Histopathologic evaluation of basilar artery atherosclerosis
There has been limited attention to pathological features of basilar artery atherosclerosis. It has been assumed that pathology of basilar artery atherosclerosis mimics that of other vascular beds. To define the nature of the basilar artery atherosclerotic lesions, we analyzed postmortem intracrania...
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Published in | Journal of the neurological sciences Vol. 307; no. 1-2; pp. 97 - 99 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Amsterdam
Elsevier B.V
15.08.2011
Elsevier |
Subjects | |
Online Access | Get full text |
ISSN | 0022-510X 1878-5883 1878-5883 |
DOI | 10.1016/j.jns.2011.05.004 |
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Abstract | There has been limited attention to pathological features of basilar artery atherosclerosis. It has been assumed that pathology of basilar artery atherosclerosis mimics that of other vascular beds.
To define the nature of the basilar artery atherosclerotic lesions, we analyzed postmortem intracranial artery samples from eight subjects with history of stroke.
Atherosclerotic lesions were present in 7/8 arteries examined, with a mean estimated stenosis of 34%. Lumen thrombus with a disrupted fibrous cap was seen in 1 lesion; the remaining 6 lesions revealed a thick fibrous cap. Neovascularity and calcification were seen in 1 lesion and mild to moderate inflammation was seen in 3 lesions. Necrotic core was present in 4/7 lesions, and was associated with plaque rupture in the only disrupted lesion.
Basilar artery atherosclerotic lesions were relatively benign in this series of patients presenting with stroke. While confirmation is needed with larger sample size, the relative paucity of neovascularity suggests a possibly distinctive histopathological profile. |
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AbstractList | There has been limited attention to pathological features of basilar artery atherosclerosis. It has been assumed that pathology of basilar artery atherosclerosis mimics that of other vascular beds.
To define the nature of the basilar artery atherosclerotic lesions, we analyzed postmortem intracranial artery samples from eight subjects with history of stroke.
Atherosclerotic lesions were present in 7/8 arteries examined, with a mean estimated stenosis of 34%. Lumen thrombus with a disrupted fibrous cap was seen in 1 lesion; the remaining 6 lesions revealed a thick fibrous cap. Neovascularity and calcification were seen in 1 lesion and mild to moderate inflammation was seen in 3 lesions. Necrotic core was present in 4/7 lesions, and was associated with plaque rupture in the only disrupted lesion.
Basilar artery atherosclerotic lesions were relatively benign in this series of patients presenting with stroke. While confirmation is needed with larger sample size, the relative paucity of neovascularity suggests a possibly distinctive histopathological profile. There has been limited attention to pathological features of basilar artery atherosclerosis. It has been assumed that pathology of basilar artery atherosclerosis mimics that of other vascular beds.INTRODUCTIONThere has been limited attention to pathological features of basilar artery atherosclerosis. It has been assumed that pathology of basilar artery atherosclerosis mimics that of other vascular beds.To define the nature of the basilar artery atherosclerotic lesions, we analyzed postmortem intracranial artery samples from eight subjects with history of stroke.METHODSTo define the nature of the basilar artery atherosclerotic lesions, we analyzed postmortem intracranial artery samples from eight subjects with history of stroke.Atherosclerotic lesions were present in 7/8 arteries examined, with a mean estimated stenosis of 34%. Lumen thrombus with a disrupted fibrous cap was seen in 1 lesion; the remaining 6 lesions revealed a thick fibrous cap. Neovascularity and calcification were seen in 1 lesion and mild to moderate inflammation was seen in 3 lesions. Necrotic core was present in 4/7 lesions, and was associated with plaque rupture in the only disrupted lesion.RESULTSAtherosclerotic lesions were present in 7/8 arteries examined, with a mean estimated stenosis of 34%. Lumen thrombus with a disrupted fibrous cap was seen in 1 lesion; the remaining 6 lesions revealed a thick fibrous cap. Neovascularity and calcification were seen in 1 lesion and mild to moderate inflammation was seen in 3 lesions. Necrotic core was present in 4/7 lesions, and was associated with plaque rupture in the only disrupted lesion.Basilar artery atherosclerotic lesions were relatively benign in this series of patients presenting with stroke. While confirmation is needed with larger sample size, the relative paucity of neovascularity suggests a possibly distinctive histopathological profile.CONCLUSIONSBasilar artery atherosclerotic lesions were relatively benign in this series of patients presenting with stroke. While confirmation is needed with larger sample size, the relative paucity of neovascularity suggests a possibly distinctive histopathological profile. To define the nature of the basilar artery atherosclerotic lesions, we analyzed postmortem intracranial artery samples from eight subjects with history of stroke. Results: Atherosclerotic lesions were present in 7/8 arteries examined, with a mean estimated stenosis of 34%. Lumen thrombus with a disrupted fibrous cap was seen in 1 lesion; the remaining 6 lesions revealed a thick fibrous cap. Neovascularity and calcification were seen in 1 lesion and mild to moderate inflammation was seen in 3 lesions. Necrotic core was present in 4/7 lesions, and was associated with plaque rupture in the only disrupted lesion. Conclusions: Basilar artery atherosclerotic lesions were relatively benign in this series of patients presenting with stroke. While confirmation is needed with larger sample size, the relative paucity of neovascularity suggests a possibly distinctive histopathological profile. Abstract Introduction There has been limited attention to pathological features of basilar artery atherosclerosis. It has been assumed that pathology of basilar artery atherosclerosis mimics that of other vascular beds. Methods To define the nature of the basilar artery atherosclerotic lesions, we analyzed postmortem intracranial artery samples from eight subjects with history of stroke. Results Atherosclerotic lesions were present in 7/8 arteries examined, with a mean estimated stenosis of 34%. Lumen thrombus with a disrupted fibrous cap was seen in 1 lesion; the remaining 6 lesions revealed a thick fibrous cap. Neovascularity and calcification were seen in 1 lesion and mild to moderate inflammation was seen in 3 lesions. Necrotic core was present in 4/7 lesions, and was associated with plaque rupture in the only disrupted lesion. Conclusions Basilar artery atherosclerotic lesions were relatively benign in this series of patients presenting with stroke. While confirmation is needed with larger sample size, the relative paucity of neovascularity suggests a possibly distinctive histopathological profile. |
Author | Narula, Navneet Csiba, Laszlo Fisher, Mark Zhou, Jun Labadzhyan, Artak Narula, Jagat |
AuthorAffiliation | Department of Anatomy & Neurobiology, UC Irvine (USA) Department of Medicine, UC Irvine (USA) Department of Pathology and Laboratory Medicine, UC Irvine (USA) Department of Neurology, University of Debrecen (Hungary) Department of Neurology, UC Irvine (USA) |
AuthorAffiliation_xml | – name: Department of Pathology and Laboratory Medicine, UC Irvine (USA) – name: Department of Medicine, UC Irvine (USA) – name: Department of Anatomy & Neurobiology, UC Irvine (USA) – name: Department of Neurology, UC Irvine (USA) – name: Department of Neurology, University of Debrecen (Hungary) |
Author_xml | – sequence: 1 givenname: Artak surname: Labadzhyan fullname: Labadzhyan, Artak organization: Department of Medicine, UC Irvine, USA – sequence: 2 givenname: Laszlo surname: Csiba fullname: Csiba, Laszlo organization: Department of Neurology, University of Debrecen, Hungary – sequence: 3 givenname: Navneet surname: Narula fullname: Narula, Navneet organization: Department of Pathology & Laboratory Medicine, UC Irvine, USA – sequence: 4 givenname: Jun surname: Zhou fullname: Zhou, Jun organization: Department of Medicine, UC Irvine, USA – sequence: 5 givenname: Jagat surname: Narula fullname: Narula, Jagat organization: Department of Medicine, UC Irvine, USA – sequence: 6 givenname: Mark surname: Fisher fullname: Fisher, Mark email: mfisher@uci.edu organization: Department of Pathology & Laboratory Medicine, UC Irvine, USA |
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Keywords | Intracranial Stroke Artery Atherosclerosis Basilar Plaque Evaluation Nervous system diseases Cardiovascular disease Basilar artery Cerebral disorder Vascular disease Anatomic pathology Central nervous system disease Circulatory system Cerebrovascular disease |
Language | English |
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Snippet | There has been limited attention to pathological features of basilar artery atherosclerosis. It has been assumed that pathology of basilar artery... Abstract Introduction There has been limited attention to pathological features of basilar artery atherosclerosis. It has been assumed that pathology of... To define the nature of the basilar artery atherosclerotic lesions, we analyzed postmortem intracranial artery samples from eight subjects with history of... |
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SubjectTerms | Aged Aged, 80 and over Artery Atherosclerosis Basilar Basilar Artery - pathology Biological and medical sciences Calcinosis - pathology Disease Progression Endothelium, Vascular - pathology Female Humans Intracranial Intracranial Arteriosclerosis - pathology Male Medical sciences Neovascularization, Pathologic - pathology Neurology Plaque Stroke Tunica Intima - pathology Vasa Vasorum - pathology Vascular diseases and vascular malformations of the nervous system Vertebrobasilar Insufficiency - pathology |
Title | Histopathologic evaluation of basilar artery atherosclerosis |
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