Histopathologic evaluation of basilar artery atherosclerosis

There has been limited attention to pathological features of basilar artery atherosclerosis. It has been assumed that pathology of basilar artery atherosclerosis mimics that of other vascular beds. To define the nature of the basilar artery atherosclerotic lesions, we analyzed postmortem intracrania...

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Published inJournal of the neurological sciences Vol. 307; no. 1-2; pp. 97 - 99
Main Authors Labadzhyan, Artak, Csiba, Laszlo, Narula, Navneet, Zhou, Jun, Narula, Jagat, Fisher, Mark
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier B.V 15.08.2011
Elsevier
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Online AccessGet full text
ISSN0022-510X
1878-5883
1878-5883
DOI10.1016/j.jns.2011.05.004

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Abstract There has been limited attention to pathological features of basilar artery atherosclerosis. It has been assumed that pathology of basilar artery atherosclerosis mimics that of other vascular beds. To define the nature of the basilar artery atherosclerotic lesions, we analyzed postmortem intracranial artery samples from eight subjects with history of stroke. Atherosclerotic lesions were present in 7/8 arteries examined, with a mean estimated stenosis of 34%. Lumen thrombus with a disrupted fibrous cap was seen in 1 lesion; the remaining 6 lesions revealed a thick fibrous cap. Neovascularity and calcification were seen in 1 lesion and mild to moderate inflammation was seen in 3 lesions. Necrotic core was present in 4/7 lesions, and was associated with plaque rupture in the only disrupted lesion. Basilar artery atherosclerotic lesions were relatively benign in this series of patients presenting with stroke. While confirmation is needed with larger sample size, the relative paucity of neovascularity suggests a possibly distinctive histopathological profile.
AbstractList There has been limited attention to pathological features of basilar artery atherosclerosis. It has been assumed that pathology of basilar artery atherosclerosis mimics that of other vascular beds. To define the nature of the basilar artery atherosclerotic lesions, we analyzed postmortem intracranial artery samples from eight subjects with history of stroke. Atherosclerotic lesions were present in 7/8 arteries examined, with a mean estimated stenosis of 34%. Lumen thrombus with a disrupted fibrous cap was seen in 1 lesion; the remaining 6 lesions revealed a thick fibrous cap. Neovascularity and calcification were seen in 1 lesion and mild to moderate inflammation was seen in 3 lesions. Necrotic core was present in 4/7 lesions, and was associated with plaque rupture in the only disrupted lesion. Basilar artery atherosclerotic lesions were relatively benign in this series of patients presenting with stroke. While confirmation is needed with larger sample size, the relative paucity of neovascularity suggests a possibly distinctive histopathological profile.
There has been limited attention to pathological features of basilar artery atherosclerosis. It has been assumed that pathology of basilar artery atherosclerosis mimics that of other vascular beds.INTRODUCTIONThere has been limited attention to pathological features of basilar artery atherosclerosis. It has been assumed that pathology of basilar artery atherosclerosis mimics that of other vascular beds.To define the nature of the basilar artery atherosclerotic lesions, we analyzed postmortem intracranial artery samples from eight subjects with history of stroke.METHODSTo define the nature of the basilar artery atherosclerotic lesions, we analyzed postmortem intracranial artery samples from eight subjects with history of stroke.Atherosclerotic lesions were present in 7/8 arteries examined, with a mean estimated stenosis of 34%. Lumen thrombus with a disrupted fibrous cap was seen in 1 lesion; the remaining 6 lesions revealed a thick fibrous cap. Neovascularity and calcification were seen in 1 lesion and mild to moderate inflammation was seen in 3 lesions. Necrotic core was present in 4/7 lesions, and was associated with plaque rupture in the only disrupted lesion.RESULTSAtherosclerotic lesions were present in 7/8 arteries examined, with a mean estimated stenosis of 34%. Lumen thrombus with a disrupted fibrous cap was seen in 1 lesion; the remaining 6 lesions revealed a thick fibrous cap. Neovascularity and calcification were seen in 1 lesion and mild to moderate inflammation was seen in 3 lesions. Necrotic core was present in 4/7 lesions, and was associated with plaque rupture in the only disrupted lesion.Basilar artery atherosclerotic lesions were relatively benign in this series of patients presenting with stroke. While confirmation is needed with larger sample size, the relative paucity of neovascularity suggests a possibly distinctive histopathological profile.CONCLUSIONSBasilar artery atherosclerotic lesions were relatively benign in this series of patients presenting with stroke. While confirmation is needed with larger sample size, the relative paucity of neovascularity suggests a possibly distinctive histopathological profile.
To define the nature of the basilar artery atherosclerotic lesions, we analyzed postmortem intracranial artery samples from eight subjects with history of stroke. Results: Atherosclerotic lesions were present in 7/8 arteries examined, with a mean estimated stenosis of 34%. Lumen thrombus with a disrupted fibrous cap was seen in 1 lesion; the remaining 6 lesions revealed a thick fibrous cap. Neovascularity and calcification were seen in 1 lesion and mild to moderate inflammation was seen in 3 lesions. Necrotic core was present in 4/7 lesions, and was associated with plaque rupture in the only disrupted lesion. Conclusions: Basilar artery atherosclerotic lesions were relatively benign in this series of patients presenting with stroke. While confirmation is needed with larger sample size, the relative paucity of neovascularity suggests a possibly distinctive histopathological profile.
Abstract Introduction There has been limited attention to pathological features of basilar artery atherosclerosis. It has been assumed that pathology of basilar artery atherosclerosis mimics that of other vascular beds. Methods To define the nature of the basilar artery atherosclerotic lesions, we analyzed postmortem intracranial artery samples from eight subjects with history of stroke. Results Atherosclerotic lesions were present in 7/8 arteries examined, with a mean estimated stenosis of 34%. Lumen thrombus with a disrupted fibrous cap was seen in 1 lesion; the remaining 6 lesions revealed a thick fibrous cap. Neovascularity and calcification were seen in 1 lesion and mild to moderate inflammation was seen in 3 lesions. Necrotic core was present in 4/7 lesions, and was associated with plaque rupture in the only disrupted lesion. Conclusions Basilar artery atherosclerotic lesions were relatively benign in this series of patients presenting with stroke. While confirmation is needed with larger sample size, the relative paucity of neovascularity suggests a possibly distinctive histopathological profile.
Author Narula, Navneet
Csiba, Laszlo
Fisher, Mark
Zhou, Jun
Labadzhyan, Artak
Narula, Jagat
AuthorAffiliation Department of Anatomy & Neurobiology, UC Irvine (USA)
Department of Medicine, UC Irvine (USA)
Department of Pathology and Laboratory Medicine, UC Irvine (USA)
Department of Neurology, University of Debrecen (Hungary)
Department of Neurology, UC Irvine (USA)
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Issue 1-2
Keywords Intracranial
Stroke
Artery
Atherosclerosis
Basilar
Plaque
Evaluation
Nervous system diseases
Cardiovascular disease
Basilar artery
Cerebral disorder
Vascular disease
Anatomic pathology
Central nervous system disease
Circulatory system
Cerebrovascular disease
Language English
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CC BY 4.0
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Snippet There has been limited attention to pathological features of basilar artery atherosclerosis. It has been assumed that pathology of basilar artery...
Abstract Introduction There has been limited attention to pathological features of basilar artery atherosclerosis. It has been assumed that pathology of...
To define the nature of the basilar artery atherosclerotic lesions, we analyzed postmortem intracranial artery samples from eight subjects with history of...
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SourceType Open Access Repository
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StartPage 97
SubjectTerms Aged
Aged, 80 and over
Artery
Atherosclerosis
Basilar
Basilar Artery - pathology
Biological and medical sciences
Calcinosis - pathology
Disease Progression
Endothelium, Vascular - pathology
Female
Humans
Intracranial
Intracranial Arteriosclerosis - pathology
Male
Medical sciences
Neovascularization, Pathologic - pathology
Neurology
Plaque
Stroke
Tunica Intima - pathology
Vasa Vasorum - pathology
Vascular diseases and vascular malformations of the nervous system
Vertebrobasilar Insufficiency - pathology
Title Histopathologic evaluation of basilar artery atherosclerosis
URI https://www.clinicalkey.com/#!/content/1-s2.0-S0022510X11002358
https://www.clinicalkey.es/playcontent/1-s2.0-S0022510X11002358
https://dx.doi.org/10.1016/j.jns.2011.05.004
https://www.ncbi.nlm.nih.gov/pubmed/21624622
https://www.proquest.com/docview/874895109
https://www.proquest.com/docview/883023798
https://pubmed.ncbi.nlm.nih.gov/PMC3141079
Volume 307
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