Sequential and co-occurring DNA damage response genetic mutations impact survival in stage III colorectal cancer patients receiving adjuvant oxaliplatin-based chemotherapy - Lin, Peng-Chan; Yeh, Yu-Min; Chan, Ren-Hao; Lin, Bo-Wen; Chen, Po-Chuan; Pan, Chien-Chang; Shen, Meng-Ru (BMC cancer, 2021)
Keywords: Adenomatous polyposis coli; Adenomatous Polyposis Coli Protein - genetics; Aged; Biomedical and Life Sciences; Biomedicine; BRCA2 protein; BRCA2 Protein - genetics; Cancer; Cancer Research; Chemotherapy; Clinical outcomes; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - drug therapy; Colorectal Neoplasms - genetics; Colorectal Neoplasms - mortality; Colorectal Neoplasms - pathology; Decision trees; Deoxyribonucleic acid; Development and progression; DNA; DNA Damage; DNA damage response gene; DNA repair; Drug resistance; Drug therapy; Evolution; Feature selection; Female; Gene mutations; Genetic aspects; Health aspects; Health Promotion and Disease Prevention; Humans; Learning algorithms; Machine learning; Male; Medical prognosis; Medicine/Public Health; Middle Aged; Mismatch repair; Mutation; Neoplasm Staging; Oncology; Oxaliplatin; Oxaliplatin - administration & dosage; p53 Protein; Patients; Phylogenetics; Phylogeny; Proto-Oncogene Proteins p21(ras) - genetics; Research Article; Risk groups; Sequential somatic mutations; Surgical Oncology; Survival; Tumor evolution; Tumor heterogeneity; Taiwan; Tumor heterogeneity; Tumor evolution; Sequential somatic mutations; DNA damage response gene; Colorectal cancer