A comprehensive introduction to the genetic basis of non-syndromic hearing loss in the Saudi Arabian population
Background Hearing loss is a clinically and genetically heterogeneous disorder. Mutations in the DFNB1 locus have been reported to be the most common cause of autosomal recessive non-syndromic hearing loss worldwide. Apart from DFNB1 , many other loci and their underlying genes have also been identi...
Saved in:
| Published in | BMC medical genetics Vol. 12; no. 1; p. 91 |
|---|---|
| Main Authors | , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
BioMed Central
04.07.2011
BioMed Central Ltd BMC |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1471-2350 1471-2350 |
| DOI | 10.1186/1471-2350-12-91 |
Cover
| Abstract | Background
Hearing loss is a clinically and genetically heterogeneous disorder. Mutations in the
DFNB1
locus have been reported to be the most common cause of autosomal recessive non-syndromic hearing loss worldwide. Apart from
DFNB1
, many other loci and their underlying genes have also been identified and the basis of our study was to provide a comprehensive introduction to the delineation of the molecular basis of non-syndromic hearing loss in the Saudi Arabian population. This was performed by screening
DFNB1
and to initiate prioritized linkage analysis or homozygosity mapping for a pilot number of families in which
DFNB1
has been excluded.
Methods
Individuals from 130 families of Saudi Arabian tribal origin diagnosed with an autosomal recessive non-syndromic sensorineural hearing loss were screened for mutations at the
DFNB1
locus by direct sequencing. If negative, genome wide linkage analysis or homozygosity mapping were performed using Affymetrix GeneChip
®
Human Mapping 250K/6.0 Arrays to identify regions containing any known-deafness causing genes that were subsequently sequenced.
Results
Our results strongly indicate that
DFNB1
only accounts for 3% of non-syndromic hearing loss in the Saudi Arabian population of ethnic ancestry. Prioritized linkage analysis or homozygosity mapping in five separate families established that their hearing loss was caused by five different known-deafness causing genes thus confirming the genetic heterogeneity of this disorder in the kingdom.
Conclusion
The overall results of this study are highly suggestive that underlying molecular basis of autosomal recessive non-syndromic deafness in Saudi Arabia is very genetically heterogeneous. In addition, we report that the preliminary results indicate that there does not seem to be any common or more prevalent loci, genes or mutations in patients with autosomal recessive non-syndromic hearing loss in patients of Saudi Arabian tribal origin. |
|---|---|
| AbstractList | Background
Hearing loss is a clinically and genetically heterogeneous disorder. Mutations in the
DFNB1
locus have been reported to be the most common cause of autosomal recessive non-syndromic hearing loss worldwide. Apart from
DFNB1
, many other loci and their underlying genes have also been identified and the basis of our study was to provide a comprehensive introduction to the delineation of the molecular basis of non-syndromic hearing loss in the Saudi Arabian population. This was performed by screening
DFNB1
and to initiate prioritized linkage analysis or homozygosity mapping for a pilot number of families in which
DFNB1
has been excluded.
Methods
Individuals from 130 families of Saudi Arabian tribal origin diagnosed with an autosomal recessive non-syndromic sensorineural hearing loss were screened for mutations at the
DFNB1
locus by direct sequencing. If negative, genome wide linkage analysis or homozygosity mapping were performed using Affymetrix GeneChip
®
Human Mapping 250K/6.0 Arrays to identify regions containing any known-deafness causing genes that were subsequently sequenced.
Results
Our results strongly indicate that
DFNB1
only accounts for 3% of non-syndromic hearing loss in the Saudi Arabian population of ethnic ancestry. Prioritized linkage analysis or homozygosity mapping in five separate families established that their hearing loss was caused by five different known-deafness causing genes thus confirming the genetic heterogeneity of this disorder in the kingdom.
Conclusion
The overall results of this study are highly suggestive that underlying molecular basis of autosomal recessive non-syndromic deafness in Saudi Arabia is very genetically heterogeneous. In addition, we report that the preliminary results indicate that there does not seem to be any common or more prevalent loci, genes or mutations in patients with autosomal recessive non-syndromic hearing loss in patients of Saudi Arabian tribal origin. Hearing loss is a clinically and genetically heterogeneous disorder. Mutations in the DFNB1 locus have been reported to be the most common cause of autosomal recessive non-syndromic hearing loss worldwide. Apart from DFNB1, many other loci and their underlying genes have also been identified and the basis of our study was to provide a comprehensive introduction to the delineation of the molecular basis of non-syndromic hearing loss in the Saudi Arabian population. This was performed by screening DFNB1 and to initiate prioritized linkage analysis or homozygosity mapping for a pilot number of families in which DFNB1 has been excluded. Individuals from 130 families of Saudi Arabian tribal origin diagnosed with an autosomal recessive non-syndromic sensorineural hearing loss were screened for mutations at the DFNB1 locus by direct sequencing. If negative, genome wide linkage analysis or homozygosity mapping were performed using Affymetrix GeneChip.sup.[R] .sup.Human Mapping 250K/6.0 Arrays to identify regions containing any known-deafness causing genes that were subsequently sequenced. Our results strongly indicate that DFNB1 only accounts for 3% of non-syndromic hearing loss in the Saudi Arabian population of ethnic ancestry. Prioritized linkage analysis or homozygosity mapping in five separate families established that their hearing loss was caused by five different known-deafness causing genes thus confirming the genetic heterogeneity of this disorder in the kingdom. The overall results of this study are highly suggestive that underlying molecular basis of autosomal recessive non-syndromic deafness in Saudi Arabia is very genetically heterogeneous. In addition, we report that the preliminary results indicate that there does not seem to be any common or more prevalent loci, genes or mutations in patients with autosomal recessive non-syndromic hearing loss in patients of Saudi Arabian tribal origin. Abstract Background Hearing loss is a clinically and genetically heterogeneous disorder. Mutations in the DFNB1 locus have been reported to be the most common cause of autosomal recessive non-syndromic hearing loss worldwide. Apart from DFNB1, many other loci and their underlying genes have also been identified and the basis of our study was to provide a comprehensive introduction to the delineation of the molecular basis of non-syndromic hearing loss in the Saudi Arabian population. This was performed by screening DFNB1 and to initiate prioritized linkage analysis or homozygosity mapping for a pilot number of families in which DFNB1 has been excluded. Methods Individuals from 130 families of Saudi Arabian tribal origin diagnosed with an autosomal recessive non-syndromic sensorineural hearing loss were screened for mutations at the DFNB1 locus by direct sequencing. If negative, genome wide linkage analysis or homozygosity mapping were performed using Affymetrix GeneChip® Human Mapping 250K/6.0 Arrays to identify regions containing any known-deafness causing genes that were subsequently sequenced. Results Our results strongly indicate that DFNB1 only accounts for 3% of non-syndromic hearing loss in the Saudi Arabian population of ethnic ancestry. Prioritized linkage analysis or homozygosity mapping in five separate families established that their hearing loss was caused by five different known-deafness causing genes thus confirming the genetic heterogeneity of this disorder in the kingdom. Conclusion The overall results of this study are highly suggestive that underlying molecular basis of autosomal recessive non-syndromic deafness in Saudi Arabia is very genetically heterogeneous. In addition, we report that the preliminary results indicate that there does not seem to be any common or more prevalent loci, genes or mutations in patients with autosomal recessive non-syndromic hearing loss in patients of Saudi Arabian tribal origin. Background Hearing loss is a clinically and genetically heterogeneous disorder. Mutations in the DFNB1 locus have been reported to be the most common cause of autosomal recessive non-syndromic hearing loss worldwide. Apart from DFNB1, many other loci and their underlying genes have also been identified and the basis of our study was to provide a comprehensive introduction to the delineation of the molecular basis of non-syndromic hearing loss in the Saudi Arabian population. This was performed by screening DFNB1 and to initiate prioritized linkage analysis or homozygosity mapping for a pilot number of families in which DFNB1 has been excluded. Methods Individuals from 130 families of Saudi Arabian tribal origin diagnosed with an autosomal recessive non-syndromic sensorineural hearing loss were screened for mutations at the DFNB1 locus by direct sequencing. If negative, genome wide linkage analysis or homozygosity mapping were performed using Affymetrix GeneChip.sup.[R] .sup.Human Mapping 250K/6.0 Arrays to identify regions containing any known-deafness causing genes that were subsequently sequenced. Results Our results strongly indicate that DFNB1 only accounts for 3% of non-syndromic hearing loss in the Saudi Arabian population of ethnic ancestry. Prioritized linkage analysis or homozygosity mapping in five separate families established that their hearing loss was caused by five different known-deafness causing genes thus confirming the genetic heterogeneity of this disorder in the kingdom. Conclusion The overall results of this study are highly suggestive that underlying molecular basis of autosomal recessive non-syndromic deafness in Saudi Arabia is very genetically heterogeneous. In addition, we report that the preliminary results indicate that there does not seem to be any common or more prevalent loci, genes or mutations in patients with autosomal recessive non-syndromic hearing loss in patients of Saudi Arabian tribal origin. Hearing loss is a clinically and genetically heterogeneous disorder. Mutations in the DFNB1 locus have been reported to be the most common cause of autosomal recessive non-syndromic hearing loss worldwide. Apart from DFNB1, many other loci and their underlying genes have also been identified and the basis of our study was to provide a comprehensive introduction to the delineation of the molecular basis of non-syndromic hearing loss in the Saudi Arabian population. This was performed by screening DFNB1 and to initiate prioritized linkage analysis or homozygosity mapping for a pilot number of families in which DFNB1 has been excluded.BACKGROUNDHearing loss is a clinically and genetically heterogeneous disorder. Mutations in the DFNB1 locus have been reported to be the most common cause of autosomal recessive non-syndromic hearing loss worldwide. Apart from DFNB1, many other loci and their underlying genes have also been identified and the basis of our study was to provide a comprehensive introduction to the delineation of the molecular basis of non-syndromic hearing loss in the Saudi Arabian population. This was performed by screening DFNB1 and to initiate prioritized linkage analysis or homozygosity mapping for a pilot number of families in which DFNB1 has been excluded.Individuals from 130 families of Saudi Arabian tribal origin diagnosed with an autosomal recessive non-syndromic sensorineural hearing loss were screened for mutations at the DFNB1 locus by direct sequencing. If negative, genome wide linkage analysis or homozygosity mapping were performed using Affymetrix GeneChip® Human Mapping 250K/6.0 Arrays to identify regions containing any known-deafness causing genes that were subsequently sequenced.METHODSIndividuals from 130 families of Saudi Arabian tribal origin diagnosed with an autosomal recessive non-syndromic sensorineural hearing loss were screened for mutations at the DFNB1 locus by direct sequencing. If negative, genome wide linkage analysis or homozygosity mapping were performed using Affymetrix GeneChip® Human Mapping 250K/6.0 Arrays to identify regions containing any known-deafness causing genes that were subsequently sequenced.Our results strongly indicate that DFNB1 only accounts for 3% of non-syndromic hearing loss in the Saudi Arabian population of ethnic ancestry. Prioritized linkage analysis or homozygosity mapping in five separate families established that their hearing loss was caused by five different known-deafness causing genes thus confirming the genetic heterogeneity of this disorder in the kingdom.RESULTSOur results strongly indicate that DFNB1 only accounts for 3% of non-syndromic hearing loss in the Saudi Arabian population of ethnic ancestry. Prioritized linkage analysis or homozygosity mapping in five separate families established that their hearing loss was caused by five different known-deafness causing genes thus confirming the genetic heterogeneity of this disorder in the kingdom.The overall results of this study are highly suggestive that underlying molecular basis of autosomal recessive non-syndromic deafness in Saudi Arabia is very genetically heterogeneous. In addition, we report that the preliminary results indicate that there does not seem to be any common or more prevalent loci, genes or mutations in patients with autosomal recessive non-syndromic hearing loss in patients of Saudi Arabian tribal origin.CONCLUSIONThe overall results of this study are highly suggestive that underlying molecular basis of autosomal recessive non-syndromic deafness in Saudi Arabia is very genetically heterogeneous. In addition, we report that the preliminary results indicate that there does not seem to be any common or more prevalent loci, genes or mutations in patients with autosomal recessive non-syndromic hearing loss in patients of Saudi Arabian tribal origin. Hearing loss is a clinically and genetically heterogeneous disorder. Mutations in the DFNB1 locus have been reported to be the most common cause of autosomal recessive non-syndromic hearing loss worldwide. Apart from DFNB1, many other loci and their underlying genes have also been identified and the basis of our study was to provide a comprehensive introduction to the delineation of the molecular basis of non-syndromic hearing loss in the Saudi Arabian population. This was performed by screening DFNB1 and to initiate prioritized linkage analysis or homozygosity mapping for a pilot number of families in which DFNB1 has been excluded. Individuals from 130 families of Saudi Arabian tribal origin diagnosed with an autosomal recessive non-syndromic sensorineural hearing loss were screened for mutations at the DFNB1 locus by direct sequencing. If negative, genome wide linkage analysis or homozygosity mapping were performed using Affymetrix GeneChip® Human Mapping 250K/6.0 Arrays to identify regions containing any known-deafness causing genes that were subsequently sequenced. Our results strongly indicate that DFNB1 only accounts for 3% of non-syndromic hearing loss in the Saudi Arabian population of ethnic ancestry. Prioritized linkage analysis or homozygosity mapping in five separate families established that their hearing loss was caused by five different known-deafness causing genes thus confirming the genetic heterogeneity of this disorder in the kingdom. The overall results of this study are highly suggestive that underlying molecular basis of autosomal recessive non-syndromic deafness in Saudi Arabia is very genetically heterogeneous. In addition, we report that the preliminary results indicate that there does not seem to be any common or more prevalent loci, genes or mutations in patients with autosomal recessive non-syndromic hearing loss in patients of Saudi Arabian tribal origin. |
| ArticleNumber | 91 |
| Audience | Academic |
| Author | Kennedy, Shelley Al-Shaikh, Abdulmoneem H Ramzan, Khushnooda Al-Owain, Mohammed Al-Mubarak, Bashayer Meyer, Brian F Bamukhayyar, Saeed S Trabzuni, Daniah Imtiaz, Faiqa Bin-Khamis, Ghada Allam, Rabab Al-Mostafa, Abeer Sogaty, Sameera Taibah, Khalid |
| AuthorAffiliation | 7 Audio-Vestibular Medicine Unit, King Fahd Hospital, PO Box 8488, Jeddah 21196, Saudi Arabia 6 ENT Department, King Fahad Hospital, PO Box 8488, Jeddah 21196, Saudi Arabia 9 College of Medicine, Al-Faisal University, PO Box 50927, Riyadh 11533, Saudi Arabia 4 Ontario Newborn Screening Program, Children's Hospital of Eastern Ontario 401 Smyth Road, Room 3127A Ottawa, Ontario K1H 8L1, Canada 5 Medical Genetics Unit, King Fahad Hospital, PO Box 8488, Jeddah 21196, Saudi Arabia 1 Department of Genetics, King Faisal Specialist Hospital & Research Centre, PO Box 3354, Riyadh 11211, Saudi Arabia 2 ENT Medical Centre, PO 340507, Riyadh 11333, Saudi Arabia 3 Department of Otololaryngology, King Faisal Specialist Hospital & Research Centre, PO Box 3354, Riyadh 11211, Saudi Arabia 8 Department of Medical Genetics, King Faisal Specialist Hospital & Research Centre, PO Box 3354, Riyadh 11211, Saudi Arabia |
| AuthorAffiliation_xml | – name: 5 Medical Genetics Unit, King Fahad Hospital, PO Box 8488, Jeddah 21196, Saudi Arabia – name: 2 ENT Medical Centre, PO 340507, Riyadh 11333, Saudi Arabia – name: 8 Department of Medical Genetics, King Faisal Specialist Hospital & Research Centre, PO Box 3354, Riyadh 11211, Saudi Arabia – name: 9 College of Medicine, Al-Faisal University, PO Box 50927, Riyadh 11533, Saudi Arabia – name: 6 ENT Department, King Fahad Hospital, PO Box 8488, Jeddah 21196, Saudi Arabia – name: 4 Ontario Newborn Screening Program, Children's Hospital of Eastern Ontario 401 Smyth Road, Room 3127A Ottawa, Ontario K1H 8L1, Canada – name: 7 Audio-Vestibular Medicine Unit, King Fahd Hospital, PO Box 8488, Jeddah 21196, Saudi Arabia – name: 1 Department of Genetics, King Faisal Specialist Hospital & Research Centre, PO Box 3354, Riyadh 11211, Saudi Arabia – name: 3 Department of Otololaryngology, King Faisal Specialist Hospital & Research Centre, PO Box 3354, Riyadh 11211, Saudi Arabia |
| Author_xml | – sequence: 1 givenname: Faiqa surname: Imtiaz fullname: Imtiaz, Faiqa email: fahmad@kfshrc.edu.sa organization: Department of Genetics, King Faisal Specialist Hospital & Research Centre – sequence: 2 givenname: Khalid surname: Taibah fullname: Taibah, Khalid organization: ENT Medical Centre – sequence: 3 givenname: Khushnooda surname: Ramzan fullname: Ramzan, Khushnooda organization: Department of Genetics, King Faisal Specialist Hospital & Research Centre – sequence: 4 givenname: Ghada surname: Bin-Khamis fullname: Bin-Khamis, Ghada organization: Department of Otololaryngology, King Faisal Specialist Hospital & Research Centre – sequence: 5 givenname: Shelley surname: Kennedy fullname: Kennedy, Shelley organization: Ontario Newborn Screening Program, Children's Hospital of Eastern Ontario – sequence: 6 givenname: Bashayer surname: Al-Mubarak fullname: Al-Mubarak, Bashayer organization: Department of Genetics, King Faisal Specialist Hospital & Research Centre – sequence: 7 givenname: Daniah surname: Trabzuni fullname: Trabzuni, Daniah organization: Department of Genetics, King Faisal Specialist Hospital & Research Centre – sequence: 8 givenname: Rabab surname: Allam fullname: Allam, Rabab organization: Department of Genetics, King Faisal Specialist Hospital & Research Centre – sequence: 9 givenname: Abeer surname: Al-Mostafa fullname: Al-Mostafa, Abeer organization: Department of Genetics, King Faisal Specialist Hospital & Research Centre – sequence: 10 givenname: Sameera surname: Sogaty fullname: Sogaty, Sameera organization: Medical Genetics Unit, King Fahad Hospital – sequence: 11 givenname: Abdulmoneem H surname: Al-Shaikh fullname: Al-Shaikh, Abdulmoneem H organization: ENT Department, King Fahad Hospital – sequence: 12 givenname: Saeed S surname: Bamukhayyar fullname: Bamukhayyar, Saeed S organization: Audio-Vestibular Medicine Unit, King Fahd Hospital – sequence: 13 givenname: Brian F surname: Meyer fullname: Meyer, Brian F organization: Department of Genetics, King Faisal Specialist Hospital & Research Centre – sequence: 14 givenname: Mohammed surname: Al-Owain fullname: Al-Owain, Mohammed organization: Department of Medical Genetics, King Faisal Specialist Hospital & Research Centre, College of Medicine, Al-Faisal University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/21726435$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kktr3DAUhU1JaR7turti6KJ04UQPy5I3hSH0MRAoNO1ayPKVR4NHciU7JP--8kw6xKUtWkhcn-_4XumcZyfOO8iy1xhdYiyqK1xyXBDKUIFJUeNn2dmxcvLkfJqdx7hFCHNB6YvslGBOqpKys8yvcu13Q4ANuGjvILduDL6d9Gi9y0efjxvIO3AwWp03KtqYe5OnLor44Nrgd6m8ARWs6_Lex5j4PXKrptbmq6Aaq1w--GHq1Wz5MntuVB_h1eN-kf349PH79Zfi5uvn9fXqptBVVY1FhUiNDaZVy-qaGQJVQzEB2qiGMVHRNFlday1K3FJdcd4goRAHIxA3ojQNvcjWB9_Wq60cgt2p8CC9snJf8KGTKqSZepBca95QZKghqIRWiZYqJrjhtOSs1jR5fTh4DVOzg1ZDuiLVL0yXX5zdyM7fSUpISQVPBu8eDYL_OUEc5c5GDX2vHPgpSiEwqhET86_eHpSdSp1ZZ3wy1LNarkjFCCUlYkl1-RdVWi2k90gJMTbVF8D7BZA0I9yPnZpilOvbb0vtm6fTHsf8nZkkuDoIdEgPHsAcJRjJOZVyzp2ccycxkTVOBPuD0HbcxyH1bfv_cOjAxWEOGAS59VNwKTf_RH4BewHyhg |
| CitedBy_id | crossref_primary_10_1002_humu_23042 crossref_primary_10_1002_lary_24332 crossref_primary_10_1038_s41431_019_0398_1 crossref_primary_10_1007_s00439_021_02332_w crossref_primary_10_1002_ajmg_b_32774 crossref_primary_10_1097_JBR_0000000000000060 crossref_primary_10_1111_ahg_12559 crossref_primary_10_1080_03014460_2023_2180087 crossref_primary_10_1186_s12920_022_01201_3 crossref_primary_10_1177_0003489415575060 crossref_primary_10_1016_j_mcp_2015_03_008 crossref_primary_10_1186_s40246_023_00562_9 crossref_primary_10_1159_000528766 crossref_primary_10_1111_ahg_12284 crossref_primary_10_1159_000540202 crossref_primary_10_1177_0003489415575058 crossref_primary_10_1016_j_gene_2020_144996 crossref_primary_10_1016_j_gene_2013_03_042 crossref_primary_10_1371_journal_pone_0136306 |
| Cites_doi | 10.1111/j.1749-6632.1991.tb19572.x 10.1086/503875 10.1038/ejhg.2009.190 10.1093/hmg/6.12.2163 10.1038/ng842 10.1086/510022 10.1093/bmb/63.1.73 10.1093/hmg/6.9.1605 10.1093/nar/16.3.1215 10.1089/gtmb.2009.0111 10.1001/archotol.127.8.927 10.1002/ajmg.1320460504 10.1002/(SICI)1096-8628(19990604)84:4<369::AID-AJMG12>3.0.CO;2-V 10.1097/00125817-200207000-00004 |
| ContentType | Journal Article |
| Copyright | Imtiaz et al; licensee BioMed Central Ltd. 2011 COPYRIGHT 2011 BioMed Central Ltd. Copyright ©2011 Imtiaz et al; licensee BioMed Central Ltd. 2011 Imtiaz et al; licensee BioMed Central Ltd. |
| Copyright_xml | – notice: Imtiaz et al; licensee BioMed Central Ltd. 2011 – notice: COPYRIGHT 2011 BioMed Central Ltd. – notice: Copyright ©2011 Imtiaz et al; licensee BioMed Central Ltd. 2011 Imtiaz et al; licensee BioMed Central Ltd. |
| DBID | C6C AAYXX CITATION CGR CUY CVF ECM EIF NPM ISR 7X8 5PM DOA |
| DOI | 10.1186/1471-2350-12-91 |
| DatabaseName | Springer Nature OA/Free Journals CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Gale In Context: Science MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: C6C name: Springer Nature OA Free Journals url: http://www.springeropen.com/ sourceTypes: Publisher – sequence: 2 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 3 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 4 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Biology |
| EISSN | 1471-2350 |
| EndPage | 91 |
| ExternalDocumentID | oai_doaj_org_article_7cc7b30f3f204eda8d3a587f734759c3 PMC3224387 A265232405 21726435 10_1186_1471_2350_12_91 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GeographicLocations | Saudi Arabia |
| GeographicLocations_xml | – name: Saudi Arabia |
| GroupedDBID | --- 0R~ 23N 2VQ 2WC 4.4 53G 5VS 6J9 7X7 88E 8AO 8FE 8FH 8FI 8FJ AAFWJ ABDBF ABUWG ACGFO ACGFS ACIHN ACPRK ACUHS ADBBV ADRAZ ADUKV AEAQA AENEX AFKRA AFPKN AHBYD AHMBA AHSBF AHYZX ALMA_UNASSIGNED_HOLDINGS AMKLP AMTXH AOIJS BAPOH BAWUL BBNVY BCNDV BENPR BFQNJ BHPHI BMC BPHCQ BVXVI C1A C6C CCPQU CS3 DIK DU5 E3Z EAD EAP EAS EBD EBS EJD EMB EMK EMOBN ESX F5P FYUFA GROUPED_DOAJ GX1 H13 HCIFZ HMCUK HYE IAO IHR INH INR IPNFZ ISR ITC KQ8 LK8 M1P M48 M7P M~E O5R O5S OK1 OVT P2P PGMZT PHGZM PHGZT PIMPY PJZUB PPXIY PQGLB PQQKQ PROAC PSQYO PUEGO RBZ RIG RNS ROL RPM RSV SBL SOJ SV3 TR2 TUS UKHRP W2D WOQ WOW XSB AAYXX ALIPV CITATION CGR CUY CVF ECM EIF NPM PMFND 7X8 5PM |
| ID | FETCH-LOGICAL-c666t-60291f136d5995f2e6b312e3bab5586314799cc841d3c677b08a07ef807f84fb3 |
| IEDL.DBID | M48 |
| ISSN | 1471-2350 |
| IngestDate | Wed Aug 27 01:12:00 EDT 2025 Thu Aug 21 13:26:32 EDT 2025 Fri Sep 05 04:08:33 EDT 2025 Tue Jun 17 20:23:58 EDT 2025 Tue Jun 10 20:44:05 EDT 2025 Fri Jun 27 04:05:11 EDT 2025 Thu Apr 03 07:07:36 EDT 2025 Tue Jul 01 02:45:46 EDT 2025 Thu Apr 24 22:58:33 EDT 2025 Sat Sep 06 07:31:47 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | Unaffected Sibling GJB6 Gene Homozygosity Mapping Multipoint Linkage Analysis Hearing Loss |
| Language | English |
| License | http://www.springer.com/tdm This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c666t-60291f136d5995f2e6b312e3bab5586314799cc841d3c677b08a07ef807f84fb3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | http://journals.scholarsportal.info/openUrl.xqy?doi=10.1186/1471-2350-12-91 |
| PMID | 21726435 |
| PQID | 881090583 |
| PQPubID | 23479 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_7cc7b30f3f204eda8d3a587f734759c3 pubmedcentral_primary_oai_pubmedcentral_nih_gov_3224387 proquest_miscellaneous_881090583 gale_infotracmisc_A265232405 gale_infotracacademiconefile_A265232405 gale_incontextgauss_ISR_A265232405 pubmed_primary_21726435 crossref_primary_10_1186_1471_2350_12_91 crossref_citationtrail_10_1186_1471_2350_12_91 springer_journals_10_1186_1471_2350_12_91 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2011-07-04 |
| PublicationDateYYYYMMDD | 2011-07-04 |
| PublicationDate_xml | – month: 07 year: 2011 text: 2011-07-04 day: 04 |
| PublicationDecade | 2010 |
| PublicationPlace | London |
| PublicationPlace_xml | – name: London – name: England |
| PublicationTitle | BMC medical genetics |
| PublicationTitleAbbrev | BMC Med Genet |
| PublicationTitleAlternate | BMC Med Genet |
| PublicationYear | 2011 |
| Publisher | BioMed Central BioMed Central Ltd BMC |
| Publisher_xml | – name: BioMed Central – name: BioMed Central Ltd – name: BMC |
| References | Bitner-Glindzicz (CR4) 2002; 63 Marazita, Ploughman, Rawlings, Remington, Arnos, Nance (CR1) 1993; 46 Al-Qahtani, Baghlab, Chaudhary, Abuzenadah, Bamanie, Daghistani, Safieh, Fida, Dallol (CR9) 2010; 14 Carrasquillo, Zlotogora, Barges, Chakravarti (CR12) 1997; 6 Riazuddin, Ahmed, Fanning, Lagziel, Kitajiri, Ramzan, Khan, Chattaraj, Friedman, Anderson, Belyantseva, Forge, Friedman (CR13) 2006; 79 Morton (CR3) 1991; 630 Friedman, Bykhovskaya, Sue, DiMauro, Bradley, Fallis-Cunningham, Paradies, Pensak, Smith, Groden, Li, Fischel-Ghodsian (CR2) 1999; 84 Woods, Cox, Springell, Hampshire, Mohamed, McKibbin, Stern, Raymond, Sandford, Malik Sharif, Karbani, Ahmed, Bond, Clayton, Inglehearn (CR6) 2006; 78 Zelante, Gasparini, Estivill, Melchionda, D'Agruma, Govea, Mila, Monica, Lutfi, Shohat, Mansfield, Delgrosso, Rappaport, Surrey, Fortina (CR10) 1997; 6 Kenneson, Van Naarden Braun, Boyle (CR5) 2002; 4 Marlin, Garabedian, Roger, Moatti, Matha, Lewin, Petit, Denoyelle (CR11) 2001; 127 Miller, Dykes, Polesky (CR7) 1988; 16 Shahin, Walsh, Rayyan, Lee, Higgins, Dickel, Lewis, Thompson, Baker, Nord, Stray, Gurwitz, Avraham, King, Kanaan (CR8) 2010; 18 Kurima, Peters, Yang, Riazuddin, Ahmed, Naz, Arnaud, Drury, Mo, Makishima, Ghosh, Menon, Deshmukh, Oddoux, Ostrer, Khan, Deininger, Hampton, Sullivan, Battey, Keats, Wilcox, Friedman, Griffith (CR14) 2002; 30 A Kenneson (826_CR5) 2002; 4 K Kurima (826_CR14) 2002; 30 S Marlin (826_CR11) 2001; 127 CG Woods (826_CR6) 2006; 78 L Zelante (826_CR10) 1997; 6 M Bitner-Glindzicz (826_CR4) 2002; 63 SA Miller (826_CR7) 1988; 16 H Shahin (826_CR8) 2010; 18 S Riazuddin (826_CR13) 2006; 79 RA Friedman (826_CR2) 1999; 84 NE Morton (826_CR3) 1991; 630 ML Marazita (826_CR1) 1993; 46 MH Al-Qahtani (826_CR9) 2010; 14 MM Carrasquillo (826_CR12) 1997; 6 19888295 - Eur J Hum Genet. 2010 Apr;18(4):407-13 8322805 - Am J Med Genet. 1993 Jun 15;46(5):486-91 17186462 - Am J Hum Genet. 2006 Dec;79(6):1040-51 12172392 - Genet Med. 2002 Jul-Aug;4(4):258-74 1952587 - Ann N Y Acad Sci. 1991;630:16-31 10340654 - Am J Med Genet. 1999 Jun 4;84(4):369-72 19929407 - Genet Test Mol Biomarkers. 2010 Feb;14(1):79-83 11493200 - Arch Otolaryngol Head Neck Surg. 2001 Aug;127(8):927-33 11850618 - Nat Genet. 2002 Mar;30(3):277-84 3344216 - Nucleic Acids Res. 1988 Feb 11;16(3):1215 16642444 - Am J Hum Genet. 2006 May;78(5):889-96 9285800 - Hum Mol Genet. 1997 Sep;6(9):1605-9 9328482 - Hum Mol Genet. 1997 Nov;6(12):2163-72 12324385 - Br Med Bull. 2002;63:73-94 |
| References_xml | – volume: 630 start-page: 16 year: 1991 end-page: 31 ident: CR3 article-title: Genetic epidemiology of hearing impairment publication-title: Ann N Y Acad Sci doi: 10.1111/j.1749-6632.1991.tb19572.x – volume: 78 start-page: 889 year: 2006 end-page: 896 ident: CR6 article-title: Quantification of homozygosity in consanguineous individuals with autosomal recessive disease publication-title: Am J Hum Genet doi: 10.1086/503875 – volume: 18 start-page: 407 year: 2010 end-page: 413 ident: CR8 article-title: Five novel loci for inherited hearing loss mapped by SNP-based homozygosity profiles in Palestinian families publication-title: Eur J Hum Genet doi: 10.1038/ejhg.2009.190 – volume: 6 start-page: 2163 year: 1997 end-page: 2172 ident: CR12 article-title: Two different connexin 26 mutations in an inbred kindred segregating non-syndromic recessive deafness: implications for genetic studies in isolated populations publication-title: Hum Mol Genet doi: 10.1093/hmg/6.12.2163 – volume: 30 start-page: 277 year: 2002 end-page: 284 ident: CR14 article-title: Dominant and recessive deafness caused by mutations of a novel gene, TMC1, required for cochlear hair-cell function publication-title: Nat Genet doi: 10.1038/ng842 – volume: 79 start-page: 1040 year: 2006 end-page: 1051 ident: CR13 article-title: Tricellulin is a tight-junction protein necessary for hearing publication-title: Am J Hum Genet doi: 10.1086/510022 – volume: 63 start-page: 73 year: 2002 end-page: 94 ident: CR4 article-title: Hereditary deafness and phenotyping in humans publication-title: Br Med Bull doi: 10.1093/bmb/63.1.73 – volume: 6 start-page: 1605 year: 1997 end-page: 1609 ident: CR10 article-title: Connexin26 mutations associated with the most common form of non-syndromic neurosensory autosomal recessive deafness (DFNB1) in Mediterraneans publication-title: Hum Mol Genet doi: 10.1093/hmg/6.9.1605 – volume: 16 start-page: 1215 year: 1988 ident: CR7 article-title: A simple salting out procedure for extracting DNA from human nucleated cells publication-title: Nucleic Acids Res doi: 10.1093/nar/16.3.1215 – volume: 14 start-page: 79 year: 2010 end-page: 83 ident: CR9 article-title: Spectrum of GJB2 mutations in a cohort of nonsyndromic hearing loss cases from the Kingdom of Saudi Arabia publication-title: Genet Test Mol Biomarkers doi: 10.1089/gtmb.2009.0111 – volume: 127 start-page: 927 year: 2001 end-page: 933 ident: CR11 article-title: Connexin 26 gene mutations in congenitally deaf children: pitfalls for genetic counseling publication-title: Arch Otolaryngol Head Neck Surg doi: 10.1001/archotol.127.8.927 – volume: 46 start-page: 486 year: 1993 end-page: 491 ident: CR1 article-title: Genetic epidemiological studies of early-onset deafness in the U.S. school-age population publication-title: Am J Med Genet doi: 10.1002/ajmg.1320460504 – volume: 84 start-page: 369 year: 1999 end-page: 372 ident: CR2 article-title: Maternally inherited nonsyndromic hearing loss publication-title: Am J Med Genet doi: 10.1002/(SICI)1096-8628(19990604)84:4<369::AID-AJMG12>3.0.CO;2-V – volume: 4 start-page: 258 year: 2002 end-page: 274 ident: CR5 article-title: GJB2 (connexin 26) variants and nonsyndromic sensorineural hearing loss: a HuGE review publication-title: Genet Med doi: 10.1097/00125817-200207000-00004 – volume: 79 start-page: 1040 year: 2006 ident: 826_CR13 publication-title: Am J Hum Genet doi: 10.1086/510022 – volume: 46 start-page: 486 year: 1993 ident: 826_CR1 publication-title: Am J Med Genet doi: 10.1002/ajmg.1320460504 – volume: 16 start-page: 1215 year: 1988 ident: 826_CR7 publication-title: Nucleic Acids Res doi: 10.1093/nar/16.3.1215 – volume: 84 start-page: 369 year: 1999 ident: 826_CR2 publication-title: Am J Med Genet doi: 10.1002/(SICI)1096-8628(19990604)84:4<369::AID-AJMG12>3.0.CO;2-V – volume: 630 start-page: 16 year: 1991 ident: 826_CR3 publication-title: Ann N Y Acad Sci doi: 10.1111/j.1749-6632.1991.tb19572.x – volume: 4 start-page: 258 year: 2002 ident: 826_CR5 publication-title: Genet Med doi: 10.1097/00125817-200207000-00004 – volume: 63 start-page: 73 year: 2002 ident: 826_CR4 publication-title: Br Med Bull doi: 10.1093/bmb/63.1.73 – volume: 127 start-page: 927 year: 2001 ident: 826_CR11 publication-title: Arch Otolaryngol Head Neck Surg doi: 10.1001/archotol.127.8.927 – volume: 14 start-page: 79 year: 2010 ident: 826_CR9 publication-title: Genet Test Mol Biomarkers doi: 10.1089/gtmb.2009.0111 – volume: 78 start-page: 889 year: 2006 ident: 826_CR6 publication-title: Am J Hum Genet doi: 10.1086/503875 – volume: 30 start-page: 277 year: 2002 ident: 826_CR14 publication-title: Nat Genet doi: 10.1038/ng842 – volume: 18 start-page: 407 year: 2010 ident: 826_CR8 publication-title: Eur J Hum Genet doi: 10.1038/ejhg.2009.190 – volume: 6 start-page: 1605 year: 1997 ident: 826_CR10 publication-title: Hum Mol Genet doi: 10.1093/hmg/6.9.1605 – volume: 6 start-page: 2163 year: 1997 ident: 826_CR12 publication-title: Hum Mol Genet doi: 10.1093/hmg/6.12.2163 – reference: 9285800 - Hum Mol Genet. 1997 Sep;6(9):1605-9 – reference: 1952587 - Ann N Y Acad Sci. 1991;630:16-31 – reference: 9328482 - Hum Mol Genet. 1997 Nov;6(12):2163-72 – reference: 17186462 - Am J Hum Genet. 2006 Dec;79(6):1040-51 – reference: 8322805 - Am J Med Genet. 1993 Jun 15;46(5):486-91 – reference: 19888295 - Eur J Hum Genet. 2010 Apr;18(4):407-13 – reference: 19929407 - Genet Test Mol Biomarkers. 2010 Feb;14(1):79-83 – reference: 11493200 - Arch Otolaryngol Head Neck Surg. 2001 Aug;127(8):927-33 – reference: 11850618 - Nat Genet. 2002 Mar;30(3):277-84 – reference: 10340654 - Am J Med Genet. 1999 Jun 4;84(4):369-72 – reference: 12172392 - Genet Med. 2002 Jul-Aug;4(4):258-74 – reference: 12324385 - Br Med Bull. 2002;63:73-94 – reference: 16642444 - Am J Hum Genet. 2006 May;78(5):889-96 – reference: 3344216 - Nucleic Acids Res. 1988 Feb 11;16(3):1215 |
| SSID | ssj0017833 |
| Score | 2.0449162 |
| Snippet | Background
Hearing loss is a clinically and genetically heterogeneous disorder. Mutations in the
DFNB1
locus have been reported to be the most common cause of... Hearing loss is a clinically and genetically heterogeneous disorder. Mutations in the DFNB1 locus have been reported to be the most common cause of autosomal... Background Hearing loss is a clinically and genetically heterogeneous disorder. Mutations in the DFNB1 locus have been reported to be the most common cause of... Abstract Background Hearing loss is a clinically and genetically heterogeneous disorder. Mutations in the DFNB1 locus have been reported to be the most common... |
| SourceID | doaj pubmedcentral proquest gale pubmed crossref springer |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 91 |
| SubjectTerms | Analysis Biomedical and Life Sciences Biomedicine Clinical-Molecular Genetics and Cytogenetics Connexin 26 Connexins - genetics Cytogenetics Demographic aspects Family Gene Function Genes, Recessive Genetic aspects Genetic Heterogeneity Genetic Linkage Genetic susceptibility Genetic Testing Hearing loss Hearing Loss - epidemiology Hearing Loss - genetics Human Genetics Humans Medical screening Methods Mutation Research Article Risk factors Saudi Arabia - epidemiology |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3NaxUxEA9SULyI1q9tqwQR1MPaZPO5x6dYqqAHa6G3kM0m9kHZLd33Dv73ndnNe3QrxYvXZAKTyWxmsvnlN4S8RcIQGb0sbRC6lHVblT5wVcY2yVZWHoLGiLb4oY9P5bczdXaj1BdiwiZ64MlwhyYE0wiWRKqYjK23rfDKmmQEMtWFkeeT1WxzmMr3B8aOReQ5bL1lJRTLpD7c6sNtG4ISaj6LRyNt_9-b843odBs5eev6dIxKR4_Jo5xO0sU0jSfkXux2yf2pwOSfXfLge746f0r6BUX4-FU8nyDrdIkY9XYij6WrnkImSMGb8FEjhdi2HGifaNd3ZSY1gGasfg1q0AuYCYwfh5z4dbsEBTySl9PLbT2wZ-T06Muvz8dlrrZQBjjCrErNqponLnSLHGSpiroRvIqi8Y1SVguwW12HYCVvRdDGNMx6ZmKyzCQrUyOekx1QKr4kNEBWEYMOomm4DEE2prYVHMxUSMq0PBTk48bmLmQqcqyIceHGI4nVDhfJ4SI5XrmaF-T9dsDlxMJxt-gnXMStGNJnjw3gVC47lfuXUxXkDbqAQ4KMDhE4v_16GNzXk59uUWmFWShTBXmXhVIP2gefHzSADZBTayZ5MJOELzjMuunG0xx2Ieyti_16cNYiblZZUOjF5HjbeWFhMcgmYbCZueRs4vOebnk-8ofDHi6FNQX5sHFelzeu4S6r7v0Pq-6Th9MfeVMyeUB2Vlfr-ApSulXzevx6rwGmgkOc priority: 102 providerName: Directory of Open Access Journals – databaseName: Springer Nature OA/Free Journals dbid: C6C link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9QwELZQEYgLgvIKFGQhJOAQiN_OcVlRFSQ4UCr1ZjmOTVeqNlWze-DfM5N4o6bQA9d4Rhrb4_E4_vwNIW-QMERGL0sbhC5l3fLSB6bK2CbZSu5h0xjQFt_10Yn8eqpOM0kSvoW5en_PrP7IIHiWXKgBQoCv1G8riLqI3Vvq5XRdYKwQmbfnH0qzLWdg5v87_l7ZgK6DI6_dkA4bz-EDcj9njHQxTvFDciuu98mdsYbk731y91u-HX9EugVFhPhlPBtR6XSFMPR25Ielm45CskfBYfDdIoXta9XTLlE4_5eZtwA-Y4FrMIOeQ09Af1A59tt2BQZ45CenF1PJr8fk5PDzz-VRmQsqlAFOKZtSV7xmiQndIs1Y4lE3gvEoGt8oZbWAcavrEKxkrQjamKayvjIx2cokK1MjnpA9MCo-IzRA4hCDDqJpmAxBNqa2HM5eKiRlWhYK8mE35i5ktnEsenHuhlOH1Q4nyeEkOcZdzQryblK4GIk2bhb9hJM4iSFD9vABHMflBedMCKYRVRKJVzK23rbCK2uSEchwGERBXqMLOOTAWCPI5pff9r37cvzDLbhWmGhWqiBvs1DqwPrg85sFGAOkzZpJHswkYZGGWTPdeZrDJkS2rWO37Z21CI1VFgx6Ojre1C-sHQYJIyibmUvOOj5vWa_OBopwCNNSWFOQ9zvndTk29TeN6vP_kH1B7o3_1k1ZyQOyt7ncxpeQnG2aV8PC_AMglTA3 priority: 102 providerName: Springer Nature |
| Title | A comprehensive introduction to the genetic basis of non-syndromic hearing loss in the Saudi Arabian population |
| URI | https://link.springer.com/article/10.1186/1471-2350-12-91 https://www.ncbi.nlm.nih.gov/pubmed/21726435 https://www.proquest.com/docview/881090583 https://pubmed.ncbi.nlm.nih.gov/PMC3224387 https://doaj.org/article/7cc7b30f3f204eda8d3a587f734759c3 |
| Volume | 12 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwhV3db9MwELdgE4gXBOOrMCoLIQEP2RLbsZ0HhLqq00DahDYq9c1KHHurVCWjHxJ74W_nzkk7MjbxUqnxuT2f73zn-Pw7Qt4jYIhwuYi05TISWcmi3CZp5EovSsFycBoh2-JEHo3Ft0k6uS4H1ApwcevWDutJjeezvV8_r76AwX8OBq_lfgILbMR4GtIM8Cb7NvwDQxU_FtdHCkqHuvIb4hbn55Yf6LiogOT_73r9l8O6mUx540Q1OKrDJ-RxG2HSQaMST8k9V-2QB03Nyasd8vC4PU1_RuoBxYzyubtostjpFNPWywZPli5rCsEhBQXDe44U3N10QWtPq7qKWpwDeIwFsYENOoORQP_Q5SxflVNgIEc8c3q5KRH2nIwPRz-GR1FbgCGysKtZRjJmWeITLkuEJfPMyYInzPEiL9JUSw5yyzJrtUhKbqVSRazzWDmvY-W18AV_QbaAKfeKUAuBhrPS8qJIhLWiUJlmsFdLrU9Vmdge2VvL3NgWnRyLZMxM2KVoaXCSDE6SSZjJkh75uOlw2QBz3E16gJO4IUNE7fCgnp-b1kCNslYVPPbcs1i4Mtclz1OtvOKIiGh5j7xDFTCImVFhUs55vloszNezUzNgMsXANE575ENL5Gvg3ubtHQeQAcJsdSh3O5Rg1LbTTNeaZrAJM-EqV68WRmtMpU01MPSyUbzNuLDWGASY0Fl1VLIz8G5LNb0IkOKwrAuuVY98WiuvWZviXVJ9_X8W35BHzSt4FcVil2wt5yv3FmK4ZdEn99VE9cn2wejk-yl8G8phP7wP6Qerxc_foz_hykSf |
| linkProvider | Scholars Portal |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9QwELZQEdALgvIKFLAQEnBIieNnjktFtYW2B9pKvVmOY9OVqk3V7B7675lJvKum0APXeEYae8aecWb8DSEfETBEBCdy47nKRdWUufNM5qGJohGlA6fRV1scqemp-HEmzxJIEr6FuZm_Z0Z9ZXB45iWXfQkBvlK_j2nLPiurdtfpAm04T7g9_2AauZwemf_v8_eGA7pdHHkrQ9o7nr0n5HGKGOlkUPFTci_Mt8iDoYfk9RZ5eJiy489IO6FYIX4VzoeqdDrDMvRmwIeli5ZCsEfBYPDdIgX3NetoGync__OEWwCfscE1iEEvYCbA37Mcu2UzAwEc4pPTy3XLr-fkdO_7ye40Tw0Vcg-3lEWuirJikXHVIMxYLIOqOSsDr10tpVEc1q2qvDeCNdwrrevCuEKHaAodjYg1f0E2QKjwilAPgUPwyvO6ZsJ7UevKlHD3kj5K3TCfkZ3Vmluf0Max6cWF7W8dRllUkkUlWVbaimXk85rhcgDauJv0GypxTYYI2f0HMBybNpzV3uuaF5HHshChcabhThodNUeEQ88z8gFNwCIGxhyLbH67ZdfZ_eNfdlIqiYFmITPyKRHFFqT3Lr1ZgDVA2KwR5faIEjapHw3TlaVZHMLKtnlol501BktjpQGBXg6Gt54X9g6DgBGY9cgkRxMfj8xn5z1EOBzTghudkS8r47XpbOruWtXX_0H7njyanhwe2IP9o59vyObwn13nhdgmG4urZXgLgdqiftdv0j-YCzMm |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9QwELZQERUXBOXRhQIWQgIOoUn8zHFZWLU8KkSp1JuV-NGuVCWrTfbAv2cm8a5IoQeu8Yw0tseecfz5G0JeI2EI9yVPtGUy4YXLk9JmIvEucMfzEoJGj7Y4kUdn_PO5OI_YnHaDdt9cSQ5vGpClqe4Oly4MS1zLwwy21CRnogcW4Nv120jUhdT5MznbXiIozVhk8_mH0igQ9Xz9f-_Kf4Sl65DJa_emfTia3yf3Yh5Jp8PEPyC3fL1H7gyVJX_tkd1v8c78IWmmFHHjK385YNXpAsHpbmCNpV1DIQWk4Eb4mpFCUFu0tAm0buokshnAZyx7DWbQK-gJ6Pcqp-XaLcCAElnL6XJbCOwROZt_-jk7SmKZhcTC2aVLZJoXWciYdEg-FnIvK5blnlVlJYSWDMatKKzVPHPMSqWqVJep8kGnKmgeKvaY7IBRfp9QC-mEt9Kyqsq4tbxShc7hRCZsEMpldkLeb8bc2MhBjqUwrkx_FtHS4CQZnCST5abIJuTtVmE50G_cLPoBJ3ErhrzZ_YdmdWHiMjTKWlWxNLCQp9y7UjtWCq2CYsh7aNmEvEIXMMiMUSP05qJct605Pv1hprkUmH6mYkLeRKHQgPW2jC8ZYAyQTGskeTCShKVrR81042kGmxDvVvtm3RqtETArNBj0ZHC8bb-wohikkaCsRi456vi4pV5c9sThsHlzptWEvNs4r4k7VnvTqD79D9mXZPf7x7n5enzy5Rm5O_x8V0nKD8hOt1r755C9ddWLfo3-Bi2nO3Y |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+comprehensive+introduction+to+the+genetic+basis+of+non-syndromic+hearing+loss+in+the+Saudi+Arabian+population&rft.jtitle=BMC+medical+genetics&rft.au=Imtiaz%2C+Faiqa&rft.au=Taibah%2C+Khalid&rft.au=Ramzan%2C+Khushnooda&rft.au=Bin-Khamis%2C+Ghada&rft.date=2011-07-04&rft.issn=1471-2350&rft.eissn=1471-2350&rft.volume=12&rft.spage=91&rft_id=info:doi/10.1186%2F1471-2350-12-91&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1471-2350&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1471-2350&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1471-2350&client=summon |