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Keywords: 631/443/319/2723; 631/45/776/1178; 631/80/82/23; Adenylate Kinase - metabolism; Adiponectin - deficiency; Adiponectin - genetics; Adiponectin - physiology; Adiponectin - therapeutic use; Animals; Apoptosis - physiology; Biomedical and Life Sciences; Biomedicine; Calcium-Calmodulin-Dependent Protein Kinase Kinase - metabolism; Cancer Research; Cellular biology; Ceramidases - drug effects; Ceramidases - metabolism; Ceramides - metabolism; Enzyme Activation; Gene Expression Regulation; Health aspects; Humans; Infectious Diseases; Insulin; Insulin - physiology; Kinetics; Leptin - deficiency; Lipids; Metabolic Diseases; Metabolism; Metabolites; Mice; Mice, Obese; Molecular Medicine; Mortality; Myocardial Infarction - drug therapy; Myocytes, Cardiac - physiology; Neurosciences; Pancreatic beta cells; Physiological aspects; Properties; Protein hormones; Receptors, Adiponectin - physiology; Signal transduction; Upstream; United States