Risk factors for hospitalization among persons with COVID-19—Colorado

• Published in: PloS one Vol. 16; no. 9; p. e0256917
• Main Authors: Vahey, Grace M., McDonald, Emily, Marshall, Kristen, Martin, Stacey W., Chun, Helen, Herlihy, Rachel, Tate, Jacqueline E., Kawasaki, Breanna, Midgley, Claire M., Alden, Nisha, Killerby, Marie E., Staples, J. Erin
• Format: Journal Article
• Language: English
• Published: San Francisco Public Library of Science 02.09.2021; Public Library of Science (PLoS)
• Subjects: Arrhythmia; Asthma; Biology and Life Sciences; Body mass index; Cardiovascular disease; Causes of; Confidence intervals; Coronaviruses; COVID-19; Demographics; Demography; Diabetes; Disease control; Disease prevention; Disease transmission; Electronic health records; Electronic medical records; Failure analysis; Health risks; Hospital care; Hospitalization; Hypertension; Illnesses; Interviews; Medical laboratories; Medical records; Medicine and Health Sciences; Metabolic disorders; Metabolic syndrome; Narcotics; Obesity; Opioids; Oxygen; Oxygen requirement; Pandemics; Patients; Public health; Questionnaires; Respiratory diseases; Respiratory failure; Risk analysis; Risk factors; Severe acute respiratory syndrome coronavirus 2; Supervision; Viral diseases; United States; Atlanta Georgia; Georgia; United States > US; China; Colorado
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0256917

Most current evidence on risk factors for hospitalization because of coronavirus disease 2019 (COVID-19) comes from studies using data abstracted primarily from electronic health records, limited to specific populations, or that fail to capture over-the-counter medications and adjust for potential confounding factors. Properly understanding risk factors for hospitalization will help improve clinical management and facilitate targeted prevention messaging and forecasting and prioritization of clinical and public health resource needs. To identify risk factors for hospitalization using patient questionnaires and chart abstraction. We randomly selected 600 of 1,738 laboratory-confirmed Colorado COVID-19 cases with known hospitalization status and illness onset during March 9-31, 2020. In April 2020, we collected demographics, social history, and medications taken in the 30 days before illness onset via telephone questionnaire and collected underlying medical conditions in patient questionnaires and medical record abstraction. Overall, 364 patients participated; 128 were hospitalized and 236 were non-hospitalized. In multivariable analysis, chronic hypoxemic respiratory failure with oxygen requirement (adjusted odds ratio [aOR] 14.64; 95% confidence interval [CI] 1.45-147.93), taking opioids (aOR 8.05; CI 1.16-55.77), metabolic syndrome (aOR 5.71; CI 1.18-27.54), obesity (aOR 3.35; CI 1.58-7.09), age [greater than or equal to]65 years (aOR 3.22; CI 1.20-7.97), hypertension (aOR 3.14; CI 1.47-6.71), arrhythmia (aOR 2.95; CI 1.00-8.68), and male sex (aOR 2.65; CI 1.44-4.88), were significantly associated with hospitalization. We identified patient characteristics, medications, and medical conditions, including some novel ones, associated with hospitalization. These data can be used to inform clinical and public health resource needs.