MicroRNA signature in patients with eosinophilic esophagitis, reversibility with glucocorticoids, and assessment as disease biomarkers
The role of microRNAs (miRNAs), a key class of regulators of mRNA expression and translation, in patients with eosinophilic esophagitis (EoE) has not been explored. We aimed to identify miRNAs dysregulated in patients with EoE and assess the potential of these miRNAs as disease biomarkers. Esophagea...
Saved in:
| Published in | Journal of allergy and clinical immunology Vol. 129; no. 4; pp. 1064 - 1075.e9 |
|---|---|
| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
New York, NY
Elsevier Inc
01.04.2012
Elsevier Elsevier Limited |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0091-6749 1097-6825 1097-6825 |
| DOI | 10.1016/j.jaci.2012.01.060 |
Cover
| Abstract | The role of microRNAs (miRNAs), a key class of regulators of mRNA expression and translation, in patients with eosinophilic esophagitis (EoE) has not been explored.
We aimed to identify miRNAs dysregulated in patients with EoE and assess the potential of these miRNAs as disease biomarkers.
Esophageal miRNA expression was profiled in patients with active EoE and those with glucocorticoid-induced disease remission. Expression profiles were compared with those of healthy control subjects and patients with chronic (noneosinophilic) esophagitis. Expression levels of the top differentially expressed miRNAs from the plasma of patients with active EoE and patients with EoE remission were compared with those of healthy control subjects.
EoE was associated with 32 differentially regulated miRNAs and was distinguished from noneosinophilic forms of esophagitis. The expression levels of the most upregulated miRNAs (miR-21 and miR-223) and the most downregulated miRNA (miR-375) strongly correlated with esophageal eosinophil levels. Bioinformatic analysis predicted interplay of miR-21 and miR-223 with key roles in the polarization of adaptive immunity and regulation of eosinophilia, and indeed, these miRNAs correlated with key elements of the EoE transcriptome. The differentially expressed miRNAs were largely reversible in patients who responded to glucocorticoid treatment. EoE remission induced a single miRNA (miR-675) likely to be involved in DNA methylation. Plasma analysis of the most upregulated esophageal miRNAs identified miR-146a, miR-146b, and miR-223 as the most differentially expressed miRNAs in the plasma.
We have identified a marked dysregulated expression of a select group of miRNAs in patients with EoE and defined their reversibility with glucocorticoid treatment and their potential value as invasive and noninvasive biomarkers. |
|---|---|
| AbstractList | The role of microRNAs (miRNAs), a key class of regulators of mRNA expression and translation, in patients with eosinophilic esophagitis (EoE) has not been explored.
We aimed to identify miRNAs dysregulated in patients with EoE and assess the potential of these miRNAs as disease biomarkers.
Esophageal miRNA expression was profiled in patients with active EoE and those with glucocorticoid-induced disease remission. Expression profiles were compared with those of healthy control subjects and patients with chronic (noneosinophilic) esophagitis. Expression levels of the top differentially expressed miRNAs from the plasma of patients with active EoE and patients with EoE remission were compared with those of healthy control subjects.
EoE was associated with 32 differentially regulated miRNAs and was distinguished from noneosinophilic forms of esophagitis. The expression levels of the most upregulated miRNAs (miR-21 and miR-223) and the most downregulated miRNA (miR-375) strongly correlated with esophageal eosinophil levels. Bioinformatic analysis predicted interplay of miR-21 and miR-223 with key roles in the polarization of adaptive immunity and regulation of eosinophilia, and indeed, these miRNAs correlated with key elements of the EoE transcriptome. The differentially expressed miRNAs were largely reversible in patients who responded to glucocorticoid treatment. EoE remission induced a single miRNA (miR-675) likely to be involved in DNA methylation. Plasma analysis of the most upregulated esophageal miRNAs identified miR-146a, miR-146b, and miR-223 as the most differentially expressed miRNAs in the plasma.
We have identified a marked dysregulated expression of a select group of miRNAs in patients with EoE and defined their reversibility with glucocorticoid treatment and their potential value as invasive and noninvasive biomarkers. Background: The role of microRNAs (miRNAs), a key class of regulators of mRNA expression and translation, in patients with eosinophilic esophagitis (EoE) has not been explored. Objective: We aimed to identify miRNAs dysregulated in patients with EoE and assess the potential of these miRNAs as disease biomarkers. Methods: Esophageal miRNA expression was profiled in patients with active EoE and those with glucocorticoid-induced disease remission. Expression profiles were compared with those of healthy control subjects and patients with chronic (noneosinophilic) esophagitis. Expression levels of the top differentially expressed miRNAs from the plasma of patients with active EoE and patients with EoE remission were compared with those of healthy control subjects. Results: EoE was associated with 32 differentially regulated miRNAs and was distinguished from noneosinophilic forms of esophagitis. The expression levels of the most upregulated miRNAs (miR-21 and miR-223) and the most downregulated miRNA (miR-375) strongly correlated with esophageal eosinophil levels. Bioinformatic analysis predicted interplay of miR-21 and miR-223 with key roles in the polarization of adaptive immunity and regulation of eosinophilia, and indeed, these miRNAs correlated with key elements of the EoE transcriptome. The differentially expressed miRNAs were largely reversible in patients who responded to glucocorticoid treatment. EoE remission induced a single miRNA (miR-675) likely to be involved in DNA methylation. Plasma analysis of the most upregulated esophageal miRNAs identified miR-146a, miR-146b, and miR-223 as the most differentially expressed miRNAs in the plasma. Conclusions: We have identified a marked dysregulated expression of a select group of miRNAs in patients with EoE and defined their reversibility with glucocorticoid treatment and their potential value as invasive and noninvasive biomarkers. The role of microRNAs (miRNAs), a key class of regulators of mRNA expression and translation, in patients with eosinophilic esophagitis (EoE) has not been explored.BACKGROUNDThe role of microRNAs (miRNAs), a key class of regulators of mRNA expression and translation, in patients with eosinophilic esophagitis (EoE) has not been explored.We aimed to identify miRNAs dysregulated in patients with EoE and assess the potential of these miRNAs as disease biomarkers.OBJECTIVEWe aimed to identify miRNAs dysregulated in patients with EoE and assess the potential of these miRNAs as disease biomarkers.Esophageal miRNA expression was profiled in patients with active EoE and those with glucocorticoid-induced disease remission. Expression profiles were compared with those of healthy control subjects and patients with chronic (noneosinophilic) esophagitis. Expression levels of the top differentially expressed miRNAs from the plasma of patients with active EoE and patients with EoE remission were compared with those of healthy control subjects.METHODSEsophageal miRNA expression was profiled in patients with active EoE and those with glucocorticoid-induced disease remission. Expression profiles were compared with those of healthy control subjects and patients with chronic (noneosinophilic) esophagitis. Expression levels of the top differentially expressed miRNAs from the plasma of patients with active EoE and patients with EoE remission were compared with those of healthy control subjects.EoE was associated with 32 differentially regulated miRNAs and was distinguished from noneosinophilic forms of esophagitis. The expression levels of the most upregulated miRNAs (miR-21 and miR-223) and the most downregulated miRNA (miR-375) strongly correlated with esophageal eosinophil levels. Bioinformatic analysis predicted interplay of miR-21 and miR-223 with key roles in the polarization of adaptive immunity and regulation of eosinophilia, and indeed, these miRNAs correlated with key elements of the EoE transcriptome. The differentially expressed miRNAs were largely reversible in patients who responded to glucocorticoid treatment. EoE remission induced a single miRNA (miR-675) likely to be involved in DNA methylation. Plasma analysis of the most upregulated esophageal miRNAs identified miR-146a, miR-146b, and miR-223 as the most differentially expressed miRNAs in the plasma.RESULTSEoE was associated with 32 differentially regulated miRNAs and was distinguished from noneosinophilic forms of esophagitis. The expression levels of the most upregulated miRNAs (miR-21 and miR-223) and the most downregulated miRNA (miR-375) strongly correlated with esophageal eosinophil levels. Bioinformatic analysis predicted interplay of miR-21 and miR-223 with key roles in the polarization of adaptive immunity and regulation of eosinophilia, and indeed, these miRNAs correlated with key elements of the EoE transcriptome. The differentially expressed miRNAs were largely reversible in patients who responded to glucocorticoid treatment. EoE remission induced a single miRNA (miR-675) likely to be involved in DNA methylation. Plasma analysis of the most upregulated esophageal miRNAs identified miR-146a, miR-146b, and miR-223 as the most differentially expressed miRNAs in the plasma.We have identified a marked dysregulated expression of a select group of miRNAs in patients with EoE and defined their reversibility with glucocorticoid treatment and their potential value as invasive and noninvasive biomarkers.CONCLUSIONSWe have identified a marked dysregulated expression of a select group of miRNAs in patients with EoE and defined their reversibility with glucocorticoid treatment and their potential value as invasive and noninvasive biomarkers. |
| Author | Besse, John A. Lu, Thomas X. Plassard, Andrew J. Sherrill, Joseph D. Martin, Lisa J. Wen, Ting Putnam, Philip E. Eby, Michael Aronow, Bruce J. Rothenberg, Marc E. Abonia, Juan Pablo Franciosi, James P. |
| AuthorAffiliation | a Division of Allergy and Immunology, University of Cincinnati College of Medicine, Cincinnati, Ohio b Graduate Program of Molecular and Developmental Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio c Physician Scientist Training Program, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio d Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio e Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio f Division of Epidemiology and Biostatistics, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio |
| AuthorAffiliation_xml | – name: c Physician Scientist Training Program, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio – name: f Division of Epidemiology and Biostatistics, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio – name: e Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio – name: d Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio – name: b Graduate Program of Molecular and Developmental Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio – name: a Division of Allergy and Immunology, University of Cincinnati College of Medicine, Cincinnati, Ohio |
| Author_xml | – sequence: 1 givenname: Thomas X. surname: Lu fullname: Lu, Thomas X. organization: Division of Allergy and Immunology, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio – sequence: 2 givenname: Joseph D. surname: Sherrill fullname: Sherrill, Joseph D. organization: Division of Allergy and Immunology, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio – sequence: 3 givenname: Ting surname: Wen fullname: Wen, Ting organization: Division of Allergy and Immunology, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio – sequence: 4 givenname: Andrew J. surname: Plassard fullname: Plassard, Andrew J. organization: Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio – sequence: 5 givenname: John A. surname: Besse fullname: Besse, John A. organization: Division of Allergy and Immunology, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio – sequence: 6 givenname: Juan Pablo surname: Abonia fullname: Abonia, Juan Pablo organization: Division of Allergy and Immunology, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio – sequence: 7 givenname: James P. surname: Franciosi fullname: Franciosi, James P. organization: Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio – sequence: 8 givenname: Philip E. surname: Putnam fullname: Putnam, Philip E. organization: Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio – sequence: 9 givenname: Michael surname: Eby fullname: Eby, Michael organization: Division of Allergy and Immunology, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio – sequence: 10 givenname: Lisa J. surname: Martin fullname: Martin, Lisa J. organization: Division of Epidemiology and Biostatistics, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio – sequence: 11 givenname: Bruce J. surname: Aronow fullname: Aronow, Bruce J. organization: Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio – sequence: 12 givenname: Marc E. surname: Rothenberg fullname: Rothenberg, Marc E. email: Rothenberg@cchmc.org organization: Division of Allergy and Immunology, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25754287$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/22391115$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFk9tu1DAQhiNURA_wAlygSAjBBbvYOTh2hSpVFSepgMTh2nKcyXa22XjxZIv2BXhuJtqWwkpsr2LL3_97ZvL7MNnrQw9J8liKqRRSvZpP587jNBMymwo5FUrcSw6kMNVE6azcSw6EMHKiqsLsJ4dEc8H7XJsHyX6W5UZKWR4kvz6ij-HLp9OUcNa7YRUhxT5dugGhHyj9icNFCoGwD8sL7NCnQLxyMxyQXqYRriAS1nwyrDfwrFv54EMc0AdsmHF9kzoiIFqwJS_TBgkcQVpjWLh4yQ4Pk_ut6wgeXX-Pku9v33w7ez85__zuw9np-cQrXQyTrGpVXUMtIS-qQla8Vc57bVTbtpXRpXCZr2sjG6dq0Kp22riyagtwpdNe5EfJycZ3uaoX0HguKLrOLiNyIWsbHNp_T3q8sLNwZfNCKVEqNnh-bRDDjxXQYBdIHrrO9RBWZI3KdS6k0Uy-2EnKqlBFpmVZ3I0KKTOZlaVk9OkWOg-r2PPMLDtVWhltRurJ323-6e_mvzPw7Bpw5F3XRtd7pFuurEqurWJObzgOCVGE1nocOBthnA52XNlYnLJzO0bRjlG0QlqOIkuzLemN-07R640IOARXCNGS5yB6aDCCH2wTcLf8ZEvuO-yRO7yENdDtqCyxxn4dH8j4PmQmhNR6HNzx_w3uuv03sC0isw |
| CODEN | JACIBY |
| CitedBy_id | crossref_primary_10_1016_j_jaci_2018_10_070 crossref_primary_10_1007_s11882_016_0648_z crossref_primary_10_1016_j_jaci_2016_01_029 crossref_primary_10_32604_biocell_2022_016822 crossref_primary_10_1016_j_arcped_2019_02_005 crossref_primary_10_1093_dote_doac018 crossref_primary_10_1016_j_gastrohep_2014_12_006 crossref_primary_10_1146_annurev_pathol_012615_044241 crossref_primary_10_1177_17562848221076888 crossref_primary_10_1007_s11010_016_2743_9 crossref_primary_10_12688_f1000research_6942_1 crossref_primary_10_1038_gene_2014_27 crossref_primary_10_1261_rna_038414_113 crossref_primary_10_33590_emjallergyimmunol_10312185 crossref_primary_10_1016_j_waojou_2020_100451 crossref_primary_10_3389_fnmol_2023_1099256 crossref_primary_10_1016_j_jaci_2019_07_049 crossref_primary_10_3390_ijms26020639 crossref_primary_10_1016_j_bpg_2015_09_012 crossref_primary_10_1016_j_abb_2021_108763 crossref_primary_10_1186_s12916_014_0224_0 crossref_primary_10_1097_PAI_0000000000000450 crossref_primary_10_1177_2152656720953378 crossref_primary_10_2500_ar_2015_6_0107 crossref_primary_10_3164_jcbn_24_193 crossref_primary_10_1517_14728214_2013_829039 crossref_primary_10_1016_j_molimm_2013_01_006 crossref_primary_10_1016_j_jaci_2016_03_012 crossref_primary_10_1038_srep06103 crossref_primary_10_1016_j_canlet_2018_03_036 crossref_primary_10_1111_all_13299 crossref_primary_10_1097_MOG_0000000000000186 crossref_primary_10_1159_000447637 crossref_primary_10_3390_genes12060801 crossref_primary_10_1016_j_jaci_2013_09_031 crossref_primary_10_1038_ajg_2015_404 crossref_primary_10_1186_s12931_020_01351_x crossref_primary_10_1371_journal_pone_0059397 crossref_primary_10_1016_j_jaci_2013_04_011 crossref_primary_10_1159_000452654 crossref_primary_10_1007_s10620_020_06566_y crossref_primary_10_3389_fped_2014_00041 crossref_primary_10_2500_aap_2023_44_220102 crossref_primary_10_1089_omi_2018_0112 crossref_primary_10_1111_joim_12568 crossref_primary_10_1155_2014_870267 crossref_primary_10_1016_j_cgh_2014_07_034 crossref_primary_10_1016_j_jaci_2012_11_007 crossref_primary_10_1111_jcmm_12353 crossref_primary_10_1016_j_anai_2012_06_014 crossref_primary_10_1038_mi_2013_90 crossref_primary_10_2174_0929867325666180601100235 crossref_primary_10_1159_000357296 crossref_primary_10_1186_1756_0500_7_403 crossref_primary_10_1159_000357295 crossref_primary_10_1016_j_jaci_2012_06_054 crossref_primary_10_1016_j_jaci_2014_10_015 crossref_primary_10_3389_fmed_2017_00108 crossref_primary_10_1016_j_jaci_2013_04_039 crossref_primary_10_1007_s11882_016_0665_y crossref_primary_10_1016_j_clim_2020_108383 crossref_primary_10_1002_cti2_1210 crossref_primary_10_1093_ecco_jcc_jjac003 crossref_primary_10_1159_000357005 crossref_primary_10_1371_journal_pone_0149257 crossref_primary_10_1152_ajpgi_00184_2022 crossref_primary_10_3928_00904481_20130619_10 crossref_primary_10_1007_s11882_015_0592_3 crossref_primary_10_3389_fimmu_2018_00170 crossref_primary_10_1096_fj_202301934R crossref_primary_10_1080_08820139_2019_1617303 crossref_primary_10_18632_oncotarget_20984 crossref_primary_10_1007_s11882_014_0424_x crossref_primary_10_1111_iep_12123 crossref_primary_10_3389_fimmu_2021_781815 crossref_primary_10_1016_j_arr_2018_10_008 crossref_primary_10_1172_jci_insight_86355 crossref_primary_10_1016_j_jaci_2023_07_021 crossref_primary_10_3389_fimmu_2019_02323 crossref_primary_10_1152_ajpgi_00121_2014 crossref_primary_10_1016_j_fertnstert_2020_01_026 crossref_primary_10_1111_cns_14291 crossref_primary_10_1016_j_giec_2015_08_006 crossref_primary_10_1371_journal_pone_0040676 crossref_primary_10_1016_j_molimm_2015_12_015 crossref_primary_10_1007_s00281_019_00777_w crossref_primary_10_1016_j_coi_2015_07_006 crossref_primary_10_1111_dote_12273 crossref_primary_10_2350_13_03_1306_OA_1 crossref_primary_10_1016_j_cellimm_2016_04_003 crossref_primary_10_3390_ijms18051050 crossref_primary_10_1136_thoraxjnl_2019_213225 crossref_primary_10_1155_2022_2961187 crossref_primary_10_3389_fmed_2017_00240 crossref_primary_10_1016_j_jaci_2014_10_041 crossref_primary_10_1097_MPG_0000000000002957 crossref_primary_10_1097_MPG_0000000000000253 crossref_primary_10_4049_jimmunol_1301309 crossref_primary_10_3390_ncrna6010010 crossref_primary_10_1007_s12016_017_8665_9 crossref_primary_10_1016_j_jaci_2022_05_030 crossref_primary_10_1053_j_gastro_2015_02_002 crossref_primary_10_3390_ijms24043669 crossref_primary_10_1016_j_jaci_2018_07_009 crossref_primary_10_1586_17474124_2014_909727 crossref_primary_10_1159_000357012 crossref_primary_10_1016_j_gtc_2014_02_003 crossref_primary_10_3389_fimmu_2023_1209874 |
| Cites_doi | 10.1093/nar/gkp427 10.1074/jbc.M110.210724 10.1016/j.athoracsur.2009.07.038 10.1002/jcb.22733 10.1038/nature06642 10.1172/JCI26679 10.1053/j.gastro.2007.10.002 10.1093/carcin/bgp181 10.1038/ncb1596 10.1073/pnas.1019055108 10.4049/jimmunol.0803560 10.1073/pnas.0804549105 10.1186/1471-2407-11-57 10.1016/j.jaci.2011.02.040 10.1016/j.jaci.2010.04.009 10.1016/j.jaci.2011.03.046 10.1016/j.jaci.2011.04.034 10.1038/labinvest.2010.194 10.1002/jso.22066 10.1046/j.1365-2540.2001.00901.x 10.3816/CLC.2009.n.006 10.1093/nar/gkm952 10.1261/rna.351707 10.1074/jbc.M110.170852 10.1073/pnas.0905063106 10.1002/jcb.21461 10.1016/j.jaci.2010.05.045 10.1053/j.gastro.2008.07.068 10.1067/mai.2001.119917 10.1038/nature09284 10.1186/1423-0127-18-24 10.1016/j.jaci.2011.05.006 10.1038/ajg.2010.412 10.1006/meth.2001.1262 10.1016/j.jaci.2011.04.005 10.1016/j.jaci.2007.10.024 10.1056/NEJMoa1106469 10.1053/j.gastro.2011.07.044 10.1002/eji.200636112 10.1007/s11010-011-0771-z 10.4049/jimmunol.1101235 10.3748/wjg.v16.i5.531 10.1097/MPG.0b013e31822200cc 10.1016/j.cell.2010.08.012 10.1038/nbt.1621 10.1016/j.jaci.2010.10.039 10.1159/000310918 10.1016/j.jaci.2010.08.050 10.1007/s10620-011-1711-1 10.1016/j.jaci.2010.01.038 10.1016/j.ccr.2010.08.013 10.4049/jimmunol.0903069 10.1186/1471-2164-9-564 10.1007/s11033-011-0854-7 10.1152/physrev.00006.2010 10.1111/j.1742-4658.2011.08089.x 10.1093/bioinformatics/btp120 10.1371/journal.pone.0000610 10.1016/j.jaci.2006.10.044 10.4049/jimmunol.182.1.433 10.1038/mi.2008.15 10.1074/jbc.M110.145698 |
| ContentType | Journal Article |
| Copyright | 2012 American Academy of Allergy, Asthma & Immunology American Academy of Allergy, Asthma & Immunology 2015 INIST-CNRS Copyright © 2012 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved. Copyright Elsevier Limited Apr 2012 2012 American Academy of Allergy, Asthma & Immunology 2012 |
| Copyright_xml | – notice: 2012 American Academy of Allergy, Asthma & Immunology – notice: American Academy of Allergy, Asthma & Immunology – notice: 2015 INIST-CNRS – notice: Copyright © 2012 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved. – notice: Copyright Elsevier Limited Apr 2012 – notice: 2012 American Academy of Allergy, Asthma & Immunology 2012 |
| DBID | AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 7SS 7T5 H94 K9. NAPCQ 7TM 7S9 L.6 7X8 5PM |
| DOI | 10.1016/j.jaci.2012.01.060 |
| DatabaseName | CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Entomology Abstracts (Full archive) Immunology Abstracts AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Premium Nucleic Acids Abstracts AGRICOLA AGRICOLA - Academic MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Entomology Abstracts AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Premium Immunology Abstracts Nucleic Acids Abstracts AGRICOLA AGRICOLA - Academic MEDLINE - Academic |
| DatabaseTitleList | MEDLINE AIDS and Cancer Research Abstracts AGRICOLA MEDLINE - Academic Entomology Abstracts |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1097-6825 |
| EndPage | 1075.e9 |
| ExternalDocumentID | PMC3466056 3382346091 22391115 25754287 10_1016_j_jaci_2012_01_060 S0091674912001881 1_s2_0_S0091674912001881 |
| Genre | Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: National Heart, Lung, and Blood Institute’s Ruth L. Kirschstein National Research Service Award grantid: F30HL104892 – fundername: NIH grantid: R01DK076893; U19 AI070235; P30 DK078392 – fundername: [NIH] grantid: T32HD046387 – fundername: NIAID NIH HHS grantid: U19 AI070235 – fundername: NHLBI NIH HHS grantid: F30HL104892 – fundername: NIDDK NIH HHS grantid: P30 DK078392 – fundername: NHLBI NIH HHS grantid: F30 HL104892 – fundername: NIDDK NIH HHS grantid: R01DK076893 – fundername: NIAID NIH HHS grantid: R37 AI045898 – fundername: NICHD NIH HHS grantid: T32HD046387 – fundername: NICHD NIH HHS grantid: T32 HD046387 – fundername: NCATS NIH HHS grantid: UL1 TR000077 – fundername: NIDDK NIH HHS grantid: R01 DK076893 – fundername: National Institute of Diabetes and Digestive and Kidney Diseases : NIDDK grantid: P30 DK078392-05 || DK – fundername: National Institute of Diabetes and Digestive and Kidney Diseases : NIDDK grantid: R01 DK076893-05 || DK – fundername: National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID grantid: U19 AI070235-07 || AI – fundername: National Institute of Child Health & Human Development : NICHD grantid: T32 HD046387-05 || HD – fundername: National Heart, Lung, and Blood Institute : NHLBI grantid: F30 HL104892-03 || HL |
| GroupedDBID | --- --K --M -~X .1- .55 .FO .GJ .XZ .~1 0R~ 1B1 1P~ 1RT 1~. 1~5 354 3O- 4.4 457 4G. 53G 5GY 5RE 5VS 7-5 71M 8F7 8FE 8FH 8P~ 9JM AAAJQ AABNK AAEDT AAEDW AAFWJ AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AARKO AATTM AAXKI AAXUO AAYWO ABBQC ABFNM ABJNI ABLJU ABMAC ABMZM ABOCM ABWVN ABXDB ACDAQ ACGFO ACGFS ACIEU ACPRK ACRLP ACRPL ACVFH ADBBV ADCNI ADEZE ADFRT ADMUD ADNMO ADVLN ADXHL AEBSH AEIPS AEKER AENEX AEUPX AFFNX AFJKZ AFPUW AFRAH AFRHN AFTJW AFXIZ AGCQF AGEKW AGHFR AGQPQ AGUBO AGYEJ AHHHB AHMBA AIEXJ AIGII AIIUN AIKHN AITUG AJRQY AJUYK AKBMS AKRWK AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ ANKPU ANZVX APXCP ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC BNPGV BPHCQ BVXVI C45 CAG CJTIS COF CS3 DU5 EBS EFJIC EFKBS EJD EO8 EO9 EP2 EP3 EX3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HDU HMK HMO HVGLF HZ~ IHE J1W J5H K-O KOM L7B LK8 LUGTX M27 M41 MO0 N4W N9A O-L O9- O9~ OAUVE OBH ODZKP OHH OHT OK0 OK1 OVD OZT P-8 P-9 P2P PC. PQQKQ PROAC Q38 R2- ROL RPZ SAE SCC SDF SDG SDP SEL SES SEW SJN SPCBC SSH SSI SSZ T5K TEORI TWZ UGJ UNMZH UV1 WH7 WOW WUQ X7M XFW YOC YQI YQJ Z5R ZGI ZXP ZY1 ~02 ~G- ~KM AACTN RIG AAYXX ACLOT CITATION EFLBG ~HD AGRNS IQODW CGR CUY CVF ECM EIF NPM 7SS 7T5 H94 K9. NAPCQ 7TM 7S9 L.6 7X8 5PM |
| ID | FETCH-LOGICAL-c684t-27f6bbeb1e3474177f66acc896fff79850a2cbb91da6be86ba89a57f4ea5a8c03 |
| IEDL.DBID | .~1 |
| ISSN | 0091-6749 1097-6825 |
| IngestDate | Tue Sep 30 15:05:01 EDT 2025 Fri Sep 05 06:50:25 EDT 2025 Mon Sep 29 03:30:34 EDT 2025 Sun Sep 28 10:47:39 EDT 2025 Wed Aug 13 11:39:00 EDT 2025 Mon Jul 21 06:06:32 EDT 2025 Mon Jul 21 09:14:23 EDT 2025 Wed Oct 01 05:09:31 EDT 2025 Thu Apr 24 23:06:47 EDT 2025 Sun Apr 06 06:53:47 EDT 2025 Wed Apr 02 07:27:20 EDT 2025 Tue Aug 26 16:36:25 EDT 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 4 |
| Keywords | microRNA miRNA glucocorticoid EoE Eosinophilic esophagitis biomarkers Human Immunopathology RNA interference Esophageal disease Micro RNA Biological marker Esophagitis Glucocorticoid Eosinophil Gene silencing Immunology Digestive diseases Reversibility |
| Language | English |
| License | https://www.elsevier.com/tdm/userlicense/1.0 CC BY 4.0 Copyright © 2012 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c684t-27f6bbeb1e3474177f66acc896fff79850a2cbb91da6be86ba89a57f4ea5a8c03 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Article-2 ObjectType-Feature-1 content type line 23 |
| OpenAccessLink | http://www.jacionline.org/article/S0091674912001881/pdf |
| PMID | 22391115 |
| PQID | 1547869891 |
| PQPubID | 105664 |
| PageCount | 12 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_3466056 proquest_miscellaneous_963830198 proquest_miscellaneous_1746428154 proquest_miscellaneous_1011212551 proquest_journals_1547869891 pubmed_primary_22391115 pascalfrancis_primary_25754287 crossref_citationtrail_10_1016_j_jaci_2012_01_060 crossref_primary_10_1016_j_jaci_2012_01_060 elsevier_sciencedirect_doi_10_1016_j_jaci_2012_01_060 elsevier_clinicalkeyesjournals_1_s2_0_S0091674912001881 elsevier_clinicalkey_doi_10_1016_j_jaci_2012_01_060 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2012-04-01 |
| PublicationDateYYYYMMDD | 2012-04-01 |
| PublicationDate_xml | – month: 04 year: 2012 text: 2012-04-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | New York, NY |
| PublicationPlace_xml | – name: New York, NY – name: United States – name: St. Louis |
| PublicationTitle | Journal of allergy and clinical immunology |
| PublicationTitleAlternate | J Allergy Clin Immunol |
| PublicationYear | 2012 |
| Publisher | Elsevier Inc Elsevier Elsevier Limited |
| Publisher_xml | – name: Elsevier Inc – name: Elsevier – name: Elsevier Limited |
| References | Sherrill, Rothenberg (bib14) 2011; 128 Jiang (bib6) 2011; 353 Cai, Cullen (bib46) 2007; 13 Blanchard, Stucke, Rodriguez-Jimenez, Burwinkel, Collins, Ahrens (bib18) 2011; 127 Valadi, Ekstrom, Bossios, Sjostrand, Lee, Lotvall (bib50) 2007; 9 Tian, Wang, Wang, Zhu, Xiao (bib51) 2010; 111 Hatley, Patrick, Garcia, Richardson, Bassel-Duby, van Rooij (bib45) 2010; 18 Yuan, Campanella, Colvin, Hamilos, Jones, Mathew (bib26) 2006; 36 Mayoral, Pipkin, Pachkov, van Nimwegen, Rao, Monticelli (bib53) 2009; 182 Liu, Lv, Qin, Gen, Zheng, Liu (bib37) 2012; 39 Assa’ad, Putnam, Collins, Akers, Jameson, Kirby (bib56) 2007; 119 Caldwell, Blanchard, Collins, Putnam, Kaul, Aceves (bib20) 2010; 125 Yi, Poy, Stoffel, Fuchs (bib36) 2008; 452 Matsushima, Isomoto, Kohno, Nakao (bib43) 2010; 82 Lin, Xiao, Liao, Chen, Xie, Huang (bib38) 2012; 105 Griffiths-Jones, Saini, van Dongen, Enright (bib21) 2008; 36 Kumar, Ahmad, Sharma, Mabalirajan, Kulshreshtha, Agrawal (bib4) 2011; 128 Wu, Zikusoka, Trindade, Dassopoulos, Harris, Bayless (bib32) 2008; 135 Li, Li, Guo, Qin, Liu, Lei (bib41) 2011; 18 Sayed, Abdellatif (bib1) 2011; 91 Liacouras, Furuta, Hirano, Atkins, Attwood, Bonis (bib9) 2011; 128 Yuan, Zeng, Liu, Gong, Tao, Cheng (bib39) 2011; 11 Corren, Lemanske, Hanania, Korenblat, Parsey, Arron (bib29) 2011; 365 Li, Lin, Li (bib42) 2011; 56 Dellon, Chen, Miller, Fritchie, Rubinas, Woosley (bib55) 2011; 106 Lu, Boldin, Chaudhry, Lin, Taganov, Hanada (bib31) 2010; 142 Mitchell, Parkin, Kroh, Fritz, Wyman, Pogosova-Agadjanyan (bib23) 2008; 105 Blanchard, Mingler, Vicario, Abonia, Wu, Lu (bib12) 2007; 120 Sato, Tsuchiya, Meltzer, Shimizu (bib17) 2011; 278 Blanchard, Mingler, McBride, Putnam, Collins, Chang (bib28) 2008; 1 Zahm, Thayu, Hand, Horner, Leonard, Friedman (bib24) 2011; 53 Blanchard, Wang, Stringer, Mishra, Fulkerson, Abonia (bib11) 2006; 116 Mishra, Wang, Pemmaraju, Collins, Fulkerson, Abonia (bib34) 2008; 134 Arroyo, Chevillet, Kroh, Ruf, Pritchard, Gibson (bib48) 2011; 108 Polikepahad, Knight, Naghavi, Oplt, Creighton, Shaw (bib30) 2010; 285 Mattes, Collison, Plank, Phipps, Foster (bib3) 2009; 106 Xiang, Tan, Zhang, Qin, Hu, Wang (bib22) 2008; 103 Rabinowits, Gercel-Taylor, Day, Taylor, Kloecker (bib49) 2009; 10 Aceves, Chen, Newbury, Dohil, Bastian, Broide (bib54) 2010; 126 Medina, Nolde, Slack (bib44) 2010; 467 Sonkoly, Janson, Majuri, Savinko, Fyhrquist, Eidsmo (bib33) 2010; 126 Assa’ad, Gupta, Collins, Thomson, Heath, Smith (bib35) 2011; 141 Tsang, Ng, Ng, Jin, Yu, Sung (bib47) 2010; 31 Lu, Hartner, Lim, Fabry, Mingler, Cole (bib8) 2011; 187 DeBrosse, Franciosi, King, Butz, Greenberg, Collins (bib10) 2011; 128 Lim, Lu, Blanchard, Rothenberg (bib15) 2011; 286 Blanchard, Stucke, Burwinkel, Caldwell, Collins, Ahrens (bib16) 2010; 184 Straumann, Bauer, Fischer, Blaser, Simon (bib19) 2001; 108 Shen, Todd, Zhang, Yu, Lingxiao, Mei (bib25) 2011; 91 Lu, Munitz, Rothenberg (bib7) 2009; 182 Collison, Mattes, Plank, Foster (bib5) 2011; 128 Abonia, Blanchard, Butz, Rainey, Collins, Stringer (bib13) 2010; 126 Smith, Watson, Michael, Hussey (bib2) 2010; 16 Sonkoly, Wei, Janson, Saaf, Lundeberg, Tengvall-Linder (bib52) 2007; 2 Tsuchiya, Fujiwara, Sato, Shimada, Tanaka, Sakai (bib40) 2011; 286 Stansfield, Andersen, Tang, Selzman (bib27) 2009; 88 Trapnell (10.1016/j.jaci.2012.01.060_bib63) 2009; 25 Chen (10.1016/j.jaci.2012.01.060_bib66) 2009; 37 Lu (10.1016/j.jaci.2012.01.060_bib7) 2009; 182 Blanchard (10.1016/j.jaci.2012.01.060_bib16) 2010; 184 Wu (10.1016/j.jaci.2012.01.060_bib32) 2008; 135 Blanchard (10.1016/j.jaci.2012.01.060_bib18) 2011; 127 Smith (10.1016/j.jaci.2012.01.060_bib2) 2010; 16 Valadi (10.1016/j.jaci.2012.01.060_bib50) 2007; 9 Blanchard (10.1016/j.jaci.2012.01.060_bib12) 2007; 120 Blanchard (10.1016/j.jaci.2012.01.060_bib28) 2008; 1 Arroyo (10.1016/j.jaci.2012.01.060_bib48) 2011; 108 Livak (10.1016/j.jaci.2012.01.060_bib58) 2001; 25 Li (10.1016/j.jaci.2012.01.060_bib41) 2011; 18 DeBrosse (10.1016/j.jaci.2012.01.060_bib10) 2011; 128 Blanchard (10.1016/j.jaci.2012.01.060_bib11) 2006; 116 Corren (10.1016/j.jaci.2012.01.060_bib29) 2011; 365 Mishra (10.1016/j.jaci.2012.01.060_bib34) 2008; 134 Stansfield (10.1016/j.jaci.2012.01.060_bib27) 2009; 88 Saini (10.1016/j.jaci.2012.01.060_bib65) 2008; 9 Polikepahad (10.1016/j.jaci.2012.01.060_bib30) 2010; 285 Zahm (10.1016/j.jaci.2012.01.060_bib24) 2011; 53 Yuan (10.1016/j.jaci.2012.01.060_bib26) 2006; 36 Griffiths-Jones (10.1016/j.jaci.2012.01.060_bib21) 2008; 36 Sherrill (10.1016/j.jaci.2012.01.060_bib14) 2011; 128 Yi (10.1016/j.jaci.2012.01.060_bib36) 2008; 452 Tsuchiya (10.1016/j.jaci.2012.01.060_bib40) 2011; 286 Lu (10.1016/j.jaci.2012.01.060_bib31) 2010; 142 Medina (10.1016/j.jaci.2012.01.060_bib44) 2010; 467 Rabinowits (10.1016/j.jaci.2012.01.060_bib49) 2009; 10 Sonkoly (10.1016/j.jaci.2012.01.060_bib52) 2007; 2 Jiang (10.1016/j.jaci.2012.01.060_bib6) 2011; 353 Lin (10.1016/j.jaci.2012.01.060_bib38) 2012; 105 Mayoral (10.1016/j.jaci.2012.01.060_bib53) 2009; 182 Mattes (10.1016/j.jaci.2012.01.060_bib3) 2009; 106 Tsang (10.1016/j.jaci.2012.01.060_bib47) 2010; 31 Griffiths-Jones (10.1016/j.jaci.2012.01.060_bib57) 2008; 36 Straumann (10.1016/j.jaci.2012.01.060_bib19) 2001; 108 Abonia (10.1016/j.jaci.2012.01.060_bib61) 2010; 126 Trapnell (10.1016/j.jaci.2012.01.060_bib64) 2010; 28 Dellon (10.1016/j.jaci.2012.01.060_bib55) 2011; 106 Assa’ad (10.1016/j.jaci.2012.01.060_bib56) 2007; 119 Sayed (10.1016/j.jaci.2012.01.060_bib1) 2011; 91 Shen (10.1016/j.jaci.2012.01.060_bib25) 2011; 91 Liu (10.1016/j.jaci.2012.01.060_bib37) 2012; 39 Blanchard (10.1016/j.jaci.2012.01.060_bib59) 2006; 116 Tian (10.1016/j.jaci.2012.01.060_bib51) 2010; 111 Lim (10.1016/j.jaci.2012.01.060_bib15) 2011; 286 Lu (10.1016/j.jaci.2012.01.060_bib8) 2011; 187 Collison (10.1016/j.jaci.2012.01.060_bib5) 2011; 128 Kumar (10.1016/j.jaci.2012.01.060_bib4) 2011; 128 Assa’ad (10.1016/j.jaci.2012.01.060_bib35) 2011; 141 Abonia (10.1016/j.jaci.2012.01.060_bib13) 2010; 126 Mitchell (10.1016/j.jaci.2012.01.060_bib23) 2008; 105 Cheverud (10.1016/j.jaci.2012.01.060_bib62) 2001; 87 Aceves (10.1016/j.jaci.2012.01.060_bib54) 2010; 126 Matsushima (10.1016/j.jaci.2012.01.060_bib43) 2010; 82 Cai (10.1016/j.jaci.2012.01.060_bib46) 2007; 13 Liacouras (10.1016/j.jaci.2012.01.060_bib9) 2011; 128 Xiang (10.1016/j.jaci.2012.01.060_bib22) 2008; 103 Sonkoly (10.1016/j.jaci.2012.01.060_bib33) 2010; 126 Sato (10.1016/j.jaci.2012.01.060_bib17) 2011; 278 Blanchard (10.1016/j.jaci.2012.01.060_bib60) 2007; 120 Caldwell (10.1016/j.jaci.2012.01.060_bib20) 2010; 125 Yuan (10.1016/j.jaci.2012.01.060_bib39) 2011; 11 Hatley (10.1016/j.jaci.2012.01.060_bib45) 2010; 18 Li (10.1016/j.jaci.2012.01.060_bib42) 2011; 56 |
| References_xml | – volume: 9 start-page: 654 year: 2007 end-page: 659 ident: bib50 article-title: Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells publication-title: Nat Cell Biol – volume: 135 start-page: 1624 year: 2008 end-page: 1635 ident: bib32 article-title: MicroRNAs are differentially expressed in ulcerative colitis and alter expression of macrophage inflammatory peptide-2 alpha publication-title: Gastroenterology – volume: 1 start-page: 289 year: 2008 end-page: 296 ident: bib28 article-title: Periostin facilitates eosinophil tissue infiltration in allergic lung and esophageal responses publication-title: Mucosal Immunol – volume: 91 start-page: 827 year: 2011 end-page: 887 ident: bib1 article-title: MicroRNAs in development and disease publication-title: Physiol Rev – volume: 125 start-page: 879 year: 2010 end-page: 888 ident: bib20 article-title: Glucocorticoid-regulated genes in eosinophilic esophagitis: a role for FKBP51 publication-title: J Allergy Clin Immunol – volume: 141 start-page: 1593 year: 2011 end-page: 1604 ident: bib35 article-title: An antibody against IL-5 reduces numbers of esophageal intraepithelial eosinophils in children with eosinophilic esophagitis publication-title: Gastroenterology – volume: 286 start-page: 420 year: 2011 end-page: 428 ident: bib40 article-title: MicroRNA-210 regulates cancer cell proliferation through targeting fibroblast growth factor receptor-like 1 (FGFRL1) publication-title: J Biol Chem – volume: 182 start-page: 4994 year: 2009 end-page: 5002 ident: bib7 article-title: MicroRNA-21 is up-regulated in allergic airway inflammation and regulates IL-12p35 expression publication-title: J Immunol – volume: 128 start-page: 1077 year: 2011 end-page: 1085 ident: bib4 article-title: Let-7 microRNA-mediated regulation of IL-13 and allergic airway inflammation publication-title: J Allergy Clin Immunol – volume: 142 start-page: 914 year: 2010 end-page: 929 ident: bib31 article-title: Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responses publication-title: Cell – volume: 120 start-page: 1292 year: 2007 end-page: 1300 ident: bib12 article-title: IL-13 involvement in eosinophilic esophagitis: transcriptome analysis and reversibility with glucocorticoids publication-title: J Allergy Clin Immunol – volume: 126 start-page: 140 year: 2010 end-page: 149 ident: bib13 article-title: Involvement of mast cells in eosinophilic esophagitis publication-title: J Allergy Clin Immunol – volume: 103 start-page: 920 year: 2008 end-page: 930 ident: bib22 article-title: Wound repair and proliferation of bronchial epithelial cells regulated by CTNNAL1 publication-title: J Cell Biochem – volume: 278 start-page: 1598 year: 2011 end-page: 1609 ident: bib17 article-title: MicroRNAs and epigenetics publication-title: FEBS J – volume: 111 start-page: 488 year: 2010 end-page: 496 ident: bib51 article-title: Visualizing of the cellular uptake and intracellular trafficking of exosomes by live-cell microscopy publication-title: J Cell Biochem – volume: 16 start-page: 531 year: 2010 end-page: 537 ident: bib2 article-title: MicroRNAs, development of Barrett’s esophagus, and progression to esophageal adenocarcinoma publication-title: World J Gastroenterol – volume: 108 start-page: 954 year: 2001 end-page: 961 ident: bib19 article-title: Idiopathic eosinophilic esophagitis is associated with a T(H)2-type allergic inflammatory response publication-title: J Allergy Clin Immunol – volume: 36 start-page: 2700 year: 2006 end-page: 2714 ident: bib26 article-title: Membrane-bound eotaxin-3 mediates eosinophil transepithelial migration in IL-4-stimulated epithelial cells publication-title: Eur J Immunol – volume: 452 start-page: 225 year: 2008 end-page: 229 ident: bib36 article-title: A skin microRNA promotes differentiation by repressing “stemness.” publication-title: Nature – volume: 88 start-page: 1916 year: 2009 end-page: 1921 ident: bib27 article-title: Periostin is a novel factor in cardiac remodeling after experimental and clinical unloading of the failing heart publication-title: Ann Thorac Surg – volume: 134 start-page: 204 year: 2008 end-page: 214 ident: bib34 article-title: Esophageal remodeling develops as a consequence of tissue specific IL-5-induced eosinophilia publication-title: Gastroenterology – volume: 39 start-page: 1239 year: 2012 end-page: 1246 ident: bib37 article-title: Role of microRNA let-7 and effect to HMGA2 in esophageal squamous cell carcinoma publication-title: Mol Biol Rep – volume: 128 start-page: 160 year: 2011 end-page: 167 ident: bib5 article-title: Inhibition of house dust mite-induced allergic airways disease by antagonism of microRNA-145 is comparable to glucocorticoid treatment publication-title: J Allergy Clin Immunol – volume: 105 start-page: 10513 year: 2008 end-page: 10518 ident: bib23 article-title: Circulating microRNAs as stable blood-based markers for cancer detection publication-title: Proc Natl Acad Sci U S A – volume: 128 start-page: 23 year: 2011 end-page: 32 ident: bib14 article-title: Genetic dissection of eosinophilic esophagitis provides insight into disease pathogenesis and treatment strategies publication-title: J Allergy Clin Immunol – volume: 31 start-page: 350 year: 2010 end-page: 358 ident: bib47 article-title: Oncofetal H19-derived miR-675 regulates tumor suppressor RB in human colorectal cancer publication-title: Carcinogenesis – volume: 285 start-page: 30139 year: 2010 end-page: 30149 ident: bib30 article-title: Proinflammatory role for let-7 microRNAS in experimental asthma publication-title: J Biol Chem – volume: 53 start-page: 26 year: 2011 end-page: 33 ident: bib24 article-title: Circulating MicroRNA is a biomarker of pediatric Crohn disease publication-title: J Pediatr Gastroenterol Nutr – volume: 56 start-page: 2849 year: 2011 end-page: 2856 ident: bib42 article-title: Epigenetic silencing of microRNA-375 regulates PDK1 expression in esophageal cancer publication-title: Dig Dis Sci – volume: 11 start-page: 57 year: 2011 ident: bib39 article-title: MicroRNA-203 inhibits cell proliferation by repressing DeltaNp63 expression in human esophageal squamous cell carcinoma publication-title: BMC Cancer – volume: 467 start-page: 86 year: 2010 end-page: 90 ident: bib44 article-title: OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma publication-title: Nature – volume: 182 start-page: 433 year: 2009 end-page: 445 ident: bib53 article-title: MicroRNA-221-222 regulate the cell cycle in mast cells publication-title: J Immunol – volume: 353 start-page: 35 year: 2011 end-page: 40 ident: bib6 article-title: The emerging role of microRNAs in asthma publication-title: Molecular and cellular biochemistry – volume: 108 start-page: 5003 year: 2011 end-page: 5008 ident: bib48 article-title: Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma publication-title: Proc Natl Acad Sci U S A – volume: 187 start-page: 3362 year: 2011 end-page: 3373 ident: bib8 article-title: MicroRNA-21 limits in vivo immune response-mediated activation of the IL-12/IFN-γ pathway, Th1 polarization, and the severity of delayed-type hypersensitivity publication-title: J Immunol – volume: 36 start-page: D154 year: 2008 end-page: D158 ident: bib21 article-title: miRBase: tools for microRNA genomics publication-title: Nucleic Acids Res – volume: 2 start-page: e610 year: 2007 ident: bib52 article-title: MicroRNAs: novel regulators involved in the pathogenesis of psoriasis? publication-title: PLoS One – volume: 119 start-page: 731 year: 2007 end-page: 738 ident: bib56 article-title: Pediatric patients with eosinophilic esophagitis: an 8-year follow-up publication-title: J Allergy Clin Immunol – volume: 13 start-page: 313 year: 2007 end-page: 316 ident: bib46 article-title: The imprinted H19 noncoding RNA is a primary microRNA precursor publication-title: RNA – volume: 126 start-page: 1198 year: 2010 end-page: 1204 ident: bib54 article-title: Mast cells infiltrate the esophageal smooth muscle in patients with eosinophilic esophagitis, express TGF-beta1, and increase esophageal smooth muscle contraction publication-title: J Allergy Clin Immunol – volume: 286 start-page: 13193 year: 2011 end-page: 13204 ident: bib15 article-title: Epigenetic regulation of the IL-13-induced human eotaxin-3 gene by CREB-binding protein-mediated histone 3 acetylation publication-title: J Biol Chem – volume: 10 start-page: 42 year: 2009 end-page: 46 ident: bib49 article-title: Exosomal microRNA: a diagnostic marker for lung cancer publication-title: Clin Lung Cancer – volume: 365 start-page: 1088 year: 2011 end-page: 1098 ident: bib29 article-title: Lebrikizumab treatment in adults with asthma publication-title: N Engl J Med – volume: 128 start-page: 3 year: 2011 end-page: 20 ident: bib9 article-title: Eosinophilic esophagitis: updated consensus recommendations for children and adults publication-title: J Allergy Clin Immunol – volume: 18 start-page: 282 year: 2010 end-page: 293 ident: bib45 article-title: Modulation of K-Ras-dependent lung tumorigenesis by MicroRNA-21 publication-title: Cancer Cell – volume: 106 start-page: 264 year: 2011 end-page: 271 ident: bib55 article-title: Tryptase staining of mast cells may differentiate eosinophilic esophagitis from gastroesophageal reflux disease publication-title: Am J Gastroenterol – volume: 126 start-page: 581 year: 2010 end-page: 589 ident: bib33 article-title: MiR-155 is overexpressed in patients with atopic dermatitis and modulates T-cell proliferative responses by targeting cytotoxic T lymphocyte-associated antigen 4 publication-title: J Allergy Clin Immunol – volume: 105 start-page: 175 year: 2012 end-page: 182 ident: bib38 article-title: MiR-142-3p as a potential prognostic biomarker for esophageal squamous cell carcinoma publication-title: J Surg Oncol – volume: 127 start-page: 208 year: 2011 end-page: 217 ident: bib18 article-title: A striking local esophageal cytokine expression profile in eosinophilic esophagitis publication-title: J Allergy Clin Immunol – volume: 82 start-page: 138 year: 2010 end-page: 144 ident: bib43 article-title: MicroRNAs and esophageal squamous cell carcinoma publication-title: Digestion – volume: 91 start-page: 579 year: 2011 end-page: 587 ident: bib25 article-title: Plasma microRNAs as potential biomarkers for non-small-cell lung cancer publication-title: Lab Invest – volume: 184 start-page: 4033 year: 2010 end-page: 4041 ident: bib16 article-title: Coordinate interaction between IL-13 and epithelial differentiation cluster genes in eosinophilic esophagitis publication-title: J Immunol – volume: 106 start-page: 18704 year: 2009 end-page: 18709 ident: bib3 article-title: Antagonism of microRNA-126 suppresses the effector function of TH2 cells and the development of allergic airways disease publication-title: Proc Natl Acad Sci U S A – volume: 128 start-page: 132 year: 2011 end-page: 138 ident: bib10 article-title: Long-term outcomes in pediatric-onset esophageal eosinophilia publication-title: J Allergy Clin Immunol – volume: 116 start-page: 536 year: 2006 end-page: 547 ident: bib11 article-title: Eotaxin-3 and a uniquely conserved gene-expression profile in eosinophilic esophagitis publication-title: J Clin Invest – volume: 18 start-page: 24 year: 2011 ident: bib41 article-title: miR-223 regulates migration and invasion by targeting Artemin in human esophageal carcinoma publication-title: J Biomed Sci – volume: 37 start-page: W305 year: 2009 ident: 10.1016/j.jaci.2012.01.060_bib66 article-title: ToppGene Suite for gene list enrichment analysis and candidate gene prioritization publication-title: Nucleic Acids Res doi: 10.1093/nar/gkp427 – volume: 286 start-page: 13193 year: 2011 ident: 10.1016/j.jaci.2012.01.060_bib15 article-title: Epigenetic regulation of the IL-13-induced human eotaxin-3 gene by CREB-binding protein-mediated histone 3 acetylation publication-title: J Biol Chem doi: 10.1074/jbc.M110.210724 – volume: 88 start-page: 1916 year: 2009 ident: 10.1016/j.jaci.2012.01.060_bib27 article-title: Periostin is a novel factor in cardiac remodeling after experimental and clinical unloading of the failing heart publication-title: Ann Thorac Surg doi: 10.1016/j.athoracsur.2009.07.038 – volume: 111 start-page: 488 year: 2010 ident: 10.1016/j.jaci.2012.01.060_bib51 article-title: Visualizing of the cellular uptake and intracellular trafficking of exosomes by live-cell microscopy publication-title: J Cell Biochem doi: 10.1002/jcb.22733 – volume: 452 start-page: 225 year: 2008 ident: 10.1016/j.jaci.2012.01.060_bib36 article-title: A skin microRNA promotes differentiation by repressing “stemness.” publication-title: Nature doi: 10.1038/nature06642 – volume: 116 start-page: 536 year: 2006 ident: 10.1016/j.jaci.2012.01.060_bib59 article-title: Eotaxin-3 and a uniquely conserved gene-expression profile in eosinophilic esophagitis publication-title: J Clin Invest doi: 10.1172/JCI26679 – volume: 134 start-page: 204 year: 2008 ident: 10.1016/j.jaci.2012.01.060_bib34 article-title: Esophageal remodeling develops as a consequence of tissue specific IL-5-induced eosinophilia publication-title: Gastroenterology doi: 10.1053/j.gastro.2007.10.002 – volume: 31 start-page: 350 year: 2010 ident: 10.1016/j.jaci.2012.01.060_bib47 article-title: Oncofetal H19-derived miR-675 regulates tumor suppressor RB in human colorectal cancer publication-title: Carcinogenesis doi: 10.1093/carcin/bgp181 – volume: 9 start-page: 654 year: 2007 ident: 10.1016/j.jaci.2012.01.060_bib50 article-title: Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells publication-title: Nat Cell Biol doi: 10.1038/ncb1596 – volume: 108 start-page: 5003 year: 2011 ident: 10.1016/j.jaci.2012.01.060_bib48 article-title: Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.1019055108 – volume: 182 start-page: 4994 year: 2009 ident: 10.1016/j.jaci.2012.01.060_bib7 article-title: MicroRNA-21 is up-regulated in allergic airway inflammation and regulates IL-12p35 expression publication-title: J Immunol doi: 10.4049/jimmunol.0803560 – volume: 105 start-page: 10513 year: 2008 ident: 10.1016/j.jaci.2012.01.060_bib23 article-title: Circulating microRNAs as stable blood-based markers for cancer detection publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0804549105 – volume: 116 start-page: 536 year: 2006 ident: 10.1016/j.jaci.2012.01.060_bib11 article-title: Eotaxin-3 and a uniquely conserved gene-expression profile in eosinophilic esophagitis publication-title: J Clin Invest doi: 10.1172/JCI26679 – volume: 11 start-page: 57 year: 2011 ident: 10.1016/j.jaci.2012.01.060_bib39 article-title: MicroRNA-203 inhibits cell proliferation by repressing DeltaNp63 expression in human esophageal squamous cell carcinoma publication-title: BMC Cancer doi: 10.1186/1471-2407-11-57 – volume: 128 start-page: 3 year: 2011 ident: 10.1016/j.jaci.2012.01.060_bib9 article-title: Eosinophilic esophagitis: updated consensus recommendations for children and adults publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2011.02.040 – volume: 126 start-page: 140 year: 2010 ident: 10.1016/j.jaci.2012.01.060_bib61 article-title: Involvement of mast cells in eosinophilic esophagitis publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2010.04.009 – volume: 128 start-page: 23 year: 2011 ident: 10.1016/j.jaci.2012.01.060_bib14 article-title: Genetic dissection of eosinophilic esophagitis provides insight into disease pathogenesis and treatment strategies publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2011.03.046 – volume: 128 start-page: 1077 year: 2011 ident: 10.1016/j.jaci.2012.01.060_bib4 article-title: Let-7 microRNA-mediated regulation of IL-13 and allergic airway inflammation publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2011.04.034 – volume: 91 start-page: 579 year: 2011 ident: 10.1016/j.jaci.2012.01.060_bib25 article-title: Plasma microRNAs as potential biomarkers for non-small-cell lung cancer publication-title: Lab Invest doi: 10.1038/labinvest.2010.194 – volume: 105 start-page: 175 year: 2012 ident: 10.1016/j.jaci.2012.01.060_bib38 article-title: MiR-142-3p as a potential prognostic biomarker for esophageal squamous cell carcinoma publication-title: J Surg Oncol doi: 10.1002/jso.22066 – volume: 87 start-page: 52 year: 2001 ident: 10.1016/j.jaci.2012.01.060_bib62 article-title: A simple correction for multiple comparisons in interval mapping genome scans publication-title: Heredity doi: 10.1046/j.1365-2540.2001.00901.x – volume: 10 start-page: 42 year: 2009 ident: 10.1016/j.jaci.2012.01.060_bib49 article-title: Exosomal microRNA: a diagnostic marker for lung cancer publication-title: Clin Lung Cancer doi: 10.3816/CLC.2009.n.006 – volume: 36 start-page: D154 year: 2008 ident: 10.1016/j.jaci.2012.01.060_bib21 article-title: miRBase: tools for microRNA genomics publication-title: Nucleic Acids Res doi: 10.1093/nar/gkm952 – volume: 13 start-page: 313 year: 2007 ident: 10.1016/j.jaci.2012.01.060_bib46 article-title: The imprinted H19 noncoding RNA is a primary microRNA precursor publication-title: RNA doi: 10.1261/rna.351707 – volume: 286 start-page: 420 year: 2011 ident: 10.1016/j.jaci.2012.01.060_bib40 article-title: MicroRNA-210 regulates cancer cell proliferation through targeting fibroblast growth factor receptor-like 1 (FGFRL1) publication-title: J Biol Chem doi: 10.1074/jbc.M110.170852 – volume: 106 start-page: 18704 year: 2009 ident: 10.1016/j.jaci.2012.01.060_bib3 article-title: Antagonism of microRNA-126 suppresses the effector function of TH2 cells and the development of allergic airways disease publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0905063106 – volume: 103 start-page: 920 year: 2008 ident: 10.1016/j.jaci.2012.01.060_bib22 article-title: Wound repair and proliferation of bronchial epithelial cells regulated by CTNNAL1 publication-title: J Cell Biochem doi: 10.1002/jcb.21461 – volume: 126 start-page: 581 year: 2010 ident: 10.1016/j.jaci.2012.01.060_bib33 article-title: MiR-155 is overexpressed in patients with atopic dermatitis and modulates T-cell proliferative responses by targeting cytotoxic T lymphocyte-associated antigen 4 publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2010.05.045 – volume: 135 start-page: 1624 year: 2008 ident: 10.1016/j.jaci.2012.01.060_bib32 article-title: MicroRNAs are differentially expressed in ulcerative colitis and alter expression of macrophage inflammatory peptide-2 alpha publication-title: Gastroenterology doi: 10.1053/j.gastro.2008.07.068 – volume: 108 start-page: 954 year: 2001 ident: 10.1016/j.jaci.2012.01.060_bib19 article-title: Idiopathic eosinophilic esophagitis is associated with a T(H)2-type allergic inflammatory response publication-title: J Allergy Clin Immunol doi: 10.1067/mai.2001.119917 – volume: 467 start-page: 86 year: 2010 ident: 10.1016/j.jaci.2012.01.060_bib44 article-title: OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma publication-title: Nature doi: 10.1038/nature09284 – volume: 18 start-page: 24 year: 2011 ident: 10.1016/j.jaci.2012.01.060_bib41 article-title: miR-223 regulates migration and invasion by targeting Artemin in human esophageal carcinoma publication-title: J Biomed Sci doi: 10.1186/1423-0127-18-24 – volume: 128 start-page: 132 year: 2011 ident: 10.1016/j.jaci.2012.01.060_bib10 article-title: Long-term outcomes in pediatric-onset esophageal eosinophilia publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2011.05.006 – volume: 106 start-page: 264 year: 2011 ident: 10.1016/j.jaci.2012.01.060_bib55 article-title: Tryptase staining of mast cells may differentiate eosinophilic esophagitis from gastroesophageal reflux disease publication-title: Am J Gastroenterol doi: 10.1038/ajg.2010.412 – volume: 25 start-page: 402 year: 2001 ident: 10.1016/j.jaci.2012.01.060_bib58 article-title: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method publication-title: Methods doi: 10.1006/meth.2001.1262 – volume: 128 start-page: 160 year: 2011 ident: 10.1016/j.jaci.2012.01.060_bib5 article-title: Inhibition of house dust mite-induced allergic airways disease by antagonism of microRNA-145 is comparable to glucocorticoid treatment publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2011.04.005 – volume: 36 start-page: D154 year: 2008 ident: 10.1016/j.jaci.2012.01.060_bib57 article-title: miRBase: tools for microRNA genomics publication-title: Nucleic Acids Res doi: 10.1093/nar/gkm952 – volume: 120 start-page: 1292 year: 2007 ident: 10.1016/j.jaci.2012.01.060_bib12 article-title: IL-13 involvement in eosinophilic esophagitis: transcriptome analysis and reversibility with glucocorticoids publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2007.10.024 – volume: 365 start-page: 1088 year: 2011 ident: 10.1016/j.jaci.2012.01.060_bib29 article-title: Lebrikizumab treatment in adults with asthma publication-title: N Engl J Med doi: 10.1056/NEJMoa1106469 – volume: 141 start-page: 1593 year: 2011 ident: 10.1016/j.jaci.2012.01.060_bib35 article-title: An antibody against IL-5 reduces numbers of esophageal intraepithelial eosinophils in children with eosinophilic esophagitis publication-title: Gastroenterology doi: 10.1053/j.gastro.2011.07.044 – volume: 36 start-page: 2700 year: 2006 ident: 10.1016/j.jaci.2012.01.060_bib26 article-title: Membrane-bound eotaxin-3 mediates eosinophil transepithelial migration in IL-4-stimulated epithelial cells publication-title: Eur J Immunol doi: 10.1002/eji.200636112 – volume: 353 start-page: 35 year: 2011 ident: 10.1016/j.jaci.2012.01.060_bib6 article-title: The emerging role of microRNAs in asthma publication-title: Molecular and cellular biochemistry doi: 10.1007/s11010-011-0771-z – volume: 187 start-page: 3362 year: 2011 ident: 10.1016/j.jaci.2012.01.060_bib8 article-title: MicroRNA-21 limits in vivo immune response-mediated activation of the IL-12/IFN-γ pathway, Th1 polarization, and the severity of delayed-type hypersensitivity publication-title: J Immunol doi: 10.4049/jimmunol.1101235 – volume: 16 start-page: 531 year: 2010 ident: 10.1016/j.jaci.2012.01.060_bib2 article-title: MicroRNAs, development of Barrett’s esophagus, and progression to esophageal adenocarcinoma publication-title: World J Gastroenterol doi: 10.3748/wjg.v16.i5.531 – volume: 53 start-page: 26 year: 2011 ident: 10.1016/j.jaci.2012.01.060_bib24 article-title: Circulating MicroRNA is a biomarker of pediatric Crohn disease publication-title: J Pediatr Gastroenterol Nutr doi: 10.1097/MPG.0b013e31822200cc – volume: 142 start-page: 914 year: 2010 ident: 10.1016/j.jaci.2012.01.060_bib31 article-title: Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responses publication-title: Cell doi: 10.1016/j.cell.2010.08.012 – volume: 126 start-page: 140 year: 2010 ident: 10.1016/j.jaci.2012.01.060_bib13 article-title: Involvement of mast cells in eosinophilic esophagitis publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2010.04.009 – volume: 28 start-page: 511 year: 2010 ident: 10.1016/j.jaci.2012.01.060_bib64 article-title: Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation publication-title: Nat Biotechnol doi: 10.1038/nbt.1621 – volume: 127 start-page: 208 year: 2011 ident: 10.1016/j.jaci.2012.01.060_bib18 article-title: A striking local esophageal cytokine expression profile in eosinophilic esophagitis publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2010.10.039 – volume: 82 start-page: 138 year: 2010 ident: 10.1016/j.jaci.2012.01.060_bib43 article-title: MicroRNAs and esophageal squamous cell carcinoma publication-title: Digestion doi: 10.1159/000310918 – volume: 126 start-page: 1198 year: 2010 ident: 10.1016/j.jaci.2012.01.060_bib54 article-title: Mast cells infiltrate the esophageal smooth muscle in patients with eosinophilic esophagitis, express TGF-beta1, and increase esophageal smooth muscle contraction publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2010.08.050 – volume: 56 start-page: 2849 year: 2011 ident: 10.1016/j.jaci.2012.01.060_bib42 article-title: Epigenetic silencing of microRNA-375 regulates PDK1 expression in esophageal cancer publication-title: Dig Dis Sci doi: 10.1007/s10620-011-1711-1 – volume: 125 start-page: 879 year: 2010 ident: 10.1016/j.jaci.2012.01.060_bib20 article-title: Glucocorticoid-regulated genes in eosinophilic esophagitis: a role for FKBP51 publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2010.01.038 – volume: 18 start-page: 282 year: 2010 ident: 10.1016/j.jaci.2012.01.060_bib45 article-title: Modulation of K-Ras-dependent lung tumorigenesis by MicroRNA-21 publication-title: Cancer Cell doi: 10.1016/j.ccr.2010.08.013 – volume: 120 start-page: 1292 year: 2007 ident: 10.1016/j.jaci.2012.01.060_bib60 article-title: IL-13 involvement in eosinophilic esophagitis: transcriptome analysis and reversibility with glucocorticoids publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2007.10.024 – volume: 184 start-page: 4033 year: 2010 ident: 10.1016/j.jaci.2012.01.060_bib16 article-title: Coordinate interaction between IL-13 and epithelial differentiation cluster genes in eosinophilic esophagitis publication-title: J Immunol doi: 10.4049/jimmunol.0903069 – volume: 9 start-page: 564 year: 2008 ident: 10.1016/j.jaci.2012.01.060_bib65 article-title: Annotation of mammalian primary microRNAs publication-title: BMC Genomics doi: 10.1186/1471-2164-9-564 – volume: 39 start-page: 1239 year: 2012 ident: 10.1016/j.jaci.2012.01.060_bib37 article-title: Role of microRNA let-7 and effect to HMGA2 in esophageal squamous cell carcinoma publication-title: Mol Biol Rep doi: 10.1007/s11033-011-0854-7 – volume: 91 start-page: 827 year: 2011 ident: 10.1016/j.jaci.2012.01.060_bib1 article-title: MicroRNAs in development and disease publication-title: Physiol Rev doi: 10.1152/physrev.00006.2010 – volume: 278 start-page: 1598 year: 2011 ident: 10.1016/j.jaci.2012.01.060_bib17 article-title: MicroRNAs and epigenetics publication-title: FEBS J doi: 10.1111/j.1742-4658.2011.08089.x – volume: 25 start-page: 1105 year: 2009 ident: 10.1016/j.jaci.2012.01.060_bib63 article-title: TopHat: discovering splice junctions with RNA-Seq publication-title: Bioinformatics doi: 10.1093/bioinformatics/btp120 – volume: 2 start-page: e610 year: 2007 ident: 10.1016/j.jaci.2012.01.060_bib52 article-title: MicroRNAs: novel regulators involved in the pathogenesis of psoriasis? publication-title: PLoS One doi: 10.1371/journal.pone.0000610 – volume: 119 start-page: 731 year: 2007 ident: 10.1016/j.jaci.2012.01.060_bib56 article-title: Pediatric patients with eosinophilic esophagitis: an 8-year follow-up publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2006.10.044 – volume: 182 start-page: 433 year: 2009 ident: 10.1016/j.jaci.2012.01.060_bib53 article-title: MicroRNA-221-222 regulate the cell cycle in mast cells publication-title: J Immunol doi: 10.4049/jimmunol.182.1.433 – volume: 1 start-page: 289 year: 2008 ident: 10.1016/j.jaci.2012.01.060_bib28 article-title: Periostin facilitates eosinophil tissue infiltration in allergic lung and esophageal responses publication-title: Mucosal Immunol doi: 10.1038/mi.2008.15 – volume: 285 start-page: 30139 year: 2010 ident: 10.1016/j.jaci.2012.01.060_bib30 article-title: Proinflammatory role for let-7 microRNAS in experimental asthma publication-title: J Biol Chem doi: 10.1074/jbc.M110.145698 |
| SSID | ssj0009389 |
| Score | 2.4324696 |
| Snippet | The role of microRNAs (miRNAs), a key class of regulators of mRNA expression and translation, in patients with eosinophilic esophagitis (EoE) has not been... Background The role of microRNAs (miRNAs), a key class of regulators of mRNA expression and translation, in patients with eosinophilic esophagitis (EoE) has... Background: The role of microRNAs (miRNAs), a key class of regulators of mRNA expression and translation, in patients with eosinophilic esophagitis (EoE) has... BACKGROUND: The role of microRNAs (miRNAs), a key class of regulators of mRNA expression and translation, in patients with eosinophilic esophagitis (EoE) has... |
| SourceID | pubmedcentral proquest pubmed pascalfrancis crossref elsevier |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 1064 |
| SubjectTerms | adaptive immunity Allergy and Immunology Bioinformatics Biological and medical sciences biomarkers Biopsy Cell Count Cluster Analysis Disease DNA methylation Eosinophilia Eosinophilic esophagitis Eosinophilic Esophagitis - genetics Eosinophilic Esophagitis - immunology Eosinophils - immunology Eosinophils - metabolism esophageal diseases Esophagitis Esophagus Esophagus - pathology Fundamental and applied biological sciences. Psychology Fundamental immunology Gastroenterology. Liver. Pancreas. Abdomen Gene expression Gene Expression Profiling gene expression regulation Gene Expression Regulation - drug effects Gene Regulatory Networks Genetic Markers glucocorticoid Glucocorticoids Glucocorticoids - pharmacology Humans Immunity Immunopathology Leukocytes (eosinophilic) Medical sciences messenger RNA microRNA MicroRNAs MicroRNAs - blood MicroRNAs - genetics miRNA Other diseases. Semiology patients Polarization Remission Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Studies transcriptome Translation |
| Title | MicroRNA signature in patients with eosinophilic esophagitis, reversibility with glucocorticoids, and assessment as disease biomarkers |
| URI | https://www.clinicalkey.com/#!/content/1-s2.0-S0091674912001881 https://www.clinicalkey.es/playcontent/1-s2.0-S0091674912001881 https://dx.doi.org/10.1016/j.jaci.2012.01.060 https://www.ncbi.nlm.nih.gov/pubmed/22391115 https://www.proquest.com/docview/1547869891 https://www.proquest.com/docview/1011212551 https://www.proquest.com/docview/1746428154 https://www.proquest.com/docview/963830198 https://pubmed.ncbi.nlm.nih.gov/PMC3466056 |
| Volume | 129 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVESC databaseName: Baden-Württemberg Complete Freedom Collection (Elsevier) customDbUrl: eissn: 1097-6825 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0009389 issn: 0091-6749 databaseCode: GBLVA dateStart: 20110101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier – providerCode: PRVESC databaseName: Elsevier ScienceDirect customDbUrl: eissn: 1097-6825 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0009389 issn: 0091-6749 databaseCode: .~1 dateStart: 19950101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier – providerCode: PRVESC databaseName: Elsevier SD Complete Freedom Collection [SCCMFC] customDbUrl: eissn: 1097-6825 dateEnd: 20200131 omitProxy: true ssIdentifier: ssj0009389 issn: 0091-6749 databaseCode: ACRLP dateStart: 19950101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier – providerCode: PRVESC databaseName: Elsevier SD Freedom Collection Journals [SCFCJ] customDbUrl: eissn: 1097-6825 dateEnd: 20200131 omitProxy: true ssIdentifier: ssj0009389 issn: 0091-6749 databaseCode: AIKHN dateStart: 19950101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier – providerCode: PRVLSH databaseName: Elsevier Journals customDbUrl: mediaType: online eissn: 1097-6825 dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0009389 issn: 0091-6749 databaseCode: AKRWK dateStart: 19710101 isFulltext: true providerName: Library Specific Holdings |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lj9MwELZWi4SQEOJNYKmMxA3CNi8_jtWKVQG1B8RKe7MmjgNZoaRqugcuHPndzCROSqEUiVse4zixJ-MZ-5vPjL2UkS6djUSoBECYyimEChyEZPsAAwCw3YTbYinmF-n7y-zyiJ0NuTAEq_S2v7fpnbX2V059a56uqopyfDVB6HVEsCDVpV8T-xfq9JvvW5iHTlTvAusoJGmfONNjvK7AVgTvijvqzo6mcu_gdHsFLTZZ2e91sc8Z_R1T-csgdX6X3fHeJZ_1H3CPHbn6Pru58OvnD9iPBeHvPi5nnHAbHacnr2ruyVVbTrOy3DVtVTcrmmmx3NE2B_CZmI9ec6J7Wns87bdeuIO8YwSLFTZVgTJQFxxGuk885H4NiFOmP4GB1u1DdnH-9tPZPPQ7MYRWqHQTxrIUeY5m3SUpuiASTwVYq7Qoy1JqlU0htnmuowJE7pTIQWnIZJk6yEDZafKIHddN7Z4wbrVyGHUX0wJdMYHxSQ6JlQoSaQFjmzhg0dAFxnqactot46sZ8GhXhrrNULeZaWSw2wL2aiyz6kk6DkonQ8-aIf0UDabBMeRgKbmvlGv9P9-ayLQobP7Qy4BlY8kd1f5njZMdtRs_Da1sRpFuwE4GPTTbtyCCNtoVFOt9Md5Gm0ELQVC75rqlCiN0WdBZPiAjUwpN8XEB43-RIeONA4RWAXvca__2HeOEhtEMm23nvxgFiNZ8905dfenozZNUYIwtnv5nsz1jt-isR1edsOPN-to9R8dxk086yzBhN2bvPsyXPwEHlHCr |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1db9MwFLWmTgIkhPgmMIaReINo-bSdx2pi6tjaB7RJe7NuXAcyoaRquof9gf1u7k2clEIpEm9tfV0ntnN8r3PuMWMfZJgV1oTCVwLAT2QAvgILPmEfYAAApt1wm87E5DL5cpVe7bHjPheGaJUO-ztMb9Ha_XLkevNoUZaU45sRhT4LiRakKP16P0kRk0dsf3x6NpmttXdj1XnBWehTBZc709G8rsGUxPCKWvXOVqly6_r0cAEN9lrRHXexzR_9nVb5yzp18pg9cg4mH3f38ITt2eopuzd1r9CfsbspUfC-zsacqButrCcvK-70VRtOG7Pc1k1Z1QvabDHc0kkH8I3Ejz5xUnxaOkrtbWfcst4xiMUG63KONlDNOQyKn_iRu9dAnJL9iQ-0bJ6zy5PPF8cT3x3G4BuhkpUfyULkOSK7jRP0QiR-FWCMykRRFDJTaQCRyfMsnIPIrRI5qAxSWSQWUlAmiF-wUVVX9hXjJlMWA-95MEdvTGCIkkNspIJYGsDwJvJY2A-BNk6pnA7M-KF7Stq1pmHTNGw6CDUOm8c-DnUWnU7HTuu4H1ndZ6AiZmpcRnbWkttq2cY99o0OdYPG-o-p6bF0qLkxu__Z4uHGtBtuDYE2pWDXYwf9PNTrqyCNNjoYFNt9PxQjbNC7IKhsfdNQgyF6Legv77CRCUWn-Hce43-xIfzGNSJTHnvZzf71NUYxraQpdtvGczEYkLL5ZklVfm8VzuNEYJgtXv9nt71j9ycX03N9fjo7e8MeUElHtjpgo9Xyxr5FP3KVHzqc-AlO8XNW |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=MicroRNA+signature+in+patients+with+eosinophilic+esophagitis%2C+reversibility+with+glucocorticoids%2C+and+assessment+as+disease+biomarkers&rft.jtitle=Journal+of+allergy+and+clinical+immunology&rft.au=Lu%2C+Thomas+X&rft.au=Sherrill%2C+Joseph+D&rft.au=Wen%2C+Ting&rft.au=Plassard%2C+Andrew+J&rft.date=2012-04-01&rft.eissn=1097-6825&rft.volume=129&rft.issue=4&rft.spage=1064&rft_id=info:doi/10.1016%2Fj.jaci.2012.01.060&rft_id=info%3Apmid%2F22391115&rft.externalDocID=22391115 |
| thumbnail_m | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=https%3A%2F%2Fcdn.clinicalkey.com%2Fck-thumbnails%2F00916749%2FS0091674911X00192%2Fcov150h.gif |