Ipragliflozin-induced adipose expansion inhibits cuff-induced vascular remodeling in mice - Mori, Kentaro; Tsuchiya, Kyoichiro; Nakamura, Suguru; Miyachi, Yasutaka; Shiba, Kumiko; Ogawa, Yoshihiro; Kitamura, Kenichiro (Cardiovascular diabetology, 2019)
Keywords: Adipocytes - drug effects; Adipocytes - metabolism; Adipocytes - pathology; Adipogenesis - drug effects; Adipose tissue; Adipose Tissue - drug effects; Adipose Tissue - metabolism; Adipose Tissue - pathology; Adipose Tissue - transplantation; Adiposity - drug effects; Angiology; Animals; Apolipoprotein E; Apolipoproteins; Cardiology; Cardiovascular diseases; Cells, Cultured; Cuff injury; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - drug therapy; Diabetes Mellitus, Type 2 - metabolism; Diabetes Mellitus, Type 2 - pathology; Diet, High-Fat; Disease Models, Animal; DNA methylation; Femoral artery; Femur; Fibrosis; Glucosides - pharmacology; Healthy adipose expansion; Hyperplasia; Inflammation; Inflammation Mediators - metabolism; Insulin Resistance; Leptin; Leukocyte migration; Macrophages; Macrophages - drug effects; Macrophages - metabolism; Male; Medicine; Medicine & Public Health; Mice, Inbred C57BL; Mice, Knockout, ApoE; Muscle, Smooth, Vascular - drug effects; Muscle, Smooth, Vascular - metabolism; Muscle, Smooth, Vascular - pathology; Myocytes, Smooth Muscle - drug effects; Myocytes, Smooth Muscle - metabolism; Myocytes, Smooth Muscle - pathology; Obesity; Obesity - metabolism; Obesity - pathology; Original Investigation; Paracrine Communication - drug effects; Pathogenesis; Pathophysiology; Perivascular adipose tissue; Rodents; Smooth muscle; Sodium; Sodium-glucose cotransporter; Sodium-Glucose Transporter 2 Inhibitors - pharmacology; Thiophenes - pharmacology; Vascular remodeling; Vascular Remodeling - drug effects; Vascular System Injuries - drug therapy; Vascular System Injuries - metabolism; Vascular System Injuries - pathology; United Kingdom--UK; United States--US; Japan; Vascular remodeling; Perivascular adipose tissue; Healthy adipose expansion; Cuff injury