Combining Functional and Tubular Damage Biomarkers Improves Diagnostic Precision for Acute Kidney Injury After Cardiac Surgery - Basu, Rajit K.; Wong, Hector R.; Krawczeski, Catherine D.; Wheeler, Derek S.; Manning, Peter B.; Chawla, Lakhmir S.; Devarajan, Prasad; Goldstein, Stuart L. (Journal of the American College of Cardiology, 2014)
Keywords: Acute Dialysis Quality Initiative; Acute Kidney Injury - diagnosis; acute kidney injury phenotypes; Acute-Phase Proteins - urine; Biological and medical sciences; biomarker combinations; Biomarkers; Biomarkers - analysis; cardiac surgery; Cardiac Surgical Procedures; Cardiology; Cardiology. Vascular system; Cardiopulmonary Bypass; Cardiovascular; Child, Preschool; Confidence intervals; Creatinine - blood; Cystatin C - blood; Female; functional acute kidney injury; Heart; Hospitals; Humans; Infant; Kidneys; Lipocalin-2; Lipocalins - urine; Male; Medical sciences; Nephrology. Urinary tract diseases; pediatric acute kidney injury; Postoperative Complications - diagnosis; Proto-Oncogene Proteins - urine; Surgery; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the heart; Urinary system involvement in other diseases. Miscellaneous; Acute Dialysis Quality Initiative; LR; pediatric acute kidney injury; uNGAL; AUC; ΔSCr; acute kidney injury phenotypes; CPB; functional acute kidney injury; biomarker combinations; uNGAL+/pCysC; cardiac surgery; pCysC; AKI; CART; urinary neutrophil gelatinase-associated lipocalin; area under the curve; classification and regression tree analysis; plasma cystatin C; likelihood ratio; change in serum creatinine from baseline; cardiopulmonary bypass; biomarker composite designating both >200 ng/mg uNGAL and >0.8 mg/l pCysC; acute kidney injury; Kidney disease; Improvement; Urinary system disease; Acute kidney injury; Biological marker; Cardiovascular disease; Circulatory system; Diagnosis; Cardiac surgery; Cardiology