UnTWISTing intestinal fibrosis: single-cell transcriptomics deciphers fibroblast heterogeneity, uncovers molecular pathways, and identifies therapeutic targets - Santacroce, Giovanni; Di Sabatino, Antonio (The Journal of clinical investigation, 2024)
Keywords: Animals; Care and treatment; Cells; Colorectal diseases; Crohn Disease - genetics; Crohn Disease - metabolism; Crohn Disease - pathology; Crohn's disease; Extracellular matrix; Fibroblasts; Fibroblasts - metabolism; Fibroblasts - pathology; Fibrosis; Gastrointestinal diseases; Genetic aspects; Health aspects; Humans; Hyperplasia; Inflammation; Inflammatory bowel disease; Intestine; Intestines - pathology; Macrophages; Macrophages - metabolism; Macrophages - pathology; Medical research; Medicine, Experimental; Microenvironments; Nuclear Proteins; Pathogenesis; Physiological aspects; RNA sequencing; Single-Cell Analysis; Smooth muscle; Therapeutic targets; Transcription factors; Transcriptome; Transcriptomics; Transforming growth factors; Twist-Related Protein 1 - genetics; Twist-Related Protein 1 - metabolism; Italy