Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis
Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomisation analyses, using summary genetic data from the UK Biobank and GWA consortia,...
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| Published in | Nature communications Vol. 11; no. 1; pp. 597 - 10 |
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| Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
30.01.2020
Nature Publishing Group Nature Portfolio |
| Subjects | |
| Online Access | Get full text |
| ISSN | 2041-1723 2041-1723 |
| DOI | 10.1038/s41467-020-14389-8 |
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| Abstract | Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomisation analyses, using summary genetic data from the UK Biobank and GWA consortia, we found that a one standard deviation increment in average acceleration was associated with lower risks of breast cancer (odds ratio [OR]: 0.51, 95% confidence interval [CI]: 0.27 to 0.98, P-value = 0.04) and colorectal cancer (OR: 0.66, 95% CI: 0.48 to 0.90, P-value = 0.01). We found similar magnitude inverse associations for estrogen positive (ER
+ve
) breast cancer and for colon cancer. Our results support a potentially causal relationship between higher physical activity levels and lower risks of breast cancer and colorectal cancer. Based on these data, the promotion of physical activity is probably an effective strategy in the primary prevention of these commonly diagnosed cancers.
Physical activity has been linked to lower risks of colorectal and breast cancer. Here, the authors present a Mendelian randomisation analysis supporting a potentially causal relationship between higher physical activity levels and lower risks of breast cancer and colorectal cancer. |
|---|---|
| AbstractList | Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomisation analyses, using summary genetic data from the UK Biobank and GWA consortia, we found that a one standard deviation increment in average acceleration was associated with lower risks of breast cancer (odds ratio [OR]: 0.51, 95% confidence interval [CI]: 0.27 to 0.98, P-value = 0.04) and colorectal cancer (OR: 0.66, 95% CI: 0.48 to 0.90, P-value = 0.01). We found similar magnitude inverse associations for estrogen positive (ER
+ve
) breast cancer and for colon cancer. Our results support a potentially causal relationship between higher physical activity levels and lower risks of breast cancer and colorectal cancer. Based on these data, the promotion of physical activity is probably an effective strategy in the primary prevention of these commonly diagnosed cancers.
Physical activity has been linked to lower risks of colorectal and breast cancer. Here, the authors present a Mendelian randomisation analysis supporting a potentially causal relationship between higher physical activity levels and lower risks of breast cancer and colorectal cancer. Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomisation analyses, using summary genetic data from the UK Biobank and GWA consortia, we found that a one standard deviation increment in average acceleration was associated with lower risks of breast cancer (odds ratio [OR]: 0.51, 95% confidence interval [CI]: 0.27 to 0.98, P-value = 0.04) and colorectal cancer (OR: 0.66, 95% CI: 0.48 to 0.90, P-value = 0.01). We found similar magnitude inverse associations for estrogen positive (ER ) breast cancer and for colon cancer. Our results support a potentially causal relationship between higher physical activity levels and lower risks of breast cancer and colorectal cancer. Based on these data, the promotion of physical activity is probably an effective strategy in the primary prevention of these commonly diagnosed cancers. Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomisation analyses, using summary genetic data from the UK Biobank and GWA consortia, we found that a one standard deviation increment in average acceleration was associated with lower risks of breast cancer (odds ratio [OR]: 0.51, 95% confidence interval [CI]: 0.27 to 0.98, P-value = 0.04) and colorectal cancer (OR: 0.66, 95% CI: 0.48 to 0.90, P-value = 0.01). We found similar magnitude inverse associations for estrogen positive (ER +ve ) breast cancer and for colon cancer. Our results support a potentially causal relationship between higher physical activity levels and lower risks of breast cancer and colorectal cancer. Based on these data, the promotion of physical activity is probably an effective strategy in the primary prevention of these commonly diagnosed cancers. Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomisation analyses, using summary genetic data from the UK Biobank and GWA consortia, we found that a one standard deviation increment in average acceleration was associated with lower risks of breast cancer (odds ratio [OR]: 0.51, 95% confidence interval [CI]: 0.27 to 0.98, P-value=0.04) and colorectal cancer (OR: 0.66, 95% CI: 0.48 to 0.90, P-value=0.01). We found similar magnitude inverse associations for estrogen positive (ER +ve ) breast cancer and for colon cancer. Our results support a potentially causal relationship between higher physical activity levels and lower risks of breast cancer and colorectal cancer. Based on these data, the promotion of physical activity is probably an effective strategy in the primary prevention of these commonly diagnosed cancers. Physical activity has been linked to lower risks of colorectal and breast cancer. Here, the authors present a Mendelian randomisation analysis supporting a potentially causal relationship between higher physical activity levels and lower risks of breast cancer and colorectal cancer. Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomisation analyses, using summary genetic data from the UK Biobank and GWA consortia, we found that a one standard deviation increment in average acceleration was associated with lower risks of breast cancer (odds ratio [OR]: 0.51, 95% confidence interval [CI]: 0.27 to 0.98, P-value = 0.04) and colorectal cancer (OR: 0.66, 95% CI: 0.48 to 0.90, P-value = 0.01). We found similar magnitude inverse associations for estrogen positive (ER +ve ) breast cancer and for colon cancer. Our results support a potentially causal relationship between higher physical activity levels and lower risks of breast cancer and colorectal cancer. Based on these data, the promotion of physical activity is probably an effective strategy in the primary prevention of these commonly diagnosed cancers. Physical activity has been linked to lower risks of colorectal and breast cancer. Here, the authors present a Mendelian randomisation analysis supporting a potentially causal relationship between higher physical activity levels and lower risks of breast cancer and colorectal cancer. Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomisation analyses, using summary genetic data from the UK Biobank and GWA consortia, we found that a one standard deviation increment in average acceleration was associated with lower risks of breast cancer (odds ratio [OR]: 0.51, 95% confidence interval [CI]: 0.27 to 0.98, P-value = 0.04) and colorectal cancer (OR: 0.66, 95% CI: 0.48 to 0.90, P-value = 0.01). We found similar magnitude inverse associations for estrogen positive (ER+ve) breast cancer and for colon cancer. Our results support a potentially causal relationship between higher physical activity levels and lower risks of breast cancer and colorectal cancer. Based on these data, the promotion of physical activity is probably an effective strategy in the primary prevention of these commonly diagnosed cancers.Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomisation analyses, using summary genetic data from the UK Biobank and GWA consortia, we found that a one standard deviation increment in average acceleration was associated with lower risks of breast cancer (odds ratio [OR]: 0.51, 95% confidence interval [CI]: 0.27 to 0.98, P-value = 0.04) and colorectal cancer (OR: 0.66, 95% CI: 0.48 to 0.90, P-value = 0.01). We found similar magnitude inverse associations for estrogen positive (ER+ve) breast cancer and for colon cancer. Our results support a potentially causal relationship between higher physical activity levels and lower risks of breast cancer and colorectal cancer. Based on these data, the promotion of physical activity is probably an effective strategy in the primary prevention of these commonly diagnosed cancers. |
| ArticleNumber | 597 |
| Author | Wu, Anna H. Kazmi, Nabila Timothy Bishop, D. Platz, Elizabeth A. Tangen, Catherine M. Harlid, Sophia Hopper, John L. Schmit, Stephanie L. Lewis, Sarah J. Gallinger, Steven J. Ulrich, Cornelia M. Travis, Ruth C. Albanes, Demetrius Ellingjord-Dale, Merete Moreno, Victor Figueiredo, Jane C. Song, Mingyang Trichopoulou, Antonia Moreno, Lorena Schoen, Robert E. Tsilidis, Konstantinos K. Li, Li Riboli, Elio Hampe, Jochen María Huerta, José Lindblom, Annika Wolk, Alicja Monninkhof, Evelyn Banbury, Barbara Van Guelpen, Bethany Giovannucci, Edward Hsu, Li Sieri, Sabina Gsur, Andrea Li, Christopher I. Masala, Giovanna White, Emily Robinson, Timothy M. Papadimitriou, Nikos Lindor, Noralane M. Berndt, Sonja I. Bueno-de-Mesquita, Bas Giles, Graham G. Thibodeau, Stephen N. Milne, Roger Jenkins, Mark A. Martin, Richard M. Offit, Kenneth Hampel, Heather Pharoah, Paul D. P. Aleksandrova, Krasimira Buchanan, Daniel D. Lynch, Brigid Newcomb, Polly A. Castellví-Bel, Sergi Chang-Claude, Jenny Markowitz, Sanford D. Gruber, Stephen B. May, Anne M. Peters, Ulrike van |
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B. organization: Division of Human Nutrition, Wageningen University and Research – sequence: 74 givenname: Bethany orcidid: 0000-0002-9692-101X surname: Van Guelpen fullname: Van Guelpen, Bethany organization: Department of Radiation Sciences, Oncology Unit, Umeå University, Wallenberg Centre for Molecular Medicine, Umeå University – sequence: 75 givenname: Pavel surname: Vodicka fullname: Vodicka, Pavel organization: Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Faculty of Medicine and Biomedical Center in Pilsen, Charles University, Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University – sequence: 76 givenname: Emily surname: White fullname: White, Emily organization: Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Department of Epidemiology, University of Washington – sequence: 77 givenname: Alicja orcidid: 0000-0001-7387-6845 surname: Wolk fullname: Wolk, Alicja organization: Institute of Environmental Medicine, Karolinska Institutet – sequence: 78 givenname: Michael O. surname: Woods fullname: Woods, Michael O. organization: Memorial University of Newfoundland, Discipline of Genetics – sequence: 79 givenname: Anna H. surname: Wu fullname: Wu, Anna H. organization: University of Southern California, Preventative Medicine – sequence: 80 givenname: Ulrike orcidid: 0000-0001-5666-9318 surname: Peters fullname: Peters, Ulrike organization: Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Department of Epidemiology, University of Washington – sequence: 81 givenname: Marc J. surname: Gunter fullname: Gunter, Marc J. organization: Section of Nutrition and Metabolism, International Agency for Research on Cancer – sequence: 82 givenname: Neil orcidid: 0000-0003-3347-8249 surname: Murphy fullname: Murphy, Neil email: MurphyN@iarc.fr organization: Section of Nutrition and Metabolism, International Agency for Research on Cancer |
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| ContentType | Journal Article |
| Copyright | The Author(s) 2020 This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Distributed under a Creative Commons Attribution 4.0 International License |
| Copyright_xml | – notice: The Author(s) 2020 – notice: This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: Distributed under a Creative Commons Attribution 4.0 International License |
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| DOI | 10.1038/s41467-020-14389-8 |
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| Snippet | Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations... Physical activity has been linked to lower risks of colorectal and breast cancer. Here, the authors present a Mendelian randomisation analysis supporting a... |
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| SubjectTerms | 45 45/23 631/67 631/67/1347 631/67/1504/1885 631/67/2324 631/67/68 Acceleration Accelerometry Breast cancer Breast Neoplasms - genetics Colon Colon cancer Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - genetics Confidence intervals Consortia Epidemiology Estrogen receptors Estrogens Exercise Female Genetic analysis Genetic Predisposition to Disease Humanities and Social Sciences Humans Life Sciences Mendelian Randomization Analysis multidisciplinary Odds Ratio Physical activity Polymorphism, Single Nucleotide - genetics Randomization Risk Factors Santé publique et épidémiologie Science Science (multidisciplinary) |
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| Title | Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis |
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