Comparison of survival rates in four inbred mouse strains under different housing conditions: effects of environmental enrichment

Housing conditions can affect the well-being of laboratory animals and thereby affect the outcomes of experiments. The appropriate environment is essential for the expression of natural behavior in animals. Here, we compared survival rates in four inbred mouse strains maintained under three differen...

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Published inEXPERIMENTAL ANIMALS Vol. 71; no. 2; pp. 150 - 160
Main Authors Kajitani, Naoyo, Matsuo, Hiroyuki, Kawakami, Kohei, Matsumoto, Ken-ichi, Yamada, Takaya
Format Journal Article
LanguageEnglish
Published Japan Japanese Association for Laboratory Animal Science 01.01.2022
Japan Science and Technology Agency
Subjects
Alopecia
Animal behavior
Animals
cloth mat flooring
Corticosterone
Enrichment
Environmental conditions
environmental enrichment
Housing
Housing conditions
inbred strain
Inbreeding
Laboratory animals
lifespan
mice
Original
Rodents
Survival
environmental enrichment
cloth mat flooring
inbred strain
mice
lifespan
Online AccessGet full text
ISSN1341-1357
0007-5124
1884-4162
1884-4170
1881-7122
1881-7122
DOI10.1538/expanim.21-0118

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Abstract Housing conditions can affect the well-being of laboratory animals and thereby affect the outcomes of experiments. The appropriate environment is essential for the expression of natural behavior in animals. Here, we compared survival rates in four inbred mouse strains maintained under three different environmental conditions. Three mouse strains (C57BL/6J, C3H/HeN, and DBA/2J) housed under environmental enrichment (EE) conditions showed improved survival; however, EE did not alter the survival rate of the fourth strain, BALB/c. None of the strains showed significant differences in body weights or plasma corticosterone levels in the three environmental conditions. For BALB/c mice, the rates of debility were higher in the EE group. Interestingly, for C57BL/6J and C3H/HeN mice, the incidence of animals with alopecia was significantly lower in the EE groups than in the control group. It is possible that the enriched environment provided greater opportunities for sheltering in a secure location in which to avoid interactions with other mice. The cloth mat flooring used for the EE group was bitten and chewed by the mice. Our findings suggest that depending on the mouse strains different responses to EE are caused with regard to health and survival rates. The results of this study provide basic data for further studies on EE.
AbstractList Housing conditions can affect the well-being of laboratory animals and thereby affect the outcomes of experiments. The appropriate environment is essential for the expression of natural behavior in animals. Here, we compared survival rates in four inbred mouse strains maintained under three different environmental conditions. Three mouse strains (C57BL/6J, C3H/HeN, and DBA/2J) housed under environmental enrichment (EE) conditions showed improved survival; however, EE did not alter the survival rate of the fourth strain, BALB/c. None of the strains showed significant differences in body weights or plasma corticosterone levels in the three environmental conditions. For BALB/c mice, the rates of debility were higher in the EE group. Interestingly, for C57BL/6J and C3H/HeN mice, the incidence of animals with alopecia was significantly lower in the EE groups than in the control group. It is possible that the enriched environment provided greater opportunities for sheltering in a secure location in which to avoid interactions with other mice. The cloth mat flooring used for the EE group was bitten and chewed by the mice. Our findings suggest that depending on the mouse strains different responses to EE are caused with regard to health and survival rates. The results of this study provide basic data for further studies on EE.
Housing conditions can affect the well-being of laboratory animals and thereby affect the outcomes of experiments. The appropriate environment is essential for the expression of natural behavior in animals. Here, we compared survival rates in four inbred mouse strains maintained under three different environmental conditions. Three mouse strains (C57BL/6J, C3H/HeN, and DBA/2J) housed under environmental enrichment (EE) conditions showed improved survival; however, EE did not alter the survival rate of the fourth strain, BALB/c. None of the strains showed significant differences in body weights or plasma corticosterone levels in the three environmental conditions. For BALB/c mice, the rates of debility were higher in the EE group. Interestingly, for C57BL/6J and C3H/HeN mice, the incidence of animals with alopecia was significantly lower in the EE groups than in the control group. It is possible that the enriched environment provided greater opportunities for sheltering in a secure location in which to avoid interactions with other mice. The cloth mat flooring used for the EE group was bitten and chewed by the mice. Our findings suggest that depending on the mouse strains different responses to EE are caused with regard to health and survival rates. The results of this study provide basic data for further studies on EE.
ArticleNumber 21-0118
Author Matsumoto, Ken-ichi
Kajitani, Naoyo
Yamada, Takaya
Kawakami, Kohei
Matsuo, Hiroyuki
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  fullname: Matsuo, Hiroyuki
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  fullname: Kawakami, Kohei
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Keywords environmental enrichment
cloth mat flooring
inbred strain
mice
lifespan
Language English
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References_xml – reference: 15. Van Loo PLP, Van de Weerd HA, Van Zutphen LFM, Baumans V. Preference for social contact versus environmental enrichment in male laboratory mice. Lab Anim. 2004; 38: 178–188.
– reference: 3. Wolfer DP, Litvin O, Morf S, Nitsch RM, Lipp HP, Würbel H. Laboratory animal welfare: cage enrichment and mouse behaviour. Nature. 2004; 432: 821–822.
– reference: 52. Kastenmayer RJ, Fain MA, Perdue KA. A retrospective study of idiopathic ulcerative dermatitis in mice with a C57BL/6 background. J Am Assoc Lab Anim Sci. 2006; 45: 8–12.
– reference: 7. Boehm GW, Sherman GF, Hoplight BJ 2nd, Hyde LA, Waters NS, Bradway DM, et al. Learning and memory in the autoimmune BXSB mouse: effects of neocortical ectopias and environmental enrichment. Brain Res. 1996; 726: 11–22.
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Snippet Housing conditions can affect the well-being of laboratory animals and thereby affect the outcomes of experiments. The appropriate environment is essential for...
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SubjectTerms Alopecia
Animal behavior
Animals
cloth mat flooring
Corticosterone
Enrichment
Environmental conditions
environmental enrichment
Housing
Housing conditions
inbred strain
Inbreeding
Laboratory animals
lifespan
mice
Original
Rodents
Survival
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Title Comparison of survival rates in four inbred mouse strains under different housing conditions: effects of environmental enrichment
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