Detecting very low allele fraction variants using targeted DNA sequencing and a novel molecular barcode-aware variant caller - Xu, Chang; Nezami Ranjbar, Mohammad R.; Wu, Zhong; DiCarlo, John; Wang, Yexun (BMC genomics, 2017)
Keywords: Algorithms; Alleles; Amplification; Analysis; Animal Genetics and Genomics; Bar codes; Base Sequence; Bayesian analysis; Bioinformatics; Biomedical and Life Sciences; Cancer research; Computational Biology - methods; Deoxyribonucleic acid; DNA; DNA Barcoding, Taxonomic; DNA sequencing; Efficiency; Enrichment; Gene Frequency; Gene mutation; Genetic Variation; Genomics; Human and rodent genomics; Life Sciences; Mathematical models; Medical research; Methodology; Methodology Article; Microarrays; Microbial Genetics and Genomics; Models, Statistical; Multiplex Polymerase Chain Reaction; Mutation; Next-generation sequencing; Nucleotide sequence; Plant Genetics and Genomics; Polymerase chain reaction; Precision medicine; Probabilistic models; Proteomics; Protocol; Quality; Reproducibility of Results; Researchers; Sensitivity and Specificity; Statistical analysis; Statistical models; Molecular barcode; Variant caller; PCR enrichment; Statistical model