Three-Dimensional Organoids Reveal Therapy Resistance of Esophageal and Oropharyngeal Squamous Cell Carcinoma Cells
Oropharyngeal and esophageal squamous cell carcinomas, especially the latter, are a lethal disease, featuring intratumoral cancer cell heterogeneity and therapy resistance. To facilitate cancer therapy in personalized medicine, three-dimensional (3D) organoids may be useful for functional characteri...
Saved in:
| Published in | Cellular and molecular gastroenterology and hepatology Vol. 7; no. 1; pp. 73 - 91 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
01.01.2019
Elsevier |
| Subjects | |
| Online Access | Get full text |
| ISSN | 2352-345X 2352-345X |
| DOI | 10.1016/j.jcmgh.2018.09.003 |
Cover
| Abstract | Oropharyngeal and esophageal squamous cell carcinomas, especially the latter, are a lethal disease, featuring intratumoral cancer cell heterogeneity and therapy resistance. To facilitate cancer therapy in personalized medicine, three-dimensional (3D) organoids may be useful for functional characterization of cancer cells ex vivo. We investigated the feasibility and the utility of patient-derived 3D organoids of esophageal and oropharyngeal squamous cell carcinomas.
We generated 3D organoids from paired biopsies representing tumors and adjacent normal mucosa from therapy-naïve patients and cell lines. We evaluated growth and structures of 3D organoids treated with 5-fluorouracil ex vivo.
Tumor-derived 3D organoids were grown successfully from 15 out of 21 patients (71.4%) and passaged with recapitulation of the histopathology of the original tumors. Successful formation of tumor-derived 3D organoids was associated significantly with poor response to presurgical neoadjuvant chemotherapy or chemoradiation therapy in informative patients (P = 0.0357, progressive and stable diseases, n = 10 vs. partial response, n = 6). The 3D organoid formation capability and 5-fluorouracil resistance were accounted for by cancer cells with high CD44 expression and autophagy, respectively. Such cancer cells were found to be enriched in patient-derived 3D organoids surviving 5-fluorouracil treatment.
The single cell-based 3D organoid system may serve as a highly efficient platform to explore cancer therapeutics and therapy resistance mechanisms in conjunction with morphological and functional assays with implications for translation in personalized medicine.
[Display omitted] |
|---|---|
| AbstractList | Oropharyngeal and esophageal squamous cell carcinomas, especially the latter, are a lethal disease, featuring intratumoral cancer cell heterogeneity and therapy resistance. To facilitate cancer therapy in personalized medicine, three-dimensional (3D) organoids may be useful for functional characterization of cancer cells ex vivo. We investigated the feasibility and the utility of patient-derived 3D organoids of esophageal and oropharyngeal squamous cell carcinomas.
We generated 3D organoids from paired biopsies representing tumors and adjacent normal mucosa from therapy-naïve patients and cell lines. We evaluated growth and structures of 3D organoids treated with 5-fluorouracil ex vivo.
Tumor-derived 3D organoids were grown successfully from 15 out of 21 patients (71.4%) and passaged with recapitulation of the histopathology of the original tumors. Successful formation of tumor-derived 3D organoids was associated significantly with poor response to presurgical neoadjuvant chemotherapy or chemoradiation therapy in informative patients (P = 0.0357, progressive and stable diseases, n = 10 vs. partial response, n = 6). The 3D organoid formation capability and 5-fluorouracil resistance were accounted for by cancer cells with high CD44 expression and autophagy, respectively. Such cancer cells were found to be enriched in patient-derived 3D organoids surviving 5-fluorouracil treatment.
The single cell-based 3D organoid system may serve as a highly efficient platform to explore cancer therapeutics and therapy resistance mechanisms in conjunction with morphological and functional assays with implications for translation in personalized medicine.
[Display omitted] Oropharyngeal and esophageal squamous cell carcinomas, especially the latter, are a lethal disease, featuring intratumoral cancer cell heterogeneity and therapy resistance. To facilitate cancer therapy in personalized medicine, three-dimensional (3D) organoids may be useful for functional characterization of cancer cells ex vivo. We investigated the feasibility and the utility of patient-derived 3D organoids of esophageal and oropharyngeal squamous cell carcinomas.Background & AimsOropharyngeal and esophageal squamous cell carcinomas, especially the latter, are a lethal disease, featuring intratumoral cancer cell heterogeneity and therapy resistance. To facilitate cancer therapy in personalized medicine, three-dimensional (3D) organoids may be useful for functional characterization of cancer cells ex vivo. We investigated the feasibility and the utility of patient-derived 3D organoids of esophageal and oropharyngeal squamous cell carcinomas.We generated 3D organoids from paired biopsies representing tumors and adjacent normal mucosa from therapy-naïve patients and cell lines. We evaluated growth and structures of 3D organoids treated with 5-fluorouracil ex vivo.MethodsWe generated 3D organoids from paired biopsies representing tumors and adjacent normal mucosa from therapy-naïve patients and cell lines. We evaluated growth and structures of 3D organoids treated with 5-fluorouracil ex vivo.Tumor-derived 3D organoids were grown successfully from 15 out of 21 patients (71.4%) and passaged with recapitulation of the histopathology of the original tumors. Successful formation of tumor-derived 3D organoids was associated significantly with poor response to presurgical neoadjuvant chemotherapy or chemoradiation therapy in informative patients (P = 0.0357, progressive and stable diseases, n = 10 vs. partial response, n = 6). The 3D organoid formation capability and 5-fluorouracil resistance were accounted for by cancer cells with high CD44 expression and autophagy, respectively. Such cancer cells were found to be enriched in patient-derived 3D organoids surviving 5-fluorouracil treatment.ResultsTumor-derived 3D organoids were grown successfully from 15 out of 21 patients (71.4%) and passaged with recapitulation of the histopathology of the original tumors. Successful formation of tumor-derived 3D organoids was associated significantly with poor response to presurgical neoadjuvant chemotherapy or chemoradiation therapy in informative patients (P = 0.0357, progressive and stable diseases, n = 10 vs. partial response, n = 6). The 3D organoid formation capability and 5-fluorouracil resistance were accounted for by cancer cells with high CD44 expression and autophagy, respectively. Such cancer cells were found to be enriched in patient-derived 3D organoids surviving 5-fluorouracil treatment.The single cell-based 3D organoid system may serve as a highly efficient platform to explore cancer therapeutics and therapy resistance mechanisms in conjunction with morphological and functional assays with implications for translation in personalized medicine.ConclusionsThe single cell-based 3D organoid system may serve as a highly efficient platform to explore cancer therapeutics and therapy resistance mechanisms in conjunction with morphological and functional assays with implications for translation in personalized medicine. Background & Aims Oropharyngeal and esophageal squamous cell carcinomas, especially the latter, are a lethal disease, featuring intratumoral cancer cell heterogeneity and therapy resistance. To facilitate cancer therapy in personalized medicine, three-dimensional (3D) organoids may be useful for functional characterization of cancer cells ex vivo . We investigated the feasibility and the utility of patient-derived 3D organoids of esophageal and oropharyngeal squamous cell carcinomas. Methods We generated 3D organoids from paired biopsies representing tumors and adjacent normal mucosa from therapy-naïve patients and cell lines. We evaluated growth and structures of 3D organoids treated with 5-fluorouracil ex vivo. Results Tumor-derived 3D organoids were grown successfully from 15 out of 21 patients (71.4%) and passaged with recapitulation of the histopathology of the original tumors. Successful formation of tumor-derived 3D organoids was associated significantly with poor response to presurgical neoadjuvant chemotherapy or chemoradiation therapy in informative patients ( P = 0.0357, progressive and stable diseases, n = 10 vs. partial response, n = 6). The 3D organoid formation capability and 5-fluorouracil resistance were accounted for by cancer cells with high CD44 expression and autophagy, respectively. Such cancer cells were found to be enriched in patient-derived 3D organoids surviving 5-fluorouracil treatment. Conclusions The single cell-based 3D organoid system may serve as a highly efficient platform to explore cancer therapeutics and therapy resistance mechanisms in conjunction with morphological and functional assays with implications for translation in personalized medicine. Oropharyngeal and esophageal squamous cell carcinomas, especially the latter, are a lethal disease, featuring intratumoral cancer cell heterogeneity and therapy resistance. To facilitate cancer therapy in personalized medicine, three-dimensional (3D) organoids may be useful for functional characterization of cancer cells . We investigated the feasibility and the utility of patient-derived 3D organoids of esophageal and oropharyngeal squamous cell carcinomas. We generated 3D organoids from paired biopsies representing tumors and adjacent normal mucosa from therapy-naïve patients and cell lines. We evaluated growth and structures of 3D organoids treated with 5-fluorouracil . Tumor-derived 3D organoids were grown successfully from 15 out of 21 patients (71.4%) and passaged with recapitulation of the histopathology of the original tumors. Successful formation of tumor-derived 3D organoids was associated significantly with poor response to presurgical neoadjuvant chemotherapy or chemoradiation therapy in informative patients ( = 0.0357, progressive and stable diseases, n = 10 vs. partial response, n = 6). The 3D organoid formation capability and 5-fluorouracil resistance were accounted for by cancer cells with high CD44 expression and autophagy, respectively. Such cancer cells were found to be enriched in patient-derived 3D organoids surviving 5-fluorouracil treatment. The single cell-based 3D organoid system may serve as a highly efficient platform to explore cancer therapeutics and therapy resistance mechanisms in conjunction with morphological and functional assays with implications for translation in personalized medicine. |
| Author | Hara, Takeo Muir, Amanda B. Uchikado, Yasuto Mori, Masaki Avadhani, Narayan G. Whelan, Kelly A. Tanaka, Koji Sasaki, Ken Omoto, Itaru Kijima, Takashi Arigami, Takaaki Sahu, Varun Doki, Yuichiro Kikuchi, Osamu Naganuma, Seiji Shimonosono, Masataka Muto, Manabu Diehl, J. Alan Ohashi, Shinya Chandramouleeswaran, Prasanna M. Kasagi, Yuta Ginsberg, Gregory G. Kita, Yoshiaki Shinden, Yoshiaki Nakagawa, Hiroshi Rustgi, Anil K. Klein-Szanto, Andres J. Giroux, Veronique Bass, Adam J. Basu, Devraj Natsugoe, Shoji |
| AuthorAffiliation | 1 Department of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan 5 Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan 8 Department of Therapeutic Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan 10 Fels Institute for Cancer Research & Molecular Biology, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania 7 Division of Pediatric Gastroenterology, Hepatology, and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 4 University of Pennsylvania Abramson Cancer Center, Philadelphia, Pennsylvania 6 Department of Otorhinolaryngology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 9 Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, Massachusetts 13 Department of Biochemistry and Molecular Biology, Hollings Cancer Center, Me |
| AuthorAffiliation_xml | – name: 10 Fels Institute for Cancer Research & Molecular Biology, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania – name: 3 Division of Gastroenterology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania – name: 4 University of Pennsylvania Abramson Cancer Center, Philadelphia, Pennsylvania – name: 11 Department of Pathology, Kochi University School of Medicine, Nankoku, Japan – name: 5 Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan – name: 8 Department of Therapeutic Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan – name: 1 Department of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan – name: 7 Division of Pediatric Gastroenterology, Hepatology, and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania – name: 6 Department of Otorhinolaryngology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania – name: 2 Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania – name: 12 Histopathology Facility and Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania – name: 9 Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, Massachusetts – name: 13 Department of Biochemistry and Molecular Biology, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina |
| Author_xml | – sequence: 1 givenname: Takashi surname: Kijima fullname: Kijima, Takashi organization: Department of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan – sequence: 2 givenname: Hiroshi surname: Nakagawa fullname: Nakagawa, Hiroshi email: nakagawh@pennmedicine.upenn.edu organization: Division of Gastroenterology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania – sequence: 3 givenname: Masataka surname: Shimonosono fullname: Shimonosono, Masataka organization: Department of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan – sequence: 4 givenname: Prasanna M. surname: Chandramouleeswaran fullname: Chandramouleeswaran, Prasanna M. organization: Division of Gastroenterology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania – sequence: 5 givenname: Takeo surname: Hara fullname: Hara, Takeo organization: Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan – sequence: 6 givenname: Varun surname: Sahu fullname: Sahu, Varun organization: Department of Otorhinolaryngology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania – sequence: 7 givenname: Yuta surname: Kasagi fullname: Kasagi, Yuta organization: Division of Pediatric Gastroenterology, Hepatology, and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania – sequence: 8 givenname: Osamu surname: Kikuchi fullname: Kikuchi, Osamu organization: Department of Therapeutic Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan – sequence: 9 givenname: Koji surname: Tanaka fullname: Tanaka, Koji organization: Division of Gastroenterology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania – sequence: 10 givenname: Veronique surname: Giroux fullname: Giroux, Veronique organization: Division of Gastroenterology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania – sequence: 11 givenname: Amanda B. surname: Muir fullname: Muir, Amanda B. organization: Division of Pediatric Gastroenterology, Hepatology, and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania – sequence: 12 givenname: Kelly A. surname: Whelan fullname: Whelan, Kelly A. organization: Division of Gastroenterology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania – sequence: 13 givenname: Shinya surname: Ohashi fullname: Ohashi, Shinya organization: Department of Therapeutic Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan – sequence: 14 givenname: Seiji surname: Naganuma fullname: Naganuma, Seiji organization: Department of Pathology, Kochi University School of Medicine, Nankoku, Japan – sequence: 15 givenname: Andres J. surname: Klein-Szanto fullname: Klein-Szanto, Andres J. organization: Histopathology Facility and Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania – sequence: 16 givenname: Yoshiaki surname: Shinden fullname: Shinden, Yoshiaki organization: Department of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan – sequence: 17 givenname: Ken surname: Sasaki fullname: Sasaki, Ken organization: Department of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan – sequence: 18 givenname: Itaru surname: Omoto fullname: Omoto, Itaru organization: Department of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan – sequence: 19 givenname: Yoshiaki surname: Kita fullname: Kita, Yoshiaki organization: Department of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan – sequence: 20 givenname: Manabu surname: Muto fullname: Muto, Manabu organization: Department of Therapeutic Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan – sequence: 21 givenname: Adam J. surname: Bass fullname: Bass, Adam J. organization: Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, Massachusetts – sequence: 22 givenname: J. Alan surname: Diehl fullname: Diehl, J. Alan organization: Department of Biochemistry and Molecular Biology, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina – sequence: 23 givenname: Gregory G. surname: Ginsberg fullname: Ginsberg, Gregory G. organization: Division of Gastroenterology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania – sequence: 24 givenname: Yuichiro surname: Doki fullname: Doki, Yuichiro organization: Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan – sequence: 25 givenname: Masaki surname: Mori fullname: Mori, Masaki organization: Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan – sequence: 26 givenname: Yasuto surname: Uchikado fullname: Uchikado, Yasuto organization: Department of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan – sequence: 27 givenname: Takaaki surname: Arigami fullname: Arigami, Takaaki organization: Department of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan – sequence: 28 givenname: Narayan G. surname: Avadhani fullname: Avadhani, Narayan G. organization: Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania – sequence: 29 givenname: Devraj surname: Basu fullname: Basu, Devraj organization: Department of Otorhinolaryngology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania – sequence: 30 givenname: Anil K. surname: Rustgi fullname: Rustgi, Anil K. email: anil2@pennmedicine.upenn.edu organization: Division of Gastroenterology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania – sequence: 31 givenname: Shoji surname: Natsugoe fullname: Natsugoe, Shoji email: natsugoe@m2.kufm.kagoshima-u.ac.jp organization: Department of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30510992$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFUttq3DAQNSWlSdN8QaH4sS92R_Kd0kDYphcIBJot9E2M5dm1XFvaSPbC_n3l3TSkgbJP0ozOOTOjM6-DE200BcFbBjEDln_o4k4O6zbmwMoYqhggeRGc8STjUZJmv06e3E-DC-c6AGBpkReQvQpOE8gYVBU_C9yytUTRZzWQdspo7MNbu0ZtVOPCH7Qln1i2ZHGz86FTbkQtKTSr8NqZTYvrGYC68aw5tDu9z9zdTziYyYUL6vtwgVYqbQbch-5N8HKFvaOLh_M8-Pnlern4Ft3cfv2-uLqJZF7kY0S84QRlWVOKTcGrWrK8yTiuyppziXlaQlMWSJhlNbK8QlmBZDV6MDRYYXIeXB50N1M9UCNJjxZ7sbFq8I0Kg0r8-6JVK9ZmK3KeQ5KUXuD9g4A19xO5UQzKST8CavLDCc7SqszTlDMPffe01mORvz_tAckBIK1xztLqEcJAzJaKTuwtFbOlAirhLfWs6hlLqhFHb5RvWPVHuJ8OXPJ_vFVkhZOKvHuNsiRH0Rh1hH_5jC97pZXE_jftyHVmsn5dnGDCcQHibl64ed9YmQDj6Szw8f8CR8v_ASS76eE |
| CitedBy_id | crossref_primary_10_1186_s13046_022_02561_5 crossref_primary_10_1038_s41575_019_0255_2 crossref_primary_10_3390_jmp4010007 crossref_primary_10_1016_j_ccell_2022_12_004 crossref_primary_10_1186_s13578_022_00775_w crossref_primary_10_1093_jpp_rgae107 crossref_primary_10_1038_s41563_020_0754_0 crossref_primary_10_1093_carcin_bgad019 crossref_primary_10_3389_fonc_2021_650891 crossref_primary_10_3389_frlct_2024_1420233 crossref_primary_10_1016_j_jff_2024_106244 crossref_primary_10_3389_fonc_2020_01727 crossref_primary_10_1016_j_drup_2022_100806 crossref_primary_10_1016_j_eng_2021_04_017 crossref_primary_10_3389_fonc_2021_826613 crossref_primary_10_1038_s41598_021_03708_8 crossref_primary_10_1111_iej_13641 crossref_primary_10_1016_j_canlet_2024_216999 crossref_primary_10_1038_s41397_022_00296_2 crossref_primary_10_1016_j_labinv_2023_100105 crossref_primary_10_1002_jso_27626 crossref_primary_10_1002_ags3_12440 crossref_primary_10_1016_j_critrevonc_2020_103190 crossref_primary_10_1093_jmcb_mjac038 crossref_primary_10_1177_20417314241255470 crossref_primary_10_1186_s40364_022_00421_0 crossref_primary_10_1093_jmcb_mjaa012 crossref_primary_10_1038_s12276_024_01272_5 crossref_primary_10_1136_jclinpath_2020_207318 crossref_primary_10_1186_s12935_024_03628_3 crossref_primary_10_1186_s12943_021_01455_y crossref_primary_10_3390_cancers15113036 crossref_primary_10_1016_j_gendis_2023_02_052 crossref_primary_10_1002_cam4_3933 crossref_primary_10_22465_kjuo_2021_19_4_197 crossref_primary_10_1186_s12967_024_05967_1 crossref_primary_10_1186_s12885_023_10692_x crossref_primary_10_1002_1878_0261_13072 crossref_primary_10_1186_s12885_023_11434_9 crossref_primary_10_1016_j_actbio_2022_04_050 crossref_primary_10_1080_23808993_2019_1685868 crossref_primary_10_1007_s13402_024_00960_8 crossref_primary_10_1007_s00109_023_02340_5 crossref_primary_10_3389_fbioe_2019_00217 crossref_primary_10_1080_23808993_2020_1715794 crossref_primary_10_1038_s43018_020_0102_y crossref_primary_10_1038_s12276_021_00654_3 crossref_primary_10_1038_s41698_023_00480_y crossref_primary_10_1080_15384047_2021_1939638 crossref_primary_10_3390_cancers11111697 crossref_primary_10_3748_wjg_v30_i20_2638 crossref_primary_10_1002_ctm2_874 crossref_primary_10_1360_SSV_2021_0315 crossref_primary_10_1111_febs_16103 crossref_primary_10_1155_2021_8292453 crossref_primary_10_1016_j_celrep_2021_109429 crossref_primary_10_1038_s41417_023_00652_9 crossref_primary_10_1007_s13577_023_01020_3 crossref_primary_10_1021_acsbiomaterials_1c00812 crossref_primary_10_1098_rsob_190274 crossref_primary_10_1038_s41392_022_01194_6 crossref_primary_10_1038_s41416_023_02167_4 crossref_primary_10_1016_j_jcmgh_2022_01_018 crossref_primary_10_1016_j_gde_2024_102227 crossref_primary_10_1016_j_bprint_2024_e00381 crossref_primary_10_1002_jmv_28388 crossref_primary_10_2147_CMAR_S260129 crossref_primary_10_1016_j_canlet_2021_03_031 crossref_primary_10_1186_s41199_020_00056_4 crossref_primary_10_3390_cells13161312 crossref_primary_10_1002_term_3248 crossref_primary_10_3390_cells9112527 crossref_primary_10_1016_j_coph_2023_102348 crossref_primary_10_1016_j_jmb_2021_167256 crossref_primary_10_3390_biom11101479 crossref_primary_10_1016_j_heliyon_2024_e30457 crossref_primary_10_3390_cancers11081156 crossref_primary_10_3390_jpm13111575 crossref_primary_10_1016_j_ccell_2025_01_003 crossref_primary_10_1038_s41374_022_00827_2 crossref_primary_10_3390_cancers13020227 crossref_primary_10_1007_s00262_024_03691_9 crossref_primary_10_1002_cam4_70129 crossref_primary_10_15252_embr_201847074 crossref_primary_10_1242_dmm_050319 crossref_primary_10_1016_j_pharmthera_2022_108276 crossref_primary_10_3389_fimmu_2022_1061388 crossref_primary_10_1038_s41416_021_01336_7 crossref_primary_10_1002_ijc_33421 crossref_primary_10_3390_cancers13194812 crossref_primary_10_1007_s00018_023_04952_z crossref_primary_10_3390_pharmaceutics14122709 crossref_primary_10_1360_SSV_2023_0145 crossref_primary_10_1002_cpsc_109 crossref_primary_10_1016_j_biopha_2022_114098 crossref_primary_10_1002_ijc_33954 crossref_primary_10_1016_j_isci_2021_103440 crossref_primary_10_1093_jmcb_mjaa035 crossref_primary_10_1158_1078_0432_CCR_19_1627 |
| Cites_doi | 10.1371/journal.pone.0021419 10.1016/j.ccell.2016.04.004 10.1016/S1470-2045(15)00040-6 10.1016/j.phrs.2004.01.006 10.1038/s41467-017-01500-9 10.1093/carcin/bgv025 10.1053/j.gastro.2011.07.050 10.1158/0008-5472.CAN-07-0562 10.1158/0008-5472.CAN-15-3377 10.1053/j.gastro.2015.08.054 10.1038/onc.2014.169 10.1007/BF01215923 10.1016/j.celrep.2014.09.027 10.1016/j.cell.2015.03.053 10.1080/15384047.2015.1040959 10.1007/s10388-009-0169-0 10.1038/cddis.2013.350 10.1016/j.jcmgh.2018.01.011 10.1002/1097-0142(19920115)69:2<277::AID-CNCR2820690202>3.0.CO;2-C 10.1054/bjoc.2000.1512 10.1056/NEJMra1314530 10.1111/febs.13250 10.1007/s10388-016-0551-7 10.1038/onc.2014.449 10.1172/JCI88941 10.1007/s10388-009-0193-0 10.1038/srep03224 10.1136/gutjnl-2015-310341 10.1101/gad.190678.112 10.1371/journal.pone.0103126 10.1126/science.1247125 10.1016/j.ejca.2008.10.026 10.3892/or.2016.5133 10.1038/nm.3802 10.1126/science.1234852 10.1245/s10434-010-0985-4 10.1038/srep22452 10.1016/j.cell.2014.08.016 10.1111/j.1442-2050.2006.00615.x 10.1038/onc.2017.102 10.1016/j.cell.2015.06.028 10.1002/1097-0142(19950815)76:4<541::AID-CNCR2820760402>3.0.CO;2-I 10.1038/onc.2010.215 10.1016/j.cell.2014.12.021 10.1016/j.jcmgh.2017.12.013 |
| ContentType | Journal Article |
| Copyright | 2019 The Authors The Authors 2019 The Authors 2019 |
| Copyright_xml | – notice: 2019 The Authors – notice: The Authors – notice: 2019 The Authors 2019 |
| DBID | 6I. AAFTH AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 5PM |
| DOI | 10.1016/j.jcmgh.2018.09.003 |
| DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 2352-345X |
| EndPage | 91 |
| ExternalDocumentID | PMC6260338 30510992 10_1016_j_jcmgh_2018_09_003 S2352345X18301243 1_s2_0_S2352345X18301243 |
| Genre | Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: University of Pennsylvania Center of Excellence in Environmental Toxicology grantid: K01DK103953; F32CA174176; T32DK007066; K08DK106444 – fundername: Ministry of Education, Culture, Sports, Science and Technology of Japan grantid: 17H04285; 15K10108 – fundername: American Cancer Society grantid: RP-10-033-01-CCE funderid: https://doi.org/10.13039/100000048 – fundername: NIH/NIDDK grantid: P30DK050306 – fundername: NIH grantid: P01CA098101; U54CA163004; R01DK114436; R01AA026297; R01AA022986; P30ES013508 funderid: https://doi.org/10.13039/100000002 – fundername: Scientific Research B – fundername: Exploratory Research – fundername: NIDCR NIH HHS grantid: R56 DE027185 – fundername: NIDDK NIH HHS grantid: T32 DK007066 – fundername: NCI NIH HHS grantid: F31 CA174176 – fundername: NIAAA NIH HHS grantid: R01 AA022986 – fundername: NIDDK NIH HHS grantid: P30 DK050306 – fundername: NIDDK NIH HHS grantid: R01 DK114436 – fundername: NIAAA NIH HHS grantid: R01 AA026297 – fundername: NIEHS NIH HHS grantid: P30 ES013508 – fundername: NCI NIH HHS grantid: P01 CA098101 – fundername: NCI NIH HHS grantid: U54 CA163004 |
| GroupedDBID | .1- .FO 0R~ 1P~ 4.4 457 53G AAEDT AAEDW AAIKJ AALRI AAXUO AAYWO ABMAC ACGFS ACVFH ADBBV ADCNI ADEZE ADRAZ ADVLN AEUPX AEVXI AEXQZ AFJKZ AFPUW AFRHN AFTJW AGHFR AIGII AITUG AJUYK AKBMS AKRWK AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ AOIJS APXCP BCNDV EBS EJD FDB GROUPED_DOAJ HYE KQ8 M41 M48 O9- OC. OK1 ON0 ROL RPM SSZ Z5R 0SF 6I. AACTN AAFTH NCXOZ AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 5PM |
| ID | FETCH-LOGICAL-c676t-e2d2e088be4ad729bc16d52af8b22ca6480d87aea55ba169ac90c1baad70da9a3 |
| IEDL.DBID | M48 |
| ISSN | 2352-345X |
| IngestDate | Thu Aug 21 13:45:55 EDT 2025 Thu Jul 10 18:23:19 EDT 2025 Mon Jul 21 05:57:46 EDT 2025 Tue Jul 01 02:11:42 EDT 2025 Thu Apr 24 23:08:31 EDT 2025 Fri Feb 23 02:26:12 EST 2024 Sun Feb 23 10:19:13 EST 2025 Tue Aug 26 16:32:13 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | 5-Fluorouracil 5FU IHC H&E SCCs CD44H OPSCC Autophagy EMT CQ ESCC DMEM 3D 3D Organoids AV FBS IC50 PI LC3 CD44 TE11R IC 50 half maximal inhibitory concentration chloroquine propidium iodide oropharyngeal squamous cell carcinoma epithelial-mesenchymal transition immunohistochemistry 3-dimensional hematoxylin and eosin esophageal squamous cell carcinoma light chain 3 squamous cell carcinomas high expression of CD44 autophagy vesicle fetal bovine serum Dulbecco’s modified Eagle medium 5-fluorouracil–resistant derivative of TE11 EMT, epithelial-mesenchymal transition CD44H, high expression of CD44 PI, propidium iodide ESCC, esophageal squamous cell carcinoma FBS, fetal bovine serum IC50, half maximal inhibitory concentration LC3, light chain 3 CQ, chloroquine SCCs, squamous cell carcinomas TE11R, 5-fluorouracil–resistant derivative of TE11 H&E, hematoxylin and eosin IHC, immunohistochemistry OPSCC, oropharyngeal squamous cell carcinoma 5FU, 5-fluorouracil DMEM, Dulbecco’s modified Eagle medium AV, autophagy vesicle 3D, 3-dimensional |
| Language | English |
| License | This is an open access article under the CC BY-NC-ND license. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c676t-e2d2e088be4ad729bc16d52af8b22ca6480d87aea55ba169ac90c1baad70da9a3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Authors share co-first authorship. Authors share co-senior authorship. |
| OpenAccessLink | http://journals.scholarsportal.info/openUrl.xqy?doi=10.1016/j.jcmgh.2018.09.003 |
| PMID | 30510992 |
| PQID | 2149864421 |
| PQPubID | 23479 |
| PageCount | 19 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_6260338 proquest_miscellaneous_2149864421 pubmed_primary_30510992 crossref_primary_10_1016_j_jcmgh_2018_09_003 crossref_citationtrail_10_1016_j_jcmgh_2018_09_003 elsevier_sciencedirect_doi_10_1016_j_jcmgh_2018_09_003 elsevier_clinicalkeyesjournals_1_s2_0_S2352345X18301243 elsevier_clinicalkey_doi_10_1016_j_jcmgh_2018_09_003 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2019-01-01 |
| PublicationDateYYYYMMDD | 2019-01-01 |
| PublicationDate_xml | – month: 01 year: 2019 text: 2019-01-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Cellular and molecular gastroenterology and hepatology |
| PublicationTitleAlternate | Cell Mol Gastroenterol Hepatol |
| PublicationYear | 2019 |
| Publisher | Elsevier Inc Elsevier |
| Publisher_xml | – name: Elsevier Inc – name: Elsevier |
| References | Whelan, Chandramouleeswaran, Tanaka, Natsuizaka, Guha, Srinivasan, Darling, Kita, Natsugoe, Winkler, Klein-Szanto, Amaravadi, Avadhani, Rustgi, Nakagawa (bib13) 2017; 36 Shimada, Imamura, Wagata, Yamaguchi, Tobe (bib29) 1992; 69 Ohashi, Miyamoto, Kikuchi, Goto, Amanuma, Muto (bib3) 2015; 149 Rustgi, El-Serag (bib2) 2014; 371 Zhao, Li, Ge, Zhang, Li, Lu, Ji, Guan, Gao, Xu, Li, Soukiasian, Koeffler, Wang, Xie (bib9) 2011; 6 Lancaster, Knoblich (bib14) 2014; 345 Nishihira, Hashimoto, Katayama, Mori, Kuroki (bib43) 1993; 119 Freed-Pastor, Prives (bib26) 2012; 26 Natsugoe, Okumura, Matsumoto, Uchikado, Setoyama, Yokomakura, Ishigami, Owaki, Aikou (bib38) 2006; 19 Okamoto, Ninomiya, Ohbatake, Hirose, Tsukada, Nakanuma, Sakai, Kinoshita, Makino, Nakamura, Hayashi, Oyama, Inokuchi, Nakagawara, Miyashita, Hidehiro, Takamura, Fushida, Ohta (bib10) 2016; 36 Wagata, Shibagaki, Imamura, Shimada, Toguchida, Yandell, Ikenaga, Tobe, Ishizaki (bib25) 1993; 53 Japan Esophageal (bib48) 2017; 14 van de Wetering, Francies, Francis, Bounova, Iorio, Pronk, van Houdt, van Gorp, Taylor-Weiner, Kester, McLaren-Douglas, Blokker, Jaksani, Bartfeld, Volckman, van Sluis, Li, Seepo, Sekhar Pedamallu, Cibulskis, Carter, McKenna, Lawrence, Lichtenstein, Stewart, Koster, Versteeg, van Oudenaarden, Saez-Rodriguez, Vries, Getz, Wessels, Stratton, McDermott, Meyerson, Garnett, Clevers (bib18) 2015; 161 Apel, Herr, Schwarz, Rodemann, Mayer (bib7) 2008; 68 Sui, Chen, Wang, Huang, Kong, Zhang, Han, Lou, Yang, Zhang, Wang, He, Pan (bib8) 2013; 4 DeWard, Cramer, Lagasse (bib22) 2014; 9 Kasagi, Chandramouleeswaran, Whelan, Tanaka, Giroux, Sharma, Wang, Benitez, DeMarshall, Tobias, Hamilton, Falk, Spergel, Klein-Szanto, Rustgi, Muir, Nakagawa (bib23) 2018; 5 Whelan, Merves, Giroux, Tanaka, Guo, Chandramouleeswaran, Benitez, Dods, Que, Masterson, Fernando, Godwin, Klein-Szanto, Chikwava, Ruchelli, Hamilton, Muir, Wang, Furuta, Falk, Spergel, Nakagawa (bib46) 2017; 66 Sato, Stange, Ferrante, Vries, Van Es, Van den Brink, Van Houdt, Pronk, Van Gorp, Siersema, Clevers (bib21) 2011; 141 Society (bib41) 2009; 6 Whelan, Muir, Nakagawa (bib24) 2018; 5 Casale, Canaparo, Serpe, Muntoni, Pepa, Costa, Mairone, Zara, Fornari, Eandi (bib35) 2004; 50 Domenge, Hill, Lefebvre, De Raucourt, Rhein, Wibault, Marandas, Coche-Dequeant, Stromboni-Luboinski, Sancho-Garnier, Luboinski (bib5) 2000; 83 Natsuizaka, Whelan, Kagawa, Tanaka, Giroux, Chandramouleeswaran, Long, Sahu, Darling, Que, Yang, Katz, Wileyto, Basu, Kita, Natsugoe, Naganuma, Klein-Szanto, Diehl, Bass, Wong, Rustgi, Nakagawa (bib28) 2017; 8 Giroux, Lento, Islam, Pitarresi, Kharbanda, Hamilton, Whelan, Long, Rhoades, Tang, Nakagawa, Lengner, Bass, Wileyto, Klein-Szanto, Wang, Rustgi (bib31) 2017; 127 Gao, Vela, Sboner, Iaquinta, Karthaus, Gopalan, Dowling, Wanjala, Undvall, Arora, Wongvipat, Kossai, Ramazanoglu, Barboza, Di, Cao, Zhang, Sirota, Ran, MacDonald, Beltran, Mosquera, Touijer, Scardino, Laudone, Curtis, Rathkopf, Morris, Danila, Slovin, Solomon, Eastham, Chi, Carver, Rubin, Scher, Clevers, Sawyers, Chen (bib20) 2014; 159 Edge, Compton (bib37) 2010; 17 Kikuchi, Ohashi, Nakai, Nakagawa, Matsuoka, Kobunai, Takechi, Amanuma, Yoshioka, Ida, Yamamoto, Okuno, Miyamoto, Nakagawa, Matsubara, Chiba, Muto (bib36) 2015; 5 Hisha, Tanaka, Kanno, Tokuyama, Komai, Ohe, Yanai, Omachi, Ueno (bib34) 2013; 3 Society. JE (bib40) 2009; 6 Ohashi, Kikuchi, Tsurumaki, Nakai, Kasai, Horimatsu, Miyamoto, Shimizu, Chiba, Muto (bib44) 2014; 9 Kikuchi, Ohashi, Horibe, Kohno, Nakai, Miyamoto, Chiba, Muto, Kawakami (bib45) 2016; 6 Eisenhauer, Therasse, Bogaerts, Schwartz, Sargent, Ford, Dancey, Arbuck, Gwyther, Mooney, Rubinstein, Shankar, Dodd, Kaplan, Lacombe, Verweij (bib39) 2009; 45 Boj, Hwang, Baker, Chio, Engle, Corbo, Jager, Ponz-Sarvise, Tiriac, Spector, Gracanin, Oni, Yu, van Boxtel, Huch, Rivera, Wilson, Feigin, Ohlund, Handly-Santana, Ardito-Abraham, Ludwig, Elyada, Alagesan, Biffi, Yordanov, Delcuze, Creighton, Wright, Park, Morsink, Molenaar, Borel Rinkes, Cuppen, Hao, Jin, Nijman, Iacobuzio-Donahue, Leach, Pappin, Hammell, Klimstra, Basturk, Hruban, Offerhaus, Vries, Clevers, Tuveson (bib19) 2015; 160 Long, Giroux, Whelan, Hamilton, Tetreault, Tanaka, Lee, Klein-Szanto, Nakagawa, Rustgi (bib12) 2015; 36 Kagawa, Natsuizaka, Whelan, Facompre, Naganuma, Ohashi, Kinugasa, Egloff, Basu, Gimotty, Klein-Szanto, Bass, Wong, Diehl, Rustgi, Nakagawa (bib27) 2015; 34 Matano, Date, Shimokawa, Takano, Fujii, Ohta, Watanabe, Kanai, Sato (bib16) 2015; 21 Sato, Clevers (bib17) 2013; 340 Sato, Kubota, Natsuizaka, Maehara, Hatanaka, Marukawa, Terashita, Suda, Ohnishi, Shimizu, Komatsu, Ohashi, Kagawa, Kinugasa, Whelan, Nakagawa, Sakamoto (bib11) 2015; 16 Dotto, Rustgi (bib1) 2016; 29 Kinugasa, Whelan, Tanaka, Natsuizaka, Long, Guo, Chang, Kagawa, Srinivasan, Guha, Yamamoto, St Clair, Avadhani, Diehl, Nakagawa (bib47) 2015; 34 Gupta, Nebreda (bib33) 2015; 282 Sato, Clevers (bib15) 2015; 161 Nakagawa, Zukerberg, Togawa, Meltzer, Nishihara, Rustgi (bib42) 1995; 76 Shapiro, van Lanschot JJB, Hulshof, van Hagen, van Berge Henegouwen, Wijnhoven, van Laarhoven, Nieuwenhuijzen, Hospers, Bonenkamp, Cuesta, Blaisse, Busch, Ten Kate, Creemers, Punt, Plukker, Verheul, Bilgen, van Dekken, van der Sangen, Rozema, Biermann, Beukema, Piet, van Rij, Reinders, Tilanus, Steyerberg, van der Gaast, group (bib4) 2015; 16 Singh, Settleman (bib6) 2010; 29 Facompre, Harmeyer, Sole, Kabraji, Belden, Sahu, Whelan, Tanaka, Weinstein, Montone, Roesch, Gimotty, Herlyn, Rustgi, Nakagawa, Ramaswamy, Basu (bib30) 2016; 76 Kalabis, Oyama, Okawa, Nakagawa, Michaylira, Stairs, Figueiredo, Mahmood, Diehl, Herlyn, Rustgi (bib32) 2008; 118 Japan Esophageal (10.1016/j.jcmgh.2018.09.003_bib48) 2017; 14 Sato (10.1016/j.jcmgh.2018.09.003_bib21) 2011; 141 Kalabis (10.1016/j.jcmgh.2018.09.003_bib32) 2008; 118 Nishihira (10.1016/j.jcmgh.2018.09.003_bib43) 1993; 119 Ohashi (10.1016/j.jcmgh.2018.09.003_bib44) 2014; 9 Ohashi (10.1016/j.jcmgh.2018.09.003_bib3) 2015; 149 Apel (10.1016/j.jcmgh.2018.09.003_bib7) 2008; 68 Wagata (10.1016/j.jcmgh.2018.09.003_bib25) 1993; 53 Rustgi (10.1016/j.jcmgh.2018.09.003_bib2) 2014; 371 Shapiro (10.1016/j.jcmgh.2018.09.003_bib4) 2015; 16 Gao (10.1016/j.jcmgh.2018.09.003_bib20) 2014; 159 Domenge (10.1016/j.jcmgh.2018.09.003_bib5) 2000; 83 Zhao (10.1016/j.jcmgh.2018.09.003_bib9) 2011; 6 Shimada (10.1016/j.jcmgh.2018.09.003_bib29) 1992; 69 Lancaster (10.1016/j.jcmgh.2018.09.003_bib14) 2014; 345 Boj (10.1016/j.jcmgh.2018.09.003_bib19) 2015; 160 Sato (10.1016/j.jcmgh.2018.09.003_bib17) 2013; 340 Natsuizaka (10.1016/j.jcmgh.2018.09.003_bib28) 2017; 8 Casale (10.1016/j.jcmgh.2018.09.003_bib35) 2004; 50 Society. JE (10.1016/j.jcmgh.2018.09.003_bib40) 2009; 6 Whelan (10.1016/j.jcmgh.2018.09.003_bib13) 2017; 36 Giroux (10.1016/j.jcmgh.2018.09.003_bib31) 2017; 127 Hisha (10.1016/j.jcmgh.2018.09.003_bib34) 2013; 3 Whelan (10.1016/j.jcmgh.2018.09.003_bib46) 2017; 66 Long (10.1016/j.jcmgh.2018.09.003_bib12) 2015; 36 Matano (10.1016/j.jcmgh.2018.09.003_bib16) 2015; 21 Natsugoe (10.1016/j.jcmgh.2018.09.003_bib38) 2006; 19 Sui (10.1016/j.jcmgh.2018.09.003_bib8) 2013; 4 Eisenhauer (10.1016/j.jcmgh.2018.09.003_bib39) 2009; 45 Kagawa (10.1016/j.jcmgh.2018.09.003_bib27) 2015; 34 Sato (10.1016/j.jcmgh.2018.09.003_bib15) 2015; 161 Kinugasa (10.1016/j.jcmgh.2018.09.003_bib47) 2015; 34 Singh (10.1016/j.jcmgh.2018.09.003_bib6) 2010; 29 Okamoto (10.1016/j.jcmgh.2018.09.003_bib10) 2016; 36 Kikuchi (10.1016/j.jcmgh.2018.09.003_bib45) 2016; 6 Freed-Pastor (10.1016/j.jcmgh.2018.09.003_bib26) 2012; 26 Facompre (10.1016/j.jcmgh.2018.09.003_bib30) 2016; 76 Kasagi (10.1016/j.jcmgh.2018.09.003_bib23) 2018; 5 Gupta (10.1016/j.jcmgh.2018.09.003_bib33) 2015; 282 Whelan (10.1016/j.jcmgh.2018.09.003_bib24) 2018; 5 DeWard (10.1016/j.jcmgh.2018.09.003_bib22) 2014; 9 Kikuchi (10.1016/j.jcmgh.2018.09.003_bib36) 2015; 5 Society (10.1016/j.jcmgh.2018.09.003_bib41) 2009; 6 Edge (10.1016/j.jcmgh.2018.09.003_bib37) 2010; 17 Sato (10.1016/j.jcmgh.2018.09.003_bib11) 2015; 16 van de Wetering (10.1016/j.jcmgh.2018.09.003_bib18) 2015; 161 Nakagawa (10.1016/j.jcmgh.2018.09.003_bib42) 1995; 76 Dotto (10.1016/j.jcmgh.2018.09.003_bib1) 2016; 29 |
| References_xml | – volume: 29 start-page: 622 year: 2016 end-page: 637 ident: bib1 article-title: Squamous cell cancers: a unified perspective on biology and genetics publication-title: Cancer Cell – volume: 345 start-page: 1247125 year: 2014 ident: bib14 article-title: Organogenesis in a dish: modeling development and disease using organoid technologies publication-title: Science – volume: 14 start-page: 1 year: 2017 end-page: 36 ident: bib48 article-title: Japanese Classification of Esophageal Cancer, 11th Edition: part I publication-title: Esophagus – volume: 36 start-page: 3333 year: 2016 end-page: 3342 ident: bib10 article-title: Expression status of CD44 and CD133 as a prognostic marker in esophageal squamous cell carcinoma treated with neoadjuvant chemotherapy followed by radical esophagectomy publication-title: Oncol Rep – volume: 3 start-page: 3224 year: 2013 ident: bib34 article-title: Establishment of a novel lingual organoid culture system: generation of organoids having mature keratinized epithelium from adult epithelial stem cells publication-title: Sci Rep – volume: 68 start-page: 1485 year: 2008 end-page: 1494 ident: bib7 article-title: Blocked autophagy sensitizes resistant carcinoma cells to radiation therapy publication-title: Cancer Res – volume: 159 start-page: 176 year: 2014 end-page: 187 ident: bib20 article-title: Organoid cultures derived from patients with advanced prostate cancer publication-title: Cell – volume: 5 start-page: 333 year: 2018 end-page: 352 ident: bib23 article-title: The esophageal organoid system reveals functional interplay between notch and cytokines in reactive epithelial changes publication-title: Cell Mol Gastroenterol Hepatol – volume: 45 start-page: 228 year: 2009 end-page: 247 ident: bib39 article-title: New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1) publication-title: Eur J Cancer – volume: 149 start-page: 1700 year: 2015 end-page: 1715 ident: bib3 article-title: Recent advances from basic and clinical studies of esophageal squamous cell carcinoma publication-title: Gastroenterology – volume: 340 start-page: 1190 year: 2013 end-page: 1194 ident: bib17 article-title: Growing self-organizing mini-guts from a single intestinal stem cell: mechanism and applications publication-title: Science – volume: 9 start-page: 701 year: 2014 end-page: 711 ident: bib22 article-title: Cellular heterogeneity in the mouse esophagus implicates the presence of a nonquiescent epithelial stem cell population publication-title: Cell Rep – volume: 76 start-page: 541 year: 1995 end-page: 549 ident: bib42 article-title: Human cyclin D1 oncogene and esophageal squamous cell carcinoma publication-title: Cancer – volume: 5 start-page: 461 year: 2018 end-page: 478 ident: bib24 article-title: Esophageal 3D culture systems as modeling tools in esophageal epithelial pathobiology and personalized medicine publication-title: Cell Mol Gastroenterol Hepatol – volume: 76 start-page: 5538 year: 2016 end-page: 5549 ident: bib30 article-title: JARID1B enables transit between distinct states of the stem-like cell population in oral cancers publication-title: Cancer Res – volume: 5 start-page: 2431 year: 2015 end-page: 2440 ident: bib36 article-title: Novel 5-fluorouracil-resistant human esophageal squamous cell carcinoma cells with dihydropyrimidine dehydrogenase overexpression publication-title: Am J Cancer Res – volume: 83 start-page: 1594 year: 2000 end-page: 1598 ident: bib5 article-title: French Groupe d'Etude des Tumeurs de la Tete et du C. Randomized trial of neoadjuvant chemotherapy in oropharyngeal carcinoma. French Groupe d'Etude des Tumeurs de la Tete et du Cou (GETTEC) publication-title: Br J Cancer – volume: 141 start-page: 1762 year: 2011 end-page: 1772 ident: bib21 article-title: Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium publication-title: Gastroenterology – volume: 53 start-page: 846 year: 1993 end-page: 850 ident: bib25 article-title: Loss of 17p, mutation of the p53 gene, and overexpression of p53 protein in esophageal squamous cell carcinomas publication-title: Cancer Res – volume: 127 start-page: 2378 year: 2017 end-page: 2391 ident: bib31 article-title: Long-lived keratin 15+ esophageal progenitor cells contribute to homeostasis and regeneration publication-title: J Clin Invest – volume: 16 start-page: 933 year: 2015 end-page: 940 ident: bib11 article-title: EGFR inhibitors prevent induction of cancer stem-like cells in esophageal squamous cell carcinoma by suppressing epithelial-mesenchymal transition publication-title: Cancer Biol Ther – volume: 69 start-page: 277 year: 1992 end-page: 284 ident: bib29 article-title: Characterization of 21 newly established esophageal cancer cell lines publication-title: Cancer – volume: 118 start-page: 3860 year: 2008 end-page: 3869 ident: bib32 article-title: A subpopulation of mouse esophageal basal cells has properties of stem cells with the capacity for self-renewal and lineage specification publication-title: J Clin Invest – volume: 6 start-page: 71 year: 2009 end-page: 94 ident: bib41 article-title: Japanese Classification of Esophageal cancer, 10th edition: parts Ⅱ and Ⅲ publication-title: Esophagus – volume: 161 start-page: 1700 year: 2015 end-page: 1700.e1 ident: bib15 article-title: SnapShot: growing organoids from stem cells publication-title: Cell – volume: 36 start-page: 4843 year: 2017 end-page: 4858 ident: bib13 article-title: Autophagy supports generation of cells with high CD44 expression via modulation of oxidative stress and Parkin-mediated mitochondrial clearance publication-title: Oncogene – volume: 36 start-page: 598 year: 2015 end-page: 606 ident: bib12 article-title: WNT10A promotes an invasive and self-renewing phenotype in esophageal squamous cell carcinoma publication-title: Carcinogenesis – volume: 119 start-page: 441 year: 1993 end-page: 449 ident: bib43 article-title: Molecular and cellular features of esophageal cancer cells publication-title: J Cancer Res Clin Oncol – volume: 6 start-page: 22452 year: 2016 ident: bib45 article-title: Novel EGFR-targeted strategy with hybrid peptide against oesophageal squamous cell carcinoma publication-title: Sci Rep – volume: 9 start-page: e103126 year: 2014 ident: bib44 article-title: Preclinical validation of talaporfin sodium-mediated photodynamic therapy for esophageal squamous cell carcinoma publication-title: PLoS One – volume: 19 start-page: 468 year: 2006 end-page: 472 ident: bib38 article-title: Randomized controlled study on preoperative chemoradiotherapy followed by surgery versus surgery alone for esophageal squamous cell cancer in a single institution publication-title: Dis Esophagus – volume: 8 start-page: 1758 year: 2017 ident: bib28 article-title: Interplay between Notch1 and Notch3 promotes EMT and tumor initiation in squamous cell carcinoma publication-title: Nat Commun – volume: 6 start-page: e21419 year: 2011 ident: bib9 article-title: Tumor initiating cells in esophageal squamous cell carcinomas express high levels of CD44 publication-title: PLoS One – volume: 371 start-page: 2499 year: 2014 end-page: 2509 ident: bib2 article-title: Esophageal carcinoma publication-title: N Engl J Med – volume: 26 start-page: 1268 year: 2012 end-page: 1286 ident: bib26 article-title: Mutant p53: one name, many proteins publication-title: Genes Dev – volume: 16 start-page: 1090 year: 2015 end-page: 1098 ident: bib4 article-title: Neoadjuvant chemoradiotherapy plus surgery versus surgery alone for oesophageal or junctional cancer (CROSS): long-term results of a randomised controlled trial publication-title: Lancet Oncol – volume: 282 start-page: 1841 year: 2015 end-page: 1857 ident: bib33 article-title: Roles of p38alpha mitogen-activated protein kinase in mouse models of inflammatory diseases and cancer publication-title: FEBS J – volume: 29 start-page: 4741 year: 2010 end-page: 4751 ident: bib6 article-title: EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer publication-title: Oncogene – volume: 34 start-page: 2347 year: 2015 end-page: 2359 ident: bib27 article-title: Cellular senescence checkpoint function determines differential Notch1-dependent oncogenic and tumor-suppressor activities publication-title: Oncogene – volume: 17 start-page: 1471 year: 2010 end-page: 1474 ident: bib37 article-title: The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM publication-title: Ann Surg Oncol – volume: 34 start-page: 5229 year: 2015 end-page: 5239 ident: bib47 article-title: Mitochondrial SOD2 regulates epithelial-mesenchymal transition and cell populations defined by differential CD44 expression publication-title: Oncogene – volume: 50 start-page: 173 year: 2004 end-page: 179 ident: bib35 article-title: Plasma concentrations of 5-fluorouracil and its metabolites in colon cancer patients publication-title: Pharmacol Res – volume: 21 start-page: 256 year: 2015 end-page: 262 ident: bib16 article-title: Modeling colorectal cancer using CRISPR-Cas9-mediated engineering of human intestinal organoids publication-title: Nat Med – volume: 4 start-page: e838 year: 2013 ident: bib8 article-title: Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment publication-title: Cell Death Dis – volume: 6 start-page: 1 year: 2009 end-page: 25 ident: bib40 article-title: Japanese Classification of Esophageal Cancer, 10th Edition: part Ⅰ publication-title: Esophagus – volume: 161 start-page: 933 year: 2015 end-page: 945 ident: bib18 article-title: Prospective derivation of a living organoid biobank of colorectal cancer patients publication-title: Cell – volume: 66 start-page: 1197 year: 2017 end-page: 1207 ident: bib46 article-title: Autophagy mediates epithelial cytoprotection in eosinophilic oesophagitis publication-title: Gut – volume: 160 start-page: 324 year: 2015 end-page: 338 ident: bib19 article-title: Organoid models of human and mouse ductal pancreatic cancer publication-title: Cell – volume: 6 start-page: e21419 year: 2011 ident: 10.1016/j.jcmgh.2018.09.003_bib9 article-title: Tumor initiating cells in esophageal squamous cell carcinomas express high levels of CD44 publication-title: PLoS One doi: 10.1371/journal.pone.0021419 – volume: 29 start-page: 622 year: 2016 ident: 10.1016/j.jcmgh.2018.09.003_bib1 article-title: Squamous cell cancers: a unified perspective on biology and genetics publication-title: Cancer Cell doi: 10.1016/j.ccell.2016.04.004 – volume: 16 start-page: 1090 year: 2015 ident: 10.1016/j.jcmgh.2018.09.003_bib4 article-title: Neoadjuvant chemoradiotherapy plus surgery versus surgery alone for oesophageal or junctional cancer (CROSS): long-term results of a randomised controlled trial publication-title: Lancet Oncol doi: 10.1016/S1470-2045(15)00040-6 – volume: 50 start-page: 173 year: 2004 ident: 10.1016/j.jcmgh.2018.09.003_bib35 article-title: Plasma concentrations of 5-fluorouracil and its metabolites in colon cancer patients publication-title: Pharmacol Res doi: 10.1016/j.phrs.2004.01.006 – volume: 8 start-page: 1758 year: 2017 ident: 10.1016/j.jcmgh.2018.09.003_bib28 article-title: Interplay between Notch1 and Notch3 promotes EMT and tumor initiation in squamous cell carcinoma publication-title: Nat Commun doi: 10.1038/s41467-017-01500-9 – volume: 118 start-page: 3860 year: 2008 ident: 10.1016/j.jcmgh.2018.09.003_bib32 article-title: A subpopulation of mouse esophageal basal cells has properties of stem cells with the capacity for self-renewal and lineage specification publication-title: J Clin Invest – volume: 36 start-page: 598 year: 2015 ident: 10.1016/j.jcmgh.2018.09.003_bib12 article-title: WNT10A promotes an invasive and self-renewing phenotype in esophageal squamous cell carcinoma publication-title: Carcinogenesis doi: 10.1093/carcin/bgv025 – volume: 141 start-page: 1762 year: 2011 ident: 10.1016/j.jcmgh.2018.09.003_bib21 article-title: Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium publication-title: Gastroenterology doi: 10.1053/j.gastro.2011.07.050 – volume: 68 start-page: 1485 year: 2008 ident: 10.1016/j.jcmgh.2018.09.003_bib7 article-title: Blocked autophagy sensitizes resistant carcinoma cells to radiation therapy publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-07-0562 – volume: 76 start-page: 5538 year: 2016 ident: 10.1016/j.jcmgh.2018.09.003_bib30 article-title: JARID1B enables transit between distinct states of the stem-like cell population in oral cancers publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-15-3377 – volume: 149 start-page: 1700 year: 2015 ident: 10.1016/j.jcmgh.2018.09.003_bib3 article-title: Recent advances from basic and clinical studies of esophageal squamous cell carcinoma publication-title: Gastroenterology doi: 10.1053/j.gastro.2015.08.054 – volume: 34 start-page: 2347 year: 2015 ident: 10.1016/j.jcmgh.2018.09.003_bib27 article-title: Cellular senescence checkpoint function determines differential Notch1-dependent oncogenic and tumor-suppressor activities publication-title: Oncogene doi: 10.1038/onc.2014.169 – volume: 119 start-page: 441 year: 1993 ident: 10.1016/j.jcmgh.2018.09.003_bib43 article-title: Molecular and cellular features of esophageal cancer cells publication-title: J Cancer Res Clin Oncol doi: 10.1007/BF01215923 – volume: 9 start-page: 701 year: 2014 ident: 10.1016/j.jcmgh.2018.09.003_bib22 article-title: Cellular heterogeneity in the mouse esophagus implicates the presence of a nonquiescent epithelial stem cell population publication-title: Cell Rep doi: 10.1016/j.celrep.2014.09.027 – volume: 161 start-page: 933 year: 2015 ident: 10.1016/j.jcmgh.2018.09.003_bib18 article-title: Prospective derivation of a living organoid biobank of colorectal cancer patients publication-title: Cell doi: 10.1016/j.cell.2015.03.053 – volume: 16 start-page: 933 year: 2015 ident: 10.1016/j.jcmgh.2018.09.003_bib11 article-title: EGFR inhibitors prevent induction of cancer stem-like cells in esophageal squamous cell carcinoma by suppressing epithelial-mesenchymal transition publication-title: Cancer Biol Ther doi: 10.1080/15384047.2015.1040959 – volume: 6 start-page: 1 year: 2009 ident: 10.1016/j.jcmgh.2018.09.003_bib40 article-title: Japanese Classification of Esophageal Cancer, 10th Edition: part Ⅰ publication-title: Esophagus doi: 10.1007/s10388-009-0169-0 – volume: 4 start-page: e838 year: 2013 ident: 10.1016/j.jcmgh.2018.09.003_bib8 article-title: Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment publication-title: Cell Death Dis doi: 10.1038/cddis.2013.350 – volume: 5 start-page: 461 year: 2018 ident: 10.1016/j.jcmgh.2018.09.003_bib24 article-title: Esophageal 3D culture systems as modeling tools in esophageal epithelial pathobiology and personalized medicine publication-title: Cell Mol Gastroenterol Hepatol doi: 10.1016/j.jcmgh.2018.01.011 – volume: 69 start-page: 277 year: 1992 ident: 10.1016/j.jcmgh.2018.09.003_bib29 article-title: Characterization of 21 newly established esophageal cancer cell lines publication-title: Cancer doi: 10.1002/1097-0142(19920115)69:2<277::AID-CNCR2820690202>3.0.CO;2-C – volume: 83 start-page: 1594 year: 2000 ident: 10.1016/j.jcmgh.2018.09.003_bib5 article-title: French Groupe d'Etude des Tumeurs de la Tete et du C. Randomized trial of neoadjuvant chemotherapy in oropharyngeal carcinoma. French Groupe d'Etude des Tumeurs de la Tete et du Cou (GETTEC) publication-title: Br J Cancer doi: 10.1054/bjoc.2000.1512 – volume: 371 start-page: 2499 year: 2014 ident: 10.1016/j.jcmgh.2018.09.003_bib2 article-title: Esophageal carcinoma publication-title: N Engl J Med doi: 10.1056/NEJMra1314530 – volume: 282 start-page: 1841 year: 2015 ident: 10.1016/j.jcmgh.2018.09.003_bib33 article-title: Roles of p38alpha mitogen-activated protein kinase in mouse models of inflammatory diseases and cancer publication-title: FEBS J doi: 10.1111/febs.13250 – volume: 14 start-page: 1 year: 2017 ident: 10.1016/j.jcmgh.2018.09.003_bib48 article-title: Japanese Classification of Esophageal Cancer, 11th Edition: part I publication-title: Esophagus doi: 10.1007/s10388-016-0551-7 – volume: 34 start-page: 5229 year: 2015 ident: 10.1016/j.jcmgh.2018.09.003_bib47 article-title: Mitochondrial SOD2 regulates epithelial-mesenchymal transition and cell populations defined by differential CD44 expression publication-title: Oncogene doi: 10.1038/onc.2014.449 – volume: 127 start-page: 2378 year: 2017 ident: 10.1016/j.jcmgh.2018.09.003_bib31 article-title: Long-lived keratin 15+ esophageal progenitor cells contribute to homeostasis and regeneration publication-title: J Clin Invest doi: 10.1172/JCI88941 – volume: 6 start-page: 71 year: 2009 ident: 10.1016/j.jcmgh.2018.09.003_bib41 article-title: Japanese Classification of Esophageal cancer, 10th edition: parts Ⅱ and Ⅲ publication-title: Esophagus doi: 10.1007/s10388-009-0193-0 – volume: 3 start-page: 3224 year: 2013 ident: 10.1016/j.jcmgh.2018.09.003_bib34 article-title: Establishment of a novel lingual organoid culture system: generation of organoids having mature keratinized epithelium from adult epithelial stem cells publication-title: Sci Rep doi: 10.1038/srep03224 – volume: 5 start-page: 2431 year: 2015 ident: 10.1016/j.jcmgh.2018.09.003_bib36 article-title: Novel 5-fluorouracil-resistant human esophageal squamous cell carcinoma cells with dihydropyrimidine dehydrogenase overexpression publication-title: Am J Cancer Res – volume: 53 start-page: 846 year: 1993 ident: 10.1016/j.jcmgh.2018.09.003_bib25 article-title: Loss of 17p, mutation of the p53 gene, and overexpression of p53 protein in esophageal squamous cell carcinomas publication-title: Cancer Res – volume: 66 start-page: 1197 year: 2017 ident: 10.1016/j.jcmgh.2018.09.003_bib46 article-title: Autophagy mediates epithelial cytoprotection in eosinophilic oesophagitis publication-title: Gut doi: 10.1136/gutjnl-2015-310341 – volume: 26 start-page: 1268 year: 2012 ident: 10.1016/j.jcmgh.2018.09.003_bib26 article-title: Mutant p53: one name, many proteins publication-title: Genes Dev doi: 10.1101/gad.190678.112 – volume: 9 start-page: e103126 year: 2014 ident: 10.1016/j.jcmgh.2018.09.003_bib44 article-title: Preclinical validation of talaporfin sodium-mediated photodynamic therapy for esophageal squamous cell carcinoma publication-title: PLoS One doi: 10.1371/journal.pone.0103126 – volume: 345 start-page: 1247125 year: 2014 ident: 10.1016/j.jcmgh.2018.09.003_bib14 article-title: Organogenesis in a dish: modeling development and disease using organoid technologies publication-title: Science doi: 10.1126/science.1247125 – volume: 45 start-page: 228 year: 2009 ident: 10.1016/j.jcmgh.2018.09.003_bib39 article-title: New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1) publication-title: Eur J Cancer doi: 10.1016/j.ejca.2008.10.026 – volume: 36 start-page: 3333 year: 2016 ident: 10.1016/j.jcmgh.2018.09.003_bib10 article-title: Expression status of CD44 and CD133 as a prognostic marker in esophageal squamous cell carcinoma treated with neoadjuvant chemotherapy followed by radical esophagectomy publication-title: Oncol Rep doi: 10.3892/or.2016.5133 – volume: 21 start-page: 256 year: 2015 ident: 10.1016/j.jcmgh.2018.09.003_bib16 article-title: Modeling colorectal cancer using CRISPR-Cas9-mediated engineering of human intestinal organoids publication-title: Nat Med doi: 10.1038/nm.3802 – volume: 340 start-page: 1190 year: 2013 ident: 10.1016/j.jcmgh.2018.09.003_bib17 article-title: Growing self-organizing mini-guts from a single intestinal stem cell: mechanism and applications publication-title: Science doi: 10.1126/science.1234852 – volume: 17 start-page: 1471 year: 2010 ident: 10.1016/j.jcmgh.2018.09.003_bib37 article-title: The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM publication-title: Ann Surg Oncol doi: 10.1245/s10434-010-0985-4 – volume: 6 start-page: 22452 year: 2016 ident: 10.1016/j.jcmgh.2018.09.003_bib45 article-title: Novel EGFR-targeted strategy with hybrid peptide against oesophageal squamous cell carcinoma publication-title: Sci Rep doi: 10.1038/srep22452 – volume: 159 start-page: 176 year: 2014 ident: 10.1016/j.jcmgh.2018.09.003_bib20 article-title: Organoid cultures derived from patients with advanced prostate cancer publication-title: Cell doi: 10.1016/j.cell.2014.08.016 – volume: 19 start-page: 468 year: 2006 ident: 10.1016/j.jcmgh.2018.09.003_bib38 article-title: Randomized controlled study on preoperative chemoradiotherapy followed by surgery versus surgery alone for esophageal squamous cell cancer in a single institution publication-title: Dis Esophagus doi: 10.1111/j.1442-2050.2006.00615.x – volume: 36 start-page: 4843 year: 2017 ident: 10.1016/j.jcmgh.2018.09.003_bib13 article-title: Autophagy supports generation of cells with high CD44 expression via modulation of oxidative stress and Parkin-mediated mitochondrial clearance publication-title: Oncogene doi: 10.1038/onc.2017.102 – volume: 161 start-page: 1700 year: 2015 ident: 10.1016/j.jcmgh.2018.09.003_bib15 article-title: SnapShot: growing organoids from stem cells publication-title: Cell doi: 10.1016/j.cell.2015.06.028 – volume: 76 start-page: 541 year: 1995 ident: 10.1016/j.jcmgh.2018.09.003_bib42 article-title: Human cyclin D1 oncogene and esophageal squamous cell carcinoma publication-title: Cancer doi: 10.1002/1097-0142(19950815)76:4<541::AID-CNCR2820760402>3.0.CO;2-I – volume: 29 start-page: 4741 year: 2010 ident: 10.1016/j.jcmgh.2018.09.003_bib6 article-title: EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer publication-title: Oncogene doi: 10.1038/onc.2010.215 – volume: 160 start-page: 324 year: 2015 ident: 10.1016/j.jcmgh.2018.09.003_bib19 article-title: Organoid models of human and mouse ductal pancreatic cancer publication-title: Cell doi: 10.1016/j.cell.2014.12.021 – volume: 5 start-page: 333 year: 2018 ident: 10.1016/j.jcmgh.2018.09.003_bib23 article-title: The esophageal organoid system reveals functional interplay between notch and cytokines in reactive epithelial changes publication-title: Cell Mol Gastroenterol Hepatol doi: 10.1016/j.jcmgh.2017.12.013 |
| SSID | ssj0001476705 |
| Score | 2.4706216 |
| Snippet | Oropharyngeal and esophageal squamous cell carcinomas, especially the latter, are a lethal disease, featuring intratumoral cancer cell heterogeneity and... Background & Aims Oropharyngeal and esophageal squamous cell carcinomas, especially the latter, are a lethal disease, featuring intratumoral cancer cell... |
| SourceID | pubmedcentral proquest pubmed crossref elsevier |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 73 |
| SubjectTerms | 3D Organoids 5-Fluorouracil Animals Autophagy Autophagy - drug effects Biopsy Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - therapy CD44 Cell Line, Tumor Chemoradiotherapy Drug Resistance, Neoplasm Endoscopy Esophageal Neoplasms - pathology Fluorouracil - pharmacology Fluorouracil - therapeutic use Gastroenterology and Hepatology Humans Hyaluronan Receptors - metabolism Mice Organoids - pathology Original Research Oropharyngeal Neoplasms - pathology Oropharyngeal Neoplasms - therapy |
| Title | Three-Dimensional Organoids Reveal Therapy Resistance of Esophageal and Oropharyngeal Squamous Cell Carcinoma Cells |
| URI | https://www.clinicalkey.com/#!/content/1-s2.0-S2352345X18301243 https://www.clinicalkey.es/playcontent/1-s2.0-S2352345X18301243 https://dx.doi.org/10.1016/j.jcmgh.2018.09.003 https://www.ncbi.nlm.nih.gov/pubmed/30510992 https://www.proquest.com/docview/2149864421 https://pubmed.ncbi.nlm.nih.gov/PMC6260338 |
| Volume | 7 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAFT databaseName: Colorado Digital library customDbUrl: eissn: 2352-345X dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0001476705 issn: 2352-345X databaseCode: KQ8 dateStart: 20150101 isFulltext: true titleUrlDefault: http://grweb.coalliance.org/oadl/oadl.html providerName: Colorado Alliance of Research Libraries – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 2352-345X dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0001476705 issn: 2352-345X databaseCode: DOA dateStart: 20150101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVLSH databaseName: Elsevier Journals customDbUrl: mediaType: online eissn: 2352-345X dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0001476705 issn: 2352-345X databaseCode: AKRWK dateStart: 20150101 isFulltext: true providerName: Library Specific Holdings – providerCode: PRVAQN databaseName: PubMed Central (PMC) customDbUrl: eissn: 2352-345X dateEnd: 99991231 omitProxy: true ssIdentifier: ssj0001476705 issn: 2352-345X databaseCode: RPM dateStart: 20150101 isFulltext: true titleUrlDefault: https://www.ncbi.nlm.nih.gov/pmc/ providerName: National Library of Medicine – providerCode: PRVFZP databaseName: Scholars Portal Journals: Open Access customDbUrl: eissn: 2352-345X dateEnd: 20250731 omitProxy: true ssIdentifier: ssj0001476705 issn: 2352-345X databaseCode: M48 dateStart: 20150101 isFulltext: true titleUrlDefault: http://journals.scholarsportal.info providerName: Scholars Portal |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwELemTUK8oPHdjVVG4pGgxHYc5wGhqds0MZWHrRV9s_xV2NSlrOkm9t9z5ySFQRkSj258ieo73_3OH78j5I1y3OZcuISZdAoJSs4Ta7hMCs59YQ1ACIv3nYef5PFYfJzkkw3SVUVtB7Bem9phPanxYvbu-9XtB5jw73-e1bpwl19wZyFTkbQU2T-3IDQxNPNhi_fjoosoZBGPNTIAHgkX-aRjIlr_nr9Fqz_R6O-HKn-JUkfb5FELL-l-Yw-PyUaonpAHw3YD_SmpR6C7kBwgp3_Dx0Hjbcz5ua_pabgB2EhHDdEANGsEl2AVdD6lh1jvAJwPdDCVBylsLm6r-MvZ1bXBNQQ6CLMZHWB9omp-aWKzfkbGR4ejwXHS1l1InCzkMgnMswDexwZhPIBv6zLpc2amyjLmjBQq9aowweS5NZksjStTl1kDnVNvSsOfk81qXoWXhPrMCQVxGIScCFNvIJ8UKodXYaJkWY-wbny1a0nJsTbGTHenzy50VIpGpei0RC7THnm7EvrWcHLc3110itPddVNwkBpM6H6xYp1YqDsb1ZmumU71GdoSmhJ4Rwj3AiTlSrLFMQ0--fcnX3d2pWGW49aNqQJoTzNIZBVAV5b1yIvGzlZ_naNfLUsYy-KOBa46IIP43SfV-dfIJI7ZLOdq5_9GaJc8hFbZLEi9IpvLxXXYA4i2tH2ytX9y-vmkH5c4-nES_gCdSj7u |
| linkProvider | Scholars Portal |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Three-Dimensional+Organoids+Reveal+Therapy+Resistance+of+Esophageal+and+Oropharyngeal+Squamous+Cell+Carcinoma+Cells&rft.jtitle=Cellular+and+molecular+gastroenterology+and+hepatology&rft.au=Kijima%2C+Takashi&rft.au=Nakagawa%2C+Hiroshi&rft.au=Shimonosono%2C+Masataka&rft.au=Chandramouleeswaran%2C+Prasanna+M.&rft.date=2019-01-01&rft.pub=Elsevier+Inc&rft.issn=2352-345X&rft.eissn=2352-345X&rft.volume=7&rft.issue=1&rft.spage=73&rft.epage=91&rft_id=info:doi/10.1016%2Fj.jcmgh.2018.09.003&rft.externalDocID=S2352345X18301243 |
| thumbnail_m | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=https%3A%2F%2Fcdn.clinicalkey.com%2Fck-thumbnails%2F2352345X%2FS2352345X18X00083%2Fcov150h.gif |