Adaptive Mutations in the JC Virus Protein Capsid Are Associated with Progressive Multifocal Leukoencephalopathy (PML) - Sunyaev, Shamil R.; Lugovskoy, Alexey; Simon, Kenneth; Gorelik, Leonid (PLoS genetics, 2009)
Keywords: Acquired immune deficiency syndrome; AIDS; Amino acids; Binding sites; Capsid Proteins - genetics; Capsid Proteins - metabolism; Computational Biology/Comparative Sequence Analysis; Computational Biology/Evolutionary Modeling; Disease; Evolution & development; Evolution, Molecular; Evolutionary Biology/Microbial Evolution and Genomics; Experiments; Gene mutations; Genetic aspects; Health aspects; HIV; Human immunodeficiency virus; Humans; JC Virus - genetics; JC Virus - isolation & purification; Leukoencephalopathy, Progressive multifocal; Leukoencephalopathy, Progressive Multifocal - metabolism; Leukoencephalopathy, Progressive Multifocal - virology; Mutation; Neurological Disorders/Infectious Diseases of the Nervous System; Patients; Phenotype; Phylogeny; Polyoma virus; Population; Proteins; Risk factors; Statistical methods; Viral proteins; Virology/Host Invasion and Cell Entry; Virology/Mechanisms of Resistance and Susceptibility, including Host Genetics; Virology/New Therapies, including Antivirals and Immunotherapy; Virology/Virus Evolution and Symbiosis; United States