Urinary corticoid to creatinine ratios using IMMULITE 2000 XPi for diagnosis of canine hypercortisolism
The urinary corticoid to creatinine ratio (UCCR) is one of the most commonly used screening tests for canine hypercortisolism (HC). In this study, a reference interval was established for UCCR using IMMULITE 2000 XPi, the latest chemiluminescence enzyme immunoassay. The diagnostic performance of thi...
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| Published in | Journal of Veterinary Medical Science Vol. 84; no. 7; pp. 954 - 959 |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Japan
JAPANESE SOCIETY OF VETERINARY SCIENCE
2022
The Japanese Society of Veterinary Science |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0916-7250 1347-7439 1347-7439 |
| DOI | 10.1292/jvms.22-0131 |
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| Abstract | The urinary corticoid to creatinine ratio (UCCR) is one of the most commonly used screening tests for canine hypercortisolism (HC). In this study, a reference interval was established for UCCR using IMMULITE 2000 XPi, the latest chemiluminescence enzyme immunoassay. The diagnostic performance of this method for UCCR in canine HC was also evaluated. The median UCCR was 1.06 × 10−5 (range: 0.28–2.49) for 58 healthy dogs, and an upper reference limit of 1.98 × 10−5 (90% confidence interval: 1.76–2.15) was determined. The median UCCR in the 12 dogs with HC (7.38 × 10−5, range 1.86–29.98) was significantly higher than that in the 16 dogs with mimic-HC (1.59 × 10−5, range 0.47–3.42, P<0.001). The area under the curve for UCCR to differentiate HC dogs from mimic-HC dogs was 0.971, with a sensitivity of 91.7% and specificity of 100% when the cut-off value was set at 3.77 × 10−5. The UCCR of 16 paired urine samples collected at home and in hospital showed that the UCCR of samples collected in the hospital was significantly higher than that of samples collected at home (mean difference 3.30 × 10−5, 95% confidence interval: 0.70–5.90, P=0.001). In summary, we established the upper reference limit for UCCR using IMMULITE 2000 XPi in dogs and confirmed that UCCR is a useful diagnostic test for HC in dogs if urine samples are collected at home. |
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| AbstractList | The urinary corticoid to creatinine ratio (UCCR) is one of the most commonly used screening tests for canine hypercortisolism (HC). In this study, a reference interval was established for UCCR using IMMULITE 2000 XPi, the latest chemiluminescence enzyme immunoassay. The diagnostic performance of this method for UCCR in canine HC was also evaluated. The median UCCR was 1.06 × 10-5 (range: 0.28-2.49) for 58 healthy dogs, and an upper reference limit of 1.98 × 10-5 (90% confidence interval: 1.76-2.15) was determined. The median UCCR in the 12 dogs with HC (7.38 × 10-5, range 1.86-29.98) was significantly higher than that in the 16 dogs with mimic-HC (1.59 × 10-5, range 0.47-3.42, P<0.001). The area under the curve for UCCR to differentiate HC dogs from mimic-HC dogs was 0.971, with a sensitivity of 91.7% and specificity of 100% when the cut-off value was set at 3.77 × 10-5. The UCCR of 16 paired urine samples collected at home and in hospital showed that the UCCR of samples collected in the hospital was significantly higher than that of samples collected at home (mean difference 3.30 × 10-5, 95% confidence interval: 0.70-5.90, P=0.001). In summary, we established the upper reference limit for UCCR using IMMULITE 2000 XPi in dogs and confirmed that UCCR is a useful diagnostic test for HC in dogs if urine samples are collected at home.The urinary corticoid to creatinine ratio (UCCR) is one of the most commonly used screening tests for canine hypercortisolism (HC). In this study, a reference interval was established for UCCR using IMMULITE 2000 XPi, the latest chemiluminescence enzyme immunoassay. The diagnostic performance of this method for UCCR in canine HC was also evaluated. The median UCCR was 1.06 × 10-5 (range: 0.28-2.49) for 58 healthy dogs, and an upper reference limit of 1.98 × 10-5 (90% confidence interval: 1.76-2.15) was determined. The median UCCR in the 12 dogs with HC (7.38 × 10-5, range 1.86-29.98) was significantly higher than that in the 16 dogs with mimic-HC (1.59 × 10-5, range 0.47-3.42, P<0.001). The area under the curve for UCCR to differentiate HC dogs from mimic-HC dogs was 0.971, with a sensitivity of 91.7% and specificity of 100% when the cut-off value was set at 3.77 × 10-5. The UCCR of 16 paired urine samples collected at home and in hospital showed that the UCCR of samples collected in the hospital was significantly higher than that of samples collected at home (mean difference 3.30 × 10-5, 95% confidence interval: 0.70-5.90, P=0.001). In summary, we established the upper reference limit for UCCR using IMMULITE 2000 XPi in dogs and confirmed that UCCR is a useful diagnostic test for HC in dogs if urine samples are collected at home. The urinary corticoid to creatinine ratio (UCCR) is one of the most commonly used screening tests for canine hypercortisolism (HC). In this study, a reference interval was established for UCCR using IMMULITE 2000 XPi, the latest chemiluminescence enzyme immunoassay. The diagnostic performance of this method for UCCR in canine HC was also evaluated. The median UCCR was 1.06 × 10 −5 (range: 0.28–2.49) for 58 healthy dogs, and an upper reference limit of 1.98 × 10 −5 (90% confidence interval: 1.76–2.15) was determined. The median UCCR in the 12 dogs with HC (7.38 × 10 −5 , range 1.86–29.98) was significantly higher than that in the 16 dogs with mimic-HC (1.59 × 10 −5 , range 0.47–3.42, P <0.001). The area under the curve for UCCR to differentiate HC dogs from mimic-HC dogs was 0.971, with a sensitivity of 91.7% and specificity of 100% when the cut-off value was set at 3.77 × 10 −5 . The UCCR of 16 paired urine samples collected at home and in hospital showed that the UCCR of samples collected in the hospital was significantly higher than that of samples collected at home (mean difference 3.30 × 10 −5 , 95% confidence interval: 0.70–5.90, P =0.001). In summary, we established the upper reference limit for UCCR using IMMULITE 2000 XPi in dogs and confirmed that UCCR is a useful diagnostic test for HC in dogs if urine samples are collected at home. The urinary corticoid to creatinine ratio (UCCR) is one of the most commonly used screening tests for canine hypercortisolism (HC). In this study, a reference interval was established for UCCR using IMMULITE 2000 XPi, the latest chemiluminescence enzyme immunoassay. The diagnostic performance of this method for UCCR in canine HC was also evaluated. The median UCCR was 1.06 × 10 (range: 0.28-2.49) for 58 healthy dogs, and an upper reference limit of 1.98 × 10 (90% confidence interval: 1.76-2.15) was determined. The median UCCR in the 12 dogs with HC (7.38 × 10 , range 1.86-29.98) was significantly higher than that in the 16 dogs with mimic-HC (1.59 × 10 , range 0.47-3.42, P<0.001). The area under the curve for UCCR to differentiate HC dogs from mimic-HC dogs was 0.971, with a sensitivity of 91.7% and specificity of 100% when the cut-off value was set at 3.77 × 10 . The UCCR of 16 paired urine samples collected at home and in hospital showed that the UCCR of samples collected in the hospital was significantly higher than that of samples collected at home (mean difference 3.30 × 10 , 95% confidence interval: 0.70-5.90, P=0.001). In summary, we established the upper reference limit for UCCR using IMMULITE 2000 XPi in dogs and confirmed that UCCR is a useful diagnostic test for HC in dogs if urine samples are collected at home. The urinary corticoid to creatinine ratio (UCCR) is one of the most commonly used screening tests for canine hypercortisolism (HC). In this study, a reference interval was established for UCCR using IMMULITE 2000 XPi, the latest chemiluminescence enzyme immunoassay. The diagnostic performance of this method for UCCR in canine HC was also evaluated. The median UCCR was 1.06 × 10−5 (range: 0.28–2.49) for 58 healthy dogs, and an upper reference limit of 1.98 × 10−5 (90% confidence interval: 1.76–2.15) was determined. The median UCCR in the 12 dogs with HC (7.38 × 10−5, range 1.86–29.98) was significantly higher than that in the 16 dogs with mimic-HC (1.59 × 10−5, range 0.47–3.42, P<0.001). The area under the curve for UCCR to differentiate HC dogs from mimic-HC dogs was 0.971, with a sensitivity of 91.7% and specificity of 100% when the cut-off value was set at 3.77 × 10−5. The UCCR of 16 paired urine samples collected at home and in hospital showed that the UCCR of samples collected in the hospital was significantly higher than that of samples collected at home (mean difference 3.30 × 10−5, 95% confidence interval: 0.70–5.90, P=0.001). In summary, we established the upper reference limit for UCCR using IMMULITE 2000 XPi in dogs and confirmed that UCCR is a useful diagnostic test for HC in dogs if urine samples are collected at home. |
| ArticleNumber | 22-0131 |
| Author | NAGATA, Noriyuki SASAKI, Noboru TAKIGUCHI, Mitsuyoshi YOKOYAMA, Nozomu HOSOYA, Kenji NAKAMURA, Kensuke SAWAMURA, Hiryu SASAOKA, Kazuyoshi IKENAKA, Yoshinori MORISHITA, Keitaro |
| Author_xml | – sequence: 1 fullname: SAWAMURA, Hiryu organization: Laboratory of Advanced Veterinary Medicine, Department of Clinical Sciences, Faculty of Veterinary Medicine, Hokkaido University, Hokkaido, Japan – sequence: 1 fullname: HOSOYA, Kenji organization: Laboratory of Advanced Veterinary Medicine, Department of Clinical Sciences, Faculty of Veterinary Medicine, Hokkaido University, Hokkaido, Japan – sequence: 1 fullname: TAKIGUCHI, Mitsuyoshi organization: Laboratory of Veterinary Internal Medicine, Department of Clinical Sciences, Faculty of Veterinary Medicine, Hokkaido University, Hokkaido, Japan – sequence: 1 fullname: YOKOYAMA, Nozomu organization: Veterinary Teaching Hospital, Faculty of Veterinary Medicine, Hokkaido University, Hokkaido, Japan – sequence: 1 fullname: NAKAMURA, Kensuke organization: Laboratory of Veterinary Internal Medicine, Department of Clinical Sciences, Faculty of Veterinary Medicine, Hokkaido University, Hokkaido, Japan – sequence: 1 fullname: SASAOKA, Kazuyoshi organization: Veterinary Teaching Hospital, Faculty of Veterinary Medicine, Hokkaido University, Hokkaido, Japan – sequence: 1 fullname: SASAKI, Noboru organization: Laboratory of Veterinary Internal Medicine, Department of Clinical Sciences, Faculty of Veterinary Medicine, Hokkaido University, Hokkaido, Japan – sequence: 1 fullname: MORISHITA, Keitaro organization: Laboratory of Advanced Veterinary Medicine, Department of Clinical Sciences, Faculty of Veterinary Medicine, Hokkaido University, Hokkaido, Japan – sequence: 1 fullname: NAGATA, Noriyuki organization: Veterinary Teaching Hospital, Faculty of Veterinary Medicine, Hokkaido University, Hokkaido, Japan – sequence: 1 fullname: IKENAKA, Yoshinori organization: Translational Research Unit, Veterinary Teaching Hospital, Faculty of Veterinary Medicine, Hokkaido University, Hokkaido, Japan |
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| Cites_doi | 10.1111/jvim.12192 10.1111/jvim.14617 10.1080/01652176.1997.9694731 10.2460/javma.1992.200.11.1637 10.2460/javma.1995.207.04.0445 10.1016/0739-7240(90)90013-P 10.1111/j.1939-165X.2011.00287.x 10.1111/j.1939-1676.1993.tb03181.x 10.1111/jvim.15079 10.1111/jvim.15735 10.1016/j.tvjl.2007.04.008 10.1111/j.1939-1676.1998.tb02146.x 10.1136/vr.c4010 10.5326/JAAHA-MS-6789 10.1016/S0195-5616(84)50078-3 10.2460/javma.244.10.1181 10.1136/vr.160.12.393 10.1053/j.tcam.2012.06.001 10.1016/S0034-5288(18)32248-3 10.1016/j.tvjl.2019.105343 10.1016/j.domaniend.2004.11.001 10.1111/vcp.12006 10.1111/j.1748-5827.2005.tb00282.x 10.1111/j.1939-1676.1991.tb00922.x 10.1177/10406387211031194 10.1136/vr.122.8.178 10.1111/j.1748-5827.1997.tb03327.x |
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| References_xml | – reference: 25. Smiley, L. E. and Peterson, M. E. 1993. Evaluation of a urine cortisol:creatinine ratio as a screening test for hyperadrenocorticism in dogs. J. Vet. Intern. Med. 7: 163–168. – reference: 5. Cerundolo, R., Lloyd, D. H., Vaessen, M. M. A. R., Mol, J. A., Kooistra, H. S. and Rijnberk, A. 2007. Alopecia in pomeranians and miniature poodles in association with high urinary corticoid:creatinine ratios and resistance to glucocorticoid feedback. Vet. Rec. 160: 393–397. – reference: 27. van Vonderen, I. K., Kooistra, H. S. and Rijnberk, A. 1998. Influence of veterinary care on the urinary corticoid:creatinine ratio in dogs. J. Vet. Intern. Med. 12: 431–435. – reference: 2. Bennaim, M., Centola, S., Ramsey, I. and Seth, M. 2019. Clinical and clinicopathological features in dogs with uncomplicated spontaneous hyperadrenocorticism diagnosed in primary care practice (2013–2014). J. Am. Anim. Hosp. Assoc. 55: 178–186. – reference: 11. Galac, S., Kooistra, H. 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| SubjectTerms | canine Cushing’s syndrome hyperadrenocorticism Internal Medicine urinary cortisol |
| Title | Urinary corticoid to creatinine ratios using IMMULITE 2000 XPi for diagnosis of canine hypercortisolism |
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