Assessing the use of a micro-sampling device for measuring blood protein levels in healthy subjects and COVID-19 patients
Background Venous phlebotomy performed by trained personnel is critical for patient diagnosis and monitoring of chronic disease, but has limitations in resource-constrained settings, and represents an infection control challenge during outbreaks. Self-collection devices have the potential to shift p...
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| Published in | PloS one Vol. 17; no. 8; p. e0272572 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
San Francisco
Public Library of Science
10.08.2022
Public Library of Science (PLoS) |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1932-6203 1932-6203 |
| DOI | 10.1371/journal.pone.0272572 |
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| Abstract | Background Venous phlebotomy performed by trained personnel is critical for patient diagnosis and monitoring of chronic disease, but has limitations in resource-constrained settings, and represents an infection control challenge during outbreaks. Self-collection devices have the potential to shift phlebotomy closer to the point of care, supporting telemedicine strategies and virtual clinical trials. Here we assess a capillary blood micro-sampling device, the Tasso Serum Separator Tube (SST), for measuring blood protein levels in healthy subjects and non-hospitalized COVID-19 patients. Methods 57 healthy controls and 56 participants with mild/moderate COVID-19 were recruited at two U.S. military healthcare facilities. Healthy controls donated Tasso SST capillary serum, venous plasma and venous serum samples at multiple time points, while COVID-19 patients donated a single Tasso SST serum sample at enrolment. Concentrations of 17 protein inflammatory biomarkers were measured in all biospecimens by Ella multi-analyte immune-assay. Results Tasso SST serum protein measurements in healthy control subjects were highly reproducible, but their agreements with matched venous samples varied. Most of the selected proteins, including CRP, Ferritin, IL-6 and PCT, were well-correlated between Tasso SST and venous serum with little sample type bias, but concentrations of D-dimer, IL-1B and IL-1Ra were not. Self-collection at home with delayed sample processing was associated with significant concentrations differences for several analytes compared to supervised, in-clinic collection with rapid processing. Finally, Tasso SST serum protein concentrations were significantly elevated in in non-hospitalized COVID-19 patients compared with healthy controls. Conclusions Self-collection of capillary blood with micro-sampling devices provides an attractive alternative to routine phlebotomy. However, concentrations of certain analytes may differ significantly from those in venous samples, and factors including user proficiency, temperature control and time lags between specimen collection and processing need to be considered for their effect on sample quality and reproducibility. |
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| AbstractList | Venous phlebotomy performed by trained personnel is critical for patient diagnosis and monitoring of chronic disease, but has limitations in resource-constrained settings, and represents an infection control challenge during outbreaks. Self-collection devices have the potential to shift phlebotomy closer to the point of care, supporting telemedicine strategies and virtual clinical trials. Here we assess a capillary blood micro-sampling device, the Tasso Serum Separator Tube (SST), for measuring blood protein levels in healthy subjects and non-hospitalized COVID-19 patients. 57 healthy controls and 56 participants with mild/moderate COVID-19 were recruited at two U.S. military healthcare facilities. Healthy controls donated Tasso SST capillary serum, venous plasma and venous serum samples at multiple time points, while COVID-19 patients donated a single Tasso SST serum sample at enrolment. Concentrations of 17 protein inflammatory biomarkers were measured in all biospecimens by Ella multi-analyte immune-assay. Tasso SST serum protein measurements in healthy control subjects were highly reproducible, but their agreements with matched venous samples varied. Most of the selected proteins, including CRP, Ferritin, IL-6 and PCT, were well-correlated between Tasso SST and venous serum with little sample type bias, but concentrations of D-dimer, IL-1B and IL-1Ra were not. Self-collection at home with delayed sample processing was associated with significant concentrations differences for several analytes compared to supervised, in-clinic collection with rapid processing. Finally, Tasso SST serum protein concentrations were significantly elevated in in non-hospitalized COVID-19 patients compared with healthy controls. Self-collection of capillary blood with micro-sampling devices provides an attractive alternative to routine phlebotomy. However, concentrations of certain analytes may differ significantly from those in venous samples, and factors including user proficiency, temperature control and time lags between specimen collection and processing need to be considered for their effect on sample quality and reproducibility. Background Venous phlebotomy performed by trained personnel is critical for patient diagnosis and monitoring of chronic disease, but has limitations in resource-constrained settings, and represents an infection control challenge during outbreaks. Self-collection devices have the potential to shift phlebotomy closer to the point of care, supporting telemedicine strategies and virtual clinical trials. Here we assess a capillary blood micro-sampling device, the Tasso Serum Separator Tube (SST), for measuring blood protein levels in healthy subjects and non-hospitalized COVID-19 patients. Methods 57 healthy controls and 56 participants with mild/moderate COVID-19 were recruited at two U.S. military healthcare facilities. Healthy controls donated Tasso SST capillary serum, venous plasma and venous serum samples at multiple time points, while COVID-19 patients donated a single Tasso SST serum sample at enrolment. Concentrations of 17 protein inflammatory biomarkers were measured in all biospecimens by Ella multi-analyte immune-assay. Results Tasso SST serum protein measurements in healthy control subjects were highly reproducible, but their agreements with matched venous samples varied. Most of the selected proteins, including CRP, Ferritin, IL-6 and PCT, were well-correlated between Tasso SST and venous serum with little sample type bias, but concentrations of D-dimer, IL-1B and IL-1Ra were not. Self-collection at home with delayed sample processing was associated with significant concentrations differences for several analytes compared to supervised, in-clinic collection with rapid processing. Finally, Tasso SST serum protein concentrations were significantly elevated in in non-hospitalized COVID-19 patients compared with healthy controls. Conclusions Self-collection of capillary blood with micro-sampling devices provides an attractive alternative to routine phlebotomy. However, concentrations of certain analytes may differ significantly from those in venous samples, and factors including user proficiency, temperature control and time lags between specimen collection and processing need to be considered for their effect on sample quality and reproducibility. BackgroundVenous phlebotomy performed by trained personnel is critical for patient diagnosis and monitoring of chronic disease, but has limitations in resource-constrained settings, and represents an infection control challenge during outbreaks. Self-collection devices have the potential to shift phlebotomy closer to the point of care, supporting telemedicine strategies and virtual clinical trials. Here we assess a capillary blood micro-sampling device, the Tasso Serum Separator Tube (SST), for measuring blood protein levels in healthy subjects and non-hospitalized COVID-19 patients.Methods57 healthy controls and 56 participants with mild/moderate COVID-19 were recruited at two U.S. military healthcare facilities. Healthy controls donated Tasso SST capillary serum, venous plasma and venous serum samples at multiple time points, while COVID-19 patients donated a single Tasso SST serum sample at enrolment. Concentrations of 17 protein inflammatory biomarkers were measured in all biospecimens by Ella multi-analyte immune-assay.ResultsTasso SST serum protein measurements in healthy control subjects were highly reproducible, but their agreements with matched venous samples varied. Most of the selected proteins, including CRP, Ferritin, IL-6 and PCT, were well-correlated between Tasso SST and venous serum with little sample type bias, but concentrations of D-dimer, IL-1B and IL-1Ra were not. Self-collection at home with delayed sample processing was associated with significant concentrations differences for several analytes compared to supervised, in-clinic collection with rapid processing. Finally, Tasso SST serum protein concentrations were significantly elevated in in non-hospitalized COVID-19 patients compared with healthy controls.ConclusionsSelf-collection of capillary blood with micro-sampling devices provides an attractive alternative to routine phlebotomy. However, concentrations of certain analytes may differ significantly from those in venous samples, and factors including user proficiency, temperature control and time lags between specimen collection and processing need to be considered for their effect on sample quality and reproducibility. Venous phlebotomy performed by trained personnel is critical for patient diagnosis and monitoring of chronic disease, but has limitations in resource-constrained settings, and represents an infection control challenge during outbreaks. Self-collection devices have the potential to shift phlebotomy closer to the point of care, supporting telemedicine strategies and virtual clinical trials. Here we assess a capillary blood micro-sampling device, the Tasso Serum Separator Tube (SST), for measuring blood protein levels in healthy subjects and non-hospitalized COVID-19 patients.BACKGROUNDVenous phlebotomy performed by trained personnel is critical for patient diagnosis and monitoring of chronic disease, but has limitations in resource-constrained settings, and represents an infection control challenge during outbreaks. Self-collection devices have the potential to shift phlebotomy closer to the point of care, supporting telemedicine strategies and virtual clinical trials. Here we assess a capillary blood micro-sampling device, the Tasso Serum Separator Tube (SST), for measuring blood protein levels in healthy subjects and non-hospitalized COVID-19 patients.57 healthy controls and 56 participants with mild/moderate COVID-19 were recruited at two U.S. military healthcare facilities. Healthy controls donated Tasso SST capillary serum, venous plasma and venous serum samples at multiple time points, while COVID-19 patients donated a single Tasso SST serum sample at enrolment. Concentrations of 17 protein inflammatory biomarkers were measured in all biospecimens by Ella multi-analyte immune-assay.METHODS57 healthy controls and 56 participants with mild/moderate COVID-19 were recruited at two U.S. military healthcare facilities. Healthy controls donated Tasso SST capillary serum, venous plasma and venous serum samples at multiple time points, while COVID-19 patients donated a single Tasso SST serum sample at enrolment. Concentrations of 17 protein inflammatory biomarkers were measured in all biospecimens by Ella multi-analyte immune-assay.Tasso SST serum protein measurements in healthy control subjects were highly reproducible, but their agreements with matched venous samples varied. Most of the selected proteins, including CRP, Ferritin, IL-6 and PCT, were well-correlated between Tasso SST and venous serum with little sample type bias, but concentrations of D-dimer, IL-1B and IL-1Ra were not. Self-collection at home with delayed sample processing was associated with significant concentrations differences for several analytes compared to supervised, in-clinic collection with rapid processing. Finally, Tasso SST serum protein concentrations were significantly elevated in in non-hospitalized COVID-19 patients compared with healthy controls.RESULTSTasso SST serum protein measurements in healthy control subjects were highly reproducible, but their agreements with matched venous samples varied. Most of the selected proteins, including CRP, Ferritin, IL-6 and PCT, were well-correlated between Tasso SST and venous serum with little sample type bias, but concentrations of D-dimer, IL-1B and IL-1Ra were not. Self-collection at home with delayed sample processing was associated with significant concentrations differences for several analytes compared to supervised, in-clinic collection with rapid processing. Finally, Tasso SST serum protein concentrations were significantly elevated in in non-hospitalized COVID-19 patients compared with healthy controls.Self-collection of capillary blood with micro-sampling devices provides an attractive alternative to routine phlebotomy. However, concentrations of certain analytes may differ significantly from those in venous samples, and factors including user proficiency, temperature control and time lags between specimen collection and processing need to be considered for their effect on sample quality and reproducibility.CONCLUSIONSSelf-collection of capillary blood with micro-sampling devices provides an attractive alternative to routine phlebotomy. However, concentrations of certain analytes may differ significantly from those in venous samples, and factors including user proficiency, temperature control and time lags between specimen collection and processing need to be considered for their effect on sample quality and reproducibility. Background Venous phlebotomy performed by trained personnel is critical for patient diagnosis and monitoring of chronic disease, but has limitations in resource-constrained settings, and represents an infection control challenge during outbreaks. Self-collection devices have the potential to shift phlebotomy closer to the point of care, supporting telemedicine strategies and virtual clinical trials. Here we assess a capillary blood micro-sampling device, the Tasso Serum Separator Tube (SST), for measuring blood protein levels in healthy subjects and non-hospitalized COVID-19 patients. Methods 57 healthy controls and 56 participants with mild/moderate COVID-19 were recruited at two U.S. military healthcare facilities. Healthy controls donated Tasso SST capillary serum, venous plasma and venous serum samples at multiple time points, while COVID-19 patients donated a single Tasso SST serum sample at enrolment. Concentrations of 17 protein inflammatory biomarkers were measured in all biospecimens by Ella multi-analyte immune-assay. Results Tasso SST serum protein measurements in healthy control subjects were highly reproducible, but their agreements with matched venous samples varied. Most of the selected proteins, including CRP, Ferritin, IL-6 and PCT, were well-correlated between Tasso SST and venous serum with little sample type bias, but concentrations of D-dimer, IL-1B and IL-1Ra were not. Self-collection at home with delayed sample processing was associated with significant concentrations differences for several analytes compared to supervised, in-clinic collection with rapid processing. Finally, Tasso SST serum protein concentrations were significantly elevated in in non-hospitalized COVID-19 patients compared with healthy controls. Conclusions Self-collection of capillary blood with micro-sampling devices provides an attractive alternative to routine phlebotomy. However, concentrations of certain analytes may differ significantly from those in venous samples, and factors including user proficiency, temperature control and time lags between specimen collection and processing need to be considered for their effect on sample quality and reproducibility. |
| Audience | Academic |
| Author | Myers, Christopher A. Krishnan, Subramaniam Sikorski, CDR Cynthia S. Schully, Kevin L. Ngauy, COL Viseth Clark, Danielle V. Mehta, Rittal Blair, Paul W. Reichert-Scrivner, Susan A. Uyehara, Catherine F. T. Dumler, J. Stephen Gregory, Melissa K. Striegel, Deborah A. Paguirigan, Carmen M. O’Connor, Kelsey Brandsma, Joost Chenoweth, Josh G. |
| AuthorAffiliation | 3 Austere Environments Consortium for Enhanced Sepsis Outcomes, Biological Defense Research Directorate, Naval Medical Research Center-Frederick, Frederick, Maryland, United States of America 5 Tripler Army Medical Center, Honolulu, Hawaii, United States of America The Ohio State University, UNITED STATES 4 Naval Health Research Center, San Diego, California, United States of America 2 Department of Pathology, School of Medicine, Uniformed Services University, Bethesda, Maryland, United States of America 1 Austere Environments Consortium for Enhanced Sepsis Outcomes, Henry M. Jackson Foundation for the Advancement of Military Medicine Inc., Bethesda, Maryland, United States of America |
| AuthorAffiliation_xml | – name: 1 Austere Environments Consortium for Enhanced Sepsis Outcomes, Henry M. Jackson Foundation for the Advancement of Military Medicine Inc., Bethesda, Maryland, United States of America – name: The Ohio State University, UNITED STATES – name: 2 Department of Pathology, School of Medicine, Uniformed Services University, Bethesda, Maryland, United States of America – name: 3 Austere Environments Consortium for Enhanced Sepsis Outcomes, Biological Defense Research Directorate, Naval Medical Research Center-Frederick, Frederick, Maryland, United States of America – name: 4 Naval Health Research Center, San Diego, California, United States of America – name: 5 Tripler Army Medical Center, Honolulu, Hawaii, United States of America |
| Author_xml | – sequence: 1 givenname: Joost orcidid: 0000-0003-2914-3403 surname: Brandsma fullname: Brandsma, Joost – sequence: 2 givenname: Josh G. surname: Chenoweth fullname: Chenoweth, Josh G. – sequence: 3 givenname: Melissa K. surname: Gregory fullname: Gregory, Melissa K. – sequence: 4 givenname: Subramaniam surname: Krishnan fullname: Krishnan, Subramaniam – sequence: 5 givenname: Paul W. surname: Blair fullname: Blair, Paul W. – sequence: 6 givenname: Deborah A. surname: Striegel fullname: Striegel, Deborah A. – sequence: 7 givenname: Rittal surname: Mehta fullname: Mehta, Rittal – sequence: 8 givenname: Kevin L. orcidid: 0000-0001-5554-0133 surname: Schully fullname: Schully, Kevin L. – sequence: 9 givenname: J. Stephen orcidid: 0000-0002-8476-1311 surname: Dumler fullname: Dumler, J. Stephen – sequence: 10 givenname: CDR Cynthia S. surname: Sikorski fullname: Sikorski, CDR Cynthia S. – sequence: 11 givenname: Kelsey surname: O’Connor fullname: O’Connor, Kelsey – sequence: 12 givenname: Susan A. surname: Reichert-Scrivner fullname: Reichert-Scrivner, Susan A. – sequence: 13 givenname: Carmen M. surname: Paguirigan fullname: Paguirigan, Carmen M. – sequence: 14 givenname: Catherine F. T. surname: Uyehara fullname: Uyehara, Catherine F. T. – sequence: 15 givenname: COL Viseth surname: Ngauy fullname: Ngauy, COL Viseth – sequence: 16 givenname: Christopher A. surname: Myers fullname: Myers, Christopher A. – sequence: 17 givenname: Danielle V. surname: Clark fullname: Clark, Danielle V. |
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| CitedBy_id | crossref_primary_10_1016_j_sampre_2025_100161 crossref_primary_10_1002_pmic_202300607 crossref_primary_10_1016_j_jpba_2024_116454 crossref_primary_10_1002_cpt_3272 crossref_primary_10_1016_j_bios_2024_116291 crossref_primary_10_1002_ansa_202300011 crossref_primary_10_1016_j_jlr_2025_100755 crossref_primary_10_1371_journal_pone_0283945 crossref_primary_10_3390_metabo13020146 |
| Cites_doi | 10.1016/j.jinf.2021.04.028 10.3389/fimmu.2021.592727 10.7861/clinmed.2020-0214 10.1046/j.1365-2257.2003.00484.x 10.2217/fvl-2020-0316 10.4155/bio-2021-0027 10.1016/j.cell.2020.10.037 10.1208/s12248-020-00524-2 10.1038/s41591-020-1051-9 10.1007/s10544-019-0412-y 10.1021/acs.analchem.1c02008 10.1186/s12245-019-0239-6 10.1016/j.cell.2022.01.012 10.1136/bmj.m3862 10.1016/j.jaci.2020.05.008 10.1093/infdis/jiaa349 10.1182/bloodadvances.2020003568 10.1038/nrdp.2016.45 10.1001/jamanetworkopen.2020.16382 |
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| References | M Cevik (pone.0272572.ref021) 2020; 371 D Cihakova (pone.0272572.ref009) 2021; 16 ER Wickremsinhe (pone.0272572.ref003) 2020; 22 Y Su (pone.0272572.ref022) 2021; 183 DK Goyal (pone.0272572.ref024) 2020; 20 DJ McCulloch (pone.0272572.ref025) 2020; 3 Covid-19 Multi-omics Blood Atlas (COMBAT) Consortium (pone.0272572.ref008) 2022; 185 KJ Williams (pone.0272572.ref007) 2021; 13 T Hendelman (pone.0272572.ref026) 2021 LAL Fliervoet (pone.0272572.ref011) 2022 T Vedin (pone.0272572.ref012) 2019; 12 BUW Lei (pone.0272572.ref001) 2019; 21 AJ Haack (pone.0272572.ref005) 2021; 93 DM Del Valle (pone.0272572.ref014) 2020; 26 F Coperchini (pone.0272572.ref020) 2021; 12 M Tong (pone.0272572.ref016) 2020; 222 E Mortaz (pone.0272572.ref019) 2021; 12 RS Hotchkiss (pone.0272572.ref023) 2016; 2 A Poudel (pone.0272572.ref018) 2021 A Vusirikala (pone.0272572.ref006) 2021; 83 ML Meizlish (pone.0272572.ref017) 2021; 5 SM Kayiran (pone.0272572.ref010) 2003; 25 H-L Wong (pone.0272572.ref013) 2008 U.S. Food and Drug Administration (pone.0272572.ref002) 2018 pone.0272572.ref004 T Herold (pone.0272572.ref015) 2020; 146 |
| References_xml | – volume: 83 start-page: 104 year: 2021 ident: pone.0272572.ref006 article-title: Seroprevalence of SARS-CoV-2 antibodies in university students: Cross-sectional study, December 2020, England publication-title: J. Infect doi: 10.1016/j.jinf.2021.04.028 – volume: 12 start-page: 592727 year: 2021 ident: pone.0272572.ref019 article-title: Increased Serum Levels of Soluble TNF-α Receptor Is Associated With ICU Mortality in COVID-19 Patients publication-title: Front. Immunol doi: 10.3389/fimmu.2021.592727 – ident: pone.0272572.ref004 – volume: 20 start-page: 248 year: 2020 ident: pone.0272572.ref024 article-title: Early intervention likely improves mortality in COVID-19 infection publication-title: Clin. Med doi: 10.7861/clinmed.2020-0214 – volume: 25 start-page: 9 issue: 1 year: 2003 ident: pone.0272572.ref010 article-title: Significant differences between capillary and venous complete blood counts in the neonatal period publication-title: Clin Lab Haematol doi: 10.1046/j.1365-2257.2003.00484.x – year: 2018 ident: pone.0272572.ref002 publication-title: Bioanalytical Method Validation. Guidance for Industry – volume: 16 year: 2021 ident: pone.0272572.ref009 article-title: High-value laboratory testing for hospitalized COVID-19 patients: a review publication-title: Future Virol doi: 10.2217/fvl-2020-0316 – volume: 13 year: 2021 ident: pone.0272572.ref007 article-title: Assessment of low volume sampling technologies: utility in nonclinical and clinical studies publication-title: Bioanalysis doi: 10.4155/bio-2021-0027 – volume: 183 start-page: 1479 year: 2021 ident: pone.0272572.ref022 article-title: Multi-Omics Resolves a Sharp Disease-State Shift between Mild and Moderate COVID-19 publication-title: Cell doi: 10.1016/j.cell.2020.10.037 – year: 2022 ident: pone.0272572.ref011 article-title: Comparison of capillary and venous blood sampling for routine coagulation assays publication-title: J Clin Biochem – year: 2021 ident: pone.0272572.ref018 article-title: D-dimer as a biomarker for assessment of COVID-19 prognosis: D-dimer levels on admission and its role in predicting disease outcome in hospitalized patients with COVID-19 publication-title: PLoS ONE – volume: 12 start-page: 668507 year: 2021 ident: pone.0272572.ref020 article-title: Interleukin-6, CXCL10 and Infiltrating Macrophages in COVID-19-Related Cytokine Storm: Not One for All But All for One! Front publication-title: Immunol – volume: 22 start-page: 135 year: 2020 ident: pone.0272572.ref003 article-title: Land O’Lakes Workshop on Microsampling: Enabling Broader Adoption publication-title: AAPS J doi: 10.1208/s12248-020-00524-2 – volume: 26 start-page: 1636 year: 2020 ident: pone.0272572.ref014 article-title: An inflammatory cytokine signature predicts COVID-19 severity and survival publication-title: Nat Med doi: 10.1038/s41591-020-1051-9 – volume: 21 start-page: 81 year: 2019 ident: pone.0272572.ref001 article-title: A review of microsampling techniques and their social impact publication-title: Biomed. Microdevices doi: 10.1007/s10544-019-0412-y – volume: 93 start-page: 13196 year: 2021 ident: pone.0272572.ref005 article-title: homeRNA: A self-sampling kit for the collection of peripheral blood and stabilization of RNA publication-title: Anal. Chem doi: 10.1021/acs.analchem.1c02008 – volume: 12 start-page: 26 issue: 1 year: 2019 ident: pone.0272572.ref012 article-title: Prospective comparison of capillary and venous brain biomarker S100B: capillary samples have large inter-sample variation and poor correlation with venous samples publication-title: Int J Emerg Med doi: 10.1186/s12245-019-0239-6 – year: 2021 ident: pone.0272572.ref026 article-title: Self-collection of capillary blood using Tasso-SST devices for Anti-SARS-CoV-2 IgG antibody testing publication-title: PLoS ONE – volume: 185 start-page: 916 issue: 5 year: 2022 ident: pone.0272572.ref008 article-title: A blood atlas of COVID-19 defines hallmarks of disease severity and specificity publication-title: Cell doi: 10.1016/j.cell.2022.01.012 – volume: 371 start-page: m3862 year: 2020 ident: pone.0272572.ref021 article-title: Virology, transmission, and pathogenesis of SARS-CoV-2 publication-title: BMJ doi: 10.1136/bmj.m3862 – year: 2008 ident: pone.0272572.ref013 article-title: Reproducibility and correlations of multiplex cytokine levels in asymptomatic persons publication-title: Cancer Epidemiol. Biomarkers Prev – volume: 146 start-page: 128 year: 2020 ident: pone.0272572.ref015 article-title: Elevated levels of IL-6 and CRP predict the need for mechanical ventilation in COVID-19 publication-title: J. Allergy Clin. Immunol doi: 10.1016/j.jaci.2020.05.008 – volume: 222 start-page: 894 year: 2020 ident: pone.0272572.ref016 article-title: Elevated Expression of Serum Endothelial Cell Adhesion Molecules in COVID-19 Patients publication-title: J. Infect. Dis doi: 10.1093/infdis/jiaa349 – volume: 5 start-page: 1164 year: 2021 ident: pone.0272572.ref017 article-title: A neutrophil activation signature predicts critical illness and mortality in COVID-19 publication-title: Blood Adv doi: 10.1182/bloodadvances.2020003568 – volume: 2 start-page: 16045 year: 2016 ident: pone.0272572.ref023 article-title: Sepsis and septic shock publication-title: Nat. Rev. Dis. Primers doi: 10.1038/nrdp.2016.45 – volume: 3 start-page: e2016382 year: 2020 ident: pone.0272572.ref025 article-title: Comparison of Unsupervised Home Self-collected Midnasal Swabs With Clinician-Collected Nasopharyngeal Swabs for Detection of SARS-CoV-2 Infection publication-title: JAMA Netw. Open doi: 10.1001/jamanetworkopen.2020.16382 |
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| Title | Assessing the use of a micro-sampling device for measuring blood protein levels in healthy subjects and COVID-19 patients |
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