UnTWISTing intestinal fibrosis: single-cell transcriptomics deciphers fibroblast heterogeneity, uncovers molecular pathways, and identifies therapeutic targets
Intestinal fibrosis is a severe complication of Crohn's disease, often requiring surgical intervention. Despite extensive research efforts, an effective treatment to prevent or reverse intestinal fibrosis remains elusive. In this issue of the JCI, Zhang, Wang, and colleagues employed single-cel...
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| Published in | The Journal of clinical investigation Vol. 134; no. 18; pp. 1 - 3 |
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| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
United States
American Society for Clinical Investigation
17.09.2024
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1558-8238 0021-9738 1558-8238 |
| DOI | 10.1172/JCI184112 |
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| Abstract | Intestinal fibrosis is a severe complication of Crohn's disease, often requiring surgical intervention. Despite extensive research efforts, an effective treatment to prevent or reverse intestinal fibrosis remains elusive. In this issue of the JCI, Zhang, Wang, and colleagues employed single-cell RNA sequencing to uncover mechanisms of the fibrotic process. They identified a key fibroblast subset of TWIST1+FAP+ cells that interacts with CXCL9+ macrophages. TWIST1 emerged as a central regulator of the fibrotic microenvironment, representing a promising therapeutic target for effectively treating intestinal fibrosis. |
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| AbstractList | Intestinal fibrosis is a severe complication of Crohn’s disease, often requiring surgical intervention. Despite extensive research efforts, an effective treatment to prevent or reverse intestinal fibrosis remains elusive. In this issue of the JCI, Zhang, Wang, and colleagues employed single-cell RNA sequencing to uncover mechanisms of the fibrotic process. They identified a key fibroblast subset of TWIST1+FAP+ cells that interacts with CXCL9+ macrophages. TWIST1 emerged as a central regulator of the fibrotic microenvironment, representing a promising therapeutic target for effectively treating intestinal fibrosis. Intestinal fibrosis is a severe complication of Crohn's disease, often requiring surgical intervention. Despite extensive research efforts, an effective treatment to prevent or reverse intestinal fibrosis remains elusive. In this issue of the JCI, Zhang, Wang, and colleagues employed single-cell RNA sequencing to uncover mechanisms of the fibrotic process. They identified a key fibroblast subset of TWISTV[FAP.sup.+] cells that interacts with [CXCL9.sup.+] macrophages. TWIST1 emerged as a central regulator of the fibrotic microenvironment, representing a promising therapeutic target for effectively treating intestinal fibrosis. Intestinal fibrosis is a severe complication of Crohn’s disease, often requiring surgical intervention. Despite extensive research efforts, an effective treatment to prevent or reverse intestinal fibrosis remains elusive. In this issue of the JCI , Zhang, Wang, and colleagues employed single-cell RNA sequencing to uncover mechanisms of the fibrotic process. They identified a key fibroblast subset of TWIST1 + FAP + cells that interacts with CXCL9 + macrophages. TWIST1 emerged as a central regulator of the fibrotic microenvironment, representing a promising therapeutic target for effectively treating intestinal fibrosis. Intestinal fibrosis is a severe complication of Crohn's disease, often requiring surgical intervention. Despite extensive research efforts, an effective treatment to prevent or reverse intestinal fibrosis remains elusive. In this issue of the JCI, Zhang, Wang, and colleagues employed single-cell RNA sequencing to uncover mechanisms of the fibrotic process. They identified a key fibroblast subset of TWIST1+FAP+ cells that interacts with CXCL9+ macrophages. TWIST1 emerged as a central regulator of the fibrotic microenvironment, representing a promising therapeutic target for effectively treating intestinal fibrosis.Intestinal fibrosis is a severe complication of Crohn's disease, often requiring surgical intervention. Despite extensive research efforts, an effective treatment to prevent or reverse intestinal fibrosis remains elusive. In this issue of the JCI, Zhang, Wang, and colleagues employed single-cell RNA sequencing to uncover mechanisms of the fibrotic process. They identified a key fibroblast subset of TWIST1+FAP+ cells that interacts with CXCL9+ macrophages. TWIST1 emerged as a central regulator of the fibrotic microenvironment, representing a promising therapeutic target for effectively treating intestinal fibrosis. |
| Audience | Academic |
| Author | Di Sabatino, Antonio Santacroce, Giovanni |
| AuthorAffiliation | 1 Department of Internal Medicine and Medical Therapeutics, University of Pavia, Pavia, Italy 2 First Department of Internal Medicine, San Matteo Hospital Foundation, Pavia, Italy |
| AuthorAffiliation_xml | – name: 1 Department of Internal Medicine and Medical Therapeutics, University of Pavia, Pavia, Italy – name: 2 First Department of Internal Medicine, San Matteo Hospital Foundation, Pavia, Italy |
| Author_xml | – sequence: 1 givenname: Giovanni surname: Santacroce fullname: Santacroce, Giovanni – sequence: 2 givenname: Antonio surname: Di Sabatino fullname: Di Sabatino, Antonio |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/39286981$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1093/ibd/izac266 10.3389/fimmu.2023.1152140 10.1111/jcmm.13465 10.3390/cells11030429 10.1136/gutjnl-2023-329963 10.1093/ibd/izaa089 10.1172/JCI179472 10.7150/thno.71722 10.1038/nm.3902 10.1016/j.mam.2024.101251 10.1053/j.gastro.2023.07.014 10.3390/microorganisms10030490 10.1371/journal.pone.0214697 10.1093/ibd/izx008 10.1038/s41592-019-0667-5 10.1016/j.cell.2020.09.009 10.1093/ecco-jcc/jjw126 10.1093/ecco-jcc/jjy201 10.1183/13993003.00474-2022 10.1007/s00018-022-04137-0 10.1016/j.celrep.2018.03.010 |
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| Copyright | COPYRIGHT 2024 American Society for Clinical Investigation Copyright American Society for Clinical Investigation Sep 2024 2024 Santacroce et al. 2024 Santacroce et al. |
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| Snippet | Intestinal fibrosis is a severe complication of Crohn's disease, often requiring surgical intervention. Despite extensive research efforts, an effective... Intestinal fibrosis is a severe complication of Crohn’s disease, often requiring surgical intervention. Despite extensive research efforts, an effective... |
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| SubjectTerms | Animals Care and treatment Cells Colorectal diseases Crohn Disease - genetics Crohn Disease - metabolism Crohn Disease - pathology Crohn's disease Extracellular matrix Fibroblasts Fibroblasts - metabolism Fibroblasts - pathology Fibrosis Gastrointestinal diseases Genetic aspects Health aspects Humans Hyperplasia Inflammation Inflammatory bowel disease Intestine Intestines - pathology Macrophages Macrophages - metabolism Macrophages - pathology Medical research Medicine, Experimental Microenvironments Nuclear Proteins Pathogenesis Physiological aspects RNA sequencing Single-Cell Analysis Smooth muscle Therapeutic targets Transcription factors Transcriptome Transcriptomics Transforming growth factors Twist-Related Protein 1 - genetics Twist-Related Protein 1 - metabolism |
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| Title | UnTWISTing intestinal fibrosis: single-cell transcriptomics deciphers fibroblast heterogeneity, uncovers molecular pathways, and identifies therapeutic targets |
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