Undetectable plasma viral load predicts normal survival in HIV-2-infected people in a West African village

• Published in: Retrovirology Vol. 7; no. 1; p. 46
• Main Authors: van der Loeff, Maarten F Schim, Larke, Natasha, Kaye, Steve, Berry, Neil, Ariyoshi, Koya, Alabi, Abraham, van Tienen, Carla, Leligdowicz, Aleksandra, Sarge-Njie, Ramu, da Silva, Zacharias, Jaye, Assan, Ricard, Dominique, Vincent, Tim, Jones, Sarah Rowland, Aaby, Peter, Jaffar, Shabbar, Whittle, Hilton
• Format: Journal Article
• Language: English
• Published: London BioMed Central 19.05.2010; BioMed Central Ltd; Springer Nature B.V; BMC
• Subjects: Adult; Animals; Antibodies; Antiretroviral drugs; Binding sites; Biomedical and Life Sciences; Biomedicine; Cancer Research; CD4 Lymphocyte Count; Cohort analysis; Cohort Studies; Demographic aspects; Epidemiology; Female; Field study; Genomes; Guinea-Bissau; Health aspects; HIV; HIV Antibodies - blood; HIV infection; HIV Infections - mortality; HIV Infections - virology; HIV testing; HIV-2 - isolation & purification; Hospitals; Human immunodeficiency virus; Human immunodeficiency virus 1; Human immunodeficiency virus 2; Humans; Infectious Diseases; Male; Measurement; Methods; Middle Aged; Mortality; Plasma; Plasma - virology; Prognosis; Prospective Studies; Protein Structure; Sparsely populated areas; Survival Analysis; Vaccine; Viral Load; Viremia; Virology; Guinea-Bissau; West Africa; Simian Immunodeficiency Virus; High Viral Load; Plasma Viral Load; Undetectable Viral Load; Viral Load
• ISSN: 1742-4690; 1742-4690
• DOI: 10.1186/1742-4690-7-46

Background There have been no previous studies of the long-term survival and temporal changes in plasma viral load among HIV-2 infected subjects. Methods 133 HIV-2 infected and 158 HIV-uninfected subjects from a rural area in North-west Guinea-Bissau, West Africa were enrolled into a prospective cohort study in 1991 and followed-up to mid-2009. Data were collected on four occasions during that period on HIV antibodies, CD4% and HIV-2 plasma viral load. Results Median age (interquartile range [IQR]) of HIV-2 infected subjects at time of enrollment was 47 (36, 60) years, similar to that of HIV-uninfected control subjects, 49 (38, 62) (p = 0.4). Median (IQR) plasma viral load and CD4 percentage were 347 (50, 4,300) copies/ml and 29 (22, 35) respectively. Overall loss to follow-up to assess vital status was small, at 6.7% and 6.3% for HIV-2 infected and uninfected subjects respectively. An additional 17 (12.8%) and 16 (10.1%) of HIV-2 infected and uninfected subjects respectively were censored during follow-up due to infection with HIV-1. The mortality rate per 100 person-years (95% CI) was 4.5 (3.6, 5.8) among HIV-2 infected subjects compared to 2.1 (1.6, 2.9) among HIV-uninfected (age-sex adjusted rate ratio 1.9 (1.3, 2.8, p < 0.001) representing a 2-fold excess mortality rate associated with HIV-2 infection. Viral load measurements were available for 98%, 78%, 77% and 61% HIV-2 infected subjects who were alive and had not become super-infected with HIV-1, in 1991, 1996, 2003 and 2006 respectively. Median plasma viral load (RNA copies per ml) (IQR) did not change significantly over time, being 150 (50, 1,554; n = 77) in 1996, 203 (50, 2,837; n = 47) in 2003 and 171 (50, 497; n = 31) in 2006. Thirty seven percent of HIV-2 subjects had undetectable viraemia (<100 copies/ml) at baseline: strikingly, mortality in this group was similar to that of the general population. Conclusions A substantial proportion of HIV-2 infected subjects in this cohort have stable plasma viral load, and those with an undetectable viral load (37%) at study entry had a normal survival rate. However, the sequential laboratory findings need to be interpreted with caution given the number of individuals who could not be re-examined.