAx6EI0TLghrmZOPrkt2ciFwKPCQYt0amP_L4W8ebyLb8mzU_ytgaeG6BHZWc5X5hiw3zJrk20xFvCMz0N89r60ye7ZxeB62C7_prRLd4e00eC6-_03KmRdaw |
| linkProvider | Scholars Portal |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwELbaIlEuFS2PbmkhSCDoIdskju3kgFB5VLu020Mf0t6CYzt0pW2y7EPV_il-IzOJE4iogEsvOcROHM-MZ76JZ8aEvPKUzxRT1GUi89wwDjNXSsZdZpSXYgX-TGHu8OCU9y7DL0M2XCE_6lwYDKusdWKpqHWh8B_5QRCW0ZiAPt5Pvrt4ahTurtZHaFRicWyWN-Cyzd71PwF_XwfB0eeLjz3XnirgKh5FczdMPYNVrGiaRZIHwsuE5mBlTWiy1JeYaepnOuVxbHSGeaLaaMNjLMTGVcwMhfeuknshBV0C60cMGwcPdAfnNj2PCv_ASkN3UuSmi7aQ0qBl_spTAhpbsJqPRlhidVzMboO7f0Ztri_yiVzeyPH4N5N49JBsWCzrHFbCt0lWTL5F7g_sbv0W2bSKY-a8tdWt9x-R8zMsIeUUmdOvwuAdQK5mAq6_g0qsLJYLD_TPzvcdaJwaHAKtL0qQI3Ntb12Z60Ivc3k9UrPH5PJOePCErOVA1W3i-AYAn6czxoQMY4Bf2pdUe5pLaSKZ0g6hNcETZcue4-kb46TcyxPg_lTUSpBNiWVTh7jNU5Oq7Mc_-n9AXjZ9sWh3eaOYfkusDkhCT2qVgUsdpSoEN1lqQQ0NAWMaaSTzO-QNSkKCqgU-UUmbIQHjYJGu5BDQIxeAgHmH7LZ6gkpQreY9kCWYLl59cIkFAGlQzoBMwC4y-NptlLJ6JrPk1-KCN9eSd3vzy6YZB8UIvdwUi7KP4GAfIpjG00pQG2oAgYTHI-CFaIlwi1ztlnx0VdY6FwIDkb0O6TbC_l8M2fn7PF6Q9d7F4CQ56Z8ePyMPAvyJgjFKdJeszacLswdIc54-L5e3Q77etT75Ccscj50 |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwELbaIhUuFS2PbmkhSCDoIbtJnNjJAaFCWXUprVBLpb0Fxw-60jZZ9qFq_xq_jpnECURUwKWXHGLn4ZnJzDfx-DMhLzzpRzKS1I248dwwCY0rRMTcSEsvQwZ-I3Ht8MkpO7oIPw6j4Qr5Ua-FwbLK2ieWjloVEv-R94KwrMYE9NEztizi82H_7eS7iztI4UxrvZ1GZSLHenkN6dvszeAQdP0yCPofvrw_cu0OA65kcTx3w8zTyGhFMxMLFnDPcMUg4upQm8wXuOrUNypjSaKVwTWjSivNEiRlYzKJNIX7rpI7nNIEywn5sEn2wI8wZpfqUe73rGV0J0WuuxgXKQ1aobDcMaCJC6v5aIR0q-NidhP0_bOC8-4in4jltRiPfwuP_ftkw-Ja56AyxE2yovMtsn5iZ-63yKZ1IjPntWW63n9Azs-QTsopjDOoSuIdQLF6Mi-mDjq0kjgXLhicne870DjV-AiMxGhNjsiVPXWprwq1zMXVSM4ekotb0cEjspaDVLeJ42sAf54yUcRFmAAUU76gylNMCB2LjHYIrQWeSkuBjjtxjNNyXo9DKlRJK0U1pVZNHeI2V00qCpB_9H-Humz6IoF3eaKYfkutP0hDTyhpIL2OMxlCyiwUp5qGgDe10CLyO-QVWkKKbgZeUQq7WgKeg4Rd6QEgScYBDbMO2W31BPcgW817YEswXDz6kB5zANXgqAGlQIyM4G230crqkczSXx8a3Lm2vJubnzfN-FCs1st1sSj7cAaxIoZhPK4MtZEGCIh7LAZd8JYJt8TVbslHlyXvOedYlOx1SLcx9v9SyM7fx_GMrIMnST8NTo-fkHsB_k_BciW6S9bm04XeA9A5z56WX7dDvt62O_kJ3LmT4A |
| linkToUnpaywall | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwELba7QEuQHl1oUVBQkAPSZ04tpPjgqhaJCrUslI5oMixHXXFNlntZoXKgd_OTOJEBIqAA5fVKn7EHk_G38QzXwh5RnXINdfM57KgfpzGha8UFz63mubIwF9ozB1-dyKOpvHbc36-QT51uTBOguAjzqtVc5KPf6rSHjhJHiBfUXt6GoRMhl2LYAGVAtxxGIueN4xD-GasxgSkTbIlOED1EdmanryffGxPmiNfRJS5dLrf9TTYrhpW_952b5azGVKiwviug6e_RlneWJcLdfVFzec_bGGHt8m3bvJt5MrnYF3ngf76Ey_kf5POHXLLgV9v0vayTTZseZdsO_Oy8l46Duz9e-TsFImmvKrwjttgeQ_wrV3U1dJDU9dQ6kKD49OzfQ8Klxb7xT0a9cxTpXGXLuxlZa5KdTnTq_tkevjmw-sj333_wdciSWo_zqlFvjGWF4kSkaSFNALwkI1tkYcKc4LDwuQiTa0pMKPXWGNFipR5QqfcsgdkVMK8d4gXWoCF1BScSxWnANJMqJihRihlE5WzMWHdMmfakaPjNzrmWXPiJ8FJakWUoSAzJ8gx8ftWi5Yc5A_1X6EG9XWR2ru5ACuZuRXMYqqMLsDxTnIdgzOtjGSWxYBErbKKh2PyAvUvQwMEQ9TK5VHAfXDxswlgTCEBJ4sx2R3UBMOhB8V7oMEwXfwNwXGWALfBhAN-gd2Tw2h3ULu6mawyaIMB0eAAQM-dvl9f_LQvxptiHF9pq3VTRwrYRRKYxsP28eilAQKSVCSwFnLw4AzENSwpZxcNI7qUGK5MxyToH7G_WpBH_9rgMbkZ4QsXjGdiu2RUL9d2D1BpnT9xtuU7SieO7Q |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Roles+of+Insulin+Receptor+Substrates+%28IRS%29+in+renal+function+and+renal+hemodynamics&rft.jtitle=PloS+one&rft.au=Hashimoto%2C+Seiji&rft.au=Tomochika+Maoka&rft.au=Kawata%2C+Tetsuya&rft.au=Mochizuki%2C+Toshio&rft.date=2020-12-03&rft.pub=Public+Library+of+Science&rft.eissn=1932-6203&rft.volume=15&rft.issue=12&rft_id=info:doi/10.1371%2Fjournal.pone.0242332&rft.externalDocID=2466769566 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1932-6203&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1932-6203&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1932-6203&client=summon |