End-joining inhibition at telomeres requires the translocase and polySUMO-dependent ubiquitin ligase Uls1

In eukaryotes, permanent inhibition of the non‐homologous end joining (NHEJ) repair pathway at telomeres ensures that chromosome ends do not fuse. In budding yeast, binding of Rap1 to telomere repeats establishes NHEJ inhibition. Here, we show that the Uls1 protein is required for the maintenance of...

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Bibliographic Details
Published inThe EMBO journal Vol. 32; no. 6; pp. 805 - 815
Main Authors Lescasse, Rachel, Pobiega, Sabrina, Callebaut, Isabelle, Marcand, Stéphane
Format Journal Article
LanguageEnglish
Published Chichester, UK John Wiley & Sons, Ltd 20.03.2013
Nature Publishing Group UK
Springer Nature B.V
EMBO Press
Nature Publishing Group
Subjects
Biochemistry, Molecular Biology
Deoxyribonucleic acid
DNA
DNA End-Joining Repair
DNA Helicases - metabolism
DNA Helicases - physiology
Down-Regulation
EMBO13
EMBO31
Eukaryotes
Inhibition
Life Sciences
NHEJ
Organisms, Genetically Modified
Peptidyl Transferases - metabolism
Peptidyl Transferases - physiology
Protein Binding
Protein Multimerization - physiology
Proteins
rap1 GTP-Binding Proteins - metabolism
Saccharomyces cerevisiae
Saccharomyces cerevisiae - genetics
Saccharomyces cerevisiae - metabolism
Saccharomyces cerevisiae Proteins - metabolism
Saccharomyces cerevisiae Proteins - physiology
Silent Information Regulator Proteins, Saccharomyces cerevisiae - metabolism
Silent Information Regulator Proteins, Saccharomyces cerevisiae - physiology
Small Ubiquitin-Related Modifier Proteins - metabolism
Small Ubiquitin-Related Modifier Proteins - physiology
STUbL
SUMO
SUMO-1 Protein - metabolism
Sumoylation - physiology
Telomerase
telomere
Telomere - metabolism
Ubiquitin-Protein Ligases - metabolism
Ubiquitin-Protein Ligases - physiology
Yeasts
SUMO
NHEJ
STUbL
telomere
Online AccessGet full text
ISSN0261-4189
1460-2075
1460-2075
DOI10.1038/emboj.2013.24

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Abstract In eukaryotes, permanent inhibition of the non‐homologous end joining (NHEJ) repair pathway at telomeres ensures that chromosome ends do not fuse. In budding yeast, binding of Rap1 to telomere repeats establishes NHEJ inhibition. Here, we show that the Uls1 protein is required for the maintenance of NHEJ inhibition at telomeres. Uls1 protein is a non‐essential Swi2/Snf2‐related translocase and a Small Ubiquitin‐related Modifier (SUMO)‐Targeted Ubiquitin Ligase (STUbL) with unknown targets. Loss of Uls1 results in telomere–telomere fusions. Uls1 requirement is alleviated by the absence of poly‐SUMO chains and by rap1 alleles lacking SUMOylation sites. Furthermore, Uls1 limits the accumulation of Rap1 poly‐SUMO conjugates. We propose that one of Uls1 functions is to clear non‐functional poly‐SUMOylated Rap1 molecules from telomeres to ensure the continuous efficiency of NHEJ inhibition. Since Uls1 is the only known STUbL with a translocase activity, it can be the general molecular sweeper for the clearance of poly‐SUMOylated proteins on DNA in eukaryotes. A STUbL with DNA‐dependent ATPase activity protects telomeres by preventing accumulation of poly‐sumoylated Rap1 on chromosome ends.
AbstractList In eukaryotes, permanent inhibition of the non-homologous end joining (NHEJ) repair pathway at telomeres ensures that chromosome ends do not fuse. In budding yeast, binding of Rap1 to telomere repeats establishes NHEJ inhibition. Here, we show that the Uls1 protein is required for the maintenance of NHEJ inhibition at telomeres. Uls1 protein is a non-essential Swi2/Snf2-related translocase and a Small Ubiquitin-related Modifier (SUMO)-Targeted Ubiquitin Ligase (STUbL) with unknown targets. Loss of Uls1 results in telomere-telomere fusions. Uls1 requirement is alleviated by the absence of poly-SUMO chains and by rap1 alleles lacking SUMOylation sites. Furthermore, Uls1 limits the accumulation of Rap1 poly-SUMO conjugates. We propose that one of Uls1 functions is to clear non-functional poly-SUMOylated Rap1 molecules from telomeres to ensure the continuous efficiency of NHEJ inhibition. Since Uls1 is the only known STUbL with a translocase activity, it can be the general molecular sweeper for the clearance of poly-SUMOylated proteins on DNA in eukaryotes.
In eukaryotes, permanent inhibition of the non‐homologous end joining (NHEJ) repair pathway at telomeres ensures that chromosome ends do not fuse. In budding yeast, binding of Rap1 to telomere repeats establishes NHEJ inhibition. Here, we show that the Uls1 protein is required for the maintenance of NHEJ inhibition at telomeres. Uls1 protein is a non‐essential Swi2/Snf2‐related translocase and a Small Ubiquitin‐related Modifier (SUMO)‐Targeted Ubiquitin Ligase (STUbL) with unknown targets. Loss of Uls1 results in telomere–telomere fusions. Uls1 requirement is alleviated by the absence of poly‐SUMO chains and by rap1 alleles lacking SUMOylation sites. Furthermore, Uls1 limits the accumulation of Rap1 poly‐SUMO conjugates. We propose that one of Uls1 functions is to clear non‐functional poly‐SUMOylated Rap1 molecules from telomeres to ensure the continuous efficiency of NHEJ inhibition. Since Uls1 is the only known STUbL with a translocase activity, it can be the general molecular sweeper for the clearance of poly‐SUMOylated proteins on DNA in eukaryotes. A STUbL with DNA‐dependent ATPase activity protects telomeres by preventing accumulation of poly‐sumoylated Rap1 on chromosome ends.
In eukaryotes, permanent inhibition of the non-homologous end joining (NHEJ) repair pathway at telomeres ensures that chromosome ends do not fuse. In budding yeast, binding of Rap1 to telomere repeats establishes NHEJ inhibition. Here, we show that the Uls1 protein is required for the maintenance of NHEJ inhibition at telomeres. Uls1 protein is a non-essential Swi2/Snf2-related translocase and a Small Ubiquitin-related Modifier (SUMO)-Targeted Ubiquitin Ligase (STUbL) with unknown targets. Loss of Uls1 results in telomere-telomere fusions. Uls1 requirement is alleviated by the absence of poly-SUMO chains and by rap1 alleles lacking SUMOylation sites. Furthermore, Uls1 limits the accumulation of Rap1 poly-SUMO conjugates. We propose that one of Uls1 functions is to clear non-functional poly-SUMOylated Rap1 molecules from telomeres to ensure the continuous efficiency of NHEJ inhibition. Since Uls1 is the only known STUbL with a translocase activity, it can be the general molecular sweeper for the clearance of poly-SUMOylated proteins on DNA in eukaryotes.In eukaryotes, permanent inhibition of the non-homologous end joining (NHEJ) repair pathway at telomeres ensures that chromosome ends do not fuse. In budding yeast, binding of Rap1 to telomere repeats establishes NHEJ inhibition. Here, we show that the Uls1 protein is required for the maintenance of NHEJ inhibition at telomeres. Uls1 protein is a non-essential Swi2/Snf2-related translocase and a Small Ubiquitin-related Modifier (SUMO)-Targeted Ubiquitin Ligase (STUbL) with unknown targets. Loss of Uls1 results in telomere-telomere fusions. Uls1 requirement is alleviated by the absence of poly-SUMO chains and by rap1 alleles lacking SUMOylation sites. Furthermore, Uls1 limits the accumulation of Rap1 poly-SUMO conjugates. We propose that one of Uls1 functions is to clear non-functional poly-SUMOylated Rap1 molecules from telomeres to ensure the continuous efficiency of NHEJ inhibition. Since Uls1 is the only known STUbL with a translocase activity, it can be the general molecular sweeper for the clearance of poly-SUMOylated proteins on DNA in eukaryotes.
A STUbL with DNA-dependent ATPase activity protects telomeres by preventing accumulation of poly-sumoylated Rap1 on chromosome ends. In eukaryotes, permanent inhibition of the non-homologous end joining (NHEJ) repair pathway at telomeres ensures that chromosome ends do not fuse. In budding yeast, binding of Rap1 to telomere repeats establishes NHEJ inhibition. Here, we show that the Uls1 protein is required for the maintenance of NHEJ inhibition at telomeres. Uls1 protein is a non-essential Swi2/Snf2-related translocase and a Small Ubiquitin-related Modifier (SUMO)-Targeted Ubiquitin Ligase (STUbL) with unknown targets. Loss of Uls1 results in telomere–telomere fusions. Uls1 requirement is alleviated by the absence of poly-SUMO chains and by rap1 alleles lacking SUMOylation sites. Furthermore, Uls1 limits the accumulation of Rap1 poly-SUMO conjugates. We propose that one of Uls1 functions is to clear non-functional poly-SUMOylated Rap1 molecules from telomeres to ensure the continuous efficiency of NHEJ inhibition. Since Uls1 is the only known STUbL with a translocase activity, it can be the general molecular sweeper for the clearance of poly-SUMOylated proteins on DNA in eukaryotes.
In eukaryotes, permanent inhibition of the non‐homologous end joining (NHEJ) repair pathway at telomeres ensures that chromosome ends do not fuse. In budding yeast, binding of Rap1 to telomere repeats establishes NHEJ inhibition. Here, we show that the Uls1 protein is required for the maintenance of NHEJ inhibition at telomeres. Uls1 protein is a non‐essential Swi2/Snf2‐related translocase and a Small Ubiquitin‐related Modifier (SUMO)‐Targeted Ubiquitin Ligase (STUbL) with unknown targets. Loss of Uls1 results in telomere–telomere fusions. Uls1 requirement is alleviated by the absence of poly‐SUMO chains and by rap1 alleles lacking SUMOylation sites. Furthermore, Uls1 limits the accumulation of Rap1 poly‐SUMO conjugates. We propose that one of Uls1 functions is to clear non‐functional poly‐SUMOylated Rap1 molecules from telomeres to ensure the continuous efficiency of NHEJ inhibition. Since Uls1 is the only known STUbL with a translocase activity, it can be the general molecular sweeper for the clearance of poly‐SUMOylated proteins on DNA in eukaryotes. A STUbL with DNA‐dependent ATPase activity protects telomeres by preventing accumulation of poly‐sumoylated Rap1 on chromosome ends.
In eukaryotes, permanent inhibition of the nonhomologous end joining (NHEJ) repair pathway at telomeres ensures that chromosome ends do not fuse. In budding yeast, binding of Rap1 to telomere repeats establishes NHEJ inhibition. Here, we show that the Uls1 protein is required for the maintenance of NHEJ inhibition at telomeres. Uls1 protein is a non-essential Swi2/Snf2- related translocase and a Small Ubiquitin-related Modifier (SUMO)-Targeted Ubiquitin Ligase (STUbL) with unknown targets. Loss of Uls1 results in telomere-telomere fusions. Uls1 requirement is alleviated by the absence of poly-SUMO chains and by rap1 alleles lacking SUMOylation sites. Furthermore, Uls1 limits the accumulation of Rap1 poly-SUMO conjugates.We propose that one of Uls1 functions is to clear non-functional poly- SUMOylated Rap1 molecules from telomeres to ensure the continuous efficiency of NHEJ inhibition. Since Uls1 is the only known STUbL with a translocase activity, it can be the general molecular sweeper for the clearance of poly- SUMOylated proteins on DNA in eukaryotes.
Author Pobiega, Sabrina
Marcand, Stéphane
Lescasse, Rachel
Callebaut, Isabelle
Author_xml – sequence: 1
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  surname: Lescasse
  fullname: Lescasse, Rachel
  organization: CEA, Direction des sciences du vivant/Institut de radiobiologie cellulaire et moléculaire/Service instabilité génétique réparation recombinaison/Laboratoire télomère et réparation du chromosome, Fontenay-aux-roses, France
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  givenname: Sabrina
  surname: Pobiega
  fullname: Pobiega, Sabrina
  organization: CEA, Direction des sciences du vivant/Institut de radiobiologie cellulaire et moléculaire/Service instabilité génétique réparation recombinaison/Laboratoire télomère et réparation du chromosome, Fontenay-aux-roses, France
– sequence: 3
  givenname: Isabelle
  surname: Callebaut
  fullname: Callebaut, Isabelle
  organization: CNRS, UMR 7590, Institut de minéralogie et de physique des milieux condensés, Université Pierre et Marie Curie, Paris, France
– sequence: 4
  givenname: Stéphane
  surname: Marcand
  fullname: Marcand, Stéphane
  email: stephane.marcand@cea.fr
  organization: CEA, Direction des sciences du vivant/Institut de radiobiologie cellulaire et moléculaire/Service instabilité génétique réparation recombinaison/Laboratoire télomère et réparation du chromosome, Fontenay-aux-roses, France
BackLink https://www.ncbi.nlm.nih.gov/pubmed/23417015$$D View this record in MEDLINE/PubMed
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ContentType Journal Article
Copyright European Molecular Biology Organization 2013
Copyright © 2013 European Molecular Biology Organization
Copyright Nature Publishing Group Mar 20, 2013
Distributed under a Creative Commons Attribution 4.0 International License
Copyright © 2013, European Molecular Biology Organization 2013 European Molecular Biology Organization
Copyright_xml – notice: European Molecular Biology Organization 2013
– notice: Copyright © 2013 European Molecular Biology Organization
– notice: Copyright Nature Publishing Group Mar 20, 2013
– notice: Distributed under a Creative Commons Attribution 4.0 International License
– notice: Copyright © 2013, European Molecular Biology Organization 2013 European Molecular Biology Organization
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Issue 6
Keywords SUMO
NHEJ
STUbL
telomere
Language English
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Distributed under a Creative Commons Attribution 4.0 International License: http://creativecommons.org/licenses/by/4.0
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Sarthy, Bae, Scrafford, Baumann (CR34) 2009; 28
Shah, Zheng, Epshtein, Carey, Bishop, Klein (CR37) 2010; 39
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SSID ssj0005871
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Snippet In eukaryotes, permanent inhibition of the non‐homologous end joining (NHEJ) repair pathway at telomeres ensures that chromosome ends do not fuse. In budding...
In eukaryotes, permanent inhibition of the non-homologous end joining (NHEJ) repair pathway at telomeres ensures that chromosome ends do not fuse. In budding...
In eukaryotes, permanent inhibition of the nonhomologous end joining (NHEJ) repair pathway at telomeres ensures that chromosome ends do not fuse. In budding...
A STUbL with DNA-dependent ATPase activity protects telomeres by preventing accumulation of poly-sumoylated Rap1 on chromosome ends. In eukaryotes, permanent...
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pubmedcentral
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proquest
pubmed
crossref
wiley
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SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 805
SubjectTerms Biochemistry, Molecular Biology
Deoxyribonucleic acid
DNA
DNA End-Joining Repair
DNA Helicases - metabolism
DNA Helicases - physiology
Down-Regulation
EMBO13
EMBO31
Eukaryotes
Inhibition
Life Sciences
NHEJ
Organisms, Genetically Modified
Peptidyl Transferases - metabolism
Peptidyl Transferases - physiology
Protein Binding
Protein Multimerization - physiology
Proteins
rap1 GTP-Binding Proteins - metabolism
Saccharomyces cerevisiae
Saccharomyces cerevisiae - genetics
Saccharomyces cerevisiae - metabolism
Saccharomyces cerevisiae Proteins - metabolism
Saccharomyces cerevisiae Proteins - physiology
Silent Information Regulator Proteins, Saccharomyces cerevisiae - metabolism
Silent Information Regulator Proteins, Saccharomyces cerevisiae - physiology
Small Ubiquitin-Related Modifier Proteins - metabolism
Small Ubiquitin-Related Modifier Proteins - physiology
STUbL
SUMO
SUMO-1 Protein - metabolism
Sumoylation - physiology
Telomerase
telomere
Telomere - metabolism
Ubiquitin-Protein Ligases - metabolism
Ubiquitin-Protein Ligases - physiology
Yeasts
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Title End-joining inhibition at telomeres requires the translocase and polySUMO-dependent ubiquitin ligase Uls1
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https://link.springer.com/article/10.1038/emboj.2013.24
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