Bacillus subtilis: a universal cell factory for industry, agriculture, biomaterials and medicine

Due to its clear inherited backgrounds as well as simple and diverse genetic manipulation systems, Bacillus subtilis is the key Gram-positive model bacterium for studies on physiology and metabolism. Furthermore, due to its highly efficient protein secretion system and adaptable metabolism, it has b...

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Published inMicrobial cell factories Vol. 19; no. 1; pp. 1 - 12
Main Authors Su, Yuan, Liu, Chuan, Fang, Huan, Zhang, Dawei
Format Journal Article
LanguageEnglish
Published London BioMed Central 03.09.2020
BioMed Central Ltd
BMC
Subjects
Additives
Agricultural industry
Agriculture
Analysis
Antibiotics
Antiinfectives and antibacterials
Antimicrobial agents
Antimicrobials
Applied Microbiology
Bacillus subtilis
Bacteria
Binding sites
Biochemicals
Biofilms
Biological products
Biomaterials
Biomedical materials
Biotechnology
Carbon
Chemistry
Chemistry and Materials Science
CRISPR
Deoxyribonucleic acid
DNA
Drug resistance
Efficiency
Enzymes
Enzymology
Factories
Genes
Genetic aspects
Genetic diversity
Genetic Engineering
Genetic manipulation
Genomes
Medicine
Metabolism
Microbial Genetics and Genomics
Microbiology
Microorganisms
Physiological aspects
Plasmids
Protein expression
Protein turnover
Proteins
Review
Genetic manipulation
Enzymes
Protein expression
Biofilms
Antimicrobials
Biochemicals
Online AccessGet full text
ISSN1475-2859
1475-2859
DOI10.1186/s12934-020-01436-8

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Abstract Due to its clear inherited backgrounds as well as simple and diverse genetic manipulation systems, Bacillus subtilis is the key Gram-positive model bacterium for studies on physiology and metabolism. Furthermore, due to its highly efficient protein secretion system and adaptable metabolism, it has been widely used as a cell factory for microbial production of chemicals, enzymes, and antimicrobial materials for industry, agriculture, and medicine. In this mini-review, we first summarize the basic genetic manipulation tools and expression systems for this bacterium, including traditional methods and novel engineering systems. Secondly, we briefly introduce its applications in the production of chemicals and enzymes, and summarize its advantages, mainly focusing on some noteworthy products and recent progress in the engineering of B. subtilis . Finally, this review also covers applications such as microbial additives and antimicrobials, as well as biofilm systems and spore formation. We hope to provide an overview for novice researchers in this area, offering them a better understanding of B. subtilis and its applications.
AbstractList Due to its clear inherited backgrounds as well as simple and diverse genetic manipulation systems, Bacillus subtilis is the key Gram-positive model bacterium for studies on physiology and metabolism. Furthermore, due to its highly efficient protein secretion system and adaptable metabolism, it has been widely used as a cell factory for microbial production of chemicals, enzymes, and antimicrobial materials for industry, agriculture, and medicine. In this mini-review, we first summarize the basic genetic manipulation tools and expression systems for this bacterium, including traditional methods and novel engineering systems. Secondly, we briefly introduce its applications in the production of chemicals and enzymes, and summarize its advantages, mainly focusing on some noteworthy products and recent progress in the engineering of B. subtilis. Finally, this review also covers applications such as microbial additives and antimicrobials, as well as biofilm systems and spore formation. We hope to provide an overview for novice researchers in this area, offering them a better understanding of B. subtilis and its applications.
Due to its clear inherited backgrounds as well as simple and diverse genetic manipulation systems, Bacillus subtilis is the key Gram-positive model bacterium for studies on physiology and metabolism. Furthermore, due to its highly efficient protein secretion system and adaptable metabolism, it has been widely used as a cell factory for microbial production of chemicals, enzymes, and antimicrobial materials for industry, agriculture, and medicine. In this mini-review, we first summarize the basic genetic manipulation tools and expression systems for this bacterium, including traditional methods and novel engineering systems. Secondly, we briefly introduce its applications in the production of chemicals and enzymes, and summarize its advantages, mainly focusing on some noteworthy products and recent progress in the engineering of B. subtilis. Finally, this review also covers applications such as microbial additives and antimicrobials, as well as biofilm systems and spore formation. We hope to provide an overview for novice researchers in this area, offering them a better understanding of B. subtilis and its applications. Keywords: Bacillus subtilis, Genetic manipulation, Protein expression, Biochemicals, Enzymes, Antimicrobials, Biofilms
Due to its clear inherited backgrounds as well as simple and diverse genetic manipulation systems, Bacillus subtilis is the key Gram-positive model bacterium for studies on physiology and metabolism. Furthermore, due to its highly efficient protein secretion system and adaptable metabolism, it has been widely used as a cell factory for microbial production of chemicals, enzymes, and antimicrobial materials for industry, agriculture, and medicine. In this mini-review, we first summarize the basic genetic manipulation tools and expression systems for this bacterium, including traditional methods and novel engineering systems. Secondly, we briefly introduce its applications in the production of chemicals and enzymes, and summarize its advantages, mainly focusing on some noteworthy products and recent progress in the engineering of B. subtilis . Finally, this review also covers applications such as microbial additives and antimicrobials, as well as biofilm systems and spore formation. We hope to provide an overview for novice researchers in this area, offering them a better understanding of B. subtilis and its applications.
Due to its clear inherited backgrounds as well as simple and diverse genetic manipulation systems, Bacillus subtilis is the key Gram-positive model bacterium for studies on physiology and metabolism. Furthermore, due to its highly efficient protein secretion system and adaptable metabolism, it has been widely used as a cell factory for microbial production of chemicals, enzymes, and antimicrobial materials for industry, agriculture, and medicine. In this mini-review, we first summarize the basic genetic manipulation tools and expression systems for this bacterium, including traditional methods and novel engineering systems. Secondly, we briefly introduce its applications in the production of chemicals and enzymes, and summarize its advantages, mainly focusing on some noteworthy products and recent progress in the engineering of B. subtilis. Finally, this review also covers applications such as microbial additives and antimicrobials, as well as biofilm systems and spore formation. We hope to provide an overview for novice researchers in this area, offering them a better understanding of B. subtilis and its applications.Due to its clear inherited backgrounds as well as simple and diverse genetic manipulation systems, Bacillus subtilis is the key Gram-positive model bacterium for studies on physiology and metabolism. Furthermore, due to its highly efficient protein secretion system and adaptable metabolism, it has been widely used as a cell factory for microbial production of chemicals, enzymes, and antimicrobial materials for industry, agriculture, and medicine. In this mini-review, we first summarize the basic genetic manipulation tools and expression systems for this bacterium, including traditional methods and novel engineering systems. Secondly, we briefly introduce its applications in the production of chemicals and enzymes, and summarize its advantages, mainly focusing on some noteworthy products and recent progress in the engineering of B. subtilis. Finally, this review also covers applications such as microbial additives and antimicrobials, as well as biofilm systems and spore formation. We hope to provide an overview for novice researchers in this area, offering them a better understanding of B. subtilis and its applications.
Abstract Due to its clear inherited backgrounds as well as simple and diverse genetic manipulation systems, Bacillus subtilis is the key Gram-positive model bacterium for studies on physiology and metabolism. Furthermore, due to its highly efficient protein secretion system and adaptable metabolism, it has been widely used as a cell factory for microbial production of chemicals, enzymes, and antimicrobial materials for industry, agriculture, and medicine. In this mini-review, we first summarize the basic genetic manipulation tools and expression systems for this bacterium, including traditional methods and novel engineering systems. Secondly, we briefly introduce its applications in the production of chemicals and enzymes, and summarize its advantages, mainly focusing on some noteworthy products and recent progress in the engineering of B. subtilis. Finally, this review also covers applications such as microbial additives and antimicrobials, as well as biofilm systems and spore formation. We hope to provide an overview for novice researchers in this area, offering them a better understanding of B. subtilis and its applications.
ArticleNumber 173
Audience Academic
Author Su, Yuan
Fang, Huan
Zhang, Dawei
Liu, Chuan
Author_xml – sequence: 1
  givenname: Yuan
  surname: Su
  fullname: Su, Yuan
  organization: College of Biotechnology, Tianjin University of Science and Technology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences
– sequence: 2
  givenname: Chuan
  surname: Liu
  fullname: Liu, Chuan
  organization: Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Key Laboratory of Systems Microbial Biotechnology, Chinese Academy of Sciences
– sequence: 3
  givenname: Huan
  surname: Fang
  fullname: Fang, Huan
  organization: Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Key Laboratory of Systems Microbial Biotechnology, Chinese Academy of Sciences
– sequence: 4
  givenname: Dawei
  orcidid: 0000-0001-5555-6151
  surname: Zhang
  fullname: Zhang, Dawei
  email: zhang_dw@tib.cas.cn
  organization: Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Key Laboratory of Systems Microbial Biotechnology, Chinese Academy of Sciences, University of Chinese Academy of Sciences
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Issue 1
Keywords Genetic manipulation
Enzymes
Protein expression
Biofilms
Antimicrobials
Biochemicals
Language English
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Snippet Due to its clear inherited backgrounds as well as simple and diverse genetic manipulation systems, Bacillus subtilis is the key Gram-positive model bacterium...
Due to its clear inherited backgrounds as well as simple and diverse genetic manipulation systems, Bacillus subtilis is the key Gram-positive model bacterium...
Abstract Due to its clear inherited backgrounds as well as simple and diverse genetic manipulation systems, Bacillus subtilis is the key Gram-positive model...
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SubjectTerms Additives
Agricultural industry
Agriculture
Analysis
Antibiotics
Antiinfectives and antibacterials
Antimicrobial agents
Antimicrobials
Applied Microbiology
Bacillus subtilis
Bacteria
Binding sites
Biochemicals
Biofilms
Biological products
Biomaterials
Biomedical materials
Biotechnology
Carbon
Chemistry
Chemistry and Materials Science
CRISPR
Deoxyribonucleic acid
DNA
Drug resistance
Efficiency
Enzymes
Enzymology
Factories
Genes
Genetic aspects
Genetic diversity
Genetic Engineering
Genetic manipulation
Genomes
Medicine
Metabolism
Microbial Genetics and Genomics
Microbiology
Microorganisms
Physiological aspects
Plasmids
Protein expression
Protein turnover
Proteins
Review
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Title Bacillus subtilis: a universal cell factory for industry, agriculture, biomaterials and medicine
URI https://link.springer.com/article/10.1186/s12934-020-01436-8
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