Whether sperm deoxyribonucleic acid fragmentation has an effect on pregnancy and miscarriage after in vitro fertilization/intracytoplasmic sperm injection: a systematic review and meta-analysis
To examine whether sperm DNA fragmentation has an effect on pregnancy and miscarriage after IVF and/or intracytoplasmic sperm injection (ICSI). Systematic review and meta-analysis. University-affiliated teaching hospital. Infertility patient(s). An exhaustive electronic literature search was conduct...
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| Published in | Fertility and sterility Vol. 102; no. 4; pp. 998 - 1005.e8 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
01.10.2014
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0015-0282 1556-5653 1556-5653 |
| DOI | 10.1016/j.fertnstert.2014.06.033 |
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| Abstract | To examine whether sperm DNA fragmentation has an effect on pregnancy and miscarriage after IVF and/or intracytoplasmic sperm injection (ICSI).
Systematic review and meta-analysis.
University-affiliated teaching hospital.
Infertility patient(s).
An exhaustive electronic literature search was conducted on MEDLINE, Google Scholar, and the Cochrane Library, from database inception to October 2013. We included clinical trials that examined the influence of sperm DNA damage on pregnancy and miscarriage of IVF/ICSI.
The outcomes of interest were pregnancy rate and miscarriage rate.
In the analysis of pregnancy, 16 cohort studies (3,106 couples) were included. Of these, 14 studies (2,756 couples, 965 pregnancies) that also mentioned miscarriage were identified in the analysis of miscarriage. Meta-analysis showed that high-level sperm DNA fragmentation has a detrimental effect on outcome of IVF/ICSI, with decreased pregnancy rate and increased miscarriage rate. The stratified analysis by type of procedure (IVF vs. ICSI) indicated that high sperm DNA damage was related to lower pregnancy rates in IVF but not in ICSI cycles, whereas it was associated with higher miscarriage rates in both IVF and ICSI cycles.
The results indicate that assays detecting sperm DNA damage should be recommended to those suffering from recurrent failure to achieve pregnancy. Selection of sperm without DNA damage for use may improve the clinical outcome of ART. The data also provide a rationale for conducting further research aimed at evaluating the underlying mechanism(s) responsible for the detrimental effect of high sperm DNA fragmentation and the potential therapy. |
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| AbstractList | Objective To examine whether sperm DNA fragmentation has an effect on pregnancy and miscarriage after IVF and/or intracytoplasmic sperm injection (ICSI). Design Systematic review and meta-analysis. Setting University-affiliated teaching hospital. Patient(s) Infertility patient(s). Intervention(s) An exhaustive electronic literature search was conducted on MEDLINE, Google Scholar, and the Cochrane Library, from database inception to October 2013. We included clinical trials that examined the influence of sperm DNA damage on pregnancy and miscarriage of IVF/ICSI. Main Outcome Measure(s) The outcomes of interest were pregnancy rate and miscarriage rate. Result(s) In the analysis of pregnancy, 16 cohort studies (3,106 couples) were included. Of these, 14 studies (2,756 couples, 965 pregnancies) that also mentioned miscarriage were identified in the analysis of miscarriage. Meta-analysis showed that high-level sperm DNA fragmentation has a detrimental effect on outcome of IVF/ICSI, with decreased pregnancy rate and increased miscarriage rate. The stratified analysis by type of procedure (IVF vs. ICSI) indicated that high sperm DNA damage was related to lower pregnancy rates in IVF but not in ICSI cycles, whereas it was associated with higher miscarriage rates in both IVF and ICSI cycles. Conclusion(s) The results indicate that assays detecting sperm DNA damage should be recommended to those suffering from recurrent failure to achieve pregnancy. Selection of sperm without DNA damage for use may improve the clinical outcome of ART. The data also provide a rationale for conducting further research aimed at evaluating the underlying mechanism(s) responsible for the detrimental effect of high sperm DNA fragmentation and the potential therapy. To examine whether sperm DNA fragmentation has an effect on pregnancy and miscarriage after IVF and/or intracytoplasmic sperm injection (ICSI). Systematic review and meta-analysis. University-affiliated teaching hospital. Infertility patient(s). An exhaustive electronic literature search was conducted on MEDLINE, Google Scholar, and the Cochrane Library, from database inception to October 2013. We included clinical trials that examined the influence of sperm DNA damage on pregnancy and miscarriage of IVF/ICSI. The outcomes of interest were pregnancy rate and miscarriage rate. In the analysis of pregnancy, 16 cohort studies (3,106 couples) were included. Of these, 14 studies (2,756 couples, 965 pregnancies) that also mentioned miscarriage were identified in the analysis of miscarriage. Meta-analysis showed that high-level sperm DNA fragmentation has a detrimental effect on outcome of IVF/ICSI, with decreased pregnancy rate and increased miscarriage rate. The stratified analysis by type of procedure (IVF vs. ICSI) indicated that high sperm DNA damage was related to lower pregnancy rates in IVF but not in ICSI cycles, whereas it was associated with higher miscarriage rates in both IVF and ICSI cycles. The results indicate that assays detecting sperm DNA damage should be recommended to those suffering from recurrent failure to achieve pregnancy. Selection of sperm without DNA damage for use may improve the clinical outcome of ART. The data also provide a rationale for conducting further research aimed at evaluating the underlying mechanism(s) responsible for the detrimental effect of high sperm DNA fragmentation and the potential therapy. To examine whether sperm DNA fragmentation has an effect on pregnancy and miscarriage after IVF and/or intracytoplasmic sperm injection (ICSI).OBJECTIVETo examine whether sperm DNA fragmentation has an effect on pregnancy and miscarriage after IVF and/or intracytoplasmic sperm injection (ICSI).Systematic review and meta-analysis.DESIGNSystematic review and meta-analysis.University-affiliated teaching hospital.SETTINGUniversity-affiliated teaching hospital.Infertility patient(s).PATIENT(S)Infertility patient(s).An exhaustive electronic literature search was conducted on MEDLINE, Google Scholar, and the Cochrane Library, from database inception to October 2013. We included clinical trials that examined the influence of sperm DNA damage on pregnancy and miscarriage of IVF/ICSI.INTERVENTION(S)An exhaustive electronic literature search was conducted on MEDLINE, Google Scholar, and the Cochrane Library, from database inception to October 2013. We included clinical trials that examined the influence of sperm DNA damage on pregnancy and miscarriage of IVF/ICSI.The outcomes of interest were pregnancy rate and miscarriage rate.MAIN OUTCOME MEASURE(S)The outcomes of interest were pregnancy rate and miscarriage rate.In the analysis of pregnancy, 16 cohort studies (3,106 couples) were included. Of these, 14 studies (2,756 couples, 965 pregnancies) that also mentioned miscarriage were identified in the analysis of miscarriage. Meta-analysis showed that high-level sperm DNA fragmentation has a detrimental effect on outcome of IVF/ICSI, with decreased pregnancy rate and increased miscarriage rate. The stratified analysis by type of procedure (IVF vs. ICSI) indicated that high sperm DNA damage was related to lower pregnancy rates in IVF but not in ICSI cycles, whereas it was associated with higher miscarriage rates in both IVF and ICSI cycles.RESULT(S)In the analysis of pregnancy, 16 cohort studies (3,106 couples) were included. Of these, 14 studies (2,756 couples, 965 pregnancies) that also mentioned miscarriage were identified in the analysis of miscarriage. Meta-analysis showed that high-level sperm DNA fragmentation has a detrimental effect on outcome of IVF/ICSI, with decreased pregnancy rate and increased miscarriage rate. The stratified analysis by type of procedure (IVF vs. ICSI) indicated that high sperm DNA damage was related to lower pregnancy rates in IVF but not in ICSI cycles, whereas it was associated with higher miscarriage rates in both IVF and ICSI cycles.The results indicate that assays detecting sperm DNA damage should be recommended to those suffering from recurrent failure to achieve pregnancy. Selection of sperm without DNA damage for use may improve the clinical outcome of ART. The data also provide a rationale for conducting further research aimed at evaluating the underlying mechanism(s) responsible for the detrimental effect of high sperm DNA fragmentation and the potential therapy.CONCLUSION(S)The results indicate that assays detecting sperm DNA damage should be recommended to those suffering from recurrent failure to achieve pregnancy. Selection of sperm without DNA damage for use may improve the clinical outcome of ART. The data also provide a rationale for conducting further research aimed at evaluating the underlying mechanism(s) responsible for the detrimental effect of high sperm DNA fragmentation and the potential therapy. |
| Author | Wang, Yonggang Zhang, Qiong Zhao, Jing Li, Yanping |
| Author_xml | – sequence: 1 givenname: Jing surname: Zhao fullname: Zhao, Jing – sequence: 2 givenname: Qiong surname: Zhang fullname: Zhang, Qiong – sequence: 3 givenname: Yonggang surname: Wang fullname: Wang, Yonggang – sequence: 4 givenname: Yanping surname: Li fullname: Li, Yanping email: zhaojing19840427@sina.com |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25190048$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1095/biolreprod59.5.1037 10.1016/j.fertnstert.2003.09.063 10.1016/j.fertnstert.2003.09.044 10.1016/S0015-0282(03)01116-6 10.1093/humrep/16.10.2160 10.1016/S1472-6483(10)60710-9 10.1023/A:1009844109023 10.1016/j.fertnstert.2007.06.018 10.1016/S0015-0282(99)00462-8 10.1016/j.fertnstert.2008.01.086 10.1093/humrep/deh590 10.1016/S0015-0282(16)56108-1 10.1093/humrep/dei266 10.1016/j.fertnstert.2006.09.019 10.1093/mutage/gem052 10.1073/pnas.88.24.11003 10.1016/S1472-6483(10)60887-5 10.1093/humrep/del326 10.1093/humrep/13.7.1864 10.1093/humrep/des261 10.1093/humrep/deh233 10.1016/j.fertnstert.2006.05.057 10.1080/014850190518125 10.1093/humrep/deh280 10.1111/j.1479-828X.2007.00723.x 10.1016/S0015-0282(01)02894-1 10.1093/humrep/14.9.2279 10.1093/humrep/del251 10.1016/j.fertnstert.2007.04.055 10.1093/humrep/17.4.990 10.1093/humrep/14.4.1039 10.1093/humrep/den321 10.1093/hmg/4.12.2227 10.1016/S0015-0282(97)81871-7 10.1016/j.fertnstert.2010.08.019 10.1136/bmj.291.6510.1693 10.1016/S0015-0282(03)02212-X 10.1093/humrep/del019 10.1007/978-1-4614-7783-9_10 10.1016/j.fertnstert.2013.03.011 10.1016/S1472-6483(10)61893-7 10.1016/S0015-0282(97)00536-0 10.1093/jn/112.3.584 10.2164/jandrol.04152 10.1016/S0015-0282(99)00267-8 10.1080/01485010290099390 10.1016/j.rbmo.2012.09.019 10.1016/j.urology.2008.07.053 10.1093/humrep/17.6.1649 10.1093/humrep/deh127 10.3109/19396368.2011.553984 10.1095/biolreprod56.3.602 10.1016/j.fertnstert.2009.10.046 10.1242/jcs.111.5.645 10.2164/jandrol.107.003194 10.1093/oxfordjournals.humrep.a135875 10.1093/humupd/dmn004 10.1016/j.rbmo.2010.03.008 10.1093/humrep/deh701 10.1111/j.1439-0272.1997.tb00305.x 10.1002/(SICI)1097-010X(19991101)284:6<696::AID-JEZ11>3.0.CO;2-E 10.1016/0027-5107(95)00251-0 10.1016/j.fertnstert.2007.02.022 10.1530/REP-07-0152 10.1016/j.rbmo.2011.07.010 10.1111/j.1442-2042.2009.02280.x |
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| IngestDate | Sun Sep 28 06:04:32 EDT 2025 Wed Jul 30 01:47:04 EDT 2025 Thu Sep 18 00:03:48 EDT 2025 Thu Apr 24 23:04:35 EDT 2025 Fri Feb 23 02:19:37 EST 2024 Sun Feb 23 10:18:42 EST 2025 Tue Aug 26 20:24:26 EDT 2025 |
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| Issue | 4 |
| Keywords | sperm DNA fragmentation assisted reproductive technology miscarriage pregnancy Sperm DNA damage |
| Language | English |
| License | Copyright © 2014. Published by Elsevier Inc. |
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| PublicationTitle | Fertility and sterility |
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| References | Sun, Jurisicova, Casper (bib44) 1997; 56 Fraga, Motchnik, Wyrobek, Rempel, Ames (bib56) 1996; 351 Werthman, Wixon, Kasperson, Evenson (bib68) 2008; 90 Sakkas, Alvarez (bib50) 2010; 93 Parmegiani, Cognigni, Filicori (bib69) 2014; 791 Griffin, Abruzzo, Millie, Sheean, Feingold, Sherman (bib21) 1995; 4 Lewis, Sterling, Young, Thompson (bib57) 1997; 67 Tremellen, Miari, Froiland, Thompson (bib58) 2007; 47 Aitken, Harkiss, Knox, Paterson, Irvine (bib55) 1998; 111 Greco, Scarselli, Iacobelli, Rienzi, Ubaldi, Ferrero (bib43) 2005; 20 Bungum, Humaidan, Spano, Jepson, Bungum, Giwercman (bib11) 2004; 19 Spano, Bonde, Hjollund, Kolstad, Cordelli, Leter (bib22) 2000; 73 Simon, Lewis (bib4) 2011; 57 Virro, Larson-Cook, Evenson (bib12) 2004; 81 Henkel, Kierspel, Hajimohammad, Stalf, Hoogendijk, Mehnert (bib35) 2003; 7 Showell, Brown, Yazdani, Stankiewicz, Hart (bib60) 2011 Robinson, Gallos, Conner, Rajkhowa, Miller, Lewis (bib41) 2012; 27 Wells G, Shea B, O' Connell D. The Newcastle-Ottawa Scale (NOS) for assessing the quality of non-randomised studies in meta-analysis. In: Proceedings or the Third Symposium on Systematic Reviews Beyond the Basics. Improving Quality and Impact. July 3–5, 2000; Oxford, United Kingdom: The Ottawa Health Research Institute; 2000. Cohen-Bacrie, Belloc, Menezo, Clement, Hamidi, Benkhalifa (bib10) 2009; 91 Perez-Crespo, Moreira, Pintado, Gutierrez-Adan (bib49) 2008; 29 Agarwal, Sharma, Desai, Prabakaran, Tavares, Sabanegh (bib53) 2009; 73 Aitken, Gordon, Harkiss, Twigg, Milne, Jennings (bib32) 1998; 59 Check, Graziano, Cohen, Krotec, Check (bib13) 2005; 51 Menezo, Hazout, Panteix, Robert, Rollet, Cohen-Bacrie (bib63) 2007; 14 Bungum, Humaidan, Axmon, Spano, Bungum, Erenpreiss (bib15) 2007; 22 Zini, Blumenfeld, Libman, Willis (bib37) 2005; 20 Esbert, Pacheco, Vidal, Florensa, Riqueros, Ballesteros, Garrido, Caldero'n (bib71) 2011; 23 Ahmadi, Ng (bib47) 1999; 284 Evenson, Jost (bib67) 2000; 22 Frydman, Prisant, Hesters, Frydman, Tachdjian, Cohen-Bacrie (bib16) 2008; 89 Kefer, Agarwal, Sabanegh (bib54) 2009; 16 Zini, Boman, Belzile, Ciampi (bib9) 2008; 23 Henkel, Hajimohammad, Stalf, Hoogendijk, Mehnert, Menkveld (bib30) 2004; 81 Morris, Ilott, Dixon, Brison (bib24) 2002; 17 Dar, Grover, Moskovtsev, Swanson, Baratz, Librach (bib20) 2013; 100 Sartorelli, Mazzucatto, de Pina-Neto (bib23) 2001; 76 Pintauro, Bergan (bib64) 1982; 112 Twigg, Irvine, Aitken (bib26) 1998; 13 Lin, Kuo-Kuang, Li, Lu, Sun, Hwu (bib17) 2008; 90 Aitken, De Iuliis (bib7) 2007; 65 Gandini, Lombardo, Paoli, Caruso, Eleuteri, Leter (bib34) 2004; 19 Ozmen, Caglar, Koster, Schopper, Diedrich, Al-Hasani (bib18) 2007; 15 Simon, Proutski, Stevenson, Jennings, Mcmanus, Lutton (bib19) 2013; 26 Oeda, Henkel, Ohmori, Schill (bib62) 1997; 29 Evenson, Jost, Marshall, Zinaman, Clegg, Purvis (bib46) 1999; 14 Ross, Morriss, Khairy, Khalaf, Braude, Coomarasamy (bib59) 2010; 20 Fatehi, Bevers, Schoevers, Roelen, Colenbrander, Gadella (bib48) 2006; 27 Giwercman, Richthoff, Hjollund, Bonde, Jepson, Frohm (bib5) 2003; 80 Tomlinson, Moffatt, Manicardi, Bizzaro, Afnan, Sakkas (bib28) 2001; 16 Pang, Chan, Lu (bib61) 1993; 60 Carrell, Liu, Peterson, Jones, Hatasaka, Erickson (bib25) 2003; 49 Tesarik, Greco, Mendoza (bib31) 2004; 19 Boe-Hansen, Fedder, Ersbøll, Christensen (bib70) 2006; 21 Tremellen (bib52) 2008; 14 Lewis, Agbaje (bib51) 2008; 23 Larson-Cook, Brannian, Hansen, Kasperson, Aamold, Evenson (bib36) 2003; 80 Simon, Lutton, McManus, Lewis (bib3) 2011; 95 Fraga, Motchnik, Shigenaga, Helbock, Jacob, Ames (bib66) 1991; 88 Donnelly, McClure, Lewis (bib65) 1999; 72 Hull, Glazener, Kelly, Conway, Foster, Hinton (bib1) 1985; 291 Zini, Meriano, Kader, Jarvi, Laskin, Cadesky (bib38) 2005; 20 Lewis (bib6) 2007; 134 de la Rochebrochard, Thonneau (bib45) 2002; 17 Collins, Barnhart, Schlegel (bib40) 2008; 89 Carrell, Wilcox, Lowy, Peterson, Jones, Erickson (bib29) 2003; 101 Ahmadi, Ng (bib27) 1999; 14 Evenson, Kasperson, Wixon (bib8) 2007; 65 Lopes, Sun, Jurisicova, Meriano, Casper (bib33) 1998; 69 Borini, Tarozzi, Bizzaro, Bonu, Fava, Flamigni (bib39) 2006; 21 Chung, Fleming, Jamieson, Yates, Coutts (bib2) 1995; 10 Benchaib, Lornage, Mazoyer, Lejeune, Salle, Francois (bib14) 2007; 87 Henkel (10.1016/j.fertnstert.2014.06.033_bib35) 2003; 7 Aitken (10.1016/j.fertnstert.2014.06.033_bib7) 2007; 65 Sakkas (10.1016/j.fertnstert.2014.06.033_bib50) 2010; 93 Lewis (10.1016/j.fertnstert.2014.06.033_bib51) 2008; 23 Kefer (10.1016/j.fertnstert.2014.06.033_bib54) 2009; 16 Sun (10.1016/j.fertnstert.2014.06.033_bib44) 1997; 56 Tomlinson (10.1016/j.fertnstert.2014.06.033_bib28) 2001; 16 Boe-Hansen (10.1016/j.fertnstert.2014.06.033_bib70) 2006; 21 Bungum (10.1016/j.fertnstert.2014.06.033_bib11) 2004; 19 Gandini (10.1016/j.fertnstert.2014.06.033_bib34) 2004; 19 Henkel (10.1016/j.fertnstert.2014.06.033_bib30) 2004; 81 Zini (10.1016/j.fertnstert.2014.06.033_bib9) 2008; 23 Griffin (10.1016/j.fertnstert.2014.06.033_bib21) 1995; 4 Hull (10.1016/j.fertnstert.2014.06.033_bib1) 1985; 291 Tremellen (10.1016/j.fertnstert.2014.06.033_bib58) 2007; 47 Bungum (10.1016/j.fertnstert.2014.06.033_bib15) 2007; 22 Menezo (10.1016/j.fertnstert.2014.06.033_bib63) 2007; 14 Ahmadi (10.1016/j.fertnstert.2014.06.033_bib47) 1999; 284 Cohen-Bacrie (10.1016/j.fertnstert.2014.06.033_bib10) 2009; 91 Fraga (10.1016/j.fertnstert.2014.06.033_bib56) 1996; 351 Evenson (10.1016/j.fertnstert.2014.06.033_bib67) 2000; 22 Lopes (10.1016/j.fertnstert.2014.06.033_bib33) 1998; 69 Carrell (10.1016/j.fertnstert.2014.06.033_bib29) 2003; 101 Check (10.1016/j.fertnstert.2014.06.033_bib13) 2005; 51 Tremellen (10.1016/j.fertnstert.2014.06.033_bib52) 2008; 14 Fatehi (10.1016/j.fertnstert.2014.06.033_bib48) 2006; 27 Larson-Cook (10.1016/j.fertnstert.2014.06.033_bib36) 2003; 80 Morris (10.1016/j.fertnstert.2014.06.033_bib24) 2002; 17 Parmegiani (10.1016/j.fertnstert.2014.06.033_bib69) 2014; 791 Werthman (10.1016/j.fertnstert.2014.06.033_bib68) 2008; 90 Ozmen (10.1016/j.fertnstert.2014.06.033_bib18) 2007; 15 Carrell (10.1016/j.fertnstert.2014.06.033_bib25) 2003; 49 Collins (10.1016/j.fertnstert.2014.06.033_bib40) 2008; 89 de la Rochebrochard (10.1016/j.fertnstert.2014.06.033_bib45) 2002; 17 Spano (10.1016/j.fertnstert.2014.06.033_bib22) 2000; 73 Giwercman (10.1016/j.fertnstert.2014.06.033_bib5) 2003; 80 Benchaib (10.1016/j.fertnstert.2014.06.033_bib14) 2007; 87 Frydman (10.1016/j.fertnstert.2014.06.033_bib16) 2008; 89 Showell (10.1016/j.fertnstert.2014.06.033_bib60) 2011 Robinson (10.1016/j.fertnstert.2014.06.033_bib41) 2012; 27 Esbert (10.1016/j.fertnstert.2014.06.033_bib71) 2011; 23 Greco (10.1016/j.fertnstert.2014.06.033_bib43) 2005; 20 Dar (10.1016/j.fertnstert.2014.06.033_bib20) 2013; 100 Lewis (10.1016/j.fertnstert.2014.06.033_bib57) 1997; 67 Simon (10.1016/j.fertnstert.2014.06.033_bib4) 2011; 57 Fraga (10.1016/j.fertnstert.2014.06.033_bib66) 1991; 88 Lewis (10.1016/j.fertnstert.2014.06.033_bib6) 2007; 134 Pintauro (10.1016/j.fertnstert.2014.06.033_bib64) 1982; 112 Simon (10.1016/j.fertnstert.2014.06.033_bib19) 2013; 26 Evenson (10.1016/j.fertnstert.2014.06.033_bib46) 1999; 14 Aitken (10.1016/j.fertnstert.2014.06.033_bib55) 1998; 111 Aitken (10.1016/j.fertnstert.2014.06.033_bib32) 1998; 59 Zini (10.1016/j.fertnstert.2014.06.033_bib37) 2005; 20 Agarwal (10.1016/j.fertnstert.2014.06.033_bib53) 2009; 73 Lin (10.1016/j.fertnstert.2014.06.033_bib17) 2008; 90 Sartorelli (10.1016/j.fertnstert.2014.06.033_bib23) 2001; 76 Twigg (10.1016/j.fertnstert.2014.06.033_bib26) 1998; 13 Chung (10.1016/j.fertnstert.2014.06.033_bib2) 1995; 10 Simon (10.1016/j.fertnstert.2014.06.033_bib3) 2011; 95 Virro (10.1016/j.fertnstert.2014.06.033_bib12) 2004; 81 Perez-Crespo (10.1016/j.fertnstert.2014.06.033_bib49) 2008; 29 Oeda (10.1016/j.fertnstert.2014.06.033_bib62) 1997; 29 10.1016/j.fertnstert.2014.06.033_bib42 Pang (10.1016/j.fertnstert.2014.06.033_bib61) 1993; 60 Evenson (10.1016/j.fertnstert.2014.06.033_bib8) 2007; 65 Zini (10.1016/j.fertnstert.2014.06.033_bib38) 2005; 20 Donnelly (10.1016/j.fertnstert.2014.06.033_bib65) 1999; 72 Ahmadi (10.1016/j.fertnstert.2014.06.033_bib27) 1999; 14 Borini (10.1016/j.fertnstert.2014.06.033_bib39) 2006; 21 Ross (10.1016/j.fertnstert.2014.06.033_bib59) 2010; 20 Tesarik (10.1016/j.fertnstert.2014.06.033_bib31) 2004; 19 26088246 - J Urol. 2015 Jul;194(1):170. doi: 10.1016/j.juro.2015.04.005. |
| References_xml | – volume: 19 start-page: 1409 year: 2004 end-page: 1417 ident: bib34 article-title: Full-term pregnancies achieved with ICSI despite high levels of sperm chromatin damage publication-title: Hum Reprod – volume: 21 start-page: 1576 year: 2006 end-page: 1582 ident: bib70 article-title: The sperm chromatin structure assay as a diagnostic tool in the human fertility clinic. publication-title: Hum Reprod – volume: 89 start-page: 92 year: 2008 end-page: 97 ident: bib16 article-title: Adequate ovarian follicular status does not prevent the decrease in pregnancy rates associated with high sperm DNA fragmentation publication-title: Fertil Steril – volume: 23 start-page: 163 year: 2008 end-page: 170 ident: bib51 article-title: Using the alkaline comet assay in prognostic tests for male infertility and assisted reproductive technology outcomes publication-title: Mutagenesis – volume: 351 start-page: 199 year: 1996 end-page: 203 ident: bib56 article-title: Smoking and low antioxidant levels increase oxidative damage to sperm DNA publication-title: Mutat Res – volume: 57 start-page: 133 year: 2011 end-page: 138 ident: bib4 article-title: Sperm DNA damage or progressive motility: which one is the better predictor of fertilization in vitro? publication-title: Syst Biol Reprod Med – volume: 69 start-page: 528 year: 1998 end-page: 532 ident: bib33 article-title: Sperm deoxyribonucleic acid fragmentation is increased in poor-quality semen samples and correlates with failed fertilization in intracytoplasmic sperm injection publication-title: Fertil Steril – volume: 16 start-page: 449 year: 2009 end-page: 457 ident: bib54 article-title: Role of antioxidants in the treatment of male infertility publication-title: Int J Urol – volume: 56 start-page: 602 year: 1997 end-page: 607 ident: bib44 article-title: Detection of deoxyribonucleic acid fragmentation in human sperm: correlation with fertilization in vitro publication-title: Biol Reprod – volume: 14 start-page: 418 year: 2007 end-page: 421 ident: bib63 article-title: Antioxidants to reduce sperm DNA fragmentation: an unexpected adverse effect publication-title: Reprod Biomed Online – volume: 20 start-page: 3476 year: 2005 end-page: 3480 ident: bib38 article-title: Potential adverse effect of sperm DNA damage on embryo quality after ICSI publication-title: Hum Reprod – start-page: CD007411 year: 2011 ident: bib60 article-title: Antioxidants for male subfertility publication-title: Cochrane Database Syst Rev – volume: 101 start-page: 1229 year: 2003 end-page: 1235 ident: bib29 article-title: Elevated sperm chromosome aneuploidy and apoptosis in patients with unexplained recurrent pregnancy loss publication-title: Obstet Gynecol – volume: 17 start-page: 1649 year: 2002 end-page: 1656 ident: bib45 article-title: Paternal age and maternal age are risk factors for miscarriage; results of a multicentre European study publication-title: Hum Reprod – volume: 111 start-page: 645 year: 1998 end-page: 656 ident: bib55 article-title: A novel signal transduction cascade in capacitating human spermatozoa characterized by a redox-regulated, cAMP-mediated induction of tyrosine phosphorylation publication-title: J Cell Sci – volume: 23 start-page: 2663 year: 2008 end-page: 2668 ident: bib9 article-title: Sperm DNA damage is associated with an increased risk of pregnancy loss after IVF and ICSI: systematic review and meta-analysis publication-title: Hum Reprod – volume: 91 start-page: 1801 year: 2009 end-page: 1805 ident: bib10 article-title: Correlation between DNA damage and sperm parameters: a prospective study of 1,633 patients publication-title: Fertil Steril – volume: 284 start-page: 696 year: 1999 end-page: 704 ident: bib47 article-title: Fertilizing ability of DNA-damaged spermatozoa publication-title: J Exp Zool – volume: 73 start-page: 461 year: 2009 end-page: 469 ident: bib53 article-title: Role of oxidative stress in pathogenesis of varicocele and infertility publication-title: Urology – volume: 60 start-page: 336 year: 1993 end-page: 343 ident: bib61 article-title: Effects of pentoxifylline on sperm motility and hyperactivation in normozoospermic and normokinetic semen publication-title: Fertil Steril – volume: 87 start-page: 93 year: 2007 end-page: 100 ident: bib14 article-title: Sperm deoxyribonucleic acid fragmentation as a prognostic indicator of assisted reproductive technology outcome publication-title: Fertil Steril – volume: 26 start-page: 68 year: 2013 end-page: 78 ident: bib19 article-title: Sperm DNA damage has a negative association with live-birth rates after IVF publication-title: Reprod Biomed Online – volume: 14 start-page: 243 year: 2008 end-page: 258 ident: bib52 article-title: Oxidative stress and male infertility—a clinical perspective publication-title: Hum Reprod Update – volume: 76 start-page: 1119 year: 2001 end-page: 1123 ident: bib23 article-title: Effect of paternal age on human sperm chromosomes publication-title: Fertil Steril – volume: 81 start-page: 1289 year: 2004 end-page: 1295 ident: bib12 article-title: Sperm chromatin structure assay (SCSA) parameters are related to fertilization, blastocyst development, and ongoing pregnancy in in vitro fertilization and intracytoplasmic sperm injection cycles publication-title: Fertil Steril – volume: 17 start-page: 990 year: 2002 end-page: 998 ident: bib24 article-title: The spectrum of DNA damage in human sperm assessed by single cell gel electrophoresis (Comet assay) and its relationship to fertilization and embryo development publication-title: Hum Reprod – volume: 14 start-page: 2279 year: 1999 end-page: 2285 ident: bib27 article-title: Developmental capacity of damaged spermatozoa publication-title: Hum Reprod – volume: 81 start-page: 965 year: 2004 end-page: 972 ident: bib30 article-title: Influence of deoxyribonucleic acid damage on fertilization and pregnancy publication-title: Fertil Steril – volume: 20 start-page: 711 year: 2010 end-page: 723 ident: bib59 article-title: A systematic review of the effect of oral antioxidants on male infertility publication-title: Reprod Biomed Online – volume: 291 start-page: 1693 year: 1985 end-page: 1697 ident: bib1 article-title: Population study of causes, treatment, and outcome of infertility publication-title: Br Med J (Clin Res Ed) – volume: 13 start-page: 1864 year: 1998 end-page: 1871 ident: bib26 article-title: Oxidative damage to DNA in human spermatozoa does not preclude pronucleus formation at intracytoplasmic sperm injection publication-title: Hum Reprod – volume: 90 start-page: 352 year: 2008 end-page: 359 ident: bib17 article-title: Sperm chromatin structure assay parameters are not related to fertilization rates, embryo quality, and pregnancy rates in in vitro fertilization and intracytoplasmic sperm injection, but might be related to spontaneous abortion rates publication-title: Fertil Steril – reference: Wells G, Shea B, O' Connell D. The Newcastle-Ottawa Scale (NOS) for assessing the quality of non-randomised studies in meta-analysis. In: Proceedings or the Third Symposium on Systematic Reviews Beyond the Basics. Improving Quality and Impact. July 3–5, 2000; Oxford, United Kingdom: The Ottawa Health Research Institute; 2000. – volume: 23 start-page: 704 year: 2011 end-page: 710 ident: bib71 article-title: Impact of sperm DNA fragmentation on the outcome of IVF with own or donated oocytes. publication-title: Reprod BioMed Online – volume: 89 start-page: 823 year: 2008 end-page: 831 ident: bib40 article-title: Do sperm DNA integrity tests predict pregnancy with in vitro fertilization? publication-title: Fertil Steril – volume: 22 start-page: 169 year: 2000 end-page: 189 ident: bib67 article-title: Sperm chromatin structure assay is useful for fertility assessment publication-title: Methods Cell Sci – volume: 16 start-page: 2160 year: 2001 end-page: 2165 ident: bib28 article-title: Interrelationships between seminal parameters and sperm nuclear DNA damage before and after density gradient centrifugation: implications for assisted conception publication-title: Hum Reprod – volume: 95 start-page: 652 year: 2011 end-page: 657 ident: bib3 article-title: Sperm DNA damage measured by the alkaline Comet assay as an independent predictor of male infertility and in vitro fertilization success publication-title: Fertil Steril – volume: 19 start-page: 1401 year: 2004 end-page: 1408 ident: bib11 article-title: The predictive value of sperm chromatin structure assay (SCSA) parameters for the outcome of intrauterine insemination, IVF and ICSI publication-title: Hum Reprod – volume: 29 start-page: 125 year: 1997 end-page: 131 ident: bib62 article-title: Scavenging effect of N-acetyl-L-cysteine against reactive oxygen species in human semen: a possible therapeutic modality for male factor infertility? publication-title: Andrologia – volume: 100 start-page: 75 year: 2013 end-page: 80 ident: bib20 article-title: In vitro fertilization- intracytoplasmic sperm injection outcome in patients with a markedly high DNA fragmentation index (>50%) publication-title: Fertil Steril – volume: 59 start-page: 1037 year: 1998 end-page: 1046 ident: bib32 article-title: Relative impact of oxidative stress on the functional competence and genomic integrity of human spermatozoa publication-title: Biol Reprod – volume: 21 start-page: 2876 year: 2006 end-page: 2881 ident: bib39 article-title: Sperm DNA fragmentation: paternal effect on early post-implantation embryo development in ART publication-title: Hum Reprod – volume: 112 start-page: 584 year: 1982 end-page: 591 ident: bib64 article-title: Effects of ascorbic acid on in vitro steroidogenesis in guinea pigs publication-title: J Nutr – volume: 20 start-page: 226 year: 2005 end-page: 230 ident: bib43 article-title: Efficient treatment of infertility due to sperm DNA damage by ICSI with testicular spermatozoa publication-title: Hum Reprod – volume: 67 start-page: 142 year: 1997 end-page: 147 ident: bib57 article-title: Comparison of individual antioxidants of sperm and seminal plasma in fertile and infertile men publication-title: Fertil Steril – volume: 90 start-page: 1800 year: 2008 end-page: 1804 ident: bib68 article-title: Significant decrease in sperm deoxyribonucleic acid fragmentation after varicocelectomy publication-title: Fertil Steril – volume: 51 start-page: 121 year: 2005 end-page: 124 ident: bib13 article-title: Effect of an abnormal sperm chromatin structural assay (SCSA) on pregnancy outcome following (IVF) with ICSI in previous IVF failures publication-title: Arch Androl – volume: 27 start-page: 2908 year: 2012 end-page: 2917 ident: bib41 article-title: The effect of sperm DNA fragmentation on miscarriage rates: a systematic review and meta-analysis publication-title: Hum Reprod – volume: 49 start-page: 49 year: 2003 end-page: 55 ident: bib25 article-title: Sperm DNA fragmentation is increased in couples with unexplained recurrent pregnancy loss publication-title: Arch Androl – volume: 19 start-page: 611 year: 2004 end-page: 615 ident: bib31 article-title: Late, but not early, paternal effect on human embryo development is related to sperm DNA fragmentation publication-title: Hum Reprod – volume: 15 start-page: 208 year: 2007 end-page: 214 ident: bib18 article-title: Relationship between sperm DNA damage, induced acrosome reaction and viability in ICSI patients publication-title: Reprod Biomed Online – volume: 22 start-page: 174 year: 2007 end-page: 179 ident: bib15 article-title: Sperm DNA integrity assessment in prediction of assisted reproduction technology outcome publication-title: Hum Reprod – volume: 29 start-page: 47 year: 2008 end-page: 54 ident: bib49 article-title: Factors from damaged sperm affect its DNA integrity and its ability to promote embryo implantation in mice publication-title: J Androl – volume: 134 start-page: 31 year: 2007 end-page: 40 ident: bib6 article-title: Is sperm evaluation useful in predicting human fertility? publication-title: Reproduction – volume: 80 start-page: 895 year: 2003 end-page: 902 ident: bib36 article-title: Relationship between the outcomes of assisted reproductive techniques and sperm DNA fragmentation as measured by the sperm chromatin structure assay publication-title: Fertil Steril – volume: 791 start-page: 151 year: 2014 end-page: 172 ident: bib69 article-title: Sperm selection: effect on sperm DNA quality publication-title: Adv Exp Med Biol – volume: 65 start-page: 81 year: 2007 end-page: 92 ident: bib7 article-title: Value of DNA integrity assays for fertility evaluation publication-title: Soc Reprod Fertil Suppl – volume: 27 start-page: 176 year: 2006 end-page: 188 ident: bib48 article-title: DNA damage in bovine sperm does not block fertilization and early embryonic development but induces apoptosis after the first cleavages publication-title: J Androl – volume: 10 start-page: 3139 year: 1995 end-page: 3141 ident: bib2 article-title: Randomized comparison of ovulation induction with and without intrauterine insemination in the treatment of unexplained infertility publication-title: Hum Reprod – volume: 72 start-page: 484 year: 1999 end-page: 495 ident: bib65 article-title: Antioxidant supplementation in vitro does not improve human sperm motility publication-title: Fertil Steril – volume: 4 start-page: 2227 year: 1995 end-page: 2232 ident: bib21 article-title: Non-disjunction in human sperm: evidence for an effect of increasing paternal age publication-title: Hum Mol Genet – volume: 73 start-page: 43 year: 2000 end-page: 50 ident: bib22 article-title: Sperm chromatin damage impairs human fertility. The Danish First Pregnancy Planner Study Team publication-title: Fertil Steril – volume: 88 start-page: 11003 year: 1991 end-page: 11006 ident: bib66 article-title: Ascorbic acid protects against endogenous oxidative DNA damage in human sperm publication-title: Proc Natl Acad Sci U S A – volume: 80 start-page: 1404 year: 2003 end-page: 1412 ident: bib5 article-title: Correlation between sperm motility and sperm chromatin structure assay parameters publication-title: Fertil Steril – volume: 20 start-page: 1018 year: 2005 end-page: 1021 ident: bib37 article-title: Beneficial effect of microsurgical varicocelectomy on human sperm DNA integrity publication-title: Hum Reprod – volume: 65 start-page: 93 year: 2007 end-page: 113 ident: bib8 article-title: Analysis of sperm DNA fragmentation using flow cytometry and other techniques publication-title: Soc Reprod Fertil Suppl – volume: 14 start-page: 1039 year: 1999 end-page: 1049 ident: bib46 article-title: Utility of the sperm chromatin structure assay as a diagnostic and prognostic tool in the human fertility clinic publication-title: Hum Reprod – volume: 93 start-page: 1027 year: 2010 end-page: 1036 ident: bib50 article-title: Sperm DNA fragmentation: mechanisms of origin, impact on reproductive outcome, and analysis publication-title: Fertil Steril – volume: 7 start-page: 477 year: 2003 end-page: 484 ident: bib35 article-title: DNA fragmentation of spermatozoa and assisted reproduction technology publication-title: Reprod Biomed Online – volume: 47 start-page: 216 year: 2007 end-page: 221 ident: bib58 article-title: A randomised control trial examining the effect of an antioxidant (Menevit) on pregnancy outcome during IVF-ICSI treatment publication-title: Aust N Z J Obstet Gynaecol – volume: 59 start-page: 1037 year: 1998 ident: 10.1016/j.fertnstert.2014.06.033_bib32 article-title: Relative impact of oxidative stress on the functional competence and genomic integrity of human spermatozoa publication-title: Biol Reprod doi: 10.1095/biolreprod59.5.1037 – volume: 81 start-page: 1289 year: 2004 ident: 10.1016/j.fertnstert.2014.06.033_bib12 article-title: Sperm chromatin structure assay (SCSA) parameters are related to fertilization, blastocyst development, and ongoing pregnancy in in vitro fertilization and intracytoplasmic sperm injection cycles publication-title: Fertil Steril doi: 10.1016/j.fertnstert.2003.09.063 – volume: 81 start-page: 965 year: 2004 ident: 10.1016/j.fertnstert.2014.06.033_bib30 article-title: Influence of deoxyribonucleic acid damage on fertilization and pregnancy publication-title: Fertil Steril doi: 10.1016/j.fertnstert.2003.09.044 – volume: 80 start-page: 895 year: 2003 ident: 10.1016/j.fertnstert.2014.06.033_bib36 article-title: Relationship between the outcomes of assisted reproductive techniques and sperm DNA fragmentation as measured by the sperm chromatin structure assay publication-title: Fertil Steril doi: 10.1016/S0015-0282(03)01116-6 – volume: 16 start-page: 2160 year: 2001 ident: 10.1016/j.fertnstert.2014.06.033_bib28 article-title: Interrelationships between seminal parameters and sperm nuclear DNA damage before and after density gradient centrifugation: implications for assisted conception publication-title: Hum Reprod doi: 10.1093/humrep/16.10.2160 – volume: 15 start-page: 208 year: 2007 ident: 10.1016/j.fertnstert.2014.06.033_bib18 article-title: Relationship between sperm DNA damage, induced acrosome reaction and viability in ICSI patients publication-title: Reprod Biomed Online doi: 10.1016/S1472-6483(10)60710-9 – volume: 22 start-page: 169 year: 2000 ident: 10.1016/j.fertnstert.2014.06.033_bib67 article-title: Sperm chromatin structure assay is useful for fertility assessment publication-title: Methods Cell Sci doi: 10.1023/A:1009844109023 – volume: 90 start-page: 352 year: 2008 ident: 10.1016/j.fertnstert.2014.06.033_bib17 article-title: Sperm chromatin structure assay parameters are not related to fertilization rates, embryo quality, and pregnancy rates in in vitro fertilization and intracytoplasmic sperm injection, but might be related to spontaneous abortion rates publication-title: Fertil Steril doi: 10.1016/j.fertnstert.2007.06.018 – volume: 73 start-page: 43 year: 2000 ident: 10.1016/j.fertnstert.2014.06.033_bib22 article-title: Sperm chromatin damage impairs human fertility. The Danish First Pregnancy Planner Study Team publication-title: Fertil Steril doi: 10.1016/S0015-0282(99)00462-8 – volume: 91 start-page: 1801 year: 2009 ident: 10.1016/j.fertnstert.2014.06.033_bib10 article-title: Correlation between DNA damage and sperm parameters: a prospective study of 1,633 patients publication-title: Fertil Steril doi: 10.1016/j.fertnstert.2008.01.086 – volume: 101 start-page: 1229 year: 2003 ident: 10.1016/j.fertnstert.2014.06.033_bib29 article-title: Elevated sperm chromosome aneuploidy and apoptosis in patients with unexplained recurrent pregnancy loss publication-title: Obstet Gynecol – volume: 20 start-page: 226 year: 2005 ident: 10.1016/j.fertnstert.2014.06.033_bib43 article-title: Efficient treatment of infertility due to sperm DNA damage by ICSI with testicular spermatozoa publication-title: Hum Reprod doi: 10.1093/humrep/deh590 – volume: 60 start-page: 336 year: 1993 ident: 10.1016/j.fertnstert.2014.06.033_bib61 article-title: Effects of pentoxifylline on sperm motility and hyperactivation in normozoospermic and normokinetic semen publication-title: Fertil Steril doi: 10.1016/S0015-0282(16)56108-1 – volume: 20 start-page: 3476 year: 2005 ident: 10.1016/j.fertnstert.2014.06.033_bib38 article-title: Potential adverse effect of sperm DNA damage on embryo quality after ICSI publication-title: Hum Reprod doi: 10.1093/humrep/dei266 – volume: 90 start-page: 1800 year: 2008 ident: 10.1016/j.fertnstert.2014.06.033_bib68 article-title: Significant decrease in sperm deoxyribonucleic acid fragmentation after varicocelectomy publication-title: Fertil Steril doi: 10.1016/j.fertnstert.2006.09.019 – volume: 23 start-page: 163 year: 2008 ident: 10.1016/j.fertnstert.2014.06.033_bib51 article-title: Using the alkaline comet assay in prognostic tests for male infertility and assisted reproductive technology outcomes publication-title: Mutagenesis doi: 10.1093/mutage/gem052 – volume: 88 start-page: 11003 year: 1991 ident: 10.1016/j.fertnstert.2014.06.033_bib66 article-title: Ascorbic acid protects against endogenous oxidative DNA damage in human sperm publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.88.24.11003 – volume: 14 start-page: 418 year: 2007 ident: 10.1016/j.fertnstert.2014.06.033_bib63 article-title: Antioxidants to reduce sperm DNA fragmentation: an unexpected adverse effect publication-title: Reprod Biomed Online doi: 10.1016/S1472-6483(10)60887-5 – volume: 22 start-page: 174 year: 2007 ident: 10.1016/j.fertnstert.2014.06.033_bib15 article-title: Sperm DNA integrity assessment in prediction of assisted reproduction technology outcome publication-title: Hum Reprod doi: 10.1093/humrep/del326 – volume: 13 start-page: 1864 year: 1998 ident: 10.1016/j.fertnstert.2014.06.033_bib26 article-title: Oxidative damage to DNA in human spermatozoa does not preclude pronucleus formation at intracytoplasmic sperm injection publication-title: Hum Reprod doi: 10.1093/humrep/13.7.1864 – volume: 27 start-page: 2908 year: 2012 ident: 10.1016/j.fertnstert.2014.06.033_bib41 article-title: The effect of sperm DNA fragmentation on miscarriage rates: a systematic review and meta-analysis publication-title: Hum Reprod doi: 10.1093/humrep/des261 – volume: 19 start-page: 1409 year: 2004 ident: 10.1016/j.fertnstert.2014.06.033_bib34 article-title: Full-term pregnancies achieved with ICSI despite high levels of sperm chromatin damage publication-title: Hum Reprod doi: 10.1093/humrep/deh233 – volume: 87 start-page: 93 year: 2007 ident: 10.1016/j.fertnstert.2014.06.033_bib14 article-title: Sperm deoxyribonucleic acid fragmentation as a prognostic indicator of assisted reproductive technology outcome publication-title: Fertil Steril doi: 10.1016/j.fertnstert.2006.05.057 – volume: 51 start-page: 121 year: 2005 ident: 10.1016/j.fertnstert.2014.06.033_bib13 article-title: Effect of an abnormal sperm chromatin structural assay (SCSA) on pregnancy outcome following (IVF) with ICSI in previous IVF failures publication-title: Arch Androl doi: 10.1080/014850190518125 – volume: 19 start-page: 1401 year: 2004 ident: 10.1016/j.fertnstert.2014.06.033_bib11 article-title: The predictive value of sperm chromatin structure assay (SCSA) parameters for the outcome of intrauterine insemination, IVF and ICSI publication-title: Hum Reprod doi: 10.1093/humrep/deh280 – volume: 47 start-page: 216 year: 2007 ident: 10.1016/j.fertnstert.2014.06.033_bib58 article-title: A randomised control trial examining the effect of an antioxidant (Menevit) on pregnancy outcome during IVF-ICSI treatment publication-title: Aust N Z J Obstet Gynaecol doi: 10.1111/j.1479-828X.2007.00723.x – volume: 76 start-page: 1119 year: 2001 ident: 10.1016/j.fertnstert.2014.06.033_bib23 article-title: Effect of paternal age on human sperm chromosomes publication-title: Fertil Steril doi: 10.1016/S0015-0282(01)02894-1 – volume: 14 start-page: 2279 year: 1999 ident: 10.1016/j.fertnstert.2014.06.033_bib27 article-title: Developmental capacity of damaged spermatozoa publication-title: Hum Reprod doi: 10.1093/humrep/14.9.2279 – volume: 21 start-page: 2876 year: 2006 ident: 10.1016/j.fertnstert.2014.06.033_bib39 article-title: Sperm DNA fragmentation: paternal effect on early post-implantation embryo development in ART publication-title: Hum Reprod doi: 10.1093/humrep/del251 – volume: 89 start-page: 823 year: 2008 ident: 10.1016/j.fertnstert.2014.06.033_bib40 article-title: Do sperm DNA integrity tests predict pregnancy with in vitro fertilization? publication-title: Fertil Steril doi: 10.1016/j.fertnstert.2007.04.055 – volume: 17 start-page: 990 year: 2002 ident: 10.1016/j.fertnstert.2014.06.033_bib24 article-title: The spectrum of DNA damage in human sperm assessed by single cell gel electrophoresis (Comet assay) and its relationship to fertilization and embryo development publication-title: Hum Reprod doi: 10.1093/humrep/17.4.990 – volume: 14 start-page: 1039 year: 1999 ident: 10.1016/j.fertnstert.2014.06.033_bib46 article-title: Utility of the sperm chromatin structure assay as a diagnostic and prognostic tool in the human fertility clinic publication-title: Hum Reprod doi: 10.1093/humrep/14.4.1039 – volume: 23 start-page: 2663 year: 2008 ident: 10.1016/j.fertnstert.2014.06.033_bib9 article-title: Sperm DNA damage is associated with an increased risk of pregnancy loss after IVF and ICSI: systematic review and meta-analysis publication-title: Hum Reprod doi: 10.1093/humrep/den321 – volume: 65 start-page: 81 year: 2007 ident: 10.1016/j.fertnstert.2014.06.033_bib7 article-title: Value of DNA integrity assays for fertility evaluation publication-title: Soc Reprod Fertil Suppl – volume: 4 start-page: 2227 year: 1995 ident: 10.1016/j.fertnstert.2014.06.033_bib21 article-title: Non-disjunction in human sperm: evidence for an effect of increasing paternal age publication-title: Hum Mol Genet doi: 10.1093/hmg/4.12.2227 – volume: 67 start-page: 142 year: 1997 ident: 10.1016/j.fertnstert.2014.06.033_bib57 article-title: Comparison of individual antioxidants of sperm and seminal plasma in fertile and infertile men publication-title: Fertil Steril doi: 10.1016/S0015-0282(97)81871-7 – volume: 95 start-page: 652 year: 2011 ident: 10.1016/j.fertnstert.2014.06.033_bib3 article-title: Sperm DNA damage measured by the alkaline Comet assay as an independent predictor of male infertility and in vitro fertilization success publication-title: Fertil Steril doi: 10.1016/j.fertnstert.2010.08.019 – volume: 291 start-page: 1693 year: 1985 ident: 10.1016/j.fertnstert.2014.06.033_bib1 article-title: Population study of causes, treatment, and outcome of infertility publication-title: Br Med J (Clin Res Ed) doi: 10.1136/bmj.291.6510.1693 – volume: 80 start-page: 1404 year: 2003 ident: 10.1016/j.fertnstert.2014.06.033_bib5 article-title: Correlation between sperm motility and sperm chromatin structure assay parameters publication-title: Fertil Steril doi: 10.1016/S0015-0282(03)02212-X – volume: 21 start-page: 1576 year: 2006 ident: 10.1016/j.fertnstert.2014.06.033_bib70 article-title: The sperm chromatin structure assay as a diagnostic tool in the human fertility clinic. publication-title: Hum Reprod doi: 10.1093/humrep/del019 – volume: 791 start-page: 151 year: 2014 ident: 10.1016/j.fertnstert.2014.06.033_bib69 article-title: Sperm selection: effect on sperm DNA quality publication-title: Adv Exp Med Biol doi: 10.1007/978-1-4614-7783-9_10 – volume: 100 start-page: 75 year: 2013 ident: 10.1016/j.fertnstert.2014.06.033_bib20 article-title: In vitro fertilization- intracytoplasmic sperm injection outcome in patients with a markedly high DNA fragmentation index (>50%) publication-title: Fertil Steril doi: 10.1016/j.fertnstert.2013.03.011 – volume: 7 start-page: 477 year: 2003 ident: 10.1016/j.fertnstert.2014.06.033_bib35 article-title: DNA fragmentation of spermatozoa and assisted reproduction technology publication-title: Reprod Biomed Online doi: 10.1016/S1472-6483(10)61893-7 – volume: 69 start-page: 528 year: 1998 ident: 10.1016/j.fertnstert.2014.06.033_bib33 article-title: Sperm deoxyribonucleic acid fragmentation is increased in poor-quality semen samples and correlates with failed fertilization in intracytoplasmic sperm injection publication-title: Fertil Steril doi: 10.1016/S0015-0282(97)00536-0 – volume: 112 start-page: 584 year: 1982 ident: 10.1016/j.fertnstert.2014.06.033_bib64 article-title: Effects of ascorbic acid on in vitro steroidogenesis in guinea pigs publication-title: J Nutr doi: 10.1093/jn/112.3.584 – volume: 27 start-page: 176 year: 2006 ident: 10.1016/j.fertnstert.2014.06.033_bib48 article-title: DNA damage in bovine sperm does not block fertilization and early embryonic development but induces apoptosis after the first cleavages publication-title: J Androl doi: 10.2164/jandrol.04152 – volume: 72 start-page: 484 year: 1999 ident: 10.1016/j.fertnstert.2014.06.033_bib65 article-title: Antioxidant supplementation in vitro does not improve human sperm motility publication-title: Fertil Steril doi: 10.1016/S0015-0282(99)00267-8 – volume: 49 start-page: 49 year: 2003 ident: 10.1016/j.fertnstert.2014.06.033_bib25 article-title: Sperm DNA fragmentation is increased in couples with unexplained recurrent pregnancy loss publication-title: Arch Androl doi: 10.1080/01485010290099390 – volume: 26 start-page: 68 year: 2013 ident: 10.1016/j.fertnstert.2014.06.033_bib19 article-title: Sperm DNA damage has a negative association with live-birth rates after IVF publication-title: Reprod Biomed Online doi: 10.1016/j.rbmo.2012.09.019 – volume: 73 start-page: 461 year: 2009 ident: 10.1016/j.fertnstert.2014.06.033_bib53 article-title: Role of oxidative stress in pathogenesis of varicocele and infertility publication-title: Urology doi: 10.1016/j.urology.2008.07.053 – volume: 17 start-page: 1649 year: 2002 ident: 10.1016/j.fertnstert.2014.06.033_bib45 article-title: Paternal age and maternal age are risk factors for miscarriage; results of a multicentre European study publication-title: Hum Reprod doi: 10.1093/humrep/17.6.1649 – ident: 10.1016/j.fertnstert.2014.06.033_bib42 – volume: 19 start-page: 611 year: 2004 ident: 10.1016/j.fertnstert.2014.06.033_bib31 article-title: Late, but not early, paternal effect on human embryo development is related to sperm DNA fragmentation publication-title: Hum Reprod doi: 10.1093/humrep/deh127 – start-page: CD007411 year: 2011 ident: 10.1016/j.fertnstert.2014.06.033_bib60 article-title: Antioxidants for male subfertility publication-title: Cochrane Database Syst Rev – volume: 57 start-page: 133 year: 2011 ident: 10.1016/j.fertnstert.2014.06.033_bib4 article-title: Sperm DNA damage or progressive motility: which one is the better predictor of fertilization in vitro? publication-title: Syst Biol Reprod Med doi: 10.3109/19396368.2011.553984 – volume: 56 start-page: 602 year: 1997 ident: 10.1016/j.fertnstert.2014.06.033_bib44 article-title: Detection of deoxyribonucleic acid fragmentation in human sperm: correlation with fertilization in vitro publication-title: Biol Reprod doi: 10.1095/biolreprod56.3.602 – volume: 93 start-page: 1027 year: 2010 ident: 10.1016/j.fertnstert.2014.06.033_bib50 article-title: Sperm DNA fragmentation: mechanisms of origin, impact on reproductive outcome, and analysis publication-title: Fertil Steril doi: 10.1016/j.fertnstert.2009.10.046 – volume: 111 start-page: 645 issue: Pt 5 year: 1998 ident: 10.1016/j.fertnstert.2014.06.033_bib55 article-title: A novel signal transduction cascade in capacitating human spermatozoa characterized by a redox-regulated, cAMP-mediated induction of tyrosine phosphorylation publication-title: J Cell Sci doi: 10.1242/jcs.111.5.645 – volume: 65 start-page: 93 year: 2007 ident: 10.1016/j.fertnstert.2014.06.033_bib8 article-title: Analysis of sperm DNA fragmentation using flow cytometry and other techniques publication-title: Soc Reprod Fertil Suppl – volume: 29 start-page: 47 year: 2008 ident: 10.1016/j.fertnstert.2014.06.033_bib49 article-title: Factors from damaged sperm affect its DNA integrity and its ability to promote embryo implantation in mice publication-title: J Androl doi: 10.2164/jandrol.107.003194 – volume: 10 start-page: 3139 year: 1995 ident: 10.1016/j.fertnstert.2014.06.033_bib2 article-title: Randomized comparison of ovulation induction with and without intrauterine insemination in the treatment of unexplained infertility publication-title: Hum Reprod doi: 10.1093/oxfordjournals.humrep.a135875 – volume: 14 start-page: 243 year: 2008 ident: 10.1016/j.fertnstert.2014.06.033_bib52 article-title: Oxidative stress and male infertility—a clinical perspective publication-title: Hum Reprod Update doi: 10.1093/humupd/dmn004 – volume: 20 start-page: 711 year: 2010 ident: 10.1016/j.fertnstert.2014.06.033_bib59 article-title: A systematic review of the effect of oral antioxidants on male infertility publication-title: Reprod Biomed Online doi: 10.1016/j.rbmo.2010.03.008 – volume: 20 start-page: 1018 year: 2005 ident: 10.1016/j.fertnstert.2014.06.033_bib37 article-title: Beneficial effect of microsurgical varicocelectomy on human sperm DNA integrity publication-title: Hum Reprod doi: 10.1093/humrep/deh701 – volume: 29 start-page: 125 year: 1997 ident: 10.1016/j.fertnstert.2014.06.033_bib62 article-title: Scavenging effect of N-acetyl-L-cysteine against reactive oxygen species in human semen: a possible therapeutic modality for male factor infertility? publication-title: Andrologia doi: 10.1111/j.1439-0272.1997.tb00305.x – volume: 284 start-page: 696 year: 1999 ident: 10.1016/j.fertnstert.2014.06.033_bib47 article-title: Fertilizing ability of DNA-damaged spermatozoa publication-title: J Exp Zool doi: 10.1002/(SICI)1097-010X(19991101)284:6<696::AID-JEZ11>3.0.CO;2-E – volume: 351 start-page: 199 year: 1996 ident: 10.1016/j.fertnstert.2014.06.033_bib56 article-title: Smoking and low antioxidant levels increase oxidative damage to sperm DNA publication-title: Mutat Res doi: 10.1016/0027-5107(95)00251-0 – volume: 89 start-page: 92 year: 2008 ident: 10.1016/j.fertnstert.2014.06.033_bib16 article-title: Adequate ovarian follicular status does not prevent the decrease in pregnancy rates associated with high sperm DNA fragmentation publication-title: Fertil Steril doi: 10.1016/j.fertnstert.2007.02.022 – volume: 134 start-page: 31 year: 2007 ident: 10.1016/j.fertnstert.2014.06.033_bib6 article-title: Is sperm evaluation useful in predicting human fertility? publication-title: Reproduction doi: 10.1530/REP-07-0152 – volume: 23 start-page: 704 year: 2011 ident: 10.1016/j.fertnstert.2014.06.033_bib71 article-title: Impact of sperm DNA fragmentation on the outcome of IVF with own or donated oocytes. publication-title: Reprod BioMed Online doi: 10.1016/j.rbmo.2011.07.010 – volume: 16 start-page: 449 year: 2009 ident: 10.1016/j.fertnstert.2014.06.033_bib54 article-title: Role of antioxidants in the treatment of male infertility publication-title: Int J Urol doi: 10.1111/j.1442-2042.2009.02280.x – reference: 26088246 - J Urol. 2015 Jul;194(1):170. doi: 10.1016/j.juro.2015.04.005. |
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| Snippet | To examine whether sperm DNA fragmentation has an effect on pregnancy and miscarriage after IVF and/or intracytoplasmic sperm injection (ICSI).
Systematic... Objective To examine whether sperm DNA fragmentation has an effect on pregnancy and miscarriage after IVF and/or intracytoplasmic sperm injection (ICSI).... To examine whether sperm DNA fragmentation has an effect on pregnancy and miscarriage after IVF and/or intracytoplasmic sperm injection (ICSI).OBJECTIVETo... |
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| SubjectTerms | Abortion, Spontaneous - etiology Abortion, Spontaneous - genetics Abortion, Spontaneous - pathology Abortion, Spontaneous - prevention & control assisted reproductive technology Chi-Square Distribution DNA Fragmentation Female Fertility Fertilization in Vitro - adverse effects Humans Infertility - diagnosis Infertility - physiopathology Infertility - therapy Internal Medicine Male miscarriage Obstetrics and Gynecology Odds Ratio Pregnancy Pregnancy Rate Risk Assessment Risk Factors Sperm DNA damage sperm DNA fragmentation Sperm Injections, Intracytoplasmic - adverse effects Spermatozoa - pathology Treatment Outcome |
| Title | Whether sperm deoxyribonucleic acid fragmentation has an effect on pregnancy and miscarriage after in vitro fertilization/intracytoplasmic sperm injection: a systematic review and meta-analysis |
| URI | https://www.clinicalkey.com/#!/content/1-s2.0-S0015028214005792 https://www.clinicalkey.es/playcontent/1-s2.0-S0015028214005792 https://dx.doi.org/10.1016/j.fertnstert.2014.06.033 https://www.ncbi.nlm.nih.gov/pubmed/25190048 https://www.proquest.com/docview/1586094113 |
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